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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Melatonin.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Melatonin and the liver

"Its use is not recommended during pregnancy or breastfeeding or for those with liver disease.[7][13]"

New studies suggest that melatonin supplementation may be a promising adjunct for liver disease.

https://www.mdpi.com/2072-6643/10/9/1135 — Preceding unsigned comment added by Dreizweins (talk • contribs) 23:57, 8 September 2020 (UTC)[reply]

Orcid IDs

@Invasive Spices: Why are you adding Orcid IDs to citations? It polutes the meta data. You are also hyping the authors. Focus on the conclusions of the study, not who wrote it. Thanks. Boghog (talk) 19:06, 24 September 2021 (UTC)[reply]

That's pretty funny coming from someone who removes and damages as much author data as you can. As for hyping the authors, I normally don't and would agree that is inappropriate, however I do so if working from a rev and the rev thinks that paper is so singular as to be worth promoting. (Also I don't see any such on this article. But I've done that elsewhere.) Invasive Spices (talk) 19:20, 24 September 2021 (UTC)[reply]
- Again, I am trying to have a serious discussion, and you refuse to directly respond. Why does every single author deserve an external link to their other publications? Boghog (talk) 19:26, 24 September 2021 (UTC)[reply]

Abbriviations

In image of head, what go SCN, RHT, MCRGC denote? Use hormonal, not humoral, reminiscent of Ancient Greek 5 humors. 98.144.238.191 (talk) 14:17, 12 June 2022 (UTC)[reply]

To add to article

Basic information to add to this article: the etymology of the word "melatonin." According to Wiktionary, it is a blend of melanin +‎ serotonin. If that's true, why not add this information to this article, in order to help make it properly encyclopedic? 173.88.246.138 (talk) 01:11, 9 March 2023 (UTC)[reply]

Useful suggestion, and done. Chhandama (talk) 09:09, 10 March 2023 (UTC)[reply]

On skin lightening in frogs

The head says that the hormone elicits skin lightening in the common frog, with a wikilink to skin whitening, where it is described as "the practice of using chemical substances in an attempt to lighten the skin or provide an even skin color by reducing the melanin concentration in the skin." That specific human practice doesn't seem to be a relevant link unless I'm missing something. Understandable mistake, but remove? Moonjail (talk) 04:13, 8 April 2023 (UTC)[reply]

I was reading this too and thinking was this someone's idea of having a wind-up? (joke). How do they make the jump from the 'brain of cows' to 'lightening skins of frogs'? Was it a lab experiment? Did a cow trip and fall on a frog and the brain splat out and made the frog lighter. So many questions with that statement that seem questionable and more like April 1. (???) CaribDigita (talk) 03:27, 14 June 2024 (UTC)[reply]

Source of melatonin not stated

this article does not state the source of melatonin used in either Rx or OTC products. If it has a synthetic source that should be under scrutiny because in the past impurities from synthetic tryptophan had caused abnormal blood cell production. Both melatonin and tryptophan have in common an indole ring . 2603:6011:F7F0:1C30:3957:B73:DB53:46D9 (talk) 03:25, 13 October 2023 (UTC)[reply]

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+== Melatonin and the liver ==
+"Its use is not recommended during pregnancy or breastfeeding or for those with liver disease.[7][13]"
-"Melatonin is rapidly absorbed and distributed, reaching peak plasma concentrations after 60 minutes of administration, and is then eliminated. Melatonin has a half life of 35–50 minutes."
+New studies suggest that melatonin supplementation may be a promising adjunct for liver disease.
-How does that work?  <!-- Template:Unsigned --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Drsruli|Drsruli]] ([[User talk:Drsruli#top|talk]] • [[Special:Contributions/Drsruli|contribs]]) 14:47, 22 July 2019 (UTC)</small> <!--Autosigned by SineBot-->
+https://www.mdpi.com/2072-6643/10/9/1135  <!-- Template:Unsigned --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Dreizweins|Dreizweins]] ([[User talk:Dreizweins#top|talk]] • [[Special:Contributions/Dreizweins|contribs]]) 23:57, 8 September 2020 (UTC)</small> <!--Autosigned by SineBot-->
+== Orcid IDs ==
-==We already have a section on this==
-And we provide a better summary of the evidence. [[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 11:47, 24 January 2020 (UTC)
+{{ping|Invasive Spices}} Why are you adding [https://en.wikipedia.org/enwiki/w/index.php?title=Melatonin&type=revision&diff=1046080980&oldid=1046039043 Orcid IDs] to citations?  It polutes the meta data. You are also hyping the authors. Focus on the conclusions of the study, not who wrote it. Thanks. [[User:Boghog|Boghog]] ([[User talk:Boghog|talk]]) 19:06, 24 September 2021 (UTC)
-=== Alzheimer's disease ===
+* That's pretty funny coming from someone who removes and damages as much author data as you can. As for hyping the authors, I normally don't and would agree that is inappropriate, however I do so if working from a rev and the rev thinks that paper is so singular as to be worth promoting. (Also I don't see any such on this article. But I've done that elsewhere.) [[User:Invasive Spices|Invasive Spices]] ([[User talk:Invasive Spices|talk]]) 19:20, 24 September 2021 (UTC)
-Hypothalamic nuclei, such as the suprachiasmatic nuclei and the lateral hypothalamic area, that are affected by β-amyloid plaques and neurofilament tangles in brains with Alzheimer's diseases are also involved in the severe disruption of the circadian rhythm and consequently, the occurrence of sleep disorders.<ref name=":3">{{Cite journal|last=Spinedi|first=Eduardo|last2=Cardinali|first2=Daniel&nbsp;P.|date=2019|title=Neuroendocrine-Metabolic Dysfunction and Sleep Disturbances in Neurodegenerative Disorders: Focus on Alzheimer’s Disease and Melatonin|url=https://www.karger.com/Article/FullText/494889|journal=Neuroendocrinology|language=en|volume=108|issue=4|pages=354–364|doi=10.1159/000494889|issn=0028-3835}}</ref> Sleep disturbances as well as poor sleep quality may contribute to the development of Alzheimer's disease, to some degree through the facilitation of β-amyloid buildup (a risk factor for Alzheimer's disease) in the human brain.<ref>{{Cite journal|last=Spira|first=Adam P.|last2=Gottesman|first2=Rebecca F.|date=April 2017|title=Sleep disturbance: an emerging opportunity for Alzheimer's disease prevention?|url=https://www.cambridge.org/core/product/identifier/S1041610216002131/type/journal_article|journal=International Psychogeriatrics|language=en|volume=29|issue=4|pages=529–531|doi=10.1017/S1041610216002131|issn=1041-6102|pmc=5493989|pmid=27938445}}</ref><ref>{{Cite journal|last=Brown|first=Belinda M.|last2=Rainey-Smith|first2=Stephanie R.|last3=Villemagne|first3=Victor L.|last4=Weinborn|first4=Michael|last5=Bucks|first5=Romola S.|last6=Sohrabi|first6=Hamid R.|last7=Laws|first7=Simon M.|last8=Taddei|first8=Kevin|last9=Macaulay|first9=S. Lance|last10=Ames|first10=David|last11=Fowler|first11=Christopher|date=2016-05-01|title=The Relationship between Sleep Quality and Brain Amyloid Burden|url=https://academic.oup.com/sleep/article/39/5/1063/2454042|journal=Sleep|language=en|volume=39|issue=5|pages=1063–1068|doi=10.5665/sleep.5756|issn=0161-8105|pmc=4835305|pmid=27091528}}</ref> Research shows that in the pre-onset stages of Alzheimer's disease, melatonin levels in the CSF are significantly lower.<ref name=":3" /> Furthermore, there is evidence in transgenic animal models of Alzheimer's disease that the exogenous administration of melatonin not only decreases the production and/or deposition of β-amyloid peptide but also increases its clearance through the glymphatic system.<ref>{{Cite journal|last=Shukla|first=Mayuri|last2=Govitrapong|first2=Piyarat|last3=Boontem|first3=Parichart|last4=Reiter|first4=Russel  J.|last5=Satayavivad|first5=Jutamaad|date=2017-08-28|title=Mechanisms of Melatonin in Alleviating Alzheimer’s Disease|url=http://www.eurekaselect.com/150847/article|journal=Current Neuropharmacology|language=en|volume=15|issue=7|doi=10.2174/1570159X15666170313123454|pmc=5652010|pmid=28294066}}</ref> Recent research concluded that exogenous melatonin administered in the preclinical phase of dementia demonstrates a significant increase in sleep quality and efficiency.<ref name=":3" />
+** Again, I am trying to have a serious discussion, and you refuse to directly respond.  Why does every single author deserve an external link to their other publications?  [[User:Boghog|Boghog]] ([[User talk:Boghog|talk]]) 19:26, 24 September 2021 (UTC)
+== Abbriviations ==
-{{reflist-talk}}
+In image of head, what go SCN, RHT, MCRGC denote? Use hormonal, not humoral, reminiscent of Ancient Greek 5 humors. [[Special:Contributions/98.144.238.191|98.144.238.191]] ([[User talk:98.144.238.191|talk]]) 14:17, 12 June 2022 (UTC)
-==Ordering==
-The ordering of this article follows [[WP:MEDMOS]] and has for some time. So restored. [[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 16:44, 29 March 2020 (UTC)
-== COVID-19 and melatonin? ==
+== To add to article ==
+Basic information to add to this article: the etymology of the word "melatonin." According to Wiktionary, it is a blend of [[melanin]] +‎ [[serotonin]]. If that's true, why not add this information to this article, in order to help make it properly encyclopedic? [[Special:Contributions/173.88.246.138|173.88.246.138]] ([[User talk:173.88.246.138|talk]]) 01:11, 9 March 2023 (UTC)
-I think that the section should be removed.  <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/97.113.124.116|97.113.124.116]] ([[User talk:97.113.124.116#top|talk]]) 05:47, 3 August 2020 (UTC)</small> <!--Autosigned by SineBot-->
-I agree that the research is too preliminary for an encyclopedia article and I deleted the entire section. [[User:Janopus|Tachyon]] ([[User talk:Janopus|talk]]) 12:38, 3 August 2020 (UTC)
+:Useful suggestion, and done. [[User:Chhandama|Chhandama]] ([[User talk:Chhandama|talk]]) 09:09, 10 March 2023 (UTC)
-== Melatonin and the liver ==
+== On skin lightening in frogs ==
-"Its use is not recommended during pregnancy or breastfeeding or for those with liver disease.[7][13]"
+The head says that the hormone elicits skin lightening in the common frog, with a wikilink to [[skin whitening]], where it is described as "the practice of using chemical substances in an attempt to lighten the skin or provide an even skin color by reducing the melanin concentration in the skin." That specific human practice doesn't seem to be a relevant link unless I'm missing something. Understandable mistake, but remove? [[User:Moonjail|Moonjail]] ([[User talk:Moonjail|talk]]) 04:13, 8 April 2023 (UTC)
-New studies suggest that melatonin supplementation may be a promising adjunct for liver disease.
+:I was reading this too and thinking was this someone's idea of having a wind-up? (joke). How do they make the jump from the 'brain of cows' to 'lightening skins of frogs'? Was it a lab experiment? Did a cow trip and fall on a frog and the brain splat out and made the frog lighter.  So many questions with that statement that seem questionable and more like April 1. (???) [[User:CaribDigita|CaribDigita]] ([[User talk:CaribDigita|talk]]) 03:27, 14 June 2024 (UTC)
-https://www.mdpi.com/2072-6643/10/9/1135  <!-- Template:Unsigned --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Dreizweins|Dreizweins]] ([[User talk:Dreizweins#top|talk]] • [[Special:Contributions/Dreizweins|contribs]]) 23:57, 8 September 2020 (UTC)</small> <!--Autosigned by SineBot-->
+== Source of melatonin not stated ==
-== Orcid IDs ==
+this article does not state the source of melatonin used in either Rx or OTC products. If it has a synthetic source that should be under scrutiny because in the past impurities from synthetic tryptophan had caused abnormal blood cell production. Both melatonin and tryptophan have in common an indole ring  . [[Special:Contributions/2603:6011:F7F0:1C30:3957:B73:DB53:46D9|2603:6011:F7F0:1C30:3957:B73:DB53:46D9]] ([[User talk:2603:6011:F7F0:1C30:3957:B73:DB53:46D9|talk]]) 03:25, 13 October 2023 (UTC)
-{{ping|Invasive Spices}} Why are you adding [https://en.wikipedia.org/enwiki/w/index.php?title=Melatonin&type=revision&diff=1046080980&oldid=1046039043 Orcid IDs] to citations?  It polutes the meta data. You are also hyping the authors. Focus on the conclusions of the study, not who wrote it. Thanks. [[User:Boghog|Boghog]] ([[User talk:Boghog|talk]]) 19:06, 24 September 2021 (UTC)
-* That's pretty funny coming from someone who removes and damages as much author data as you can. As for hyping the authors, I normally don't and would agree that is inappropriate, however I do so if working from a rev and the rev thinks that paper is so singular as to be worth promoting. (Also I don't see any such on this article. But I've done that elsewhere.) [[User:Invasive Spices|Invasive Spices]] ([[User talk:Invasive Spices|talk]]) 19:20, 24 September 2021 (UTC)
-** Again, I am trying to have a serious discussion, and you refuse to directly respond.  Why does every single author deserve an external link to their other publications?  [[User:Boghog|Boghog]] ([[User talk:Boghog|talk]]) 19:26, 24 September 2021 (UTC)