User:Bleuie/Evaluate an Article: Difference between revisions
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| ⚫ | ----Oxcarbazepine (brand name Trileptal), has been historically used [[Off-label use|off-label]] by psychiatrists as a [[mood stabilizer]].However due to the limited data supporting efficacy it is typically reserved for patients for whom other medications have not worked or are [[Contraindication|contraindicated]] <ref>{{Cite journal |last=Brown |first=Brandon |last2=Tong |first2=Brian |last3=Pro |first3=Luke |last4=Kitten |first4=Suzanna |date=2024-06-01 |title=Oxcarbazepine for the treatment of bipolar and depressive disorders in the outpatient setting: A retrospective chart review |url=https://www.sciencedirect.com/science/article/pii/S2772598724000175#:~:text=Oxcarbazepine%20was%20modestly%20effective%20in,treatments%20are%20ineffective%20or%20unsuitable. |journal=Psychiatry Research Communications |volume=4 |issue=2 |pages=100171 |doi=10.1016/j.psycom.2024.100171 |issn=2772-5987}}</ref> <ref>{{Cite web |title=Oxcarbazepine for acute affective episodes of bipolar disorder |url=https://www.cochrane.org/CD004857/DEPRESSN_oxcarbazepine-for-acute-affective-episodes-of-bipolar-disorder |access-date=2024-12-01 |website=www.cochrane.org |language=en}}</ref>. |
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''There is limited data analyzing the impact of oxcarbazepine on a human fetus. Animal studies have shown increased fetal abnormalities in pregnant rats and rabbits exposed to oxcarbazepine during pregnancy. In addition, oxcarbazepine is structurally similar to carbamazepine, which is considered to be [[Teratology|teratogenic]] in humans (pregnancy category D). Oxcarbazepine should only be used during pregnancy if the benefits justify the risks.'' |
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| ⚫ | ----Oxcarbazepine is [[Pregnancy category|pregnancy category C]] in the US. <ref>{{Cite web |title= |url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021014s036lbl.pdf}}</ref>There is limited data supporting it's safety in pregnancy. Several alternative medications with similar efficacy profiles provide significantly more robust data to support safety during pregnancy. <ref>{{Cite web |last=Health |first=MGH Center for Women's Mental |date=2017-06-07 |title=Oxcarbazepine (Trileptal) and Pregnancy: Do We Have Enough Information? - MGH Center for Women's Mental Health |url=https://womensmentalhealth.org/posts/oxcarbazepine-trileptal-pregnancy-enough-information/ |access-date=2024-12-01 |language=en-US}}</ref> However limited recent research shows similar rates of [[Teratology|fetal malformations]] in exposed pregnancies to the general non-[[teratogen]] exposed population.<ref>{{Cite web |last=Health |first=MGH Center for Women's Mental |date=2019-04-22 |title=Clinical Update (2019): Is Oxcarbazepine (Trileptal) Safe to Use During Pregnancy? - MGH Center for Women's Mental Health |url=https://womensmentalhealth.org/posts/clinical-update-2019-is-oxcarbazepine-trileptal-safe-to-use-during-pregnancy/ |access-date=2024-12-01 |language=en-US}}</ref> Careful consideration of the risks, benefits, alternatives, and expert advise is needed when considering Oxcarbazepine use during pregnancy. |
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| ⚫ | Historically Oxcarbazepine was considered to be teratogenic in humans due to animal studies which have shown increased fetal abnormalities in pregnant rats and rabbits exposed to oxcarbazepine during pregnancy. Additionally it's similar structure of to carbamazepine, raised concern as it is teratogenic in humans (pregnancy category D).<ref>{{Cite web |title=Reprotox • Login |url=https://reprotox.org/login |access-date=2024-12-01 |website=reprotox.org}}</ref> <ref>{{Cite journal |last=Erisgin |first=Zuleyha |last2=Ayas |first2=Bulent |last3=Nyengaard |first3=Jens R. |last4=Ercument Beyhun |first4=N. |last5=Terzi |first5=Yuksel |date=2019-02-01 |title=The neurotoxic effects of prenatal gabapentin and oxcarbazepine exposure on newborn rats |url=https://www.tandfonline.com/doi/full/10.1080/14767058.2017.1383378 |journal=The Journal of Maternal-Fetal & Neonatal Medicine |language=en |volume=32 |issue=3 |pages=461–471 |doi=10.1080/14767058.2017.1383378 |issn=1476-7058}}</ref> |
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'''References:''' |
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'''(new section under "medical uses")''' |
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| ⚫ | Oxcarbazepine (brand name Trileptal), |
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'''Pregnancy:''' |
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| ⚫ | Oxcarbazepine is [[Pregnancy category|pregnancy category C]] in the US. <ref>{{Cite web |title= |url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021014s036lbl.pdf}}</ref>There is limited data supporting safety in pregnancy. Several alternative medications with similar efficacy profiles provide significantly more robust data to support safety during pregnancy. <ref>{{Cite web |last=Health |first=MGH Center for Women's Mental |date=2017-06-07 |title=Oxcarbazepine (Trileptal) and Pregnancy: Do We Have Enough Information? - MGH Center for Women's Mental Health |url=https://womensmentalhealth.org/posts/oxcarbazepine-trileptal-pregnancy-enough-information/ |access-date=2024-12-01 |language=en-US}}</ref> |
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| ⚫ | Historically Oxcarbazepine was considered to be |
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Latest revision as of 06:58, 5 December 2024
Psychiatric Uses:
[edit]Oxcarbazepine (brand name Trileptal), has been historically used off-label by psychiatrists as a mood stabilizer.However due to the limited data supporting efficacy it is typically reserved for patients for whom other medications have not worked or are contraindicated [1] [2].
(addendum to pregnancy section)
Pregnancy:
[edit]Oxcarbazepine is pregnancy category C in the US. [3]There is limited data supporting it's safety in pregnancy. Several alternative medications with similar efficacy profiles provide significantly more robust data to support safety during pregnancy. [4] However limited recent research shows similar rates of fetal malformations in exposed pregnancies to the general non-teratogen exposed population.[5] Careful consideration of the risks, benefits, alternatives, and expert advise is needed when considering Oxcarbazepine use during pregnancy.
Historically Oxcarbazepine was considered to be teratogenic in humans due to animal studies which have shown increased fetal abnormalities in pregnant rats and rabbits exposed to oxcarbazepine during pregnancy. Additionally it's similar structure of to carbamazepine, raised concern as it is teratogenic in humans (pregnancy category D).[6] [7]
References:
- ^ Brown, Brandon; Tong, Brian; Pro, Luke; Kitten, Suzanna (2024-06-01). "Oxcarbazepine for the treatment of bipolar and depressive disorders in the outpatient setting: A retrospective chart review". Psychiatry Research Communications. 4 (2): 100171. doi:10.1016/j.psycom.2024.100171. ISSN 2772-5987.
- ^ "Oxcarbazepine for acute affective episodes of bipolar disorder". www.cochrane.org. Retrieved 2024-12-01.
- ^ https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021014s036lbl.pdf.
{{cite web}}: Missing or empty|title=(help) - ^ Health, MGH Center for Women's Mental (2017-06-07). "Oxcarbazepine (Trileptal) and Pregnancy: Do We Have Enough Information? - MGH Center for Women's Mental Health". Retrieved 2024-12-01.
- ^ Health, MGH Center for Women's Mental (2019-04-22). "Clinical Update (2019): Is Oxcarbazepine (Trileptal) Safe to Use During Pregnancy? - MGH Center for Women's Mental Health". Retrieved 2024-12-01.
- ^ "Reprotox • Login". reprotox.org. Retrieved 2024-12-01.
- ^ Erisgin, Zuleyha; Ayas, Bulent; Nyengaard, Jens R.; Ercument Beyhun, N.; Terzi, Yuksel (2019-02-01). "The neurotoxic effects of prenatal gabapentin and oxcarbazepine exposure on newborn rats". The Journal of Maternal-Fetal & Neonatal Medicine. 32 (3): 461–471. doi:10.1080/14767058.2017.1383378. ISSN 1476-7058.