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{{Short description|Protein in humans}}
==C13orf16==
{{infobox gene}}


⚫
'''Chromosome 13 open reading frame 16''' is a [[protein]] in [[homo sapiens]] encoded by the ''C13orf16'' [[gene]]. There is one alias name, '''TEX29''', for the high testis expression of this gene due to [[spermatogenesis]].<ref name=":0">{{Cite web |title=Home - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref><ref name=":1">{{Cite web |title=GeneCards |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=TEX29 |access-date=December 13, 2024 |website=GeneCards}}</ref>
<nowiki>{{Infobox_gene}}</nowiki>
==> Gene==
⚫
Chromosome 13 open reading frame 16 is a [[protein]] in [[homo sapiens|''Homo sapiens'']], encoded by the ''C13orf16'' [[gene]]. There is one alias name, TEX29, for the high testis expression of this gene due to [[spermatogenesis]].<ref name=":0">{{Cite web |title=Home - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref><ref name=":1">{{Cite web |title=GeneCards |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=TEX29 |access-date=December 13, 2024 |website=GeneCards}}</ref>


⚫
C13orf16 in Homo sapiens is located on the long arm of chromosome 13 at q34.<ref name=":1" /> The spliced gene is 859 [[Nucleotide|nucleotides]], has 7 [[exons]] and is located on the plus strand.<ref name=":0" />
'''<u>Gene Location</u>'''


⚫
C13orf16 is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the [[hippocampus]] and [[cerebellum]].<ref name=":0" /><ref>{{Cite web |title=AceView: Gene:C13orf16, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. |url=https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=c13orf16&submit=Go |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref>
⚫
''C13orf16'' in ''Homo sapiens'' is located on the long arm of chromosome 13 at q34.<ref name=":1" /> The spliced gene is 859 [[Nucleotide|nucleotides]], has 7 [[exons]], and is located on the plus strand.<ref name=":0" />


⚫
== Protein ==
'''<u>Gene Regulation</u>'''
⚫
The human C13orf16 protein encoded by the [[mRNA]] sequence is 174 amino acids in length.<ref name=":2">{{Cite web |title=Home - Protein - NCBI |url=https://www.ncbi.nlm.nih.gov/protein/ |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref> The molecular weight without post-transitional modifications is 18.4 KD<ref name=":3">{{Cite web |title=SAPS |url=https://www.ebi.ac.uk/jdispatcher/seqstats/saps |access-date=2024-12-14 |website=www.ebi.ac.uk}}</ref> and the basal [[isoelectric point]] value is 4.99 pH.<ref>{{Cite web |title=PhosphoSitePlus |url=https://www.phosphosite.org/homeAction.action |access-date=2024-12-14 |website=www.phosphosite.org}}</ref>


⚫
Human C13orf16 is localized both intracellularly, in the [[Cell nucleus|nucleus]], and extracellularly with one [[transmembrane domain]] from amino acids 80-102.<ref name=":2" /> There are no [[asparagine]]s, resulting in no [[N-glycosylation]] sites.<ref name=":3" />
⚫
''C13orf16'' is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the [[hippocampus]] and [[cerebellum]].<ref name=":0" /><ref>{{Cite web |title=AceView: Gene:C13orf16, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. |url=https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=c13orf16&submit=Go |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref>


⚫
There are five interacting proteins for human C13orf16, all identified by physical interactions.<ref name=":1" /><ref name=":4">{{Cite web |title=GeneMANIA |url=https://genemania.org/search/homo-sapiens/c13orf16/ |access-date=2024-12-14 |website=genemania.org}}</ref><ref name=":5">{{Cite web |title=TEX29 Result Summary {{!}} BioGRID |url=https://thebiogrid.org/125748/summary/homo-sapiens/tex29.html |access-date=2024-12-14 |website=thebiogrid.org}}</ref>
⚫
==> Protein==
⚫
The Human ''C13orf16'' protein encoded by the [[mRNA]] sequence is 174 amino acids in length.<ref name=":2">{{Cite web |title=Home - Protein - NCBI |url=https://www.ncbi.nlm.nih.gov/protein/ |access-date=2024-12-14 |website=www.ncbi.nlm.nih.gov}}</ref> The molecular weight without post-transitional modifications is 18.4 KD<ref name=":3">{{Cite web |title=SAPS |url=https://www.ebi.ac.uk/jdispatcher/seqstats/saps |access-date=2024-12-14 |website=www.ebi.ac.uk}}</ref> and the basal [[isoelectric point]] value is 4.99 pH.<ref>{{Cite web |title=PhosphoSitePlus |url=https://www.phosphosite.org/homeAction.action |access-date=2024-12-14 |website=www.phosphosite.org}}</ref>


'''<u>Protein Regulation</u>'''

⚫
Human ''C13orf16'' is localized both intracellularly, in the [[nucleus]], and extracellularly with one [[transmembrane domain]] from amino acids 80-102.<ref name=":2" /> There are no [[Asparagine|asparagines]], resulting in no [[N-glycosylation]] sites.<ref name=":3" />

<u>'''Interacting Proteins'''</u>

⚫
There are five interacting proteins for Human ''C13orf16'', all identified by physical interactions.<ref name=":1" /><ref name=":4">{{Cite web |title=GeneMANIA |url=https://genemania.org/search/homo-sapiens/c13orf16/ |access-date=2024-12-14 |website=genemania.org}}</ref><ref name=":5">{{Cite web |title=TEX29 Result Summary {{!}} BioGRID |url=https://thebiogrid.org/125748/summary/homo-sapiens/tex29.html |access-date=2024-12-14 |website=thebiogrid.org}}</ref>
{| class="wikitable"
{| class="wikitable"
⚫
|+ Interacting proteins for human C13orf16 protein<ref name=":1" /><ref name=":4" /><ref name=":5" />
⚫
|'''Abbreviated Name'''
|-
⚫
|'''Full Name'''
⚫
! Abbreviated Name
⚫
|'''Brief Description'''
⚫
! Full Name
⚫
! Brief Description
|-
|-
|PTS
|PTS
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|Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport
|Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport
|}
|}
⚫
Table 1: Interacting proteins for Human ''C13orf16'' protein.<ref name=":1" /><ref name=":4" /><ref name=":5" />


==> Homology/Evolution==
== Homology and evolution==
The C13orf16 protein was only found to have [[orthologs]] in [[Placentalia|placental mammals]] and most distantly found in the [[Proboscidea]] [[taxonomic group]].<ref name=":6">{{Cite web |title=Protein BLAST: search protein databases using a protein query |url=https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins |access-date=2024-12-14 |website=blast.ncbi.nlm.nih.gov}}</ref>
The C13orf16 protein was only found to have [[orthologs]] in [[Placentalia|placental mammals]] and most distantly found in the [[Proboscidea]] [[taxonomic group]].<ref name=":6">{{Cite web |title=Protein BLAST: search protein databases using a protein query |url=https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins |access-date=2024-12-14 |website=blast.ncbi.nlm.nih.gov}}</ref>
In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human ''C13orf16'' protein.<ref>{{Cite web |title=TimeTree :: The Timescale of Life |url=https://timetree.org/ |access-date=2024-12-14 |website=timetree.org |language=en}}</ref>
In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human C13orf16 protein.<ref>{{Cite web |title=TimeTree :: The Timescale of Life |url=https://timetree.org/ |access-date=2024-12-14 |website=timetree.org |language=en}}</ref>
{| class="wikitable"
{| class="wikitable"
⚫
|+ Orthologs of human C13orf16 protein
|-
|Genus & Species
|Genus & Species
|Common Name
|Common Name
|Taxonomic Group
|Taxonomic Group
|Date of Divergence (MYA)
|Date of Divergence (MYA)
|Accession Number
|Accession Number<ref name=":2" />
|Sequence Length (aa)
|Sequence Length (aa)
|Sequence Identity to Human Protein
|Sequence Identity to Human Protein
Line 67: Line 62:
|-
|-
|''Homo sapiens''
|''Homo sapiens''
|Human
|[[Human]]
|Primates
|[[Primate|Primates]]
|0
|0
|NP_001290062
|NP_001290062
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|-
|-
|''Nomascus leucogenys''
|''Nomascus leucogenys''
|Northern Gibbon
|[[Gibbon|Northern Gibbon]]
|Primates
|[[Primate|Primates]]
|19.5
|19.5
|XP_012362426
|XP_012362426
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|-
|-
|''Macaca mulatta''
|''Macaca mulatta''
|Rhesus Macaque
|[[Rhesus macaque|Rhesus Macaque]]
|Primates
|[[Primate|Primates]]
|28.8
|28.8
|XP_028693172
|XP_028693172
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|-
|-
|''Cebus imitator''
|''Cebus imitator''
|White-faced Capuchin
|[[White-faced capuchin|White-faced Capuchin]]
|Primates
|[[Primate|Primates]]
|43
|43
|XP_037585341
|XP_037585341
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|-
|-
|''Peromyscus maniculatus bairdii''
|''Peromyscus maniculatus bairdii''
|Deer Mouse
|[[Deer Mouse]]
|Rodentia
|[[Rodent|Rodentia]]
|87
|87
|XP_042118685
|XP_042118685
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|-
|-
|''Peromyscus leucopus''
|''Peromyscus leucopus''
|White-Footed Mouse
|[[White-footed mouse|White-Footed Mouse]]
|Rodentia
|[[Rodent|Rodentia]]
|87
|87
|XP_037067483
|XP_037067483
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|-
|-
|''Oryctolagus cuniculus''
|''Oryctolagus cuniculus''
|European Rabbit
|[[European rabbit|European Rabbit]]
|Lagomorpha
|[[Lagomorpha]]
|87
|87
|XP_051685630
|XP_051685630
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|-
|-
|''Phoca vitulina''
|''Phoca vitulina''
|Harbor Seal
|[[Harbor seal|Harbor Seal]]
|Carnivora
|[[Carnivora]]
|94
|94
|XP_032258415
|XP_032258415
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|-
|-
|''Neofelis nebulosa''
|''Neofelis nebulosa''
|Clouded Leopard
|[[Clouded leopard|Clouded Leopard]]
|Carnivora
|[[Carnivora]]
|94
|94
|XP_058598545
|XP_058598545
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|-
|-
|''Phacochoerus africanus''
|''Phacochoerus africanus''
|Warthog
|[[Warthog]]
|Artiodactyla
|[[Artiodactyl|Artiodactyla]]
|94
|94
|XP_047612273
|XP_047612273
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|-
|-
|''Balaenoptera ricei''
|''Balaenoptera ricei''
|Rice's Whale
|[[Rice's whale|Rice's Whale]]
|Artiodactyla
|[[Artiodactyl|Artiodactyla]]
|94
|94
|XP_059759229
|XP_059759229
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|-
|-
|''Hyaena hyaena''
|''Hyaena hyaena''
|Striped Hyena
|[[Striped hyena|Striped Hyena]]
|Carnivora
|[[Carnivora]]
|94
|94
|XP_039082615
|XP_039082615
Line 175: Line 170:
|-
|-
|''Ailuropoda melanoleuca''
|''Ailuropoda melanoleuca''
|Giant Panda
|[[Giant panda|Giant Panda]]
|Carnivora
|[[Carnivora]]
|94
|94
|XP_034521380
|XP_034521380
Line 184: Line 179:
|-
|-
|''Hippopotamus amphibius kiboko''
|''Hippopotamus amphibius kiboko''
|East African Hippo
|[[Hippopotamus|East African Hippo]]
|Artiodactyla
|[[Artiodactyl|Artiodactyla]]
|94
|94
|XP_057563793
|XP_057563793
Line 193: Line 188:
|-
|-
|''Artibeus jamaicensis''
|''Artibeus jamaicensis''
|Jamacian Fruit Bat
|[[Jamaican fruit bat|Jamacian Fruit Bat]]
|Chiroptera
|[[Chiroptera]]
|94
|94
|XP_036993559.2
|XP_036993559.2
Line 202: Line 197:
|-
|-
|''Vulpes lagopus''
|''Vulpes lagopus''
|Arctic Fox
|[[Arctic fox|Arctic Fox]]
|Carnivora
|[[Carnivora]]
|94
|94
|XP_041586767
|XP_041586767
Line 211: Line 206:
|-
|-
|''Equus caballus''
|''Equus caballus''
|Horse
|[[Horse]]
|Perissodactyla
|[[Perissodactyla]]
|94
|94
|XP_005601398
|XP_005601398
Line 220: Line 215:
|-
|-
|''Talpa occidentalis''
|''Talpa occidentalis''
|Spanish Mole
|[[Spanish mole|Spanish Mole]]
|Talpidae
|[[Talpidae]]
|94
|94
|XP_037383406
|XP_037383406
Line 229: Line 224:
|-
|-
|''Diceros bicornis minor''
|''Diceros bicornis minor''
|Black Rhino
|[[Black rhinoceros|Black Rhino]]
|Perissodactyla
|[[Perissodactyla]]
|94
|94
|XP_058403718
|XP_058403718
Line 238: Line 233:
|-
|-
|''Elephas maximus indicus''
|''Elephas maximus indicus''
|Indian Elephant
|[[Indian elephant|Indian Elephant]]
|Proboscidea
|[[Proboscidea]]
|99
|99
|XP_049723476
|XP_049723476
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|35.10%
|35.10%
|}
|}
⚫
Table 2: Orthologs of Human ''C13orf16'' protein.


==> References==
== References ==
{{reflist}}



[[Category:Genes on human chromosome 13]]
[[Category:Human proteins]]

Latest revision as of 09:45, 19 December 2024

TEX29
Identifiers
AliasesTEX29, C13orf16, bA474D23.1, testis expressed 29
External IDsHomoloGene: 51840; GeneCards: TEX29; OMA:TEX29 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

121793

n/a

Ensembl

ENSG00000153495

n/a

UniProt

Q8N6K0

n/a

RefSeq (mRNA)

NM_152324
NM_001303133

n/a

RefSeq (protein)

NP_001290062
NP_689537

n/a

Location (UCSC)Chr 13: 111.32 – 111.34 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Chromosome 13 open reading frame 16 is a protein in homo sapiens encoded by the C13orf16 gene. There is one alias name, TEX29, for the high testis expression of this gene due to spermatogenesis.[3][4]

C13orf16 in Homo sapiens is located on the long arm of chromosome 13 at q34.[4] The spliced gene is 859 nucleotides, has 7 exons and is located on the plus strand.[3]

C13orf16 is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the hippocampus and cerebellum.[3][5]

Protein

[edit]

The human C13orf16 protein encoded by the mRNA sequence is 174 amino acids in length.[6] The molecular weight without post-transitional modifications is 18.4 KD[7] and the basal isoelectric point value is 4.99 pH.[8]

Human C13orf16 is localized both intracellularly, in the nucleus, and extracellularly with one transmembrane domain from amino acids 80-102.[6] There are no asparagines, resulting in no N-glycosylation sites.[7]

There are five interacting proteins for human C13orf16, all identified by physical interactions.[4][9][10]

Interacting proteins for human C13orf16 protein[4][9][10]
Abbreviated Name Full Name Brief Description
PTS 6-Pyruvoyltetrahydropterin Synthase Elimination of inorganic triphosphate from dihydroneopterin triphosphate

(2nd and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP)

SLC16A2 Solute Carrier Family 16 Member 2 Non-redundant, thyroid hormone transporter
STEAP3 STEAP Family Member 3, Metalloreductase Iron transporter, can reduce both iron (Fe3+) and copper (Cu2+) cations
SLC4A7 Solute Carrier Family 4  Member 7 Sodium bicarbonate cotransporter, transports sodium and bicarbonate ions in a 1:1 ratio, considered an electroneutral cotransporter
SLC6A15 Solute Carrier Family 6 Member 15 Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport

Homology and evolution

[edit]

The C13orf16 protein was only found to have orthologs in placental mammals and most distantly found in the Proboscidea taxonomic group.[11] In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human C13orf16 protein.[12]

Orthologs of human C13orf16 protein
Genus & Species Common Name Taxonomic Group Date of Divergence (MYA) Accession Number[6] Sequence Length (aa) Sequence Identity to Human Protein Sequence Similarity to Human Protein
Homo sapiens Human Primates 0 NP_001290062 174 100% 100%
Nomascus leucogenys Northern Gibbon Primates 19.5 XP_012362426 173 91% 94.80%
Macaca mulatta Rhesus Macaque Primates 28.8 XP_028693172 182 44.30% 51.70%
Cebus imitator White-faced Capuchin Primates 43 XP_037585341 179 70.60% 77.80%
Peromyscus maniculatus bairdii Deer Mouse Rodentia 87 XP_042118685 176 27.20% 38.60%
Peromyscus leucopus White-Footed Mouse Rodentia 87 XP_037067483 176 26.70% 38.60%
Oryctolagus cuniculus European Rabbit Lagomorpha 87 XP_051685630 143 25.80% 30.80%
Phoca vitulina Harbor Seal Carnivora 94 XP_032258415 162 34% 43.50%
Neofelis nebulosa Clouded Leopard Carnivora 94 XP_058598545 165 34.00% 45.20%
Phacochoerus africanus Warthog Artiodactyla 94 XP_047612273 171 32.10% 41.80%
Balaenoptera ricei Rice's Whale Artiodactyla 94 XP_059759229 147 29.30% 36.40%
Hyaena hyaena Striped Hyena Carnivora 94 XP_039082615 151 29.00% 39.40%
Ailuropoda melanoleuca Giant Panda Carnivora 94 XP_034521380 147 25% 31.20%
Hippopotamus amphibius kiboko East African Hippo Artiodactyla 94 XP_057563793 147 23.70% 34.30%
Artibeus jamaicensis Jamacian Fruit Bat Chiroptera 94 XP_036993559.2 149 21.70% 30.40%
Vulpes lagopus Arctic Fox Carnivora 94 XP_041586767 178 21.7%% 30.0%%
Equus caballus Horse Perissodactyla 94 XP_005601398 136 20.80% 27.00%
Talpa occidentalis Spanish Mole Talpidae 94 XP_037383406 162 19.30% 25.00%
Diceros bicornis minor Black Rhino Perissodactyla 94 XP_058403718 181 18.80% 24%
Elephas maximus indicus Indian Elephant Proboscidea 99 XP_049723476 145 23.80% 35.10%

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153495 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b c "Home - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  4. ^ a b c d "GeneCards". GeneCards. Retrieved December 13, 2024.
  5. ^ "AceView: Gene:C13orf16, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  6. ^ a b c "Home - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  7. ^ a b "SAPS". www.ebi.ac.uk. Retrieved 2024-12-14.
  8. ^ "PhosphoSitePlus". www.phosphosite.org. Retrieved 2024-12-14.
  9. ^ a b "GeneMANIA". genemania.org. Retrieved 2024-12-14.
  10. ^ a b "TEX29 Result Summary | BioGRID". thebiogrid.org. Retrieved 2024-12-14.
  11. ^ "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2024-12-14.
  12. ^ "TimeTree :: The Timescale of Life". timetree.org. Retrieved 2024-12-14.
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