Isoflavone 2'-hydroxylase: Difference between revisions
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{{infobox enzyme |
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| Name = Isoflavone 2'-hydroxylase |
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| EC_number = 1.14.14.90 |
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:an isoflavone + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> a 2'-hydroxyisoflavone + NADP<sup>+</sup> + H<sub>2</sub>O |
:an isoflavone + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> a 2'-hydroxyisoflavone + NADP<sup>+</sup> + H<sub>2</sub>O |
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The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[isoflavone]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], [[hydrogen ion|H<sup>+</sup>]], and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[2'-hydroxyisoflavone]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], and [[water|H<sub>2</sub>O]]. |
The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[isoflavone]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], [[hydrogen ion|H<sup>+</sup>]], and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[2'-hydroxyisoflavone]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], and [[water|H<sub>2</sub>O]]. |
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This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is '''isoflavone,NADPH:oxygen oxidoreductase (2'-hydroxylating)'''. Other names in common use include '''isoflavone 2'-monooxygenase''', '''CYP81E1''', and '''CYP Ge-3'''. This enzyme participates in [[isoflavonoid biosynthesis]]. |
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The [[List of enzymes|systematic name]] of this enzyme class is '''isoflavone,NADPH:oxygen oxidoreductase (2'-hydroxylating)'''. Other names in common use include '''isoflavone 2'-monooxygenase''', '''CYP81E1''', and '''CYP Ge-3'''. This enzyme participates in [[isoflavonoid biosynthesis]]. |
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==References== |
== References == |
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{{reflist|1}} |
{{reflist|1}} |
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| ⚫ | * {{cite journal |vauthors=Akashi T, Aoki T, Ayabe S | date = 1998 | title = CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2'-hydroxylase | journal = Biochem. Biophys. Res. Commun. | volume = 251 | pages = 67–70 | pmid = 9790908 | doi = 10.1006/bbrc.1998.9414 | issue = 1 }} |
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{{Enzyme references|EC_number=1.14.13.89|IUBMB_EC_number=1/14/13/89}} |
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{{Cytochrome P450}} |
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==External links== |
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{{Portal bar|Biology|border=no}} |
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{{Enzyme links|EC_number=1.14.13.89|IUBMB_EC_number=1/14/13/89}} |
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[[Category:NADPH-dependent enzymes]] |
[[Category:NADPH-dependent enzymes]] |
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[[Category:Enzymes of unknown structure]] |
[[Category:Enzymes of unknown structure]] |
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[[Category:Isoflavonoids metabolism]] |
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Latest revision as of 13:52, 11 January 2024
| Isoflavone 2'-hydroxylase | |||||||||
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| Identifiers | |||||||||
| EC no. | 1.14.14.90 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, an isoflavone 2'-hydroxylase (EC 1.14.14.90, Formerly EC 1.14.13.89) is an enzyme that catalyzes the chemical reaction
- an isoflavone + NADPH + H+ + O2 a 2'-hydroxyisoflavone + NADP+ + H2O
The 4 substrates of this enzyme are isoflavone, NADPH, H+, and O2, whereas its 3 products are 2'-hydroxyisoflavone, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is isoflavone,NADPH:oxygen oxidoreductase (2'-hydroxylating). Other names in common use include isoflavone 2'-monooxygenase, CYP81E1, and CYP Ge-3. This enzyme participates in isoflavonoid biosynthesis.
References
[edit]- Akashi T, Aoki T, Ayabe S (1998). "CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2'-hydroxylase". Biochem. Biophys. Res. Commun. 251 (1): 67–70. doi:10.1006/bbrc.1998.9414. PMID 9790908.
