Jump to content

TRA (gene): Difference between revisions

Edit links
From Wikipedia, the free encyclopedia
Browse history interactively
← Previous edit
Content deleted Content added
VisualWikitext
DOI bot (talk | contribs)
44,709 edits
m Citation maintenance. You can use this bot yourself! Please report any bugs.
Citation bot (talk | contribs)
Bots
5,352,306 edits
Add: s2cid. | Use this bot. Report bugs. | Suggested by Whoop whoop pull up | Category:Genes on human chromosome | #UCB_Category 371/484
 
(37 intermediate revisions by 24 users not shown)
Line 1: Line 1:
{{Short description|Protein-coding gene in the species Homo sapiens}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{For|the female-specific protein transformer gene in Drosophila melanogaster|Tra (gene)}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''T-cell receptor alpha locus''' is a [[protein]] that in humans is encoded by the '''TRA''' [[gene]], also known as TCRA or TRA@.<ref name="pmid3875152">{{cite journal |vauthors=Erikson J, Williams DL, Finan J, Nowell PC, Croce CM | title = Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias | journal = Science | volume = 229 | issue = 4715 | pages = 784–6 |date=Sep 1985 | pmid = 3875152 | doi =10.1126/science.3875152 | bibcode = 1985Sci...229..784E }}</ref><ref name="pmid3875483">{{cite journal |vauthors=Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN | title = The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia | journal = EMBO J | volume = 4 | issue = 6 | pages = 1461–5 |date=Oct 1985 | pmid = 3875483 | pmc = 554368 | doi = 10.1002/j.1460-2075.1985.tb03803.x}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRA@ T cell receptor alpha locus| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6955}}</ref> It contributes the alpha chain to the larger TCR protein ([[T-cell receptor]]).
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = T cell receptor alpha locus
| HGNCid = 12027
| Symbol = TRA@
| AltSymbols =; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; TCRA; TCRD; TRA; TRDD3
| OMIM = 186880
| ECnumber =
| Homologene =
| MGIid =
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042287 |text = MHC protein binding}} {{GNF_GO|id=GO:0042605 |text = peptide antigen binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006968 |text = cellular defense response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6955
| Hs_Ensembl =
| Hs_RefseqProtein =
| Hs_RefseqmRNA =
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''T cell receptor alpha locus''', also known as '''TRA@''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRA@ T cell receptor alpha locus| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6955| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
==References==
{{reflist}}
{{reflist}}

==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | author=Kenwrick S |title=Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene |journal=Hum. Mol. Genet. |volume=1 |issue= 3 |pages= 179–86 |year= 1993 |pmid= 1303175 |doi=10.1093/hmg/1.3.179 |name-list-style=vanc| author2=Levinson B | author3=Taylor S | display-authors=3 | last4=Shapiro | first4=Amy | last5=Gitschier | first5=Jane }}
{{PBB_Further_reading
*{{cite journal | author=Suzuki CK |title=Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP |journal=J. Cell Biol. |volume=114 |issue= 2 |pages= 189–205 |year= 1991 |pmid= 1649196 |doi=10.1083/jcb.114.2.189 | pmc=2289081 |name-list-style=vanc| author2=Bonifacino JS | author3=Lin AY | display-authors=3 | last4=Davis | first4=MM | last5=Klausner | first5=RD }}
| citations =
*{{cite journal | author=Kenwrick S, Levinson B, Taylor S, ''et al.'' |title=Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene. |journal=Hum. Mol. Genet. |volume=1 |issue= 3 |pages= 179–86 |year= 1993 |pmid= 1303175 |doi= }}
*{{cite journal |vauthors=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=10.1101/gad.5.5.880 |doi-access=free }}
*{{cite journal | author=Suzuki CK, Bonifacino JS, Lin AY, ''et al.'' |title=Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP. |journal=J. Cell Biol. |volume=114 |issue= 2 |pages= 189–205 |year= 1991 |pmid= 1649196 |doi= }}
*{{cite journal |vauthors=Koning F, Maloy WL, Coligan JE |title=The implications of subunit interactions for the structure of the T cell receptor-CD3 complex |journal=Eur. J. Immunol. |volume=20 |issue= 2 |pages= 299–305 |year= 1990 |pmid= 2138083 |doi=10.1002/eji.1830200211 |s2cid=2180901 }}
*{{cite journal | author=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi= }}
*{{cite journal | author=Dyer MJ |title=T-cell receptor delta/alpha rearrangements in lymphoid neoplasms |journal=Blood |volume=74 |issue= 3 |pages= 1073–83 |year= 1989 |pmid= 2546634 |doi= 10.1182/blood.V74.3.1073.1073|doi-access=free }}
*{{cite journal | author=Koning F, Maloy WL, Coligan JE |title=The implications of subunit interactions for the structure of the T cell receptor-CD3 complex. |journal=Eur. J. Immunol. |volume=20 |issue= 2 |pages= 299–305 |year= 1990 |pmid= 2138083 |doi= }}
*{{cite journal |vauthors=Chilson OP, Kelly-Chilson AE |title=Mitogenic lectins bind to the antigen receptor on human lymphocytes |journal=Eur. J. Immunol. |volume=19 |issue= 2 |pages= 389–96 |year= 1989 |pmid= 2703017 |doi=10.1002/eji.1830190225 |s2cid=22340836 }}
*{{cite journal | author=Dyer MJ |title=T-cell receptor delta/alpha rearrangements in lymphoid neoplasms. |journal=Blood |volume=74 |issue= 3 |pages= 1073–83 |year= 1989 |pmid= 2546634 |doi= }}
*{{cite journal | author=Yanagi Y |title=Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 10 |pages= 3430–4 |year= 1985 |pmid= 3873654 |doi=10.1073/pnas.82.10.3430 | pmc=397789 |name-list-style=vanc| author2=Chan A | author3=Chin B | display-authors=3 | last4=Minden | first4=M | last5=Mak | first5=TW |bibcode=1985PNAS...82.3430Y |doi-access=free }}
*{{cite journal | author=Sim GK |title=Primary structure of human T-cell receptor alpha-chain |journal=Nature |volume=312 |issue= 5996 |pages= 771–5 |year= 1985 |pmid= 6440030 |doi=10.1038/312771a0 |name-list-style=vanc| author2=Yagüe J | author3=Nelson J | display-authors=3 | last4=Marrack | first4=Philippa | last5=Palmer | first5=Edward | last6=Augustin | first6=Andrei | last7=Kappler | first7=John |s2cid=4350315 }}
*{{cite journal | author=Chilson OP, Kelly-Chilson AE |title=Mitogenic lectins bind to the antigen receptor on human lymphocytes. |journal=Eur. J. Immunol. |volume=19 |issue= 2 |pages= 389–96 |year= 1989 |pmid= 2703017 |doi= }}
*{{cite journal | author=Yanagi Y, Chan A, Chin B, ''et al.'' |title=Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 10 |pages= 3430–4 |year= 1985 |pmid= 3873654 |doi= }}
*{{cite journal |vauthors=Kearse KP, Roberts JL, Singer A |title=TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes |journal=Immunity |volume=2 |issue= 4 |pages= 391–9 |year= 1995 |pmid= 7719941 |doi= 10.1016/1074-7613(95)90147-7 |doi-access= free }}
*{{cite journal | author=Erikson J, Williams DL, Finan J, ''et al.'' |title=Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias. |journal=Science |volume=229 |issue= 4715 |pages= 784–6 |year= 1985 |pmid= 3875152 |doi= }}
*{{cite journal |vauthors=Manolios N, Kemp O, Li ZG |title=The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains |journal=Eur. J. Immunol. |volume=24 |issue= 1 |pages= 84–92 |year= 1994 |pmid= 8020575 |doi=10.1002/eji.1830240114 |s2cid=85378646 }}
*{{cite journal | author=Rabbitts TH, Lefranc MP, Stinson MA, ''et al.'' |title=The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia. |journal=EMBO J. |volume=4 |issue= 6 |pages= 1461–5 |year= 1985 |pmid= 3875483 |doi= }}
*{{cite journal |vauthors=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629–39 |year= 1997 |pmid= 9119227 |doi=10.1101/gad.11.5.629 |doi-access=free }}
*{{cite journal | author=Sim GK, Yagüe J, Nelson J, ''et al.'' |title=Primary structure of human T-cell receptor alpha-chain. |journal=Nature |volume=312 |issue= 5996 |pages= 771–5 |year= 1985 |pmid= 6440030 |doi= }}
*{{cite journal |vauthors=San José E, Sahuquillo AG, Bragado R, Alarcón B |title=Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model |journal=Eur. J. Immunol. |volume=28 |issue= 1 |pages= 12–21 |year= 1998 |pmid= 9485181 |doi=10.1002/(SICI)1521-4141(199801)28:01<12::AID-IMMU12>3.0.CO;2-9 |s2cid=85318973 }}
*{{cite journal | author=Kearse KP, Roberts JL, Singer A |title=TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes. |journal=Immunity |volume=2 |issue= 4 |pages= 391–9 |year= 1995 |pmid= 7719941 |doi= }}
*{{cite journal | author=Ding YH |title=Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids |journal=Immunity |volume=8 |issue= 4 |pages= 403–11 |year= 1998 |pmid= 9586631 |doi=10.1016/S1074-7613(00)80546-4 |name-list-style=vanc| author2=Smith KJ | author3=Garboczi DN | display-authors=3 | last4=Utz | first4=Ursula | last5=Biddison | first5=William E. | last6=Wiley | first6=Don C. | doi-access=free }}
*{{cite journal | author=Manolios N, Kemp O, Li ZG |title=The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains. |journal=Eur. J. Immunol. |volume=24 |issue= 1 |pages= 84–92 |year= 1994 |pmid= 8020575 |doi= }}
*{{cite journal | author=Kirchgessner H |title=The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain |journal=J. Exp. Med. |volume=193 |issue= 11 |pages= 1269–84 |year= 2001 |pmid= 11390434 |doi=10.1084/jem.193.11.1269 | pmc=2193385 |name-list-style=vanc| author2=Dietrich J | author3=Scherer J | display-authors=3 | last4=Isomaki | first4=P. | last5=Korinek | first5=V. | last6=Hilgert | first6=I. | last7=Bruyns | first7=E. | last8=Leo | first8=A. | last9=Cope | first9=A. P. }}
*{{cite journal | author=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro. |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629–39 |year= 1997 |pmid= 9119227 |doi= }}
*{{cite journal | author=Shelton JG |title=Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits |journal=Mol. Immunol. |volume=38 |issue= 4 |pages= 259–65 |year= 2001 |pmid= 11566319 |doi=10.1016/S0161-5890(01)00062-1 |name-list-style=vanc| author2=Gülland S | author3=Nicolson K | display-authors=3 | last4=Kearse | first4=Kelly P | last5=Thomas Bäckström | first5=B }}
⚫
*{{cite journal | author=Pietra G |title=The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition |journal=Eur. J. Immunol. |volume=31 |issue= 12 |pages= 3687–93 |year= 2002 |pmid= 11745389 |doi=10.1002/1521-4141(200112)31:12<3687::AID-IMMU3687>3.0.CO;2-C |name-list-style=vanc| author2=Romagnani C | author3=Falco M | display-authors=3 | last4=Vitale | first4=Massimo | last5=Castriconi | first5=Roberta | last6=Pende | first6=Daniela | last7=Millo | first7=Enrico | last8=Anfossi | first8=Simone | last9=Biassoni | first9=Roberto | doi-access=free }}
*{{cite journal | author=San José E, Sahuquillo AG, Bragado R, Alarcón B |title=Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model. |journal=Eur. J. Immunol. |volume=28 |issue= 1 |pages= 12–21 |year= 1998 |pmid= 9485181 |doi= }}
*{{cite journal | author=Ding YH, Smith KJ, Garboczi DN, ''et al.'' |title=Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. |journal=Immunity |volume=8 |issue= 4 |pages= 403–11 |year= 1998 |pmid= 9586631 |doi= }}
*{{cite journal |vauthors=Hennecke J, Wiley DC |title=Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity |journal=J. Exp. Med. |volume=195 |issue= 5 |pages= 571–81 |year= 2002 |pmid= 11877480 |doi=10.1084/jem.20011194 | pmc=2193773 }}
*{{cite journal | author=García P |title=Human T cell receptor-mediated recognition of HLA-E |journal=Eur. J. Immunol. |volume=32 |issue= 4 |pages= 936–44 |year= 2002 |pmid= 11920559 |doi=10.1002/1521-4141(200204)32:4<936::AID-IMMU936>3.0.CO;2-M |name-list-style=vanc| author2=Llano M | author3=de Heredia AB | display-authors=3 | last4=Willberg | first4=Christian B. | last5=Caparrós | first5=Esther | last6=Aparicio | first6=Pedro | last7=Braud | first7=Véronique M. | last8=López-Botet | first8=Miguel | doi-access=free }}
*{{cite journal | author=Kirchgessner H, Dietrich J, Scherer J, ''et al.'' |title=The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. |journal=J. Exp. Med. |volume=193 |issue= 11 |pages= 1269–84 |year= 2001 |pmid= 11390434 |doi= }}
*{{cite journal | author=Shelton JG, Gülland S, Nicolson K, ''et al.'' |title=Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits. |journal=Mol. Immunol. |volume=38 |issue= 4 |pages= 259–65 |year= 2001 |pmid= 11566319 |doi= }}
⚫
*{{cite journal | author=Pietra G, Romagnani C, Falco M, ''et al.'' |title=The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition. |journal=Eur. J. Immunol. |volume=31 |issue= 12 |pages= 3687–93 |year= 2002 |pmid= 11745389 |doi= }}
*{{cite journal | author=Hennecke J, Wiley DC |title=Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity. |journal=J. Exp. Med. |volume=195 |issue= 5 |pages= 571–81 |year= 2002 |pmid= 11877480 |doi= }}
*{{cite journal | author=García P, Llano M, de Heredia AB, ''et al.'' |title=Human T cell receptor-mediated recognition of HLA-E. |journal=Eur. J. Immunol. |volume=32 |issue= 4 |pages= 936–44 |year= 2002 |pmid= 11920559 |doi= }}
}}
{{refend}}
{{refend}}

{{Immunoglobulin superfamily immune receptors}}

{{DEFAULTSORT:TRA}}
[[Category:Proteins]]



{{protein-stub}}
{{protein-stub}}

Latest revision as of 00:14, 15 October 2022

For the female-specific protein transformer gene in Drosophila melanogaster, see Tra (gene).
TRA
Identifiers
AliasesTRA, IMD7, TCRA, TRA@, TRAC, T-cell receptor alpha locus, TCRD, T cell receptor alpha locus
External IDsGeneCards: TRA; OMA:TRA - orthologs
Orthologs
SpeciesHumanMouse
Entrez

6955

n/a

Ensembl

n/a

n/a

UniProt

P0DSE1

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@.[2][3][4] It contributes the alpha chain to the larger TCR protein (T-cell receptor).


References

[edit]
  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ Erikson J, Williams DL, Finan J, Nowell PC, Croce CM (Sep 1985). "Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias". Science. 229 (4715): 784–6. Bibcode:1985Sci...229..784E. doi:10.1126/science.3875152. PMID 3875152.
  3. ^ Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN (Oct 1985). "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia". EMBO J. 4 (6): 1461–5. doi:10.1002/j.1460-2075.1985.tb03803.x. PMC 554368. PMID 3875483.
  4. ^ "Entrez Gene: TRA@ T cell receptor alpha locus".

Further reading

[edit]


Stub icon

This protein-related article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=TRA_(gene)&oldid=1116130699"