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{{Short description|Protein found in humans}}
{{PBB|geneid=7025}}
{{Infobox_gene}}
'''COUP-TF1''' (<u>COUP</u> <u>T</u>ranscription <u>F</u>actor <u>1</u>) also known as '''NR2F1''' (<u>N</u>uclear <u>R</u>eceptor subfamily <u>2</u>, group <u>F</u>, member <u>1</u>) is a [[protein]] that in humans is encoded by the ''NR2F1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7025| accessdate = }}</ref><ref name="pmid8530078">{{cite journal | author = Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY | title = Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes | journal = Genomics | volume = 29 | issue = 1 | pages = 240–6 | year = 1995 | month = September | pmid = 8530078 | doi = 10.1006/geno.1995.1237| url = }}</ref> This protein is a member of [[nuclear receptor|nuclear hormone receptor]] family of [[steroid hormone receptor]]s.
'''COUP-TF1''' (<u>COUP</u> <u>T</u>ranscription <u>F</u>actor <u>1</u>) also known as '''NR2F1''' (<u>N</u>uclear <u>R</u>eceptor subfamily <u>2</u>, group <u>F</u>, member <u>1</u>) is a [[protein]] that in humans is encoded by the ''NR2F1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7025}}</ref><ref name="pmid8530078">{{cite journal | vauthors = Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY | title = Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes | journal = Genomics | volume = 29 | issue = 1 | pages = 240–6 | date = Sep 1995 | pmid = 8530078 | doi = 10.1006/geno.1995.1237 | doi-access = free }}</ref> This protein is a member of [[nuclear receptor|nuclear hormone receptor]] family of [[steroid hormone receptor]]s.


== Function ==
== Function ==


Coup (chicken [[ovalbumin]] upstream promoter) [[transcription factor]] binds to the ovalbumin [[promoter (biology)|promoter]] and, in conjunction with another protein ([[GTF2B|S300-II]]) stimulates [[initiation of transcription]].<ref name="pmid3796602">{{cite journal | author = Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW | title = Identification of two factors required for transcription of the ovalbumin gene | journal = Mol. Cell. Biol. | volume = 6 | issue = 12 | pages = 4259–67 | date=1 December 1986| pmid = 3796602 | pmc = 367207 | url = http://mcb.asm.org/cgi/content/abstract/6/12/4259 | doi = 10.1128/MCB.6.12.4259 }}</ref><ref name="pmid3040258">{{cite journal | author = Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW | title = Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II) | journal = Cell | volume = 50 | issue = 5 | pages = 701–9 | year = 1987 | month = August | pmid = 3040258 | doi = 10.1016/0092-8674(87)90328-X | url = }}</ref> COUP-TF1 binds to both direct repeats and [[palindromes]] of the 5'-AGGTCA-3' motif.<ref name="pmid9101138">{{cite journal | author = Tsai SY, Tsai MJ | title = Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age | journal = Endocr. Rev. | volume = 18 | issue = 2 | pages = 229–40 | year = 1997 | month = April | pmid = 9101138 | doi = 10.1210/er.18.2.229| url = }}</ref>
Coup (chicken [[ovalbumin]] upstream promoter) [[transcription factor]] binds to the ovalbumin [[promoter (biology)|promoter]] and, in conjunction with another protein ([[GTF2B|S300-II]]) stimulates [[initiation of transcription]].<ref name="pmid3796602">{{cite journal | vauthors = Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW | title = Identification of two factors required for transcription of the ovalbumin gene | journal = Molecular and Cellular Biology | volume = 6 | issue = 12 | pages = 4259–67 | date = Dec 1986 | pmid = 3796602 | pmc = 367207 | doi = 10.1128/MCB.6.12.4259 }}</ref><ref name="pmid3040258">{{cite journal | vauthors = Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW | title = Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II) | journal = Cell | volume = 50 | issue = 5 | pages = 701–9 | date = Aug 1987 | pmid = 3040258 | doi = 10.1016/0092-8674(87)90328-X | s2cid = 25136877 }}</ref> COUP-TF1 binds to both direct repeats and [[palindromes]] of the 5'-AGGTCA-3' motif.<ref name="pmid9101138">{{cite journal |author2-link=Ming-Jer Tsai | vauthors = Tsai SY, Tsai MJ | title = Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age | journal = Endocrine Reviews | volume = 18 | issue = 2 | pages = 229–40 | date = Apr 1997 | doi = 10.1210/edrv.18.2.0294 | pmid = 9101138 | doi-access = free }}</ref>


== Interactions ==
== Interactions ==


COUP-TFI has been shown to [[Protein-protein interaction|interact]] with:
COUP-TFI has been shown to [[Protein-protein interaction|interact]] with:
* [[BCL11A]],<ref name="pmid10744719">{{cite journal | author = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors | journal = J. Biol. Chem. | volume = 275 | issue = 14 | pages = 10315–22 | year = 2000 | month = April | pmid = 10744719 | doi = 10.1074/jbc.275.14.10315| url = | pmc = 2819356 }}</ref>
* [[BCL11A]],<ref name="pmid10744719">{{cite journal | vauthors = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = The Journal of Biological Chemistry | volume = 275 | issue = 14 | pages = 10315–22 | date = Apr 2000 | pmid = 10744719 | pmc = 2819356 | doi = 10.1074/jbc.275.14.10315 | doi-access = free }}</ref>
* [[BCL11B]],<ref name=pmid10744719/>
* [[BCL11B]],<ref name=pmid10744719/>
* [[COPS2]],<ref name="pmid10207062">{{cite journal | author = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a Highly Conserved Protein with Characteristics of a Corepressor for Members of the Nuclear Hormone Receptor Superfamily | journal = Mol. Cell. Biol. | volume = 19 | issue = 5 | pages = 3383–94 | date=1 May 1999| pmid = 10207062 | pmc = 84131 | url = http://mcb.asm.org/cgi/content/abstract/19/5/3383 }}</ref> and
* [[COPS2]],<ref name="pmid10207062">{{cite journal | vauthors = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3383–94 | date = May 1999 | pmid = 10207062 | pmc = 84131 | doi=10.1128/mcb.19.5.3383}}</ref> and
* [[estrogen receptor alpha|ESR1]].<ref name="pmid12093745">{{cite journal | author = Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F | title = Formation of an hERα–COUP-TFI complex enhances hERα AF-1 through Ser118 phosphorylation by MAPK | journal = EMBO J. | volume = 21 | issue = 13 | pages = 3443–53 | year = 2002 | month = July | pmid = 12093745 | pmc = 126093 | doi = 10.1093/emboj/cdf344 | url = }}</ref>
* [[estrogen receptor alpha|ESR1]].<ref name="pmid12093745">{{cite journal | vauthors = Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F | title = Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3443–53 | date = Jul 2002 | pmid = 12093745 | pmc = 126093 | doi = 10.1093/emboj/cdf344 }}</ref>


==References==
==Clinical==

Mutations in this gene have been associated with [[Bosch-Boonstra-Schaaf optic atrophy syndrome]].<ref name=Hobbs2020>Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62</ref>

== References ==
{{Reflist}}
{{Reflist}}
{{clear}}


==Further reading==
==External links==
* {{UCSC gene info|NR2F1}}
⚫
{{Refbegin | 2}}
* {{UCSC gene info|NR2F2}}
{{PBB_Further_reading

| citations =
== Further reading ==
*{{cite journal | author=Kliewer SA, Umesono K, Heyman RA, ''et al.'' |title=Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1448–52 |year= 1992 |pmid= 1311101 |doi=10.1073/pnas.89.4.1448 | pmc=48468 }}
⚫
{{Refbegin|33em}}
*{{cite journal | author=Berrodin TJ, Marks MS, Ozato K, ''et al.'' |title=Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein |journal=Mol. Endocrinol. |volume=6 |issue= 9 |pages= 1468–78 |year= 1992 |pmid= 1331778 |doi=10.1210/me.6.9.1468 }}
*{{cite journal | author=Ing NH, Beekman JM, Tsai SY, ''et al.'' |title=Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II) |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 17617–23 |year= 1992 |pmid= 1517211 |doi= }}
* {{cite journal | vauthors = Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM | title = Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 4 | pages = 1448–52 | date = Feb 1992 | pmid = 1311101 | pmc = 48468 | doi = 10.1073/pnas.89.4.1448 | bibcode = 1992PNAS...89.1448K | doi-access = free }}
*{{cite journal | author=Wang LH, Tsai SY, Cook RG, ''et al.'' |title=COUP transcription factor is a member of the steroid receptor superfamily |journal=Nature |volume=340 |issue= 6229 |pages= 163–6 |year= 1989 |pmid= 2739739 |doi= 10.1038/340163a0 }}
* {{cite journal | vauthors = Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA | title = Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein | journal = Molecular Endocrinology | volume = 6 | issue = 9 | pages = 1468–78 | date = Sep 1992 | doi = 10.1210/mend.6.9.1331778 | pmid = 1331778 | s2cid = 24291055 | doi-access = free }}
*{{cite journal | author=Miyajima N, Kadowaki Y, Fukushige S, ''et al.'' |title=Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other |journal=Nucleic Acids Res. |volume=16 |issue= 23 |pages= 11057–74 |year= 1989 |pmid= 2905047 |doi=10.1093/nar/16.23.11057 | pmc=338996 }}
* {{cite journal | vauthors = Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW | title = Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II) | journal = The Journal of Biological Chemistry | volume = 267 | issue = 25 | pages = 17617–23 | date = Sep 1992 | doi = 10.1016/S0021-9258(19)37087-5 | pmid = 1517211 | doi-access = free }}
*{{cite journal | author=Sawaya BE, Rohr O, Aunis D, Schaeffer E |title=Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23572–6 |year= 1996 |pmid= 8798567 |doi=10.1074/jbc.271.38.23572 }}
* {{cite journal | vauthors = Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW | title = COUP transcription factor is a member of the steroid receptor superfamily | journal = Nature | volume = 340 | issue = 6229 | pages = 163–6 | date = Jul 1989 | pmid = 2739739 | doi = 10.1038/340163a0 | bibcode = 1989Natur.340..163W | s2cid = 4364164 }}
*{{cite journal | author=Rohr O, Aunis D, Schaeffer E |title=COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 31149–55 |year= 1998 |pmid= 9388268 |doi=10.1074/jbc.272.49.31149 }}
* {{cite journal | vauthors = Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T | title = Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other | journal = Nucleic Acids Research | volume = 16 | issue = 23 | pages = 11057–74 | date = Dec 1988 | pmid = 2905047 | pmc = 338996 | doi = 10.1093/nar/16.23.11057 }}
*{{cite journal | author=Dressel U, Thormeyer D, Altincicek B, ''et al.'' |title=Alien, a Highly Conserved Protein with Characteristics of a Corepressor for Members of the Nuclear Hormone Receptor Superfamily |journal=Mol. Cell. Biol. |volume=19 |issue= 5 |pages= 3383–94 |year= 1999 |pmid= 10207062 |doi= | pmc=84131 }}
* {{cite journal | vauthors = Sawaya BE, Rohr O, Aunis D, Schaeffer E | title = Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells | journal = The Journal of Biological Chemistry | volume = 271 | issue = 38 | pages = 23572–6 | date = Sep 1996 | pmid = 8798567 | doi = 10.1074/jbc.271.38.23572 | doi-access = free }}
*{{cite journal | author=Klinge CM, Kaur K, Swanson HI |title=The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1 |journal=Arch. Biochem. Biophys. |volume=373 |issue= 1 |pages= 163–74 |year= 2000 |pmid= 10620335 |doi= 10.1006/abbi.1999.1552 }}
* {{cite journal | vauthors = Rohr O, Aunis D, Schaeffer E | title = COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 49 | pages = 31149–55 | date = Dec 1997 | pmid = 9388268 | doi = 10.1074/jbc.272.49.31149 | doi-access = free }}
*{{cite journal | author=Rohr O, Schwartz C, Hery C, ''et al.'' |title=The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2654–60 |year= 2000 |pmid= 10644726 |doi=10.1074/jbc.275.4.2654 }}
* {{cite journal | vauthors = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3383–94 | date = May 1999 | pmid = 10207062 | pmc = 84131 | doi = 10.1128/mcb.19.5.3383}}
*{{cite journal | author=Sugiyama T, Wang JC, Scott DK, Granner DK |title=Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3446–54 |year= 2000 |pmid= 10652338 |doi=10.1074/jbc.275.5.3446 }}
* {{cite journal | vauthors = Klinge CM, Kaur K, Swanson HI | title = The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1 | journal = Archives of Biochemistry and Biophysics | volume = 373 | issue = 1 | pages = 163–74 | date = Jan 2000 | pmid = 10620335 | doi = 10.1006/abbi.1999.1552 }}
*{{cite journal | author=Vlahou A, Flytzanis CN |title=Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle |journal=Dev. Biol. |volume=218 |issue= 2 |pages= 284–98 |year= 2000 |pmid= 10656770 |doi= 10.1006/dbio.1999.9456 }}
* {{cite journal | vauthors = Rohr O, Schwartz C, Hery C, Aunis D, Tardieu M, Schaeffer E | title = The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells | journal = The Journal of Biological Chemistry | volume = 275 | issue = 4 | pages = 2654–60 | date = Jan 2000 | pmid = 10644726 | doi = 10.1074/jbc.275.4.2654 | doi-access = free }}
*{{cite journal | author=Avram D, Fields A, Pretty On Top K, ''et al.'' |title=Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10315–22 |year= 2000 |pmid= 10744719 |doi=10.1074/jbc.275.14.10315 | pmc=2819356 }}
* {{cite journal | vauthors = Sugiyama T, Wang JC, Scott DK, Granner DK | title = Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene | journal = The Journal of Biological Chemistry | volume = 275 | issue = 5 | pages = 3446–54 | date = Feb 2000 | pmid = 10652338 | doi = 10.1074/jbc.275.5.3446 | doi-access = free }}
*{{cite journal | author=Gay F, Anglade I, Gong Z, Salbert G |title=The LIM/homeodomain protein islet-1 modulates estrogen receptor functions |journal=Mol. Endocrinol. |volume=14 |issue= 10 |pages= 1627–48 |year= 2001 |pmid= 11043578 |doi=10.1210/me.14.10.1627 }}
* {{cite journal | vauthors = Vlahou A, Flytzanis CN | title = Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle | journal = Developmental Biology | volume = 218 | issue = 2 | pages = 284–98 | date = Feb 2000 | pmid = 10656770 | doi = 10.1006/dbio.1999.9456 | doi-access = free }}
*{{cite journal | author=You M, Fischer M, Cho WK, Crabb D |title=Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors |journal=Arch. Biochem. Biophys. |volume=398 |issue= 1 |pages= 79–86 |year= 2002 |pmid= 11811951 |doi= 10.1006/abbi.2001.2713 }}
* {{cite journal | vauthors = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = The Journal of Biological Chemistry | volume = 275 | issue = 14 | pages = 10315–22 | date = Apr 2000 | pmid = 10744719 | pmc = 2819356 | doi = 10.1074/jbc.275.14.10315 | doi-access = free }}
*{{cite journal | author=Lin F, Kolluri SK, Chen GQ, Zhang XK |title=Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21414–22 |year= 2002 |pmid= 11934895 |doi= 10.1074/jbc.M201885200 }}
* {{cite journal | vauthors = Gay F, Anglade I, Gong Z, Salbert G | title = The LIM/homeodomain protein islet-1 modulates estrogen receptor functions | journal = Molecular Endocrinology | volume = 14 | issue = 10 | pages = 1627–48 | date = Oct 2000 | pmid = 11043578 | doi = 10.1210/me.14.10.1627 | doi-access = free }}
*{{cite journal | author=Métivier R, Gay FA, Hübner MR, ''et al.'' |title=Formation of an hERα–COUP-TFI complex enhances hERα AF-1 through Ser118 phosphorylation by MAPK |journal=EMBO J. |volume=21 |issue= 13 |pages= 3443–53 |year= 2002 |pmid= 12093745 |doi= 10.1093/emboj/cdf344 | pmc=126093 }}
* {{cite journal | vauthors = You M, Fischer M, Cho WK, Crabb D | title = Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors | journal = Archives of Biochemistry and Biophysics | volume = 398 | issue = 1 | pages = 79–86 | date = Feb 2002 | pmid = 11811951 | doi = 10.1006/abbi.2001.2713 | doi-access = free }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
* {{cite journal | vauthors = Lin F, Kolluri SK, Chen GQ, Zhang XK | title = Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21414–22 | date = Jun 2002 | pmid = 11934895 | doi = 10.1074/jbc.M201885200 | doi-access = free }}
*{{cite journal | author=Yu X, Mertz JE |title=Distinct Modes of Regulation of Transcription of Hepatitis B Virus by the Nuclear Receptors HNF4α and COUP-TF1 |journal=J. Virol. |volume=77 |issue= 4 |pages= 2489–99 |year= 2003 |pmid= 12551987 |doi=10.1128/JVI.77.4.2489-2499.2003 | pmc=141100 }}
* {{cite journal | vauthors = Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F | title = Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3443–53 | date = Jul 2002 | pmid = 12093745 | pmc = 126093 | doi = 10.1093/emboj/cdf344 }}
* {{cite journal | vauthors = Yu X, Mertz JE | title = Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1 | journal = Journal of Virology | volume = 77 | issue = 4 | pages = 2489–99 | date = Feb 2003 | pmid = 12551987 | pmc = 141100 | doi = 10.1128/JVI.77.4.2489-2499.2003 }}
}}
{{Refend}}
{{Refend}}


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{{Transcription factors|g2}}
{{Transcription factors|g2}}


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{{DEFAULTSORT:Coup-Tfi}}
{{DEFAULTSORT:Coup-Tfi}}
[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]

{{gene-5-stub}}

Latest revision as of 00:10, 6 October 2023

NR2F1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNR2F1, BBOAS, BBSOAS, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1, nuclear receptor subfamily 2 group F member 1, COUPTF1
External IDsOMIM: 132890; MGI: 1352451; HomoloGene: 21158; GeneCards: NR2F1; OMA:NR2F1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7025

13865

Ensembl

ENSG00000175745

ENSMUSG00000069171

UniProt

P10589

Q60632

RefSeq (mRNA)

NM_005654

NM_010151
NM_001347538
NM_001347539

RefSeq (protein)

NP_005645

Location (UCSC)Chr 5: 93.58 – 93.59 MbChr 13: 78.34 – 78.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.[5][6] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

Function

[edit]

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[7][8] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.[9]

Interactions

[edit]

COUP-TFI has been shown to interact with:

Clinical

[edit]

Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.[13]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175745 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069171 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
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  12. ^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The EMBO Journal. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.
  13. ^ Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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