Jump to content

Bunyamwera orthobunyavirus: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous edit
Content deleted Content added
VisualWikitext
wording, changed links slightly, and added and linked the word 'enveloped' in lead sentence
No edit summary
 
(57 intermediate revisions by 32 users not shown)
Line 1: Line 1:
{{Short description|Species of virus}}
{{Taxobox
{{Virusbox
<!-- Color parameter is not needed -- automatically assigned -->
| name = ''Orthobunyavirus''
| parent = Orthobunyavirus
⚫
| species = Bunyamwera orthobunyavirus
⚫
| virus_group = v
| ordo = ''Unassigned''
| synonyms = *''Bunyamwera virus''
| synonyms_ref = <ref name="TaxoHist">{{cite web |title=ICTV Taxonomy history: ''Bunyamwera orthobunyavirus'' |url=https://ictv.global/taxonomy/taxondetails?taxnode_id=20180100 |website=International Committee on Taxonomy of Viruses (ICTV) |access-date=31 January 2019 |language=en |format=html}}</ref>
| familia = [[Bunyaviridae]]
| subdivision_ranks = Isolates
⚫
| genus = [[Orthobunyavirus]]
| subdivision_ref = <ref name="ICTV9">{{cite web |title=ICTV 9th Report (2011) ''Bunyaviridae'' |url=https://ictv.global/report/chapter/peribunyaviridae |website=International Committee on Taxonomy of Viruses (ICTV) |access-date=31 January 2019 |language=en |format=html |quote=Bunya: from Bunyamwera, place in Uganda, where type virus was isolated.}}</ref>
⚫
| species = ''Bunyamwera virus''
| subdivision =
*[[Batai virus]]
*[[Birao virus]]
*[[Bozo virus]]
*[[Bunyamwera virus - 1943 prototype]]
*[[Bunyamwera virus Laguna Larga]]
*[[Cache Valley virus]]
*[[Ebinur Lake virus]]
*[[Fort Sherman virus]]
*[[Germiston virus]]
*[[Iaco virus]]
*[[Ilesha virus]]
*[[Lokern virus]]
*[[Maguari virus]]
*[[Mboke virus]]
*[[Ngari virus]]
*[[Northway virus]]
*[[Playas virus]]
*[[Potosi virus]]
*[[Santa Rosa virus]]
*[[Shokwe virus]]
*[[Tensaw virus]]
*[[Tlacotalpan virus]]
*[[Tucunduba virus]]
*[[Xingu virus]]
}}
}}


The '''''Bunyamwera virus''''' is a [[Negative-sense ssRNA virus|Negative-sense single stranded]] [[Viral envelope|envelope]] [[RNA virus]]. It is the [[type species]] of the [[Orthobunyavirus]] [[genus]], it is in the [[Bunyaviridae]] [[Family (biology)|family]].
'''''Bunyamwera orthobunyavirus''''' ('''BUNV''') is a [[Negative-sense ssRNA virus|negative-sense, single-stranded]] [[Viral envelope|enveloped]] [[RNA virus]]. It is assigned to the ''[[Orthobunyavirus]]'' [[genus]], in the ''[[Bunyavirales]]'' order.


The Bunyamwera virus can infect both humans and ''[[Aedes aegypti]]'' (the Yellowfever mosquito)<ref>http://www.uniprot.org/taxonomy/35304</ref>.
''Bunyamwera orthobunyavirus'' can infect both humans and ''[[Aedes aegypti]]'' (yellow fever mosquito).<ref>{{Cite web | url=https://www.uniprot.org/taxonomy/35304 | title=Bunyamwera virus (BUNV)}}</ref>

It is named for [[Bunyamwera]], a town in western [[Uganda]], where it was isolated in 1943. [[Reassortment|Reassortant]] viruses derived from ''Bunyamwera orthobunyavirus'', such as ''[[Ngari virus]]'', have been associated with large outbreaks of [[Viral hemorrhagic fever|viral haemorrhagic fever]] in [[Kenya]] and [[Somalia]].<ref>{{Cite journal|title = Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa|vauthors = Gerrard SR, Li L, Barrett AD, Nichol ST|date = 2004|journal = J Virol |doi = 10.1128/JVI.78.16.8922-8926.2004|pmid = 15280501|pmc = 479050|volume=78|issue = 16|pages=8922–6}}</ref><ref>{{Cite journal|title = Genome sequence analysis of in vitro and in vivo phenotypes of Bunyamwera and Ngari virus isolates from northern Kenya|vauthors = Odhiambo C, Venter M, Limbaso K, Swanepoel R, Sang R|date = 2014|journal = PLOS ONE |doi = 10.1371/journal.pone.0105446|pmid = 25153316|pmc=4143288|volume=9|issue = 8|pages=e105446|bibcode = 2014PLoSO...9j5446O|doi-access = free}}</ref><ref>{{cite journal|last1=Briese|first1=T.|last2=Bird|first2=B.|last3=Kapoor|first3=V.|last4=Nichol|first4=S. T.|last5=Lipkin|first5=W. I.|title=Batai and Ngari Viruses: M Segment Reassortment and Association with Severe Febrile Disease Outbreaks in East Africa|journal=Journal of Virology|date=12 May 2006|volume=80|issue=11|pages=5627–5630|doi=10.1128/JVI.02448-05|pmid=16699043|pmc=1472162}}</ref>

== Molecular biology ==
[[File:Genome of Bunyamwera virus.gif|thumb|Genome of Bunyamwera virus]]
The genetic structure of ''Bunyamwera orthobunyavirus'' is typical for ''[[Bunyavirales]]'' viruses, which are an order of enveloped [[Negative-sense single-stranded RNA virus|negative-sense, single-stranded]] [[RNA]] viruses with a [[genome]] split into three parts—Small (S), Middle (M), and Large (L). The L RNA segment encodes an RNA-dependent [[RNA polymerase]] (L protein), the M RNA segment encodes two surface [[glycoprotein]]s (Gc and Gn) and a [[Viral nonstructural protein|nonstructural protein]] (NSm), while the S RNA segment encodes a nucleocapsid protein (N) and, in an alternative overlapping [[reading frame]], a second nonstructural protein (NSs).<ref>{{Cite book|title=Bunyaviridae: molecular and cellular biology|last1=Plyusnin|first1=Alexander|last2=Elliott|first2=Richard M|date=2011-01-01|publisher=Caister Academic Press|isbn=9781904455905|location=Norfolk, UK|language=en|oclc = 711044654}}</ref> The genomic RNA segments are encapsidated by copies of the N protein in the form of [[ribonucleoprotein]] (RNP) complexes.<ref>{{Cite journal|last1=Ariza|first1=Antonio|last2=Tanner|first2=Sian J.|last3=Walter|first3=Cheryl T.|last4=Dent|first4=Kyle C.|last5=Shepherd|first5=Dale A.|last6=Wu|first6=Weining|last7=Matthews|first7=Susan V.|last8=Hiscox|first8=Julian A.|last9=Green|first9=Todd J.|date=2013-06-01|title=Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization|journal=Nucleic Acids Research|volume=41|issue=11|pages=5912–5926|doi=10.1093/nar/gkt268|issn=0305-1048|pmc=3675483|pmid=23595147}}</ref> The N protein is the most abundant protein in virus particles and infected cells and, therefore, the main target in many serological and molecular diagnostics.<ref>{{Cite journal|last1=Bilk|first1=S.|last2=Schulze|first2=C.|last3=Fischer|first3=M.|last4=Beer|first4=M.|last5=Hlinak|first5=A.|last6=Hoffmann|first6=B.|date=2012-09-14|title=Organ distribution of Schmallenberg virus RNA in malformed newborns|journal=Veterinary Microbiology|volume=159|issue=1–2|pages=236–238|doi=10.1016/j.vetmic.2012.03.035|pmid=22516190}}</ref><ref>{{Cite journal|last1=Bréard|first1=Emmanuel|last2=Lara|first2=Estelle|last3=Comtet|first3=Loïc|last4=Viarouge|first4=Cyril|last5=Doceul|first5=Virginie|last6=Desprat|first6=Alexandra|last7=Vitour|first7=Damien|last8=Pozzi|first8=Nathalie|last9=Cay|first9=Ann Brigitte|date=2013-01-15|title=Validation of a Commercially Available Indirect Elisa Using a Nucleocapside Recombinant Protein for Detection of Schmallenberg Virus Antibodies|journal=PLOS ONE|volume=8|issue=1|pages=e53446|doi=10.1371/journal.pone.0053446|issn=1932-6203|pmc=3546048|pmid=23335964|bibcode=2013PLoSO...853446B|doi-access=free}}</ref>

==Disease in humans==

{{Infobox medical condition (new)
| name = Bunyamwera fever
⚫
| synonyms =
| image =
⚫
| alt =
| caption =
| pronounce =
| field = [[Infectious disease (medical speciality)|Infectious disease]]
| symptoms =
| complications =
| onset =
| duration =
| types =
| causes =
| risks =
| diagnosis =
| differential =
| prevention =
| treatment =
| medication =
| prognosis =
| frequency =
| deaths =
}}

In humans, ''Bunyamwera orthobunyavirus'' causes Bunyamwera fever.


==References==
==References==
Line 17: Line 77:
{{Reflist}}
{{Reflist}}


== External links ==
⚫
{{Virus-stub}}
{{Medical resources
| DiseasesDB =
| ICD10 = {{ICD10|A|92|8}}
| ICD9 = {{ICD9|066.3}}
| ICDO =
| OMIM =
| MedlinePlus =
| eMedicineSubj =
| eMedicineTopic =
| MeSH =
| GeneReviewsNBK =
| GeneReviewsName =
}}
{{Zoonotic viral diseases}}
{{Taxonbar|from=Q4997969}}


[[Category:Viruses]]
[[Category:Orthobunyaviruses]]

[[Category:Bunyaviruses]]

⚫
{{Virus-stub}}

Latest revision as of 00:38, 28 April 2024

Bunyamwera orthobunyavirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Peribunyaviridae
Genus: Orthobunyavirus
Species:
Bunyamwera orthobunyavirus
Isolates[1]
Synonyms[2]
  • Bunyamwera virus

Bunyamwera orthobunyavirus (BUNV) is a negative-sense, single-stranded enveloped RNA virus. It is assigned to the Orthobunyavirus genus, in the Bunyavirales order.

Bunyamwera orthobunyavirus can infect both humans and Aedes aegypti (yellow fever mosquito).[3]

It is named for Bunyamwera, a town in western Uganda, where it was isolated in 1943. Reassortant viruses derived from Bunyamwera orthobunyavirus, such as Ngari virus, have been associated with large outbreaks of viral haemorrhagic fever in Kenya and Somalia.[4][5][6]

Molecular biology

[edit]
Genome of Bunyamwera virus

The genetic structure of Bunyamwera orthobunyavirus is typical for Bunyavirales viruses, which are an order of enveloped negative-sense, single-stranded RNA viruses with a genome split into three parts—Small (S), Middle (M), and Large (L). The L RNA segment encodes an RNA-dependent RNA polymerase (L protein), the M RNA segment encodes two surface glycoproteins (Gc and Gn) and a nonstructural protein (NSm), while the S RNA segment encodes a nucleocapsid protein (N) and, in an alternative overlapping reading frame, a second nonstructural protein (NSs).[7] The genomic RNA segments are encapsidated by copies of the N protein in the form of ribonucleoprotein (RNP) complexes.[8] The N protein is the most abundant protein in virus particles and infected cells and, therefore, the main target in many serological and molecular diagnostics.[9][10]

Disease in humans

[edit]
Bunyamwera fever
SpecialtyInfectious disease

In humans, Bunyamwera orthobunyavirus causes Bunyamwera fever.

References

[edit]
  1. ^ "ICTV 9th Report (2011) Bunyaviridae" (html). International Committee on Taxonomy of Viruses (ICTV). Retrieved 31 January 2019. Bunya: from Bunyamwera, place in Uganda, where type virus was isolated.
  2. ^ "ICTV Taxonomy history: Bunyamwera orthobunyavirus" (html). International Committee on Taxonomy of Viruses (ICTV). Retrieved 31 January 2019.
  3. ^ "Bunyamwera virus (BUNV)".
  4. ^ Gerrard SR, Li L, Barrett AD, Nichol ST (2004). "Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa". J Virol. 78 (16): 8922–6. doi:10.1128/JVI.78.16.8922-8926.2004. PMC 479050. PMID 15280501.
  5. ^ Odhiambo C, Venter M, Limbaso K, Swanepoel R, Sang R (2014). "Genome sequence analysis of in vitro and in vivo phenotypes of Bunyamwera and Ngari virus isolates from northern Kenya". PLOS ONE. 9 (8): e105446. Bibcode:2014PLoSO...9j5446O. doi:10.1371/journal.pone.0105446. PMC 4143288. PMID 25153316.
  6. ^ Briese, T.; Bird, B.; Kapoor, V.; Nichol, S. T.; Lipkin, W. I. (12 May 2006). "Batai and Ngari Viruses: M Segment Reassortment and Association with Severe Febrile Disease Outbreaks in East Africa". Journal of Virology. 80 (11): 5627–5630. doi:10.1128/JVI.02448-05. PMC 1472162. PMID 16699043.
  7. ^ Plyusnin, Alexander; Elliott, Richard M (2011-01-01). Bunyaviridae: molecular and cellular biology. Norfolk, UK: Caister Academic Press. ISBN 9781904455905. OCLC 711044654.
  8. ^ Ariza, Antonio; Tanner, Sian J.; Walter, Cheryl T.; Dent, Kyle C.; Shepherd, Dale A.; Wu, Weining; Matthews, Susan V.; Hiscox, Julian A.; Green, Todd J. (2013-06-01). "Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization". Nucleic Acids Research. 41 (11): 5912–5926. doi:10.1093/nar/gkt268. ISSN 0305-1048. PMC 3675483. PMID 23595147.
  9. ^ Bilk, S.; Schulze, C.; Fischer, M.; Beer, M.; Hlinak, A.; Hoffmann, B. (2012-09-14). "Organ distribution of Schmallenberg virus RNA in malformed newborns". Veterinary Microbiology. 159 (1–2): 236–238. doi:10.1016/j.vetmic.2012.03.035. PMID 22516190.
  10. ^ Bréard, Emmanuel; Lara, Estelle; Comtet, Loïc; Viarouge, Cyril; Doceul, Virginie; Desprat, Alexandra; Vitour, Damien; Pozzi, Nathalie; Cay, Ann Brigitte (2013-01-15). "Validation of a Commercially Available Indirect Elisa Using a Nucleocapside Recombinant Protein for Detection of Schmallenberg Virus Antibodies". PLOS ONE. 8 (1): e53446. Bibcode:2013PLoSO...853446B. doi:10.1371/journal.pone.0053446. ISSN 1932-6203. PMC 3546048. PMID 23335964.
[edit]


Stub icon

This virus-related article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=Bunyamwera_orthobunyavirus&oldid=1221120866"