Micro-compounding: Difference between revisions
Content deleted Content added
Citation bot (talk | contribs) Altered pages. Add: pmid, isbn, authors 1-1. Removed parameters. Formatted dashes. Some additions/deletions were parameter name changes. | Use this bot. Report bugs. | Suggested by Jay8g | #UCB_toolbar |
|||
| (40 intermediate revisions by 21 users not shown) | |||
| Line 1: | Line 1: | ||
| ⚫ | |||
{{Multiple issues| |
|||
| ⚫ | |||
{{orphan|date=July 2012}}}} |
|||
| ⚫ | '''Micro-compounding''' |
||
| ⚫ | '''Micro-compounding''' is the mixing or processing of [[polymer]] formulations in the melt on a small scale, typically milliliters. It is popular for [[research and development]] because it gives faster, more reliable results with smaller samples and less cost. Its applications include [[pharmaceutical]], [[biomedical]], and [[nutritional]] areas. |
||
| ⚫ | |||
==Design== |
|||
Micro-compounding is typically performed with a tabletop, twin screw micro-compounder, or micro-extruder with a working volume of 5 or 15 milliliters. With such small volumes, it is difficult to have sufficient mixing in a continuous extruder. Therefore, micro-compounders typically have a batch mode (recirculation) and a conical shape. |
|||
| ⚫ | The L/D of a continuous [[plastic extrusion#Screw design|twin screw extruder]] is mimicked in a batch micro-compounder by the recirculation mixing time, which is controlled by a manual valve. With this valve, the recirculation can be interrupted to unload the formulation in either a strand or an [[injection moulding|injection moulder]], a film device or a fiber line. Typical recirculation times are one to three minutes, depending on the ease of dispersive and distributive mixing of the formulation.{{cn|date=April 2024}} |
||
==Benefits== |
==Benefits== |
||
Micro-compounding can now produce films, fibers, and test samples (rods, rings, tablets) from mixtures as small as 5 ml in less than ten minutes. The small footprint requires less lab space than for a parallel twin screw extruder.<ref>Qizheng Dou, Xiaomin Zhu, Karin Peter, Dan E. Demco, Martin Möller, Claudiu Melian, J. Sol-Gel Sci Technol (2008) 48: 51-60</ref><ref>{{Cite journal|doi=10.1016/j.polymer.2006.10.013 |title=Properties and morphology of nanocomposites based on styrenic polymers, Part II: Effects of maleic anhydride units |date=2006 |last1=Stretz |first1=H.A. |last2=Paul |first2=D.R. |journal=Polymer |volume=47 |issue=26 |pages=8527–8535 }}</ref><ref>{{cite journal|doi=10.1002/pc.20392 |title=Microcompounding of organoclay–ABS/PA6 blend-based nanocomposites |date=2008 |last1=Ozkoc |first1=Guralp |last2=Bayram |first2=Goknur |last3=Tiesnitsch |first3=Johan |journal=Polymer Composites |volume=29 |issue=4 |pages=345–356 }}</ref><ref>{{cite journal|doi=10.1002/pc.20846 |title=Production of poly(lactic acid)/Organoclay nanocomposite scaffolds by microcompounding and polymer/Particle leaching |date=2010 |last1=Ozkoc |first1=Guralp |last2=Kemaloglu |first2=Sebnem |last3=Quaedflieg |first3=Martin |journal=Polymer Composites |volume=31 |issue=4 |pages=674–683 }}</ref><ref>{{cite journal|doi=10.1002/app.27460 |title=Effects of microcompounding process parameters on the properties of ABS/Polyamide-6 blends based nanocomposites |date=2008 |last1=Özkoç |first1=Güralp |last2=Bayram |first2=Göknur |last3=Quaedflieg |first3=Martin |journal=Journal of Applied Polymer Science |volume=107 |issue=5 |pages=3058–3070 }}</ref> One micro-extruder, developed to test whether drug delivery enabled improved bioavailability of poorly soluble drugs or the sustained release of [[active ingredients]]{{Clarification needed | reason=what options?|date=April 2024}} show or require sensitive and water destroying invasives.<ref>Markus Thommes, APV Drug Delivery Focus Group Newsletter - 1/2012</ref><ref>{{Cite journal |date=2003-05-14 |editor-last=Ghebre-Sellassie |editor-first=Isaac |editor2-last=Ghebre-Selassie |editor2-first=Isaac |editor3-last=Martin |editor3-first=Charles E. |editor4-last=Zhang |editor4-first=Feng |editor5-last=DiNunzio |editor5-first=James |editor6-last=Martin |editor6-first=Charles |title=Pharmaceutical Extrusion Technology |url=http://dx.doi.org/10.1201/9780203911532 |doi=10.1201/9780203911532|journal=International Journal of Pharmaceutics |volume= 133|issue= 1–2|pages=1–271 |isbn=978-0-203-91153-2 |via=www.sciencedirect.com |language=en-us}}</ref><ref>{{Cite journal |last=Bodor |first=Nicholas |date=February 1984 |title=Techniques of Solubilization of Drugs|series=Drugs and the Pharmaceutical Sciences Series|url=http://dx.doi.org/10.1002/jps.2600730245 |journal=Journal of Pharmaceutical Sciences |volume=73 |issue=2 |pages=288 |doi=10.1002/jps.2600730245 |issn=0022-3549}}</ref><ref>{{Cite journal |last1=Litvinov |first1=V. M. |last2=Guns |first2=S. |last3=Adriaensens |first3=P. |last4=Scholtens |first4=B. J. R. |last5=Quaedflieg |first5=M. P. |last6=Carleer |first6=R. |last7=Van den Mooter |first7=G. |date=2012-10-01 |title=Solid State Solubility of Miconazole in Poly[(ethylene glycol)- g -vinyl alcohol] Using Hot-Melt Extrusion |url=https://pubs.acs.org/doi/10.1021/mp300280k |journal=Molecular Pharmaceutics |language=en |volume=9 |issue=10 |pages=2924–2932 |doi=10.1021/mp300280k |pmid=22905779 |issn=1543-8384}}</ref><ref>{{cite conference|first=Toshiro |last=Sakai|conference=APV Experts‘ Workshop on Hot Melt Extrusion |date= 6 November 2012}}</ref><ref>{{Cite journal |last1=Sakai |first1=Toshiro |last2=Thommes |first2=Markus |date=2014-01-17 |title=Investigation into mixing capability and solid dispersion preparation using the DSM Xplore Pharma Micro Extruder |url=https://academic.oup.com/jpp/article/66/2/218-231/6127922 |journal=Journal of Pharmacy and Pharmacology |language=en |volume=66 |issue=2 |pages=218–231 |doi=10.1111/jphp.12085 |issn=2042-7158}}</ref> |
|||
With such table top laboratory equipment it is now also possible to produce films, fibers and test samples (rods, rings, tablets) from mixtures as small as 5 ml in less than 10 min. By the small footprint less lab space is needed than for a parallel twin screw extruder. Because of these benefits screening of optimum formulations in R&D is really feasible and affordable. |
|||
<ref>Qizheng Dou, Xiaomin Zhu, Karin Peter, Dan E. Demco, Martin Möller, Claudiu Melian, J. Sol-Gel Sci Technol (2008) 48: 51-60</ref><ref>Stretz HA, Paul DR, Polymer (2006), doi: 10.1016/j.polymer.2006.10.013</ref><ref>Ozkoc, G., Bayram, G. and Tiesnitsch, J. (2008), Microcompounding of organoclay–ABS/PA6 blend-based nanocomposites. Polym Compos, 29: 345–356. doi: 10.1002/pc.20392</ref><ref>Ozkoc, G., Kemaloglu, S. and Quaedflieg, M. (2010), Production of poly(lactic acid)/organoclay nanocomposite scaffolds by microcompounding and polymer/particle leaching. Polymer Composites, 31: 674–683. doi: 10.1002/pc.20846</ref><ref>Özkoç, G., Bayram, G. and Quaedflieg, M. (2008), Effects of microcompounding process parameters on the properties of ABS/polyamide-6 blends based nanocomposites. Polym Compos, J. Appl. Polym. Sci., 107: 3058–3070. doi: 10.1002/app.27460</ref> |
|||
In pharmaceutical and biomedical R&D, where sample costs are a key issue, an easy to clean, 2 to 5 ml GMP compliant pharma micro-extruder was developed. This equipment is used for testing the improvement of bioavailability of poorly soluble drugs or realizing sustained release of dispersed or dissolved APIs. As pharmaceutical formulations are usually difficult to feed because of fluffy, static powders, this pharma micro-extruder has special options to easily fill and easily clean, which further speeds up the R&D process.<ref>Markus Thommes, APV Drug Delivery Focus Group Newsletter - 1/2012</ref><ref>Pharmaceutical Extrusion Technology, ed. Isaac Ghebre-Sellassie, Charles Martin, Drugs and the Pharmaceutical Sciences, Volume 133, Informa Healthcare, 2007</ref><ref>V. M. Litvinov, S. Guns, P. Adriaensens, B. J. R. Scholtens, M. P. Quaedflieg, R. Carleer, and G. Van den Mooter, Solid State Solubility of Miconazole in Poly[(ethylene glycol)-g-vinyl alcohol] Using Hot-Melt Extrusion., Mol. Pharmaceutics, 2012, 9 (10), pp 2924–2932 |
|||
DOI: 10.1021/mp300280k</ref> |
|||
==References== |
==References== |
||
| Line 18: | Line 18: | ||
[[Category:Polymer chemistry]] |
[[Category:Polymer chemistry]] |
||
[[Category:Chemical processes]] |
[[Category:Chemical processes]] |
||
[9] |
|||
Latest revision as of 03:12, 22 September 2024
 | This article needs additional citations for verification. (August 2012) |
Micro-compounding is the mixing or processing of polymer formulations in the melt on a small scale, typically milliliters. It is popular for research and development because it gives faster, more reliable results with smaller samples and less cost. Its applications include pharmaceutical, biomedical, and nutritional areas.
Design
[edit]Micro-compounding is typically performed with a tabletop, twin screw micro-compounder, or micro-extruder with a working volume of 5 or 15 milliliters. With such small volumes, it is difficult to have sufficient mixing in a continuous extruder. Therefore, micro-compounders typically have a batch mode (recirculation) and a conical shape.
The L/D of a continuous twin screw extruder is mimicked in a batch micro-compounder by the recirculation mixing time, which is controlled by a manual valve. With this valve, the recirculation can be interrupted to unload the formulation in either a strand or an injection moulder, a film device or a fiber line. Typical recirculation times are one to three minutes, depending on the ease of dispersive and distributive mixing of the formulation.[citation needed]
Benefits
[edit]Micro-compounding can now produce films, fibers, and test samples (rods, rings, tablets) from mixtures as small as 5 ml in less than ten minutes. The small footprint requires less lab space than for a parallel twin screw extruder.[1][2][3][4][5] One micro-extruder, developed to test whether drug delivery enabled improved bioavailability of poorly soluble drugs or the sustained release of active ingredients[clarification needed] show or require sensitive and water destroying invasives.[6][7][8][9][10][11]
References
[edit]- ^ Qizheng Dou, Xiaomin Zhu, Karin Peter, Dan E. Demco, Martin Möller, Claudiu Melian, J. Sol-Gel Sci Technol (2008) 48: 51-60
- ^ Stretz, H.A.; Paul, D.R. (2006). "Properties and morphology of nanocomposites based on styrenic polymers, Part II: Effects of maleic anhydride units". Polymer. 47 (26): 8527–8535. doi:10.1016/j.polymer.2006.10.013.
- ^ Ozkoc, Guralp; Bayram, Goknur; Tiesnitsch, Johan (2008). "Microcompounding of organoclay–ABS/PA6 blend-based nanocomposites". Polymer Composites. 29 (4): 345–356. doi:10.1002/pc.20392.
- ^ Ozkoc, Guralp; Kemaloglu, Sebnem; Quaedflieg, Martin (2010). "Production of poly(lactic acid)/Organoclay nanocomposite scaffolds by microcompounding and polymer/Particle leaching". Polymer Composites. 31 (4): 674–683. doi:10.1002/pc.20846.
- ^ Özkoç, Güralp; Bayram, Göknur; Quaedflieg, Martin (2008). "Effects of microcompounding process parameters on the properties of ABS/Polyamide-6 blends based nanocomposites". Journal of Applied Polymer Science. 107 (5): 3058–3070. doi:10.1002/app.27460.
- ^ Markus Thommes, APV Drug Delivery Focus Group Newsletter - 1/2012
- ^ Ghebre-Sellassie, Isaac; Ghebre-Selassie, Isaac; Martin, Charles E.; Zhang, Feng; DiNunzio, James; Martin, Charles, eds. (2003-05-14). "Pharmaceutical Extrusion Technology". International Journal of Pharmaceutics. 133 (1–2): 1–271. doi:10.1201/9780203911532. ISBN 978-0-203-91153-2 – via www.sciencedirect.com.
- ^ Bodor, Nicholas (February 1984). "Techniques of Solubilization of Drugs". Journal of Pharmaceutical Sciences. Drugs and the Pharmaceutical Sciences Series. 73 (2): 288. doi:10.1002/jps.2600730245. ISSN 0022-3549.
- ^ Litvinov, V. M.; Guns, S.; Adriaensens, P.; Scholtens, B. J. R.; Quaedflieg, M. P.; Carleer, R.; Van den Mooter, G. (2012-10-01). "Solid State Solubility of Miconazole in Poly[(ethylene glycol)- g -vinyl alcohol] Using Hot-Melt Extrusion". Molecular Pharmaceutics. 9 (10): 2924–2932. doi:10.1021/mp300280k. ISSN 1543-8384. PMID 22905779.
- ^ Sakai, Toshiro (6 November 2012). APV Experts‘ Workshop on Hot Melt Extrusion.
{{cite conference}}: Missing or empty|title=(help) - ^ Sakai, Toshiro; Thommes, Markus (2014-01-17). "Investigation into mixing capability and solid dispersion preparation using the DSM Xplore Pharma Micro Extruder". Journal of Pharmacy and Pharmacology. 66 (2): 218–231. doi:10.1111/jphp.12085. ISSN 2042-7158.