Talk:Lamotrigine: Difference between revisions

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Latest revision as of 14:11, 27 June 2024

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Sleep disturb % is misstated.

Not, "However, a retrospective study of 109 patients' medical records found that 6.7% of patients experienced an "alerting effect" resulting in intolerable insomnia, for which the treatment had to be discontinued. (65)"

It's only 6.4%.

65) Sadler M (March 1999). "Lamotrigine associated with insomnia". Epilepsia. 40 (3): 322–5. doi:10.1111/j.1528-1157.1999.tb00712.x. PMID 10080513. S2CID 43902298. 98.144.238.191 (talk) 17:28, 29 June 2022 (UTC)[reply]

How to take this medication. Empty stomach? With food? Time of day? Etc. 68.66.100.253 (talk) 14:36, 8 January 2024 (UTC)[reply]

Receptor activity listed in article not found in cited source

Receptor activity is listed as antagonistic at 5-HT3 and σ receptors with IC50 of 18 μM and 145 μM, respectively. The inline citation is [5] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d7e3572d-56fe-4727-2bb4-013ccca22678. Neither the live webpage cited nor the archived version make any mention of antagonistic activity at 5-HT3 or σ receptors unless I'm mistaken. Moreover, the ligands section of the sigma receptor page lists Lamotrigine as an *agonist* of the σ receptors with two inline citations, one of which I can't access and the other of which makes no mention of activity at σ receptors at all. UriNation69420 (talk) 17:21, 26 June 2024 (UTC)[reply]

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+== Sleep disturb % is misstated. ==
+Not, "However, a retrospective study of 109 patients' medical records found that 6.7% of patients experienced an "alerting effect" resulting in intolerable insomnia, for which the treatment had to be discontinued. (65)"
+It's only 6.4%.
+) Sadler M (March 1999). "Lamotrigine associated with insomnia". Epilepsia. 40 (3): 322–5. doi:10.1111/j.1528-1157.1999.tb00712.x. PMID 10080513. S2CID 43902298. [[Special:Contributions/98.144.238.191|98.144.238.191]] ([[User talk:98.144.238.191|talk]]) 17:28, 29 June 2022 (UTC)
+How to take this medication. Empty stomach? With food? Time of day? Etc. [[Special:Contributions/68.66.100.253|68.66.100.253]] ([[User talk:68.66.100.253|talk]]) 14:36, 8 January 2024 (UTC)
+== Receptor activity listed in article not found in cited source ==
+Receptor activity is listed as antagonistic at 5-HT3 and σ receptors with IC50 of 18 μM and 145 μM, respectively. The inline citation is [5] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d7e3572d-56fe-4727-2bb4-013ccca22678. Neither the live webpage cited nor the archived version make any mention of antagonistic activity at 5-HT3 or σ receptors unless I'm mistaken. Moreover, the ligands section of the [[sigma receptor]] page lists Lamotrigine as an *agonist* of the σ receptors with two inline citations, one of which I can't access and the other of which makes no mention of activity at σ receptors at all. [[User:UriNation69420|UriNation69420]] ([[User talk:UriNation69420|talk]]) 17:21, 26 June 2024 (UTC)