British Biotech: Difference between revisions
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{{Short description|British based Biotechnology company}} |
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{{EngvarB|date=September 2013}} |
{{EngvarB|date=September 2013}} |
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{{Infobox company |
{{Infobox company |
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| name = British Biotech <small>''plc''<br>([[London Stock Exchange|LSE]]:BBG [[Nasdaq]]:BBIOY)</small> |
| name = British Biotech <small>''plc''<br />([[London Stock Exchange|LSE]]:BBG [[Nasdaq]]:BBIOY)</small> |
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| logo = |
| logo = |
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| fate = Merged |
| fate = Merged |
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| successor = |
| successor = [[Vernalis plc]] |
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| foundation = 1986 |
| foundation = 1986 |
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| defunct = 2003 |
| defunct = 2003 |
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| location = [[Oxford]], United Kingdom |
| location = [[Oxford]], United Kingdom |
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| industry = [[Biotechnology]] |
| industry = [[Biotechnology]] |
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| key_people = '''CEO'''<br>Keith McCullagh, 1986–1998<br>Elliot Goldstein, 1998–2002<br>Tim Edwards, 2002–2003<br>'''Chair'''<br>Brian Richards, 1986–1998<br>Christopher Hampson, 1998–2002<br>Peter Fellner, 2002–2003 |
| key_people = '''CEO'''<br />Keith McCullagh, 1986–1998<br />Elliot Goldstein, 1998–2002<br />Tim Edwards, 2002–2003<br />'''Chair'''<br />Brian Richards, 1986–1998<br />Christopher Hampson, 1998–2002<br />Peter Fellner, 2002–2003 |
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| products = |
| products = |
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| num_employees = 500 |
| num_employees = 500 |
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}} |
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'''British Biotech''' was a British |
'''British Biotech''' was a British-based [[biotech]]nology company founded as '''British Biotechnology Limited''' in 1986 by former [[G. D. Searle & Company|G D Searle]] managers Keith McCullagh and Brian Richards.<ref name="searle">{{cite web|last=Rosen |first=Michael S. |year=2003 |url=http://www.midwestbusiness.com/printer/article.asp?newsletterID=4627 |title=The Final Death Knell of Chicago's G.D. Searle |publisher=Midwest Business |accessdate=12 May 2003 |url-status=dead |archiveurl=https://web.archive.org/web/20070927070247/http://www.midwestbusiness.com/printer/article.asp?newsletterID=4627 |archivedate=27 September 2007}}</ref> |
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| ⚫ | |||
| first = |
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| authorlink = |
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|author2= Michael S. Rosen |
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| year = 2003 |
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| url = http://www.midwestbusiness.com/printer/article.asp?newsletterID=4627 |
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| title = The Final Death Knell of Chicago's G.D. Searle |
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| work = |
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| publisher = Midwest Business |
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| accessdate = 12 May 2003 |
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}} {{Dead link|date=October 2010|bot=H3llBot}}</ref> |
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It was the first British biotech company to be publicly listed when it was floated on 1 July 1992.<ref name="ipo">{{cite web |
It was the first British biotech company to be publicly listed when it was floated on 1 July 1992.<ref name="ipo">{{cite web |
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| last = |
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| first = |
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| authorlink = |
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| year = 1992 |
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| url = http://www.nea.com/PortfolioCompanies/SummaryReports/IPO/index.cfm?SR=88 |
| url = http://www.nea.com/PortfolioCompanies/SummaryReports/IPO/index.cfm?SR=88 |
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| title = BBIOY IPO |
| title = BBIOY IPO |
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| work = IPO Summary Report |
| work = IPO Summary Report |
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| publisher = NEA |
| publisher = NEA |
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| date = 1 December 1992 |
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| access-date = 1 August 2006 |
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| ⚫ | |||
| archive-url = https://web.archive.org/web/20070928035326/http://www.nea.com/PortfolioCompanies/SummaryReports/IPO/index.cfm?SR=88 |
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| archive-date = 28 September 2007 |
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| url-status = dead |
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| ⚫ | |||
==Controversy== |
==Controversy== |
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In 1996, despite having no compounds on or near the market, the company was temporarily valued at nearly $2.5 billion,<ref name="gaffe7">{{cite |
In 1996, despite having no compounds on or near the market, the company was temporarily valued at nearly $2.5 billion,<ref name="gaffe7">{{cite journal |
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| last = |
| last =Hodgson |
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| first = |
| first =John |
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| authorlink = |
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|author2= John Hodgson |
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| year = 2006 |
| year = 2006 |
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| url = http://www.nature.com/nbt/journal/v24/n3/full/nbt0306-270.html |
| url = http://www.nature.com/nbt/journal/v24/n3/full/nbt0306-270.html |
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| title = Ten years of biotech gaffes |
| title = Ten years of biotech gaffes |
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| |
| journal = Nature Biotechnology |
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| volume =24 |
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| ⚫ | |||
| pages =270–273 |
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| publisher = Nature Publishing Group |
| publisher = Nature Publishing Group |
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| doi =10.1038/nbt0306-270 |
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| pmid =16525384 |
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| s2cid =560311 |
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| accessdate = 8 March 2006 |
| accessdate = 8 March 2006 |
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}}</ref> largely on the basis of its two main development drugs: ''[[marimastat]]'' (a novel [[Matrix metalloproteinase#Inhibitors|matrix metalloprotease inhibitor]] for cancer treatment<ref name="jco">{{cite web |
}}</ref> largely on the basis of its two main development drugs: ''[[marimastat]]'' (a novel [[Matrix metalloproteinase#Inhibitors|matrix metalloprotease inhibitor]] for cancer treatment<ref name="jco">{{cite web |author1=Wojtowicz-Praga S |author2=Torri J |author3=Johnson M |author4=Steen V |author5=Marshall J |author6=Ness E |author7=Dickson R |author8=Sale M |author9=Rasmussen HS |author10=Chiodo TA |author11=Hawkins MJ |year=1998 |url=http://www.jco.org/cgi/content/abstract/16/6/2150 |title=Phase I trial of Marimastat |work=Journal of Clinical Oncology |publisher=American Society of Clinical Oncology |accessdate= |archive-url=https://web.archive.org/web/20050512065616/http://www.jco.org/cgi/content/abstract/16/6/2150 |archive-date=12 May 2005 |url-status=dead }}</ref>) and [[lexipafant]] (''Zacutex'', for [[pancreatitis]]). ''[[Batimastat]]'' (codename BB94) progressed as far as stage 3 in its clinical trial, although not orally bioavailable, there are other methods of administration, including transdermal. |
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| last = |
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| authorlink = |
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|author=Wojtowicz-Praga S, Torri J, Johnson M, Steen V, Marshall J, Ness E, Dickson R, Sale M, Rasmussen HS, Chiodo TA, Hawkins MJ. |
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| year = 1998 |
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| url = http://www.jco.org/cgi/content/abstract/16/6/2150 |
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| title = Phase I trial of Marimastat |
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| work = Journal of Clinical Oncology |
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| publisher = American Society of Clinical Oncology |
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| accessdate = 16 June 1998 |
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}}</ref>) and ''zacutex'' (for [[pancreatitis]]). |
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In February 1998, Dr Andrew Millar was dismissed as Head of Clinical Research and went on to make allegations that "the Board were running a business plan consistent only with extreme and unfounded optimism".<ref name="report">{{cite web |
In February 1998, Dr Andrew Millar was dismissed as Head of Clinical Research and went on to make allegations that "the Board were running a business plan consistent only with extreme and unfounded optimism".<ref name="report">{{cite web |
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| last = |
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| first = |
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| authorlink = |
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| year = 1998 |
| year = 1998 |
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| url = |
| url = https://publications.parliament.uk/pa/cm199798/cmselect/cmsctech/888/88804.htm |
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| title = Fifth Report |
| title = Fifth Report |
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| work = Select Committee on Science and Technology |
| work = Select Committee on Science and Technology |
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| publisher = House of Commons |
| publisher = House of Commons |
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| accessdate = |
| accessdate = |
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}}</ref> These events were the subject of an inquiry by the [[House of Commons of the United Kingdom|House of Commons]] [[Select Committee on Science and Technology]] in August 1998 which absolved Dr Millar of any responsibility for the company's problems.<ref name="report" /> |
}}</ref> These events were the subject of an inquiry by the [[House of Commons of the United Kingdom|House of Commons]] [[Select Committee on Science and Technology]] in August 1998 which absolved Dr Millar of any responsibility for the company's problems.<ref name="report" /> |
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Subsequent investigations by the [[Securities and Exchange Commission]], [[Food and Drug Administration]], [[London Stock Exchange]] and the [[European Medicines Evaluation Agency]] found that British Biotech had wilfully misled the public about the progress of marimastat<ref name="sec">{{cite web |
Subsequent investigations by the [[Securities and Exchange Commission]], [[Food and Drug Administration]], [[London Stock Exchange]] and the [[European Medicines Evaluation Agency]] found that British Biotech had wilfully misled the public about the progress of marimastat<ref name="sec">{{cite web |
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| last = |
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| first = |
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| authorlink = |
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| year = 1999 |
| year = 1999 |
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| url = http://www.nature.com/nbt/journal/v17/n7/full/nbt0799_624b.html |
| url = http://www.nature.com/nbt/journal/v17/n7/full/nbt0799_624b.html |
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| work = [[Nature Biotechnology]] |
| work = [[Nature Biotechnology]] |
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| publisher = Nature Publishing Group |
| publisher = Nature Publishing Group |
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| accessdate = |
| accessdate = |
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}}</ref> and that [[blind experiment|unblinding data]] before the end of clinical trials does not necessarily invalidate the results.<ref name="ipupdate">{{cite web |
}}</ref> and that [[blind experiment|unblinding data]] before the end of clinical trials does not necessarily invalidate the results.<ref name="ipupdate">{{cite web |
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| last = |
| last = Khan |
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| first = |
| first = Alex |
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| authorlink = |
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|author2= Alex Khan |
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| year = 1999 |
| year = 1999 |
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| url = http://www.ipit-update.com/plant01.htm |
| url = http://www.ipit-update.com/plant01.htm |
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| work = IP/IT Update |
| work = IP/IT Update |
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| publisher = NIPC |
| publisher = NIPC |
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| archive-url = https://web.archive.org/web/20061027151425/http://www.ipit-update.com/plant01.htm |
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| accessdate = 15 February 1999 |
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| archive-date = 27 October 2006 |
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| url-status = dead |
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| first = |
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| authorlink = |
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| year = 2001 |
| year = 2001 |
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| url = http://www.mult-sclerosis.org/news/May2001/MMPIPhaseIIICancerTrialMMPIsMaybeUsefulinMS.html |
| url = http://www.mult-sclerosis.org/news/May2001/MMPIPhaseIIICancerTrialMMPIsMaybeUsefulinMS.html |
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| title = Marimastat Update |
| title = Marimastat Update |
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| |
| website = |
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| publisher = [[BusinessWire]] |
| publisher = [[BusinessWire]] |
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| accessdate = |
| accessdate = |
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}}</ref> |
}}</ref> |
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Further development of |
Further development of Zacutex was abandoned due to poor clinical trial results.<ref name="zaputex">{{cite web |
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| last = |
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| first = |
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| authorlink = |
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| year = 1998 |
| year = 1998 |
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| url = http://www.bbcactive.com/BroadCastLearning/asp/catalogue/productdetail.asp?productcode=21241 |
| url = http://www.bbcactive.com/BroadCastLearning/asp/catalogue/productdetail.asp?productcode=21241 |
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| work = Select Committee on Science and Technology |
| work = Select Committee on Science and Technology |
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| publisher = House of Commons |
| publisher = House of Commons |
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| accessdate = |
| accessdate = |
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}}</ref> |
}}</ref> |
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The corporate politics behind the downfall of British Biotech was later recorded for a [[BBC2]] Series ''Blood on the Carpet''.<ref name="bloodcarpet">{{cite web |
The corporate politics behind the downfall of British Biotech was later recorded for a [[BBC2]] Series ''Blood on the Carpet''.<ref name="bloodcarpet">{{cite web |
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| last = |
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| first = |
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| authorlink = |
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| year = 2001 |
| year = 2001 |
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| url = http://www.bbcactive.com/BroadCastLearning/asp/catalogue/productdetail.asp?productcode=21241 |
| url = http://www.bbcactive.com/BroadCastLearning/asp/catalogue/productdetail.asp?productcode=21241 |
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| title = BBC2's Blood on the Carpet |
| title = BBC2's Blood on the Carpet |
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| |
| website = |
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| publisher = BBC |
| publisher = BBC |
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| accessdate = |
| accessdate = |
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}}</ref> |
}}</ref> |
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== Disappearance == |
== Disappearance == |
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In 2003, |
In 2003, British Biotech merged with RiboTargets and then into [[Vernalis Group]]. The British Biotech company name disappeared after this merger and remaining staff integrated into the new [[Vernalis plc]] organisation in [[Winnersh]], Berkshire. |
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| ⚫ | |||
| ⚫ | |||
==References== |
==References== |
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{{Reflist}} |
{{Reflist}} |
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| ⚫ | |||
| ⚫ | |||
[[Category:Biotechnology companies of the United Kingdom]] |
[[Category:Biotechnology companies of the United Kingdom]] |
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[[Category:Companies based in Oxford]] |
[[Category:Companies based in Oxford]] |
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[[Category:Biotechnology companies established in 1986]] |
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[[Category:Biotechnology companies disestablished in 2003]] |
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[[Category:1986 establishments in England]] |
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[[Category:2003 disestablishments in England]] |
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Latest revision as of 12:53, 30 January 2024
| Industry | Biotechnology |
|---|---|
| Founded | 1986 |
| Defunct | 2003 |
| Fate | Merged |
| Successor | Vernalis plc |
| Headquarters | Oxford, United Kingdom |
Key people | CEO Keith McCullagh, 1986–1998 Elliot Goldstein, 1998–2002 Tim Edwards, 2002–2003 Chair Brian Richards, 1986–1998 Christopher Hampson, 1998–2002 Peter Fellner, 2002–2003 |
Number of employees | 500 |
British Biotech was a British-based biotechnology company founded as British Biotechnology Limited in 1986 by former G D Searle managers Keith McCullagh and Brian Richards.[1] It was the first British biotech company to be publicly listed when it was floated on 1 July 1992.[2]
Controversy
[edit]In 1996, despite having no compounds on or near the market, the company was temporarily valued at nearly $2.5 billion,[3] largely on the basis of its two main development drugs: marimastat (a novel matrix metalloprotease inhibitor for cancer treatment[4]) and lexipafant (Zacutex, for pancreatitis). Batimastat (codename BB94) progressed as far as stage 3 in its clinical trial, although not orally bioavailable, there are other methods of administration, including transdermal.
In February 1998, Dr Andrew Millar was dismissed as Head of Clinical Research and went on to make allegations that "the Board were running a business plan consistent only with extreme and unfounded optimism".[5] These events were the subject of an inquiry by the House of Commons Select Committee on Science and Technology in August 1998 which absolved Dr Millar of any responsibility for the company's problems.[5]
Subsequent investigations by the Securities and Exchange Commission, Food and Drug Administration, London Stock Exchange and the European Medicines Evaluation Agency found that British Biotech had wilfully misled the public about the progress of marimastat[6] and that unblinding data before the end of clinical trials does not necessarily invalidate the results.[7] Marimastat underwent Phase III trials in collaboration with Schering-Plough Corporation.[8] Further development of Zacutex was abandoned due to poor clinical trial results.[9]
The corporate politics behind the downfall of British Biotech was later recorded for a BBC2 Series Blood on the Carpet.[10]
Disappearance
[edit]In 2003, British Biotech merged with RiboTargets and then into Vernalis Group. The British Biotech company name disappeared after this merger and remaining staff integrated into the new Vernalis plc organisation in Winnersh, Berkshire.
References
[edit]- ^ Rosen, Michael S. (2003). "The Final Death Knell of Chicago's G.D. Searle". Midwest Business. Archived from the original on 27 September 2007. Retrieved 12 May 2003.
- ^ "BBIOY IPO". IPO Summary Report. NEA. 1 December 1992. Archived from the original on 28 September 2007. Retrieved 1 August 2006.
- ^ Hodgson, John (2006). "Ten years of biotech gaffes". Nature Biotechnology. 24 (3). Nature Publishing Group: 270–273. doi:10.1038/nbt0306-270. PMID 16525384. S2CID 560311. Retrieved 8 March 2006.
- ^ Wojtowicz-Praga S; Torri J; Johnson M; Steen V; Marshall J; Ness E; Dickson R; Sale M; Rasmussen HS; Chiodo TA; Hawkins MJ (1998). "Phase I trial of Marimastat". Journal of Clinical Oncology. American Society of Clinical Oncology. Archived from the original on 12 May 2005.
- ^ a b "Fifth Report". Select Committee on Science and Technology. House of Commons. 1998.
- ^ "British Biotech settles up". Nature Biotechnology. Nature Publishing Group. 1999.
- ^ Khan, Alex (1999). "Shedding Biotech's Bad Name". IP/IT Update. NIPC. Archived from the original on 27 October 2006.
- ^ "Marimastat Update". BusinessWire. 2001.
- ^ "Zacutex UK Phase III clinical data presented at American Gastroenterological Association". Select Committee on Science and Technology. House of Commons. 1998.
- ^ "BBC2's Blood on the Carpet". BBC. 2001.