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{{Short description|Turkish gynecologist}}
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{{self-published|date=January 2016}}
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{{COI|date=January 2016}}
{{external links|date=January 2016}}
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{{Infobox scientist
{{Infobox scientist
| name = Serdar Bulun
| name = Serdar Bulun
| image = BulunWikiPic.jpg
| image =
| alt =
| alt =
| caption =
| caption =
| birth_place = [[Malatya]], [[Turkey]]
| birth_place = [[Malatya]], [[Turkey]]
| residence = {{ublist |[[Chicago, Illinois]] |[[United States]]}}
| fields = {{ublist |[[Obstetrics and Gynecology]] |[[Reproductive endocrinology and infertility]]}}
⚫
| workplaces = {{ublist |[[Northwestern University]] |[https://www.nm.org/location/prentice-womens-hospital Prentice Women's Hospital] | [[Northwestern Memorial Hospital]]}}
| fields = {{ublist |[[Obstetrics and Gynecology]] |[[Reproductive endocrinology and infertility]]}}
⚫
| website = http://www.feinberg.northwestern.edu/sites/obgyn/research/labs/bulun/index.html
⚫
| workplaces = {{ublist |[[Northwestern University]] |[https://www.nm.org/location/prentice-womens-hospital Prentice Women's Hospital] | [[Northwestern Memorial Hospital]]}}
⚫
|website = http://www.feinberg.northwestern.edu/sites/obgyn/research/labs/bulun/index.html
}}
}}


'''Serdar Bulun, MD''' is a gynecologist, who has special interest in the common gynecologic diseases, endometriosis and uterine fibroids.<ref name="bulun 2009">[http://www.ncbi.nlm.nih.gov/pubmed/19144942 Bulun SE. Endometriosis.''N Engl J Med''.2009;360:268-79].</ref><ref name="bulun 2013">[http://www.ncbi.nlm.nih.gov/pubmed/24088094 Bulun SE. Uterine fibroids.''N Engl J Med''.2013;369:1344-55.]</ref><ref name="attar 2006" /><ref name="ono 2013" /><ref name="dyson 2014">[http://www.ncbi.nlm.nih.gov/pubmed/?term=Dyson+MT%2C+Roqueiro+D%2C+Monsivais+D%2C+et+al.+Genome-wide+DNA+methylation+analysis+predicts+an+epigenetic+switch+for+GATA+factor+expression+in+endometriosis.+PLoS+Genet.+2014%3B10(3)%3Ae1004158. Dyson MT, Roqueiro D, Monsivais D, et al. Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis.''PLoS Genet''.2014;10(3):e1004158.]</ref>
'''Serdar Bulun''' is a gynecologist, with a special interest in the common gynecologic diseases, [[endometriosis]] and [[uterine fibroids]].<ref name="bulun 2009">{{cite journal | pmid = 19144942 | doi=10.1056/NEJMra0804690 | volume=360 | title=Endometriosis | journal=N Engl J Med | pages=268–79 | last1 = Bulun | first1 = SE| issue=3 | year=2009 }}</ref><ref name="bulun 2013">{{cite journal | pmid = 24088094 | doi=10.1056/NEJMra1209993 | volume=369 | title=Uterine fibroids | journal=N Engl J Med | pages=1344–55 | last1 = Bulun | first1 = SE| issue=14 | year=2013 }}</ref><ref name="attar 2006" /><ref name="ono 2013" /><ref name="dyson 2014">[https://www.ncbi.nlm.nih.gov/pubmed/?term=Dyson+MT%2C+Roqueiro+D%2C+Monsivais+D%2C+et+al.+Genome-wide+DNA+methylation+analysis+predicts+an+epigenetic+switch+for+GATA+factor+expression+in+endometriosis.+PLoS+Genet.+2014%3B10(3)%3Ae1004158. Dyson MT, Roqueiro D, Monsivais D, et al. Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis.''PLoS Genet''.2014;10(3):e1004158.]</ref>

He currently serves as the obstetrician and gynecologist-in-chief of the [https://www.nm.org/location/prentice-womens-hospital Prentice Women’s Hospital] of [[Northwestern Memorial Hospital]] in Chicago, IL and Chair of [http://www.feinberg.northwestern.edu/sites/obgyn/ Northwestern University’s Department of Obstetrics and Gynecology].

Bulun was born in [[Malatya]], Turkey in 1959 and moved to Istanbul to attend [[Robert College]] and thereafter [[Istanbul University]] School of Medicine (Çapa Tıp Fakültesi). He received his residency training in obstetrics and gynecology at the [[University at Buffalo]] in New York and pursued a sub-specialty fellowship in reproductive endocrinology-infertility at the [[University of Texas Southwestern Medical Center at Dallas]]. Starting from 2003, he has set up a comprehensive women’s health research program at Northwestern, and recruited and supported numerous faculty who focus on steroid hormone-related pathology of uterine, breast and ovarian disorders.<ref name="kim 2013">[http://www.ncbi.nlm.nih.gov/pubmed/23303565 Kim JJ, Kurita T, ‘’’Bulun SE’’’. Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer.’’Endocr Rev’’.2013;34(1):130-162.]</ref> Throughout his career, Bulun has been awarded over $70 million of research funding in [[endometriosis]], [[uterine fibroids]] and [[breast cancer]]. In his laboratory, he mentored many PhD and MD-PhD students and postdoctoral research fellows.<ref name="bulun 2009" /><ref name="bulun 2013" /><ref name="bulun 2005">[http://www.ncbi.nlm.nih.gov/pubmed/?term=Regulation+of+aromatase+expression+in+estrogen-responsive+breast+and+uterine+disease%3A+from+bench+to+treatment Bulun SE, Lin Z, Imir G, et al. Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment.''Pharmacol Rev''.2005;57:359-83.]</ref>

Bulun discovered the epigenetic basis of [[endometriosis]] and introduced [[aromatase inhibitors]] as a novel class of drugs to effectively treat it.<ref name="attar 2006">[http://www.ncbi.nlm.nih.gov/pubmed/?term=Aromatase+inhibitors%3A+the+next+generation+of+therapeutics+for+endometriosis%3F Attar E, Bulun SE. Aromatase inhibitors: the next generation of therapeutics for endometriosis?''Fertil Steril''.2006;85:1307-18.]</ref> His team isolated tumor stem cells from uterine fibroids and targeted these to treat this disease.<ref name="ono 2013">[http://www.ncbi.nlm.nih.gov/pubmed/?term=Paracrine+activation+of+WNT%2Fbeta-catenin+pathway+in+uterine+leiomyoma+stem+cells+promotes+tumor+growth Ono M, Yin P, Navarro A, et al. Paracrine activation of WNT/beta-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.''Proc Natl Acad Sci USA''.2013;110:17053-8.]</ref><ref name="ono 2012">[http://www.ncbi.nlm.nih.gov/pubmed/22570742 Ono M, Qiang W, Serna VA, et al. Role of stem cells in human uterine leiomyoma growth.''PLoS One''.2012;7(5):e36935.]</ref> He also contributed significantly to the genetics and systems biology aspects of hormone-responsive disorders of the breast including cancer.<ref name="shozu 2003">[http://www.ncbi.nlm.nih.gov/pubmed/?term=Estrogen+excess+associated+with+novel+gain-of-function+mutations+affecting+the+aromatase+gene Shozu M, Sebastian S, Takayama K, et al. Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene.''N Engl J Med''.2003;348:1855-65.]</ref><ref name="demura 2007">[http://www.ncbi.nlm.nih.gov/pubmed/?term=Regional+rearrangements+in+chromosome+15q21+cause+formation+of+cryptic+promoters+for+the+CYP19+(aromatase)+gene. Demura M, Martin RM, Shozu M, et al. Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene.''Hum Mol Genet''.2007;16:2529-41.]</ref><ref name="zhou 2001">[http://www.ncbi.nlm.nih.gov/pubmed/?term=Malignant+breast+epithelial+cells+stimulate+aromatase+expression+via+promoter+II+in+human+adipose+fibroblasts%3A+an+epithelial-stromal+interaction+in+breast+tumors+mediated+by+CCAAT%2Fenhancer+binding+protein+beta. Zhou J, Gurates B, Yang S, Sebastian S, Bulun SE. Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.''Cancer Res''.2001;61:2328-34.]</ref> He has published more than 200 scientific articles including reports in top-ranked journals such as the [[New England Journal of Medicine]], [[Nature Medicine]], and the [[Proceedings of the National Academy of Sciences of the USA]]; 65 of these articles have been cited more than 100 times – his h-index is currently 71.{{citation needed|date=January 2016}}


== Biography ==
⚫
Bulun is the editor-in-chief of [https://www.thieme-connect.com/products/ejournals/journal/10.1055/s-00000072 Seminars in Reproductive Medicine].<ref name=thieme>{{cite web|title=Thieme Medical Publishers|url=https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1567816|website=Thieme}}</ref> He has been elected to the [[National Academy of Medicine]] (formerly known as the Institute of Medicine), the [[Association of American Physicians]] and the [[American Society for Clinical Investigation]].<ref name=nam>{{cite web|title=News Center|url=http://news.feinberg.northwestern.edu/2015/10/bulun-elected-to-national-academy-of-medicine/|website=Northwestern Medicine}}</ref><ref name=asci>{{cite web|title=Serdar E. Bulun, M.D.|url=https://www.the-asci.org/controllers/asci/AsciProfileController.php?pid=500282|website=The American Society for Clinical Investigation}}</ref><ref name=aap>{{cite web|title=Member Directory|url=https://aap-online.org/admin/members.php?search=1|website=Association for American Physicians}}</ref> He served as the 2015 president for the [http://www.sri-online.org/ Society for Reproductive Investigation].<ref name=sri>{{cite web|title=SRI Presidents|url=http://www.sri-online.org/about-sri/history-of-sri/sri-presidents|website=Society for Reproductive Investigation}}</ref> He has received the [[National Institutes of Health]]-MERIT award for his work in [[endometriosis]] and the [[American Society of Reproductive Medicine]] Distinguished Researcher Award.<ref name="nih merit award">{{cite web|title=Endometriosis and Retinoids|url=http://grantome.com/grant/NIH/R37-HD038691-12S1|website=Grantome}}</ref><ref name="asrm award">{{cite web|title=ASRM2012: Serdar Bulun honoured as distinguished researcher|url=http://endometriosis.org/news/congress-highlights/asrm2012-serdar-bulun-honoured-as-distinguished-researcher/|website=endometriosis.org}}</ref>
Bulun was born in [[Malatya]], Turkey in 1959 and moved to Istanbul to attend [[Robert College]] and thereafter [[Istanbul University]] School of Medicine (Çapa Tıp Fakültesi). He completed his residency in obstetrics and gynecology at the [[University at Buffalo]] in New York and pursued a sub-specialty fellowship in reproductive endocrinology-infertility at the [[University of Texas Southwestern Medical Center at Dallas]]. Starting from 2003, he established a comprehensive women’s health research program at Northwestern, and recruited and supported numerous faculty who focus on steroid hormone-related pathology of uterine, breast and ovarian disorders.<ref name="kim 2013">{{cite journal | pmid = 23303565 | doi=10.1210/er.2012-1043 | volume=34 | title=Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer | pmc=3565104 | journal=Endocr Rev | pages=130–62 | last1 = Kim | first1 = JJ | last2 = Kurita | first2 = T | last3 = Bulun | first3 = SE| issue=1 | year=2013 }}</ref> Throughout his career, Dr. Bulun has been awarded over $70 million of research funding in [[endometriosis]], [[uterine fibroids]] and [[breast cancer]].<ref name="attar 2006" /><ref name="ono 2013">[https://www.ncbi.nlm.nih.gov/pubmed/?term=Paracrine+activation+of+WNT%2Fbeta-catenin+pathway+in+uterine+leiomyoma+stem+cells+promotes+tumor+growth Ono M, Yin P, Navarro A, et al. Paracrine activation of WNT/beta-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.''Proc Natl Acad Sci USA''.2013;110:17053-8.]</ref><ref name="dyson 2014" /><ref name="kim 2013" /><ref name="bulun 2005">[https://www.ncbi.nlm.nih.gov/pubmed/?term=Regulation+of+aromatase+expression+in+estrogen-responsive+breast+and+uterine+disease%3A+from+bench+to+treatment '''Bulun SE''', Lin Z, Imir G, et al. Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment.''Pharmacol Rev''.2005;57:359-83.]</ref><ref name="shozu 2003">[https://www.ncbi.nlm.nih.gov/pubmed/?term=Estrogen+excess+associated+with+novel+gain-of-function+mutations+affecting+the+aromatase+gene Shozu M, Sebastian S, Takayama K, et al. Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene.''N Engl J Med''.2003;348:1855-65.]</ref><ref name="demura 2007">[https://www.ncbi.nlm.nih.gov/pubmed/?term=Regional+rearrangements+in+chromosome+15q21+cause+formation+of+cryptic+promoters+for+the+CYP19+(aromatase)+gene. Demura M, Martin RM, Shozu M, et al. Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene.''Hum Mol Genet''.2007;16:2529-41.]</ref><ref name="ono 2012">{{cite journal | pmid = 22570742 | doi=10.1371/journal.pone.0036935 | volume=7 | title=Role of stem cells in human uterine leiomyoma growth | pmc=3343011 | journal=PLOS ONE | pages=e36935 | last1 = Ono | first1 = M | last2 = Qiang | first2 = W | last3 = Serna | first3 = VA | last4 = Yin | first4 = P | last5 = Coon | last6 = Navarro | first6 = A | last7 = Monsivais | first7 = D | last8 = Kakinuma | first8 = T | last9 = Dyson | first9 = M | last10 = Druschitz | first10 = S | last11 = Unno | first11 = K | last12 = Kurita | first12 = T | last13 = Bulun | first13 = SE| issue=5 | year=2012 | bibcode=2012PLoSO...736935O | doi-access=free }}</ref><ref name="attia 2000">{{cite journal | pmid = 10946900 | doi=10.1210/jcem.85.8.6739 | volume=85 | title=Progesterone receptor isoform A but not B is expressed in endometriosis | journal=J Clin Endocrinol Metab | pages=2897–902 | last1 = Attia | first1 = GR | last2 = Zeitoun | first2 = K | last3 = Edwards | first3 = D | last4 = Johns | first4 = A | last5 = Carr | first5 = BR | last6 = Bulun | first6 = SE| issue=8 | year=2000 | doi-access = free }}</ref><ref name="zhou 2001">[https://www.ncbi.nlm.nih.gov/pubmed/?term=Malignant+breast+epithelial+cells+stimulate+aromatase+expression+via+promoter+II+in+human+adipose+fibroblasts%3A+an+epithelial-stromal+interaction+in+breast+tumors+mediated+by+CCAAT%2Fenhancer+binding+protein+beta. Zhou J, Gurates B, Yang S, Sebastian S, Bulun SE. Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.''Cancer Res''.2001;61:2328-34.]</ref>


== Academic career ==
== Key Scientific Contributions to Medicine ==
Bulun discovered the epigenetic basis of [[endometriosis]] leading to progesterone resistance in this disease, and introduced [[aromatase inhibitors]] as a novel class of drugs to treat it.<ref name="bulun 2009" /><ref name="attar 2006">[https://www.ncbi.nlm.nih.gov/pubmed/?term=Aromatase+inhibitors%3A+the+next+generation+of+therapeutics+for+endometriosis%3F Attar E, Bulun SE. Aromatase inhibitors: the next generation of therapeutics for endometriosis?''Fertil Steril''.2006;85:1307-18.]</ref><ref name="dyson 2014" /><ref name="attia 2000" /> His team isolated tumor stem cells from [[uterine fibroids]] and targeted these to treat this disease.<ref name="bulun 2013" /><ref name="ono 2013" /><ref name="kim 2013" /><ref name="ono 2012" /> His team discovered the first set of gain-of-function mutations affecting the aromatase gene leading to breast development and estrogen excess in prepubertal humans and contributed to the genetics and systems biology aspects of hormone-responsive disorders of the breast, including cancer.<ref name="bulun 2005" /><ref name="shozu 2003" /><ref name="demura 2007" /><ref name="zhou 2001" />
* Introduced aromatase inhibitors as a novel treatment for endometriosis<ref name="attar 2006" />
* Discovered the key epigenetic defects in endometriosis leading to progesterone resistance<ref name="bulun 2009" /><ref name="attia 2000">[http://www.ncbi.nlm.nih.gov/pubmed/10946900 Attia GR, Zeitoun K, Edwards D, Johns A, Carr BR, ‘’’Bulun SE’’’. Progesterone receptor isoform A but not B is expressed in endometriosis.''J Clin Endocrinol Meta''.2000;85(8):2897-2902.]</ref>
* Isolated and therapeutically targeted stem cells in uterine fibroids<ref name="bulun 2013" /><ref name="ono 2012" />
* Discovered the first set of gain-of-function mutations affecting the aromatase gene leading to breast development and estrogen excess in prepubertal boys and girls<ref name="shozu 2003" /><ref name="demura 2007" />


⚫
Bulun is the editor-in-chief of [[Seminars in Reproductive Medicine]].<ref name=thieme>{{cite journal|title=Thieme Medical Publishers|doi=10.1055/s-0035-1567816|pmid=26565385|year=2015|last1=Bulun|first1=S. E.|journal=Seminars in Reproductive Medicine|volume=33|issue=6|pages=373–4}}</ref> He has been elected to the [[National Academy of Medicine]] (formerly known as the Institute of Medicine), the [[Association of American Physicians]] and the [[American Society for Clinical Investigation]].<ref name=nam>{{cite web|title=News Center|url=http://news.feinberg.northwestern.edu/2015/10/bulun-elected-to-national-academy-of-medicine/|website=Northwestern Medicine|date=19 October 2015 }}</ref><ref name=asci>{{cite web|title=Serdar E. Bulun, M.D.|url=https://www.the-asci.org/controllers/asci/AsciProfileController.php?pid=500282|website=The American Society for Clinical Investigation}}</ref><ref name=aap>{{cite web|title=Member Directory|url=https://aap-online.org/admin/members.php?search=1|website=Association for American Physicians}}</ref> He served as the 2015 president for the [http://www.sri-online.org/ Society for Reproductive Investigation].<ref name=sri>{{cite web|title=SRI Presidents|url=http://www.sri-online.org/about-sri/history-of-sri/sri-presidents|website=Society for Reproductive Investigation}}</ref> He has received the [[National Institutes of Health]]-MERIT award for his work in [[endometriosis]] and the [[American Society of Reproductive Medicine]] Distinguished Researcher Award.<ref name="nih merit award">{{cite web|title=Endometriosis and Retinoids|url=http://grantome.com/grant/NIH/R37-HD038691-12S1|website=Grantome}}</ref><ref name="asrm award">{{cite web|title=ASRM2012: Serdar Bulun honoured as distinguished researcher|url=http://endometriosis.org/news/congress-highlights/asrm2012-serdar-bulun-honoured-as-distinguished-researcher/|website=endometriosis.org}}</ref>
== Key Honors ==
{{BLP unsourced section|date=January 2016}}
⚫
* [[National Academy of Medicine]]<ref name=nam /> (formerly Institute of Medicine, IOM, elected 2015)
⚫
* John J. Sciarra Professor of Obstetrics and Gynecology, [[Northwestern University]]<ref name=sciarra>{{cite web|title=Faculty Profiles|url=http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=16755|website=Northwestern Medicine}}</ref> (2012–present)
⚫
* [[Association of American Physicians]]<ref name=aap /> (AAP, elected 2012)
⚫
* [[American Society for Reproductive Medicine]] (ASRM) Distinguished Researcher Award<ref name="asrm award" /> (2012)
⚫
* [[National Institutes of Health]] MERIT (R37) Award HD38691<ref name="nih merit award" /> (2010-2020)
⚫
* George H. Gardner Professor of Clinical Gynecology, [[Northwestern University]]<ref name="george gardner">{{cite web|title=Bulun Appointed Garder Clinical Professor|url=http://www.northwestern.edu/newscenter/stories/2006/11/bulun_mobile.html|website=Northwestern University News Center}}</ref> (2006-2012)
⚫
* [[American Society for Clinical Investigation]]<ref name=asci /> (ASCI, elected 2003)


== External links ==
== Honors ==
⚫
* [[National Academy of Medicine]] (formerly Institute of Medicine, IOM, elected 2015)<ref name=nam />
* http://www.feinberg.northwestern.edu/sites/obgyn/research/labs/bulun/index.html
⚫
* John J. Sciarra Professor of Obstetrics and Gynecology, [[Northwestern University]] (2012–present)<ref name=sciarra>{{cite web|title=Faculty Profiles|url=http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=16755|website=Northwestern Medicine}}</ref>
* http://www.feinberg.northwestern.edu/sites/obgyn/
⚫
* [[Association of American Physicians]] (AAP, elected 2012)<ref name=aap />
⚫
* [[American Society for Reproductive Medicine]] (ASRM) Distinguished Researcher Award (2012)<ref name="asrm award" />
⚫
* [[National Institutes of Health]] MERIT (R37) Award HD38691 (2010-2020)<ref name="nih merit award" />
⚫
* George H. Gardner Professor of Clinical Gynecology, [[Northwestern University]] (2006-2012)<ref name="george gardner">{{cite web|title=Bulun Appointed Gardner Clinical Professor|url=http://www.northwestern.edu/newscenter/stories/2006/11/bulun_mobile.html|website=Northwestern University News Center}}</ref>
⚫
* [[American Society for Clinical Investigation]] (ASCI, elected 2003)<ref name=asci />


== References ==
== References ==
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[[Category:Year of birth missing (living people)]]
[[Category:Year of birth missing (living people)]]
[[Category:Living people]]
[[Category:Living people]]
[[Category:American gynecologists]]
[[Category:Istanbul University Faculty of Medicine alumni]]
[[Category:Members of the National Academy of Medicine]]

Latest revision as of 21:43, 30 December 2024

Serdar Bulun
Born
Malatya, Turkey
Scientific career
Fields
Institutions
Websitehttp://www.feinberg.northwestern.edu/sites/obgyn/research/labs/bulun/index.html

Serdar Bulun is a gynecologist, with a special interest in the common gynecologic diseases, endometriosis and uterine fibroids.[1][2][3][4][5]

Biography

[edit]

Bulun was born in Malatya, Turkey in 1959 and moved to Istanbul to attend Robert College and thereafter Istanbul University School of Medicine (Çapa Tıp Fakültesi). He completed his residency in obstetrics and gynecology at the University at Buffalo in New York and pursued a sub-specialty fellowship in reproductive endocrinology-infertility at the University of Texas Southwestern Medical Center at Dallas. Starting from 2003, he established a comprehensive women’s health research program at Northwestern, and recruited and supported numerous faculty who focus on steroid hormone-related pathology of uterine, breast and ovarian disorders.[6] Throughout his career, Dr. Bulun has been awarded over $70 million of research funding in endometriosis, uterine fibroids and breast cancer.[3][4][5][6][7][8][9][10][11][12]

Academic career

[edit]

Bulun discovered the epigenetic basis of endometriosis leading to progesterone resistance in this disease, and introduced aromatase inhibitors as a novel class of drugs to treat it.[1][3][5][11] His team isolated tumor stem cells from uterine fibroids and targeted these to treat this disease.[2][4][6][10] His team discovered the first set of gain-of-function mutations affecting the aromatase gene leading to breast development and estrogen excess in prepubertal humans and contributed to the genetics and systems biology aspects of hormone-responsive disorders of the breast, including cancer.[7][8][9][12]

Bulun is the editor-in-chief of Seminars in Reproductive Medicine.[13] He has been elected to the National Academy of Medicine (formerly known as the Institute of Medicine), the Association of American Physicians and the American Society for Clinical Investigation.[14][15][16] He served as the 2015 president for the Society for Reproductive Investigation.[17] He has received the National Institutes of Health-MERIT award for his work in endometriosis and the American Society of Reproductive Medicine Distinguished Researcher Award.[18][19]

Honors

[edit]

References

[edit]
  1. ^ a b Bulun, SE (2009). "Endometriosis". N Engl J Med. 360 (3): 268–79. doi:10.1056/NEJMra0804690. PMID 19144942.
  2. ^ a b Bulun, SE (2013). "Uterine fibroids". N Engl J Med. 369 (14): 1344–55. doi:10.1056/NEJMra1209993. PMID 24088094.
  3. ^ a b c Attar E, Bulun SE. Aromatase inhibitors: the next generation of therapeutics for endometriosis?Fertil Steril.2006;85:1307-18.
  4. ^ a b c Ono M, Yin P, Navarro A, et al. Paracrine activation of WNT/beta-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.Proc Natl Acad Sci USA.2013;110:17053-8.
  5. ^ a b c Dyson MT, Roqueiro D, Monsivais D, et al. Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis.PLoS Genet.2014;10(3):e1004158.
  6. ^ a b c Kim, JJ; Kurita, T; Bulun, SE (2013). "Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer". Endocr Rev. 34 (1): 130–62. doi:10.1210/er.2012-1043. PMC 3565104. PMID 23303565.
  7. ^ a b Bulun SE, Lin Z, Imir G, et al. Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment.Pharmacol Rev.2005;57:359-83.
  8. ^ a b Shozu M, Sebastian S, Takayama K, et al. Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene.N Engl J Med.2003;348:1855-65.
  9. ^ a b Demura M, Martin RM, Shozu M, et al. Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene.Hum Mol Genet.2007;16:2529-41.
  10. ^ a b Ono, M; Qiang, W; Serna, VA; Yin, P; Coon; Navarro, A; Monsivais, D; Kakinuma, T; Dyson, M; Druschitz, S; Unno, K; Kurita, T; Bulun, SE (2012). "Role of stem cells in human uterine leiomyoma growth". PLOS ONE. 7 (5): e36935. Bibcode:2012PLoSO...736935O. doi:10.1371/journal.pone.0036935. PMC 3343011. PMID 22570742.
  11. ^ a b Attia, GR; Zeitoun, K; Edwards, D; Johns, A; Carr, BR; Bulun, SE (2000). "Progesterone receptor isoform A but not B is expressed in endometriosis". J Clin Endocrinol Metab. 85 (8): 2897–902. doi:10.1210/jcem.85.8.6739. PMID 10946900.
  12. ^ a b Zhou J, Gurates B, Yang S, Sebastian S, Bulun SE. Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.Cancer Res.2001;61:2328-34.
  13. ^ Bulun, S. E. (2015). "Thieme Medical Publishers". Seminars in Reproductive Medicine. 33 (6): 373–4. doi:10.1055/s-0035-1567816. PMID 26565385.
  14. ^ a b "News Center". Northwestern Medicine. 19 October 2015.
  15. ^ a b "Serdar E. Bulun, M.D." The American Society for Clinical Investigation.
  16. ^ a b "Member Directory". Association for American Physicians.
  17. ^ "SRI Presidents". Society for Reproductive Investigation.
  18. ^ a b "Endometriosis and Retinoids". Grantome.
  19. ^ a b "ASRM2012: Serdar Bulun honoured as distinguished researcher". endometriosis.org.
  20. ^ "Faculty Profiles". Northwestern Medicine.
  21. ^ "Bulun Appointed Gardner Clinical Professor". Northwestern University News Center.
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