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{{Short description|American cancer biologist and neurobiologist}}
{{Use mdy dates|date=December 2021}}
{{COI|date=December 2017}}
{{Infobox scientist
{{Infobox scientist
|name = Don W. Cleveland
| name = Don W. Cleveland
|image = Photograph_of_Don_W._Cleveland_(taken_in_August,_2013).jpg
| image = Cleveland Don.jpg
|image_size =
| image_size =
|caption =
| caption = Cleveland in 2013
|birth_date = {{Birth date and age|1950|08|26}}
| birth_date = {{Birth date and age|1950|08|26}}
|birth_place = [[Waynesville, Missouri|Waynesville]], [[Missouri]]
| birth_place = [[Waynesville, Missouri|Waynesville]], [[Missouri]]
|death_date =
| death_date =
|death_place =
| death_place =
|residence = [[California]]
| citizenship =
|citizenship =
| nationality = American
|nationality = [[United States]]
| ethnicity =
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| field = [[Centromere]]s, [[aneuploidy]] and [[Carcinogenesis|tumorigenesis]]<br />Mechanism and therapy in human [[Neurodegeneration|neurodegenerative]] disease
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|ethnicity =
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| work_institutions = [[Ludwig Cancer Research]]<br />[[University of California, San Diego]]<br />[[Johns Hopkins University]]
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|field = [[Centromeres, aneuploidy and tumorigenesis]]<br />[[Mechanism and therapy in human neurodegenerative disease]]
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| alma_mater = [[Princeton University]] (PhD)<br />[[New Mexico State University]] (BS)
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|work_institutions = [[Ludwig Cancer Research]]<br />[[University of California, San Diego]]<br />[[Johns Hopkins University]]
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| doctoral_advisor = [[Marc W. Kirschner]]
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|alma_mater = [[Princeton University]] (PhD)<br />[[New Mexico State University, Las Cruces, New Mexico]] (BS)
| academic_advisors = [[William J. Rutter|William Rutter]]
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|doctoral_advisor = [[Marc W. Kirschner]]
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| doctoral_students =
|postdoctoral_advisors = [[William Rutter]]
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| known_for =
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|doctoral_students =
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| author_abbrev_bot =
|known_for =
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|author_abbrev_bot =
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| influences =
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|author_abbrev_zoo =
|influences =
| influenced =
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| prizes = [[National Academy of Sciences]], 2006<br />[[American Academy of Arts and Sciences]], 2006<br />[[Institute of Medicine]], 2012<br />[[Breakthrough Prize in Life Sciences]], 2018
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|influenced =
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|prizes = [[National Academy of Sciences]], 2006]]<br />[[American Academy of Arts and Sciences]], 2006]]<br />[[Institute of Medicine]], 2012]]
}}
}}


'''Don W. Cleveland''' (born 1950 in Waynesville, MO) is an American cancer biologist and neurobiologist.
'''Don W. Cleveland''' (born 1950 in [[Waynesville, MO]]) is an American cancer [[biologist]] and [[Neuroscientist|neurobiologist]].


Cleveland is currently the Department Chair of Cellular and Molecular Medicine<ref>{{cite web|title=Don Cleveland Named New Chair Cellular and Molecular Medicine at UC San Diego School of Medicine|url=http://ucsdnews.ucsd.edu/archive/newsrel/awards/12-08DonCleveland.asp|publisher=Debra Kain|accessdate=December 15, 2008}}</ref> and Distinguished Professor of Medicine, Cellular and Molecular Medicine and Neurosciences<ref>{{cite web|title=Four Department of Medicine Faculty Members Are on 2015 Thomson Reuters Highly Cited Researchers List|url=https://mednews.ucsd.edu/2016/02/02/2015-thomson-reuters-highly-cited-researchers-list/|website=News From The Department of Medicine|publisher=Regents of the University of California|accessdate=February 2, 2016}}</ref> at the [[University of California at San Diego]], and Head, Laboratory for Cell Biology at the San Diego branch of [[Ludwig Cancer Research]].<ref name=":3">{{cite web|title=DON CLEVELAND LAB|url=http://www.ludwigcancerresearch.org/location/san-diego-branch/don-cleveland-lab|website=DON CLEVELAND LAB|publisher=LUDWIG INSTITUTE FOR CANCER RESEARCH LTD}}</ref>
Cleveland is currently the Department Chair of Cellular and Molecular Medicine<ref>{{cite web|title=Don Cleveland Named New Chair Cellular and Molecular Medicine at UC San Diego School of Medicine|url=http://ucsdnews.ucsd.edu/archive/newsrel/awards/12-08DonCleveland.asp|publisher=Debra Kain|access-date=December 15, 2008}}</ref> and Distinguished Professor of Medicine, Cellular and Molecular Medicine and Neurosciences<ref>{{cite web|title=Four Department of Medicine Faculty Members Are on 2015 Thomson Reuters Highly Cited Researchers List|url=https://mednews.ucsd.edu/2016/02/02/2015-thomson-reuters-highly-cited-researchers-list/|website=News From The Department of Medicine|publisher=Regents of the University of California|access-date=February 2, 2016|archive-url=https://web.archive.org/web/20170124153830/https://mednews.ucsd.edu/2016/02/02/2015-thomson-reuters-highly-cited-researchers-list/|archive-date=January 24, 2017|url-status=dead}}</ref> at the [[University of California at San Diego]], and Head, Laboratory for Cell Biology at the San Diego branch of [[Ludwig Cancer Research]].<ref name=":3">{{cite web|title=DON CLEVELAND LAB|url=http://www.ludwigcancerresearch.org/location/san-diego-branch/don-cleveland-lab|website=DON CLEVELAND LAB|publisher=LUDWIG INSTITUTE FOR CANCER RESEARCH LTD|access-date=September 28, 2015|archive-url=https://web.archive.org/web/20181212203926/https://www.ludwigcancerresearch.org/location/san-diego-branch/don-cleveland-lab|archive-date=December 12, 2018|url-status=dead}}</ref>


== Biography ==
== Biography ==
Cleveland grew up in Las Cruces, New Mexico. He earned a B.S. in physics in 1972 from New Mexico State University, and graduated as the valedictorian for the College of Arts and Sciences.<ref name=":3" />
Cleveland grew up in Las Cruces, New Mexico. He earned a B.S. in physics in 1972 from [[New Mexico State University]], and graduated as the valedictorian for the College of Arts and Sciences.<ref name=":3" />


Cleveland started graduate school at [[Princeton University]] in 1972, switching mid-year into biochemistry. He worked with [[Marc Kirschner]] and graduated with a PhD in 1977. As a graduate student, Cleveland provided the initial identification and characterization of [[Tau protein|tau]], showing it to have characteristics of a natively unfolded protein.<ref>{{cite journal|last1=Mandelkow|first1=E.-M.|last2=Mandelkow|first2=E.|title=Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration|journal=Cold Spring Harbor Perspectives in Medicine|date=20 March 2012|volume=2|issue=7|pages=a006247–a006247|doi=10.1101/cshperspect.a006247|url=http://perspectivesinmedicine.cshlp.org/content/early/2012/03/20/cshperspect.a006247.full.pdf}}</ref> Tau is now recognized to misaccumulate in Alzheimer's disease and to be the basis for chronic brain injury.<ref name=":1">{{Cite journal|url = |title = Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.|last = McKee|date = 2009|journal = J. Neuropath Exp Neurol|doi = 10.1097/NEN.0b013e3181a9d503|pmid = |access-date = |display-authors=etal}}</ref> He also developed and published a peptide fingerprinting technique<ref>{{Cite journal|url = http://cmm.ucsd.edu/cleveland/linked/cleveland_et_al__1977__j._biol._chem._252__1102-1106.pdf|title = Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.|author1=Cleveland, D.W. |author2=Fischer, S.G. |author3=Kirschner, M.W. |author4= Laemmli, U.K. |last-author-amp=yes|date = 1977|journal = J. Biol. Chem.|pmid = 320200 }}</ref> that was so popular that it became a citation classic <ref>{{cite journal|last1=Kresge|first1=Nicole|last2=Simoni|first2=Robert D.|last3=Hill|first3=Robert L.|title=The Development of Cleveland Peptide Mapping by Don W. Cleveland|journal=The Journal of Biological Chemistry|date=August 18, 2006|volume=281|issue=33|page=e27|url=http://www.jbc.org/content/281/33/e27.full.pdf+html?sid=377e5fc2-1cf8-46b5-8575-5196b2248bf2}}</ref> Cleveland did postdoctoral work with [[William J. Rutter]] at the [[University of California, San Francisco|University of California at San Francisco]] from 1978 to 1981. Cleveland was the first to clone [[tubulin]]<ref>{{cite journal|last1=Janke|first1=Carsten|title=The tubulin code: Molecular components, readout mechanisms, and functions|journal=The Journal of Cell Biology|date=18 August 2014|volume=206|issue=4|pages=461–472|doi=10.1083/jcb.201406055}}</ref><ref>{{cite journal|last1=Cleveland|first1=Don W.|last2=Lopata|first2=Margaret A.|last3=MacDonald|first3=Raymond J.|last4=Cowan|first4=Nicholas J.|last5=Rutter|first5=William J.|last6=Kirschner|first6=Marc|title=Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes.|journal=Cell|date=May 1980|volume=20|issue=1|page=95|pmid=6893015|url=http://ac.els-cdn.com/009286748090238X/1-s2.0-009286748090238X-main.pdf?_tid=76968350-00d7-11e6-a182-00000aab0f02&acdnat=1460483788_cb6ae695ef3911c36fda68ba4e27448d|doi=10.1016/0092-8674(80)90238-x}}</ref> [[actin]] and [[keratin]]<ref>{{cite journal|last1=Fuchs|first1=Elaine V.|last2=Coppock|first2=Susan M.|last3=Green|first3=Howard|last4=Cleveland|first4=Don W.|title=Two distinct classes of keratin genes and their evolutionary significance.|journal=Cell|date=November 1981|volume=27|issue=1|page=75|pmid=6173133|url=http://ac.els-cdn.com/009286748090238X/1-s2.0-009286748090238X-main.pdf?_tid=76968350-00d7-11e6-a182-00000aab0f02&acdnat=1460483788_cb6ae695ef3911c36fda68ba4e27448d|doi=10.1016/0092-8674(81)90362-7}}</ref>
Cleveland started graduate school at [[Princeton University]] in 1972, switching mid-year into biochemistry. He worked with [[Marc Kirschner]] and graduated with a Ph.D. in 1977. Cleveland's doctoral dissertation was titled "Purification and properties of tau, a microtubule associated protein which induces assembly of microtubules from purified tubulin".<ref>{{Cite book|last=Cleveland|first=Don W.|url=https://catalog.princeton.edu/catalog/1627821|title=Purification and properties of tau, a microtubule associated protein which induces assembly of microtubules from purified tubulin|date=1977|language=en}}</ref> As a graduate student, Cleveland provided the initial identification and characterization of [[Tau protein|tau]], showing it to have characteristics of a natively unfolded protein.<ref>{{cite journal|last1=Mandelkow|first1=E.-M.|last2=Mandelkow|first2=E.|title=Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration|journal=Cold Spring Harbor Perspectives in Medicine|date=March 20, 2012|volume=2|issue=7|pages=a006247|doi=10.1101/cshperspect.a006247|url=http://perspectivesinmedicine.cshlp.org/content/early/2012/03/20/cshperspect.a006247.full.pdf|pmc=3385935|pmid=22762014}}</ref> Tau is now recognized to accumulate in Alzheimer's disease and to be the basis for chronic brain injury.<ref name=":1">{{Cite journal|title = Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.|last = McKee|date = 2009|journal = J Neuropathol Exp Neurol|doi = 10.1097/NEN.0b013e3181a9d503|pmid = 19535999|display-authors=etal|pmc=2945234|volume=68|issue = 7|pages=709–35}}</ref> He also developed and published a peptide fingerprinting technique<ref>{{Cite journal|url = http://cmm.ucsd.edu/cleveland/linked/cleveland_et_al__1977__j._biol._chem._252__1102-1106.pdf|title = Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.|author1=Cleveland, D.W. |author2=Fischer, S.G. |author3=Kirschner, M.W. |author4= Laemmli, U.K. |name-list-style=amp|date = 1977|journal = J. Biol. Chem.|pmid = 320200 |volume=252 |issue = 3|pages=1102–6|doi = 10.1016/S0021-9258(19)75212-0|doi-access= free}}</ref> that was so popular that it became a citation classic <ref>{{cite journal|last1=Kresge|first1=Nicole|last2=Simoni|first2=Robert D.|last3=Hill|first3=Robert L.|title=The Development of Cleveland Peptide Mapping by Don W. Cleveland|journal=The Journal of Biological Chemistry|date=August 18, 2006|volume=281|issue=33|page=e27|doi=10.1016/S0021-9258(19)46364-3|url=http://www.jbc.org/content/281/33/e27.full.pdf+html?sid=377e5fc2-1cf8-46b5-8575-5196b2248bf2|doi-access=free}}</ref> Cleveland did postdoctoral work with [[William J. Rutter]] at the [[University of California, San Francisco|University of California at San Francisco]] from 1978 to 1981. Cleveland was the first to clone [[tubulin]]<ref>{{cite journal|last1=Janke|first1=Carsten|title=The tubulin code: Molecular components, readout mechanisms, and functions|journal=The Journal of Cell Biology|date=August 18, 2014|volume=206|issue=4|pages=461–472|doi=10.1083/jcb.201406055|pmid=25135932|pmc=4137062}}</ref><ref>{{cite journal|last1=Cleveland|first1=Don W.|last2=Lopata|first2=Margaret A.|last3=MacDonald|first3=Raymond J.|last4=Cowan|first4=Nicholas J.|last5=Rutter|first5=William J.|last6=Kirschner|first6=Marc|title=Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes.|journal=Cell|date=May 1980|volume=20|issue=1|pages=95–105|pmid=6893015|url=http://ac.els-cdn.com/009286748090238X/1-s2.0-009286748090238X-main.pdf?_tid=76968350-00d7-11e6-a182-00000aab0f02&acdnat=1460483788_cb6ae695ef3911c36fda68ba4e27448d|doi=10.1016/0092-8674(80)90238-x|s2cid=54326866}}</ref> [[actin]] and [[keratin]]<ref>{{cite journal|last1=Fuchs|first1=Elaine V.|last2=Coppock|first2=Susan M.|last3=Green|first3=Howard|last4=Cleveland|first4=Don W.|title=Two distinct classes of keratin genes and their evolutionary significance.|journal=Cell|date=November 1981|volume=27|issue=1|pages=75–84|pmid=6173133|url=http://ac.els-cdn.com/009286748090238X/1-s2.0-009286748090238X-main.pdf?_tid=76968350-00d7-11e6-a182-00000aab0f02&acdnat=1460483788_cb6ae695ef3911c36fda68ba4e27448d|doi=10.1016/0092-8674(81)90362-7|s2cid=38166670}}</ref>


From 1981 through 1995, Cleveland was on the faculty of the Department of Biological Chemistry at the [[Johns Hopkins School of Medicine|Johns Hopkins University School of Medicine]]. In 1995, he accepted a position at the San Diego Branch of Ludwig Cancer Research at the University of California at San Diego. Since 2008, he has been Chair of the Department of Cellular and Molecular Medicine.
From 1981 through 1995, Cleveland was on the faculty of the Department of Biological Chemistry at the [[Johns Hopkins School of Medicine|Johns Hopkins University School of Medicine]]. In 1995, he accepted a position at the San Diego Branch of Ludwig Cancer Research at the [[University of California at San Diego]]. Since 2008, he has been Chair of the Department of Cellular and Molecular Medicine.


== Contributions to Science ==
== Contributions to Science ==
Cleveland has made pioneering discoveries of the mechanisms of chromosome movement and cell-cycle control during normal cellular division, as well as of the principles of neuronal cell development and their relationship to the defects that contribute to inherited neurodegenerative disease.<ref>{{cite web|title=Dr. Don Cleveland of Ludwig Institute for Cancer Research elected to Institute of Medicine|url=http://www.eurekalert.org/pub_releases/2012-10/lifc-ddc101212.php|website=EurekAlert!|publisher=American Association for the Advancement of Science (AAAS)}}</ref> Cleveland's research looks at the molecular genetics of axonal growth and motor neuron disease and the cell biology of mammalian chromosome movement.<ref>{{cite web|title=UC San Diego Researchers Cited Among "World's Most Influential Scientific Minds"|url=http://ucsdnews.ucsd.edu/pressrelease/uc_san_diego_researchers_cited_among_worlds_most_influential_scientific_min|website=UC San Diego News Center|publisher=UC San Diego}}</ref>
Cleveland has made pioneering discoveries of the mechanisms of chromosome movement and cell-cycle control during normal cellular division, as well as of the principles of neuronal cell development and their relationship to the defects that contribute to inherited neurodegenerative disease.<ref>{{cite web|title=Dr. Don Cleveland of Ludwig Institute for Cancer Research elected to Institute of Medicine|url=http://www.eurekalert.org/pub_releases/2012-10/lifc-ddc101212.php|website=EurekAlert!|publisher=American Association for the Advancement of Science (AAAS)}}</ref> Cleveland's research looks at the molecular genetics of axonal growth and motor neuron disease and the cell biology of mammalian chromosome movement.<ref>{{cite web|title=UC San Diego Researchers Cited Among "World's Most Influential Scientific Minds"|url=http://ucsdnews.ucsd.edu/pressrelease/uc_san_diego_researchers_cited_among_worlds_most_influential_scientific_min|website=UC San Diego News Center|publisher=UC San Diego}}</ref>


Most recently, his research has achieved a significant breakthrough in treating Huntington's disease, an inherited and degenerative brain disorder for which there is no cure. A one-time injection of a new DNA-based drug treatment - known as ASO (short for antisense oligonucleotide) - blocked the activity of the gene whose mutation causes the disease. A single treatment silenced the mutated gene responsible for the disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.<ref>{{cite web|title=Potential treatment for Huntington's disease, found effective, safe in mice, monkeys|url=http://www.eurekalert.org/pub_releases/2016-02/aaon-ptf022216.php|website=EurekAlert!|publisher=American Association for the Advancement of Science (AAAS)}}</ref> This drug, called IONIS-HTTRx, was developed by scientists at Ionis Pharmaceuticals in collaboration with partners CHDI Foundation, Roche Pharmaceuticals and academic collaborators at University of California, San Diego and is now in a Phase 1/2a clinical study.<ref>{{cite web|title=Huntington's Drug That Silences Gene at Root of Disease Now in Phase 1 Clinical Test|url=http://huntingtonsdiseasenews.com/2016/02/29/potential-treatment-for-huntingtons-disease-found-effective-safe-in-mice-monkeys-enters-clinical-testing/|website=Huntington's Disease News|publisher=BioNews Services LLC}}</ref>
Most recently, his research has achieved a significant breakthrough in treating Huntington's disease, an inherited and degenerative brain disorder for which there is no cure. A one-time injection of a new DNA-based drug treatment - known as ASO (short for antisense oligonucleotide) - blocked the activity of the gene whose mutation causes the disease. A single treatment silenced the mutated gene responsible for the disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.<ref>{{cite web|title=Potential treatment for Huntington's disease, found effective, safe in mice, monkeys|url=http://www.eurekalert.org/pub_releases/2016-02/aaon-ptf022216.php|website=EurekAlert!|publisher=American Association for the Advancement of Science (AAAS)}}</ref> This drug, called IONIS-HTTRx, was developed by scientists at Ionis Pharmaceuticals in collaboration with partners CHDI Foundation, Roche Pharmaceuticals and academic collaborators at University of California, San Diego. The Phase 3 clinical trial was recently halted for lack of efficacy.<ref>{{cite web|title=Tominersen for Huntington's disease
|url=https://huntingtonsdiseasenews.com/ionis-httrx-rg6042/|website=Huntington's Disease News|publisher=BioNews Services LLC}}</ref>


== Books ==
== Books ==
''Cell and Molecular Biology of the Cytoskeleton: Molecular Mechanisms Controlling Tubulin Synthesis''
''Cell and Molecular Biology of the Cytoskeleton: Molecular Mechanisms Controlling Tubulin Synthesis''
Edited by Jerry W. Shay
Edited by Jerry W. Shay
(Plenum Press, 1986), ISBN 978-1-4612-9269-2
(Plenum Press, 1986), {{ISBN|978-1-4612-9269-2}}


With Toni L. Williamson, ''Mouse Models in the Study of Genetic Neurological Disorders: Mouse Models of Amyotrophic Lateral Sclerosis''
With Toni L. Williamson, ''Mouse Models in the Study of Genetic Neurological Disorders: Mouse Models of Amyotrophic Lateral Sclerosis''
Edited by Brian Popko
Edited by Brian Popko
(Kluwer Academic/Plenum Publishers, 1999), ISBN 0-306-45965-5
(Kluwer Academic/Plenum Publishers, 1999), {{ISBN|0-306-45965-5}}


With Nicholas G. Theodorakis, ''Control of Messenger RNA Stability: Translationally Coupled Degradation of Tubulin mRNA
With Nicholas G. Theodorakis, ''Control of Messenger RNA Stability: Translationally Coupled Degradation of Tubulin mRNA'' Edited by Joel Belasco and George Brawerman
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(Academic Press, Inc., 1993) {{ISBN|0-12-084782-5}}
''Edited By Joel Belasco and George Brawerman
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(Academic Press, Inc., 1993) ISBN 0-12-084782-5


== Select honors ==
== Select honors ==
Elected Member, [[National Academy of Sciences]], 2006<ref>{{cite web|title=UCSD Faculty Members of the National Academy of Sciences|url=https://academicaffairs.ucsd.edu/faculty/awards/nas.html|publisher=UC San Diego}}</ref>
* Elected Member, [[National Academy of Sciences]], 2006<ref>{{cite web|title=UCSD Faculty Members of the National Academy of Sciences|url=https://academicaffairs.ucsd.edu/faculty/awards/nas.html|publisher=UC San Diego}}</ref>
* Elected Member, Institute of Medicine (IOM), 2012<ref>{{Cite web|url = http://ucsdnews.ucsd.edu/pressrelease/two_from_ucsd_school_of_medicine_named_members_of_the_institute_of_medicine|title = Two from UCSD School of Medicine Named Members of the Institute of Medicine}}</ref>

Elected Member, Institute of Medicine (IOM), 2012<ref>{{Cite web|url = http://ucsdnews.ucsd.edu/pressrelease/two_from_ucsd_school_of_medicine_named_members_of_the_institute_of_medicine|title = Two from UCSD School of Medicine Named Members of the Institute of Medicine|date = |accessdate = |website = |publisher = }}</ref>
* Elected Fellow, [[American Academy of Arts and Sciences]], 2006<ref>{{Cite web|url=http://www.eurekalert.org/pub_releases/2006-04/uoc--sus042406.php|title=Six UCSD scholars elected fellows of American Academy of Arts and Sciences|last=American Academy of Arts & Sciences}}</ref>
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* Elected Fellow, [[American Academy of Microbiology]], 2006<ref>{{cite web|title=ASM Society Directory|url=http://accounts.asm.org/directory/academy/|publisher=American Society for Microbiology|access-date=September 23, 2015|archive-date=May 25, 2017|archive-url=https://web.archive.org/web/20170525180454/http://accounts.asm.org/directory/academy/|url-status=dead}}</ref><ref>{{cite web|title=ASM Members Elected to National Academy of Sciences|url=http://www.asm.org/ccLibraryFiles/FILENAME/000000002408/znw00706000338.pdf|publisher=American Society for Microbiology|access-date=April 12, 2016|archive-date=January 24, 2017|archive-url=https://web.archive.org/web/20170124153656/http://www.asm.org/ccLibraryFiles/FILENAME/000000002408/znw00706000338.pdf|url-status=dead}}</ref>

Elected Fellow, [[American Academy of Arts and Sciences]], 2006<ref>{{Cite web|url=http://www.eurekalert.org/pub_releases/2006-04/uoc--sus042406.php|title=Six UCSD scholars elected fellows of American Academy of Arts and Sciences|last=American Academy of Arts & Sciences|date=|website=|publisher=|accessdate=}}</ref>
* Elected Fellow, [[American Association for the Advancement of Science]] (AAAS), 2009<ref>{{Cite web|url = http://www.aaas.org/news/aaas-members-elected-fellows-3|title = AAAS Members Elected as Fellows|date = December 18, 2009}}</ref>
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* President, [[American Society for Cell Biology]], 2013<ref>{{cite web|title=President's Column|url=http://www.ascb.org/files/1301presidents.pdf|website=The American Society for Cell Biology}}</ref>

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* Sheila Essey Prize, [[American Academy of Neurology]], April 1999<ref>{{Cite web|url = http://www.alsa.org/research/for-researchers/shelia-essey-award/?referrer=https://www.google.com/|title = The Sheila Essey Award for ALS Research}}</ref>
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Elected Fellow, [[American Academy of Microbiology]], 2006<ref>{{cite web|title=ASM Society Directory|url=http://accounts.asm.org/directory/academy/|publisher=American Society for Microbiology}}</ref><ref>{{cite web|title=ASM Members Elected to National Academy of Sciences|url=http://www.asm.org/ccLibraryFiles/FILENAME/000000002408/znw00706000338.pdf|publisher=American Society for Microbiology}}</ref>
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* Outstanding Scientist Award, Playing to Win for Life Foundation, September 2004

Elected Fellow, [[American Association for the Advancement of Science]] (AAAS), 2009<ref>{{Cite web|url = http://www.aaas.org/news/aaas-members-elected-fellows-3|title = AAAS Members Elected as Fellows|date = December 18, 2009|accessdate = |website = |publisher = }}</ref>
* Wings Over Wall Street and MDA Outstanding Scientist, October 2007<ref>{{Cite web|url = http://wingsoverwallstreet.org/awards/|title = Wings Over Wall Street Diamond Award}}</ref>
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* 2012 Research Award, The Huntington's Disease Society of America

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* Katharine Berkan Judd Award, [[Memorial Sloan Kettering Cancer Center|Memorial Sloan Kettering]], 2012<ref>{{Cite web|url = https://www.mskcc.org/blog/2012-commencement-and-academic-convocation|title = 2012 Commencement and Academic Convocation|date = June 13, 2012}}</ref>
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President, [[American Society for Cell Biology]], 2013<ref>{{cite web|title=President's Column|url=http://www.ascb.org/files/1301presidents.pdf|website=The American Society for Cell Biology|publisher=The American Society for Cell Biology}}</ref>
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* The Ricketts Award, University of Chicago, 2012

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* The Gerson Distinguished Scholar Award, Univ. of Pittsburgh, 2014
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Sheila Essey Prize, [[American Academy of Neurology]], April, 1999<ref>{{Cite web|url = http://www.alsa.org/research/for-researchers/shelia-essey-award/?referrer=https://www.google.com/|title = The Sheila Essey Award for ALS Research|date = |accessdate = |website = |publisher = }}</ref>
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* Essey Prize for ALS Research, [[The ALS Association]], 2014<ref>{{Cite web|url = http://webgw.alsa.org/site/PageServer?pagename=GW_7_2014_A_Night_at_the_Esseys|title = A Night at the Esseys|date = June 5, 2014}}</ref>

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* UCSD Chancellor's Award for Excellence in Postdoctoral Scholar Mentoring, 2014<ref>{{Cite web|url = http://adminrecords.ucsd.edu/Notices/2014/2014-9-18-1.html|title = Excellence in Postdoctoral Scholar Mentoring and Postdoctoral Scholar Awards|date = September 18, 2014}}</ref>
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Outstanding Scientist Award, Playing to Win for Life Foundation, September, 2004
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* Thomas Reuters' 2015 listing of "The World's Most Influential Scientific Minds" 2015<ref>{{cite web |title=Ludwig scientists named to Thomson Reuters' list of world's most influential scientific minds |url=https://www.ludwigcancerresearch.org/news/ludwig-scientists-named-thomson-reuters’-list-world’s-most-influential-scientific-minds |website=Ludwig Cancer Research |publisher=2016 LUDWIG INSTITUTE FOR CANCER RESEARCH LTD |access-date=October 30, 2018}}</ref>

Wings Over Wall Street and MDA Outstanding Scientist, October, 2007<ref>{{Cite web|url = http://wingsoverwallstreet.org/awards/|title = Wings Over Wall Street Diamond Award|date = |accessdate = |website = |publisher = }}</ref>
* [[Breakthrough Prize in Life Sciences]], 2018 <ref>{{Cite web|url=https://breakthroughprize.org/Laureates/2|title=Breakthrough Prize – Life Sciences Breakthrough Prize – Laureates|website=breakthroughprize.org|accessdate=December 13, 2021}}</ref>
* NOMIS Distinguished Scientist Awardee, 2018<ref>{{cite web |last1=Foundation |first1=Nomis |title=Don W. Cleveland, NOMIS Distinguished Scientist Awardee 2018 |url=https://nomisfoundation.ch/awards/don-cleveland-nomis-distinguished-scientist-2018/ |website=Nomis Foundation |publisher=2016 The NOMIS Foundation, Zurich, Switzerland |access-date=October 30, 2018}}</ref>

*ASCB E.B. Wilson Medal, 2022 <ref>{{cite web | url=https://www.newswise.com/articles/american-society-for-cell-biology-announces-2022-honorific-awards-and-recognition | title=American Society for Cell Biology announces 2022 honorific awards and recognition }}</ref>
⚫
2012 Research Award, The Huntington's Disease Society of America

⚫
Katharine Berkan Judd Award, [[Memorial Sloan Kettering Cancer Center|Memorial Sloan Kettering]], 2012<ref>{{Cite web|url = https://www.mskcc.org/blog/2012-commencement-and-academic-convocation|title = 2012 Commencement and Academic Convocation|date = June 13, 2012|accessdate = |website = |publisher = }}</ref>

⚫
The Ricketts Award, University of Chicago, 2012

⚫
The Gerson Distinguished Scholar Award, Univ. of Pittsburgh, 2014

⚫
Essey Prize for ALS Research, [[The ALS Association]], 2014<ref>{{Cite web|url = http://webgw.alsa.org/site/PageServer?pagename=GW_7_2014_A_Night_at_the_Esseys|title = A Night at the Esseys|date = June 5, 2014|accessdate = |website = |publisher = }}</ref>

⚫
UCSD Chancellor's Award for Excellence in Postdoctoral Scholar Mentoring, 2014<ref>{{Cite web|url = http://adminrecords.ucsd.edu/Notices/2014/2014-9-18-1.html|title = Excellence in Postdoctoral Scholar Mentoring and Postdoctoral Scholar Awards|date = September 18, 2014|accessdate = |website = |publisher = }}</ref>

⚫
Thomas Reuters' 2015 listing of "The World's Most Influential Scientific Minds" 2015<ref>{{cite web|title=Ludwig scientists named to Thomson Reuters’ list of world's most influential scientific minds|website=News Releases|publisher=Ludwig Institute for Cancer Research}}</ref>

== Lab members ==
Current http://cmm.ucsd.edu/cleveland/dwclab_009.htm

Previous http://cmm.ucsd.edu/cleveland/dwclab_010.htm

== All Cleveland publications ==
http://cmm.ucsd.edu/cleveland/dwclab_003.htm <ref>{{cite web|title=Don W. Cleveland|url=https://scholar.google.com/citations?user=cCbj_PsAAAAJ&hl=en&citsig=AMstHGSFZDldeqQy8_HxVFYsRJx1I0jqug|website=Google Scholar|publisher=Google|accessdate=15 August 2016}}</ref>


== References ==
== References ==
{{reflist}}
{{Reflist}}


== External links ==
== External links ==
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* [https://www.youtube.com/watch?v=aXtUI-2q47A Lou Gehrig's Disease (ALS): UCSD Team's Stem Cell Therapy Rationale]
* [https://www.youtube.com/watch?v=aXtUI-2q47A Lou Gehrig's Disease (ALS): UCSD Team's Stem Cell Therapy Rationale]
* [https://www.youtube.com/watch?v=1dzJY2us52k 2014 "Commitment to a Cure" Essey Award Winners Newsreel]
* [https://www.youtube.com/watch?v=1dzJY2us52k 2014 "Commitment to a Cure" Essey Award Winners Newsreel]
* [https://www.youtube.com/watch?v=qaHotFANMcQ 2017 "Don Cleveland CSHL Leading Strand"]
* [http://www.uctv.tv/brain/search-details.aspx?showID=32505 2017 "Designer DNA Drugs with Don Cleveland - On Our Mind"]
* [https://www.youtube.com/watch?v=vBUgFLzOLsE 2017 "Don Cleveland Wins Breakthrough Prize"]
* [https://nomisfoundation.ch/awards/don-cleveland-nomis-distinguished-scientist-2018/ 2018 Don W. Cleveland, NOMIS Distinguished Scientist Awardee"]

{{Breakthrough Prize laureates}}
{{Authority control}}


{{DEFAULTSORT:Cleveland, Don W.}}
{{DEFAULTSORT:Cleveland, Don W.}}
[[Category:1950 births]]
[[Category:1950 births]]
[[Category:People from Pulaski County, Missouri]]
[[Category:People from Waynesville, Missouri]]
[[Category:University of California, San Diego faculty]]
[[Category:University of California, San Diego faculty]]
[[Category:Princeton University alumni, 1970–79]]
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[[Category:University of California, San Francisco alumni]]
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[[Category:Johns Hopkins University faculty]]
[[Category:Johns Hopkins University faculty]]
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[[Category:People from Las Cruces, New Mexico]]
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[[Category:Living people]]
[[Category:Living people]]
[[Category:Fellows of the American Academy of Microbiology]]
[[Category:Members of the National Academy of Medicine]]

Latest revision as of 21:56, 17 September 2024

Don W. Cleveland
Cleveland in 2013
Born (1950-08-26) August 26, 1950 (age 74)
Waynesville, Missouri
NationalityAmerican
Alma materPrinceton University (PhD)
New Mexico State University (BS)
AwardsNational Academy of Sciences, 2006
American Academy of Arts and Sciences, 2006
Institute of Medicine, 2012
Breakthrough Prize in Life Sciences, 2018
Scientific career
FieldsCentromeres, aneuploidy and tumorigenesis
Mechanism and therapy in human neurodegenerative disease
InstitutionsLudwig Cancer Research
University of California, San Diego
Johns Hopkins University
Doctoral advisorMarc W. Kirschner
Other academic advisorsWilliam Rutter

Don W. Cleveland (born 1950 in Waynesville, MO) is an American cancer biologist and neurobiologist.

Cleveland is currently the Department Chair of Cellular and Molecular Medicine[1] and Distinguished Professor of Medicine, Cellular and Molecular Medicine and Neurosciences[2] at the University of California at San Diego, and Head, Laboratory for Cell Biology at the San Diego branch of Ludwig Cancer Research.[3]

Biography

[edit]

Cleveland grew up in Las Cruces, New Mexico. He earned a B.S. in physics in 1972 from New Mexico State University, and graduated as the valedictorian for the College of Arts and Sciences.[3]

Cleveland started graduate school at Princeton University in 1972, switching mid-year into biochemistry. He worked with Marc Kirschner and graduated with a Ph.D. in 1977. Cleveland's doctoral dissertation was titled "Purification and properties of tau, a microtubule associated protein which induces assembly of microtubules from purified tubulin".[4] As a graduate student, Cleveland provided the initial identification and characterization of tau, showing it to have characteristics of a natively unfolded protein.[5] Tau is now recognized to accumulate in Alzheimer's disease and to be the basis for chronic brain injury.[6] He also developed and published a peptide fingerprinting technique[7] that was so popular that it became a citation classic [8] Cleveland did postdoctoral work with William J. Rutter at the University of California at San Francisco from 1978 to 1981. Cleveland was the first to clone tubulin[9][10] actin and keratin[11]

From 1981 through 1995, Cleveland was on the faculty of the Department of Biological Chemistry at the Johns Hopkins University School of Medicine. In 1995, he accepted a position at the San Diego Branch of Ludwig Cancer Research at the University of California at San Diego. Since 2008, he has been Chair of the Department of Cellular and Molecular Medicine.

Contributions to Science

[edit]

Cleveland has made pioneering discoveries of the mechanisms of chromosome movement and cell-cycle control during normal cellular division, as well as of the principles of neuronal cell development and their relationship to the defects that contribute to inherited neurodegenerative disease.[12] Cleveland's research looks at the molecular genetics of axonal growth and motor neuron disease and the cell biology of mammalian chromosome movement.[13]

Most recently, his research has achieved a significant breakthrough in treating Huntington's disease, an inherited and degenerative brain disorder for which there is no cure. A one-time injection of a new DNA-based drug treatment - known as ASO (short for antisense oligonucleotide) - blocked the activity of the gene whose mutation causes the disease. A single treatment silenced the mutated gene responsible for the disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.[14] This drug, called IONIS-HTTRx, was developed by scientists at Ionis Pharmaceuticals in collaboration with partners CHDI Foundation, Roche Pharmaceuticals and academic collaborators at University of California, San Diego. The Phase 3 clinical trial was recently halted for lack of efficacy.[15]

Books

[edit]

Cell and Molecular Biology of the Cytoskeleton: Molecular Mechanisms Controlling Tubulin Synthesis Edited by Jerry W. Shay (Plenum Press, 1986), ISBN 978-1-4612-9269-2

With Toni L. Williamson, Mouse Models in the Study of Genetic Neurological Disorders: Mouse Models of Amyotrophic Lateral Sclerosis Edited by Brian Popko (Kluwer Academic/Plenum Publishers, 1999), ISBN 0-306-45965-5

With Nicholas G. Theodorakis, Control of Messenger RNA Stability: Translationally Coupled Degradation of Tubulin mRNA Edited by Joel Belasco and George Brawerman (Academic Press, Inc., 1993) ISBN 0-12-084782-5

Select honors

[edit]

References

[edit]
  1. ^ "Don Cleveland Named New Chair Cellular and Molecular Medicine at UC San Diego School of Medicine". Debra Kain. Retrieved December 15, 2008.
  2. ^ "Four Department of Medicine Faculty Members Are on 2015 Thomson Reuters Highly Cited Researchers List". News From The Department of Medicine. Regents of the University of California. Archived from the original on January 24, 2017. Retrieved February 2, 2016.
  3. ^ a b "DON CLEVELAND LAB". DON CLEVELAND LAB. LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. Archived from the original on December 12, 2018. Retrieved September 28, 2015.
  4. ^ Cleveland, Don W. (1977). Purification and properties of tau, a microtubule associated protein which induces assembly of microtubules from purified tubulin.
  5. ^ Mandelkow, E.-M.; Mandelkow, E. (March 20, 2012). "Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration" (PDF). Cold Spring Harbor Perspectives in Medicine. 2 (7): a006247. doi:10.1101/cshperspect.a006247. PMC 3385935. PMID 22762014.
  6. ^ McKee; et al. (2009). "Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury". J Neuropathol Exp Neurol. 68 (7): 709–35. doi:10.1097/NEN.0b013e3181a9d503. PMC 2945234. PMID 19535999.
  7. ^ Cleveland, D.W.; Fischer, S.G.; Kirschner, M.W. & Laemmli, U.K. (1977). "Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis" (PDF). J. Biol. Chem. 252 (3): 1102–6. doi:10.1016/S0021-9258(19)75212-0. PMID 320200.
  8. ^ Kresge, Nicole; Simoni, Robert D.; Hill, Robert L. (August 18, 2006). "The Development of Cleveland Peptide Mapping by Don W. Cleveland". The Journal of Biological Chemistry. 281 (33): e27. doi:10.1016/S0021-9258(19)46364-3.
  9. ^ Janke, Carsten (August 18, 2014). "The tubulin code: Molecular components, readout mechanisms, and functions". The Journal of Cell Biology. 206 (4): 461–472. doi:10.1083/jcb.201406055. PMC 4137062. PMID 25135932.
  10. ^ Cleveland, Don W.; Lopata, Margaret A.; MacDonald, Raymond J.; Cowan, Nicholas J.; Rutter, William J.; Kirschner, Marc (May 1980). "Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes" (PDF). Cell. 20 (1): 95–105. doi:10.1016/0092-8674(80)90238-x. PMID 6893015. S2CID 54326866.
  11. ^ Fuchs, Elaine V.; Coppock, Susan M.; Green, Howard; Cleveland, Don W. (November 1981). "Two distinct classes of keratin genes and their evolutionary significance" (PDF). Cell. 27 (1): 75–84. doi:10.1016/0092-8674(81)90362-7. PMID 6173133. S2CID 38166670.
  12. ^ "Dr. Don Cleveland of Ludwig Institute for Cancer Research elected to Institute of Medicine". EurekAlert!. American Association for the Advancement of Science (AAAS).
  13. ^ "UC San Diego Researchers Cited Among "World's Most Influential Scientific Minds"". UC San Diego News Center. UC San Diego.
  14. ^ "Potential treatment for Huntington's disease, found effective, safe in mice, monkeys". EurekAlert!. American Association for the Advancement of Science (AAAS).
  15. ^ "Tominersen for Huntington's disease". Huntington's Disease News. BioNews Services LLC.
  16. ^ "UCSD Faculty Members of the National Academy of Sciences". UC San Diego.
  17. ^ "Two from UCSD School of Medicine Named Members of the Institute of Medicine".
  18. ^ American Academy of Arts & Sciences. "Six UCSD scholars elected fellows of American Academy of Arts and Sciences".
  19. ^ "ASM Society Directory". American Society for Microbiology. Archived from the original on May 25, 2017. Retrieved September 23, 2015.
  20. ^ "ASM Members Elected to National Academy of Sciences" (PDF). American Society for Microbiology. Archived from the original (PDF) on January 24, 2017. Retrieved April 12, 2016.
  21. ^ "AAAS Members Elected as Fellows". December 18, 2009.
  22. ^ "President's Column" (PDF). The American Society for Cell Biology.
  23. ^ "The Sheila Essey Award for ALS Research".
  24. ^ "Wings Over Wall Street Diamond Award".
  25. ^ "2012 Commencement and Academic Convocation". June 13, 2012.
  26. ^ "A Night at the Esseys". June 5, 2014.
  27. ^ "Excellence in Postdoctoral Scholar Mentoring and Postdoctoral Scholar Awards". September 18, 2014.
  28. ^ "Ludwig scientists named to Thomson Reuters' list of world's most influential scientific minds". Ludwig Cancer Research. 2016 LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. Retrieved October 30, 2018.
  29. ^ "Breakthrough Prize – Life Sciences Breakthrough Prize – Laureates". breakthroughprize.org. Retrieved December 13, 2021.
  30. ^ Foundation, Nomis. "Don W. Cleveland, NOMIS Distinguished Scientist Awardee 2018". Nomis Foundation. 2016 The NOMIS Foundation, Zurich, Switzerland. Retrieved October 30, 2018.
  31. ^ "American Society for Cell Biology announces 2022 honorific awards and recognition".
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