Adiponectin receptor 1: Difference between revisions

ADIPOR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WXV
Identifiers
Aliases	ADIPOR1, adiponectin receptor 1, ACDCR1, CGI45, PAQR1, TESBP1A, CGI-45
External IDs	OMIM: 607945; MGI: 1919924; HomoloGene: 69199; GeneCards: ADIPOR1; OMA:ADIPOR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,958,572 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,361,089 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; skin of leg; ; bone marrow; ; skin of abdomen; ; islet of Langerhans; ; olfactory zone of nasal mucosa; ; right lung; ; minor salivary glands; ; upper lobe of left lung;
	Top expressed in
	blood; ; granulocyte; ; stroma of bone marrow; ; knee joint; ; fetal liver hematopoietic progenitor cell; ; neural layer of retina; ; triceps brachii muscle; ; atrium; ; medial head of gastrocnemius muscle; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	adipokinetic hormone receptor activity; adiponectin binding; metal ion binding; identical protein binding; protein heterodimerization activity; protein kinase binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; intrinsic component of plasma membrane; plasma membrane;
Biological process	glucose homeostasis; lipid metabolism; leptin-mediated signaling pathway; adiponectin-activated signaling pathway; fatty acid metabolic process; regulation of lipid metabolic process; regulation of glucose metabolic process; negative regulation of cell growth; fatty acid oxidation; hormone-mediated signaling pathway; positive regulation of insulin receptor signaling pathway; positive regulation of receptor signaling pathway via JAK-STAT; negative regulation of epithelial to mesenchymal transition; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of epithelial cell migration; negative regulation of NIK/NF-kappaB signaling; G protein-coupled receptor signaling pathway; regulation of fatty acid biosynthetic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	51094
	72674
	ENSG00000159346
	ENSMUSG00000026457
	Q96A54
	Q91VH1
	NM_001290553; NM_001290557; NM_001290629; NM_015999
	NM_028320; NM_001306069
	NP_001277482; NP_001277486; NP_001277558; NP_057083
	NP_001292998; NP_082596
	Wikidata
View/Edit Human	View/Edit Mouse

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Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene.^[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1.^[6]

Structure

Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.^[5]

Function

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.^[5]^[7] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.^[8]

Ligands

Agonists

Peptide

Adiponectin
ADP-355^[9]
ADP-399^[9]

Non-peptide

Antagonists

Peptide

ADP-400^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159346 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026457 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
^ Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, et al. (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
^ "Entrez Gene: ADIPOR1 adiponectin receptor 1".
^ University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
^ ^a ^b ^c Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, et al. (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.
^ Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, et al. (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID 24172895. S2CID 4447039.
^ ^a ^b ^c ^d Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, et al. (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.

External links

Human ADIPOR1 genome location and ADIPOR1 gene details page in the UCSC Genome Browser.

Crimmins NA, Martin LJ (September 2007). "Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance". Obesity Reviews. 8 (5): 419–23. doi:10.1111/j.1467-789X.2007.00348.x. PMID 17716299. S2CID 825474.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
Kharroubi I, Rasschaert J, Eizirik DL, Cnop M (December 2003). "Expression of adiponectin receptors in pancreatic beta cells". Biochemical and Biophysical Research Communications. 312 (4): 1118–22. doi:10.1016/j.bbrc.2003.11.042. PMID 14651988.
Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, et al. (May 2004). "Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes". Diabetologia. 47 (5): 816–20. doi:10.1007/s00125-004-1359-x. PMID 15105989.
Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, et al. (August 2004). "Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance". Diabetes. 53 (8): 2132–6. doi:10.2337/diabetes.53.8.2132. PMID 15277397.
Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, et al. (September 2004). "Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism". Diabetes. 53 (9): 2195–201. doi:10.2337/diabetes.53.9.2195. PMID 15331527.
Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, et al. (October 2004). "Adiponectin and its receptors are expressed in bone-forming cells". Bone. 35 (4): 842–9. doi:10.1016/j.bone.2004.06.008. PMID 15454091.
Punyadeera C, Zorenc AH, Koopman R, McAinch AJ, Smit E, Manders R, et al. (March 2005). "The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle". European Journal of Endocrinology. 152 (3): 427–36. doi:10.1530/eje.1.01872. hdl:10536/DRO/DU:30008881. PMID 15757860.
Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, et al. (July 2005). "Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes". Diabetologia. 48 (7): 1307–14. doi:10.1007/s00125-005-1806-3. PMID 15918014.
Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'connell JR, et al. (July 2005). "Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish". Diabetes. 54 (7): 2245–50. doi:10.2337/diabetes.54.7.2245. PMID 15983228.
Neumeier M, Weigert J, Schäffler A, Weiss T, Kirchner S, Laberer S, et al. (September 2005). "Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors". Biochemical and Biophysical Research Communications. 334 (3): 924–9. doi:10.1016/j.bbrc.2005.06.187. PMID 16023994.
Zhang J, Holt H, Wang C, Hadid OH, Byrne CD (August 2005). "Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men". Diabetes Care. 28 (8): 2058–60. doi:10.2337/diacare.28.8.2058. PMID 16043761.
Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, et al. (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
Jonsson JR, Moschen AR, Hickman IJ, Richardson MM, Kaser S, Clouston AD, et al. (December 2005). "Adiponectin and its receptors in patients with chronic hepatitis C". Journal of Hepatology. 43 (6): 929–36. doi:10.1016/j.jhep.2005.05.030. PMID 16139921.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159346 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026457 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12802337-5] Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.

[TangHu2005-6] Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, et al. (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.

[entrez-7] "Entrez Gene: ADIPOR1 adiponectin receptor 1".

[Dennis-8] University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016

[pmid25368867-9] Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, et al. (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.

[pmid24172895-10] Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, et al. (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID 24172895. S2CID 4447039.

[pmid23691032-11] Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, et al. (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
+{{cs1 config|name-list-style=vanc|display-authors=6}}
 {{Infobox_gene}}
-'''Adiponectin receptor 1''' ('''AdipoR1''') is a [[protein]] which in humans is encoded by the ''ADIPOR1''  [[gene]].<ref name="pmid12802337">{{cite journal | vauthors = Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T | title = Cloning of adiponectin receptors that mediate antidiabetic metabolic effects | journal = Nature | volume = 423 | issue = 6941 | pages = 762–9 | date = June 2003 | pmid = 12802337 | doi = 10.1038/nature01705 }}</ref> It is a member of the [[progestin and adipoQ receptor]] family (PAQR), and is also known as '''PAQR1'''.<ref name="TangHu2005">{{cite journal | vauthors = Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD | title = PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif | journal = Journal of Molecular Evolution | volume = 61 | issue = 3 | pages = 372–80 | date = September 2005 | pmid = 16044242 | doi = 10.1007/s00239-004-0375-2 }}</ref>
+'''Adiponectin receptor 1''' ('''AdipoR1''') is a [[protein]] which in humans is encoded by the ''ADIPOR1''  [[gene]].<ref name="pmid12802337">{{cite journal | vauthors = Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T | title = Cloning of adiponectin receptors that mediate antidiabetic metabolic effects | journal = Nature | volume = 423 | issue = 6941 | pages = 762–9 | date = June 2003 | pmid = 12802337 | doi = 10.1038/nature01705 | bibcode = 2003Natur.423..762Y | s2cid = 52860797 }}</ref> It is a member of the [[progestin and adipoQ receptor]] (PAQR) family, and is also known as '''PAQR1'''.<ref name="TangHu2005">{{cite journal | vauthors = Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD | title = PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif | journal = Journal of Molecular Evolution | volume = 61 | issue = 3 | pages = 372–80 | date = September 2005 | pmid = 16044242 | doi = 10.1007/s00239-004-0375-2 | bibcode = 2005JMolE..61..372T | s2cid = 31473802 }}</ref>
 ==Structure==
@@ Line 6: / Line 8: @@
 == Function ==
-The [[adiponectin receptor]]s, AdipoR1 and [[AdipoR2]], serve as receptors for globular and full-length [[adiponectin]]  and mediate increased [[AMP-activated protein kinase|AMPK]] and [[Peroxisome proliferator-activated receptor alpha|PPAR-α]] ligand activities, as well as [[fatty acid]] oxidation and glucose uptake by adiponectin.<ref name="pmid12802337"/><ref name="entrez">{{cite web | title = Entrez Gene: ADIPOR1 adiponectin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51094| accessdate = }}</ref>
+The [[adiponectin receptor]]s, AdipoR1 and [[AdipoR2]], serve as receptors for globular and full-length [[adiponectin]]  and mediate increased [[AMP-activated protein kinase|AMPK]] and [[Peroxisome proliferator-activated receptor alpha|PPAR-α]] ligand activities, as well as [[fatty acid]] oxidation and glucose uptake by adiponectin.<ref name="pmid12802337"/><ref name="entrez">{{cite web | title = Entrez Gene: ADIPOR1 adiponectin receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51094}}</ref> In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called [[Ordinary_researchers]].<ref name="Dennis">[https://www.science.org/content/article/university-tokyo-investigate-data-manipulation-charges-against-six-prominent-research University of Tokyo to investigate data manipulation charges against six prominent research groups] ScienceInsider, Dennis Normile, Sep 20, 2016</ref>
 ==Ligands==
@@ Line 14: / Line 16: @@
 ====Peptide====
 * [[Adiponectin]]
-* [[ADP-355]]<ref name="pmid25368867">{{cite journal | vauthors = Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S | title = Development of second generation peptides modulating cellular adiponectin receptor responses | journal = Frontiers in Chemistry | volume = 2 | issue =  | pages = 93 | year = 2014 | pmid = 25368867 | pmc = 4201147 | doi = 10.3389/fchem.2014.00093 }}</ref>
+* ADP-355<ref name="pmid25368867">{{cite journal | vauthors = Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S | title = Development of second generation peptides modulating cellular adiponectin receptor responses | journal = Frontiers in Chemistry | volume = 2 | pages = 93 | year = 2014 | pmid = 25368867 | pmc = 4201147 | doi = 10.3389/fchem.2014.00093 | bibcode = 2014FrCh....2...93O | doi-access = free }}</ref>
-* [[ADP-399]]<ref name="pmid25368867" />
+* ADP-399<ref name="pmid25368867" />
 ====Non-peptide====
-* [[AdipoRon]]<ref name="pmid24172895">{{cite journal | vauthors = Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T | title = A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity | journal = Nature | volume = 503 | issue = 7477 | pages = 493–9 | date = November 2013 | pmid = 24172895 | doi = 10.1038/nature12656 }}</ref>
+* [[AdipoRon]]<ref name="pmid24172895">{{cite journal | vauthors = Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T | title = A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity | journal = Nature | volume = 503 | issue = 7477 | pages = 493–9 | date = November 2013 | pmid = 24172895 | doi = 10.1038/nature12656 | bibcode = 2013Natur.503..493O | s2cid = 4447039 }}</ref>
-* [[(–)-Arctigenin]]<ref name="pmid23691032">{{cite journal | vauthors = Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z | title = Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay | journal = PloS One | volume = 8 | issue = 5 | pages = e63354 | year = 2013 | pmid = 23691032 | pmc = 3653934 | doi = 10.1371/journal.pone.0063354 }}</ref>
+* (−)-Arctigenin<ref name="pmid23691032">{{cite journal | vauthors = Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z | title = Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay | journal = PLOS ONE | volume = 8 | issue = 5 | pages = e63354 | year = 2013 | pmid = 23691032 | pmc = 3653934 | doi = 10.1371/journal.pone.0063354 | bibcode = 2013PLoSO...863354S | doi-access = free }}</ref>
 * [[Arctiin]]<ref name="pmid23691032" />
 * [[Gramine]]<ref name="pmid23691032" />
@@ Line 27: / Line 29: @@
 ====Peptide====
-* [[ADP-400]]<ref name="pmid25368867" />
+* ADP-400<ref name="pmid25368867" />
 == See also ==
@@ Line 41: / Line 43: @@
 == Further reading ==
 {{refbegin | 2}}
-* {{cite journal | vauthors = Crimmins NA, Martin LJ | title = Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance | journal = Obesity Reviews | volume = 8 | issue = 5 | pages = 419–23 | date = September 2007 | pmid = 17716299 | doi = 10.1111/j.1467-789X.2007.00348.x }}
+* {{cite journal | vauthors = Crimmins NA, Martin LJ | title = Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance | journal = Obesity Reviews | volume = 8 | issue = 5 | pages = 419–23 | date = September 2007 | pmid = 17716299 | doi = 10.1111/j.1467-789X.2007.00348.x | s2cid = 825474 }}
-* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
+* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
-* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
+* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
 * {{cite journal | vauthors = Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Research | volume = 10 | issue = 5 | pages = 703–13 | date = May 2000 | pmid = 10810093 | pmc = 310876 | doi = 10.1101/gr.10.5.703 }}
-* {{cite journal | vauthors = Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T | title = Cloning of adiponectin receptors that mediate antidiabetic metabolic effects | journal = Nature | volume = 423 | issue = 6941 | pages = 762–9 | date = June 2003 | pmid = 12802337 | doi = 10.1038/nature01705 }}
+* {{cite journal | vauthors = Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T | title = Cloning of adiponectin receptors that mediate antidiabetic metabolic effects | journal = Nature | volume = 423 | issue = 6941 | pages = 762–9 | date = June 2003 | pmid = 12802337 | doi = 10.1038/nature01705 | bibcode = 2003Natur.423..762Y | s2cid = 52860797 }}
 * {{cite journal | vauthors = Kharroubi I, Rasschaert J, Eizirik DL, Cnop M | title = Expression of adiponectin receptors in pancreatic beta cells | journal = Biochemical and Biophysical Research Communications | volume = 312 | issue = 4 | pages = 1118–22 | date = December 2003 | pmid = 14651988 | doi = 10.1016/j.bbrc.2003.11.042 }}
-* {{cite journal | vauthors = Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort R, DeFronzo RA, Mandarino LJ, Ravussin E | title = Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes | journal = Diabetologia | volume = 47 | issue = 5 | pages = 816–20 | date = May 2004 | pmid = 15105989 | doi = 10.1007/s00125-004-1359-x }}
+* {{cite journal | vauthors = Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort R, DeFronzo RA, Mandarino LJ, Ravussin E | title = Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes | journal = Diabetologia | volume = 47 | issue = 5 | pages = 816–20 | date = May 2004 | pmid = 15105989 | doi = 10.1007/s00125-004-1359-x | doi-access = free }}
-* {{cite journal | vauthors = Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, Elbein SC | title = Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance | journal = Diabetes | volume = 53 | issue = 8 | pages = 2132–6 | date = August 2004 | pmid = 15277397 | doi = 10.2337/diabetes.53.8.2132 }}
+* {{cite journal | vauthors = Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, Elbein SC | title = Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance | journal = Diabetes | volume = 53 | issue = 8 | pages = 2132–6 | date = August 2004 | pmid = 15277397 | doi = 10.2337/diabetes.53.8.2132 | doi-access = free }}
-* {{cite journal | vauthors = Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, Péterfi C, Weisser M, Machicao F, Stumvoll M, Häring HU | title = Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism | journal = Diabetes | volume = 53 | issue = 9 | pages = 2195–201 | date = September 2004 | pmid = 15331527 | doi = 10.2337/diabetes.53.9.2195 }}
+* {{cite journal | vauthors = Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, Péterfi C, Weisser M, Machicao F, Stumvoll M, Häring HU | title = Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism | journal = Diabetes | volume = 53 | issue = 9 | pages = 2195–201 | date = September 2004 | pmid = 15331527 | doi = 10.2337/diabetes.53.9.2195 | doi-access = free }}
 * {{cite journal | vauthors = Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE | title = Adiponectin and its receptors are expressed in bone-forming cells | journal = Bone | volume = 35 | issue = 4 | pages = 842–9 | date = October 2004 | pmid = 15454091 | doi = 10.1016/j.bone.2004.06.008 }}
-* {{cite journal | vauthors = Punyadeera C, Zorenc AH, Koopman R, McAinch AJ, Smit E, Manders R, Keizer HA, Cameron-Smith D, van Loon LJ | title = The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle | journal = European Journal of Endocrinology / European Federation of Endocrine Societies | volume = 152 | issue = 3 | pages = 427–36 | date = March 2005 | pmid = 15757860 | doi = 10.1530/eje.1.01872 }}
+* {{cite journal | vauthors = Punyadeera C, Zorenc AH, Koopman R, McAinch AJ, Smit E, Manders R, Keizer HA, Cameron-Smith D, van Loon LJ | title = The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle | journal = European Journal of Endocrinology| volume = 152 | issue = 3 | pages = 427–36 | date = March 2005 | pmid = 15757860 | doi = 10.1530/eje.1.01872 | doi-access = free | hdl = 10536/DRO/DU:30008881 | hdl-access = free }}
-* {{cite journal | vauthors = Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T | title = Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes | journal = Diabetologia | volume = 48 | issue = 7 | pages = 1307–14 | date = July 2005 | pmid = 15918014 | doi = 10.1007/s00125-005-1806-3 }}
+* {{cite journal | vauthors = Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T | title = Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes | journal = Diabetologia | volume = 48 | issue = 7 | pages = 1307–14 | date = July 2005 | pmid = 15918014 | doi = 10.1007/s00125-005-1806-3 | doi-access = free }}
-* {{cite journal | vauthors = Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'connell JR, Mitchell BD, Shuldiner AR | title = Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish | journal = Diabetes | volume = 54 | issue = 7 | pages = 2245–50 | date = July 2005 | pmid = 15983228 | doi = 10.2337/diabetes.54.7.2245 }}
+* {{cite journal | vauthors = Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'connell JR, Mitchell BD, Shuldiner AR | title = Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish | journal = Diabetes | volume = 54 | issue = 7 | pages = 2245–50 | date = July 2005 | pmid = 15983228 | doi = 10.2337/diabetes.54.7.2245 | doi-access = free }}
 * {{cite journal | vauthors = Neumeier M, Weigert J, Schäffler A, Weiss T, Kirchner S, Laberer S, Schölmerich J, Buechler C | title = Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors | journal = Biochemical and Biophysical Research Communications | volume = 334 | issue = 3 | pages = 924–9 | date = September 2005 | pmid = 16023994 | doi = 10.1016/j.bbrc.2005.06.187 }}
-* {{cite journal | vauthors = Zhang J, Holt H, Wang C, Hadid OH, Byrne CD | title = Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men | journal = Diabetes Care | volume = 28 | issue = 8 | pages = 2058–60 | date = August 2005 | pmid = 16043761 | doi = 10.2337/diacare.28.8.2058 }}
+* {{cite journal | vauthors = Zhang J, Holt H, Wang C, Hadid OH, Byrne CD | title = Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men | journal = Diabetes Care | volume = 28 | issue = 8 | pages = 2058–60 | date = August 2005 | pmid = 16043761 | doi = 10.2337/diacare.28.8.2058 | doi-access = free }}
-* {{cite journal | vauthors = Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD | title = PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif | journal = Journal of Molecular Evolution | volume = 61 | issue = 3 | pages = 372–80 | date = September 2005 | pmid = 16044242 | doi = 10.1007/s00239-004-0375-2 }}
+* {{cite journal | vauthors = Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD | title = PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif | journal = Journal of Molecular Evolution | volume = 61 | issue = 3 | pages = 372–80 | date = September 2005 | pmid = 16044242 | doi = 10.1007/s00239-004-0375-2 | bibcode = 2005JMolE..61..372T | s2cid = 31473802 }}
 * {{cite journal | vauthors = Jonsson JR, Moschen AR, Hickman IJ, Richardson MM, Kaser S, Clouston AD, Powell EE, Tilg H | title = Adiponectin and its receptors in patients with chronic hepatitis C | journal = Journal of Hepatology | volume = 43 | issue = 6 | pages = 929–36 | date = December 2005 | pmid = 16139921 | doi = 10.1016/j.jhep.2005.05.030 }}
 {{refend}}
 {{Cell surface receptors}}
-{{Neuropeptidergics}}
 [[Category:7TM receptors]]
 {{gene-1-stub}}