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{{Short description|American molecular biologist}}
'''Phillip D. Zamore, Ph.D'''., is an American molecular biologist and developed the first ''in vitro'' system for studying the mechanism of RNA interference (RNAi). He is the ''Gretchen Stone Cook Professor of Biomedical Sciences and Professor of Biochemistry and Molecular Pharmacology''<ref name=":0">{{Cite web|url=https://profiles.umassmed.edu/display/132965|title=Phillip Zamore {{!}} Profiles RNS|website=profiles.umassmed.edu|language=en|access-date=2018-10-30}}</ref> at [[University of Massachusetts Medical School]], located in Worcester, MA. Dr. Zamore is the Chair of the RNA Therapeutics Institute (RTI) at UMass Medical School, established in 2009, and has been a [[Howard Hughes Medical Institute]] Investigator since 2008<ref name=":1">{{Cite news|url=https://www.hhmi.org/scientists/phillip-d-zamore|title=Phillip D. Zamore, PhD {{!}} HHMI.org|work=HHMI.org|access-date=2018-10-30|language=en}}</ref>.  
{{Infobox scientist
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| name = Phillip D. Zamore
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| fields = [[Biochemistry]], [[molecular biology]]
| workplaces = [[University of Massachusetts Chan Medical School]], [[Howard Hughes Medical Institute]]
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| alma_mater = [[Harvard University]], [[Whitehead Institute]]
| thesis_title = <!--(or | thesis1_title = and | thesis2_title = )-->
| thesis_url = <!--(or | thesis1_url = and | thesis2_url = )-->The structure and function of the mammalian splicing factor U2AF
| thesis_year = <!--(or | thesis1_year = and | thesis2_year = )-->
| doctoral_advisor = <!--(or | doctoral_advisors = )—>Michael R. Green
| academic_advisors = [[Michael R. Green (biologist)|Michael Green]], [[Ruth Lehmann]], [[David Bartel]], and James R. Williamson
| doctoral_students = Yukihide Tomari, Zhao Zhang, Elif Sarinay Cenik
| notable_students =
| known_for = small RNA biology and therapeutics
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| website = {{URL|https://zamorelab.umassmed.edu/}}
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'''Phillip D. Zamore''' is an American molecular biologist and biochemist who co-developed the first ''in vitro'' system for studying the mechanism of [[RNA interference]] (RNAi). He is the ''Gretchen Stone Cook Professor of Biomedical Sciences''<ref name=":0">{{Cite web|url=https://profiles.umassmed.edu/display/132965|title=Phillip Zamore {{!}} Profiles RNS|website=profiles.umassmed.edu|language=en|access-date=2018-10-30}}</ref> at [[University of Massachusetts Chan Medical School]], Worcester, Massachusetts. Zamore is chair of the [https://www.umassmed.edu/rti/ RNA Therapeutics Institute (RTI)], established in 2009, and has been a [[Howard Hughes Medical Institute]] Investigator since 2008.<ref name=":1">{{Cite news|url=https://www.hhmi.org/scientists/phillip-d-zamore|title=Phillip D. Zamore, PhD |work=HHMI.org|access-date=2018-10-30|language=en}}</ref>  


== Research ==
== Research ==
The Zamore lab at RTI focuses on understanding the underlying processes of RNAi; how small RNAs (miRNA, siRNA, piRNA) are involved in gene regulation networks<ref>{{Cite journal|last=Smith|first=R. J.|last2=Bryant|first2=R. G.|date=1975-10-27|title=Metal substitutions incarbonic anhydrase: a halide ion probe study|url=https://www.ncbi.nlm.nih.gov/pubmed/3|journal=Biochemical and Biophysical Research Communications|volume=66|issue=4|pages=1281–1286|issn=0006-291X|pmid=3}}</ref>. In addition to a focus on basic research, the Zamore lab is working with Dr. Neil Aronin, MD, to develop siRNA-based drugs to treat Huntington’s disease (HD)<ref name=":1" />. Dr. Zamore has more than 40,000 citations on Google Scholar<ref>{{Cite web|url=https://scholar.google.com/citations?user=xYLmV7YAAAAJ&hl=en&oi=ao|title=Phillip D. Zamore - Google Scholar Citations|website=scholar.google.com|access-date=2018-10-30}}</ref>.
The Zamore lab seeks to understand the molecular mechanisms and biological functions of RNAi and related pathways in animals, including how small RNAs (microRNAs, small interfering RNAs, and PIWI-interacting RNAs) regulate gene expression and suppress transposons.<ref>{{Cite web|url=https://www.zamorelab.umassmed.edu/|title=Phillip Zamore's Laboratory|website=Phillip Zamore's Laboratory|language=en|access-date=2018-11-09}}</ref> In addition to a focus on basic research, the Zamore lab is working to develop novel nucleic acid-based drugs to treat human disease.<ref name=":1" /> Dr. Zamore has more than 60,000 citations on Google Scholar.<ref>{{Cite web|url=https://scholar.google.com/citations?user=xYLmV7YAAAAJ&hl=en&oi=ao|title=Phillip D. Zamore - Google Scholar Citations|website=scholar.google.com|access-date=2018-10-30}}</ref>


== Biography ==
== Biography ==
Dr. Zamore received his A.B. in Biochemistry and Molecular Biology from Harvard University in Cambridge, MA, in 1986 and continued graduate studies with Dr. Michael Green at Harvard, receiving his Ph.D. in 1992<ref name=":0" />. After completing postdoctoral studies The Whitehead Institute for Biomedical Research at MIT and the Skirball Institute at New York University Medical Center with Ruth Lehmann<ref name=":0" />, Dr. Zamore began his academic career as an Assistant Professor in the Department of Biochemistry and Molecular Pharmacology in 1999 at UMass Medical School in Worcester, MA where he is now the ''Gretchen Stone Cook Professor of Biomedical Sciences and Professor of Biochemistry and Molecular Pharmacology''.
Zamore received his A.B. in biochemistry and molecular biology from Harvard University in Cambridge, Massachusetts, in 1986 and continued graduate studies with [[Michael Green (biologist)|Michael Green]] at Harvard, receiving his Ph.D. in 1992.<ref name=":0" /> After completing postdoctoral studies at The Whitehead Institute for Biomedical Research, MIT, and the Skirball Institute at New York University Medical Center with Ruth Lehmann, James R. Williamson, and David Bartel, Zamore began his academic career as an assistant professor in the Department of Biochemistry and Molecular Pharmacology in 1999 at UMass Medical School in Worcester, Massachusetts. A member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences, Zamore has trained 40 PhD and MD/PhD students and post-doctoral scholars.

== Involvement with Biotechnology ==
Dr. Zamore’s research has led to a career in biotechnology, co-founding [[Alnylam Pharmaceuticals|Alynlam Pharmaceuticals]]<ref>{{Citation|title=Alnylam Pharmaceuticals|date=2018-08-11|url=https://en.wikipedia.org/enwiki/w/index.php?title=Alnylam_Pharmaceuticals&oldid=854388313|work=Wikipedia|language=en|access-date=2018-10-30}}</ref> in 2002. Alnylam is dedicated to bringing RNAi based therapies to market and developed the first-ever FDA approved RNAi drug, [[Patisiran]], gaining FDA approval in August 2018<ref>{{Cite news|url=https://www.statnews.com/2018/08/10/fda-alnylam-rnai-patisiran-onpattro/|title=FDA approval of Alnylam drug is first ever for RNAi-based therapy - STAT|date=2018-08-10|work=STAT|access-date=2018-10-30|language=en-US}}</ref>. Dr. Zamore currently sits on the scientific advisor board for Alnylam<ref>{{Cite web|url=http://www.alnylam.com/our-science/alnylam-scientific-advisory-board/+|title=Alnylam SAB|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref>. In 2014, Dr. Zamore co-founded another RNAi based company; Voyager Therapeutics<ref>{{Cite web|url=https://www.voyagertherapeutics.com/about-us/founders/|title=Founders {{!}} Voyager Therapeutics|website=www.voyagertherapeutics.com|language=en-US|access-date=2018-10-30}}</ref>, which focuses on developing therapeutics for neurodegenerative disorders.

== Selected Awards and Honors ==


== Involvement with biotechnology ==
# ''Invented Here!'' Honoree, Boston Patent Law Association, for US patent US 9,226,976, “RAAV- Based Compositions and Methods for Treating Alpha-1 Anti-Trypsin Deficiencies,” October 2017
Zamore's research has led to a career in biotechnology, co-founding [[Alnylam Pharmaceuticals]] in 2002.<ref name=":2">{{Cite web|url=http://www.alnylam.com/our-science/alnylam-scientific-advisory-board/+|title=Alnylam SAB|last=|first=|date=|website=|archive-url=|archive-date=|access-date=}}</ref> Alnylam is dedicated to bringing RNAi based therapies to market and developed the first-ever FDA approved RNAi drug, [[Patisiran]], gaining FDA approval in August 2018.<ref>{{Cite news|url=https://www.statnews.com/2018/08/10/fda-alnylam-rnai-patisiran-onpattro/|title=FDA approval of Alnylam drug is first ever for RNAi-based therapy - STAT|date=2018-08-10|work=STAT|access-date=2018-10-30|language=en-US}}</ref> In 2014, Dr. Zamore co-founded another RNAi based company; Voyager Therapeutics,<ref>{{Cite web |url=https://www.voyagertherapeutics.com/about-us/founders/|title=Founders |publisher=Voyager Therapeutics |access-date=2018-10-30}}</ref> which focuses on developing therapeutics for neurodegenerative disorders.
# Paper of the Year (Salomon et al., Cell 2015), Oligonucleotide Therapeutics Society<ref>{{Cite news|url=https://www.oligotherapeutics.org/awards-grants/paper-of-the-year/|title=Paper of the Year - Oligonucleotide Therapeutics Society|work=Oligonucleotide Therapeutics Society|access-date=2018-10-30|language=en-US}}</ref>
# “The World’s Most Influential Scientific Minds 2014,” Molecular Biology & Genetics, Thomson-Reuters<ref>{{Cite news|url=https://www.umassmed.edu/news/news-archives/2014/07/three-umms-scientists-named-in-2014-thomson-reuters-report-on-most-influential-scientific-minds/|title=Three UMMS scientists named in 2014 Thomson Reuters Report on most influential scientific minds|date=2014-07-10|work=University of Massachusetts Medical School|access-date=2018-10-30|language=en-US}}</ref>
# Top 20 Translational Researchers of 2014, Nature Biotechnology<ref>{{Cite web|url=https://www.nature.com/bioent/2015/150801/fig_tab/bioe.2015.9_T1.html|title=Table 1 : Top 20 translational researchers of 2014 : Bioentrepreneur|website=www.nature.com|language=en|access-date=2018-10-30}}</ref>
# Fellow, National Academy of Inventors, December 2014<ref>{{Cite web|url=http://academyofinventors.org/wp/skin/search-fellows.asp?qFellows=Z&Qa=%25&qSort=FASC|title=Search Fellows - National Academy of Inventors|website=academyofinventors.org|language=en|access-date=2018-10-30}}</ref>
# Outstanding Research Achievement, ''Nature Biotechnology'' SciCafé June 2009
# Schering-Plough Award, American Society of Biochemistry and Molecular Biology, April 2009
# Top 20 Most Highly Cited Researchers in Molecular Biology and Genetics, 2002–2006, ScienceWatch (Thomson Scientific)<ref name=":1" />
# Most Highly Cited Researchers, 2002–2012 (Thomson-Reuters)<ref name=":0" />
# Recipient, Chancellor’s Medal for Excellence in Scholarship, University of Massachusetts Medical School<ref>{{Cite web|url=https://www.umassmed.edu/chancellor/office/chancellors-medals/|title=Chancellor's Medals|website=University of Massachusetts Medical School|language=en-US|access-date=2018-10-30}}</ref>


== Selected awards and honors ==
<nowiki>-----</nowiki>Note: this list is incomplete, for more information visit https://www.zamorelab.umassmed.edu/


*RNA Society / Cold Spring Harbor Laboratory Press Distinguished Research Mentor Award, 2024
== Selected Publications ==
*Member, National Academy of Medicine, 2023<ref>{{Cite web |date=October 9, 2023 |title=National Academy of Medicine Elects 100 New Members |url=https://nam.edu/national-academy-of-medicine-elects-100-new-members-2023/}}</ref>
*Member, National Academy of Sciences, 2023<ref>{{Cite web |title=2023 NAS Election |url=http://www.nasonline.org/news-and-multimedia/news/2023-nas-election.html |access-date=2023-05-09 |website=www.nasonline.org}}</ref>
*Fellow, American Academy of Arts and Sciences, 2023<ref>{{Cite web |title=New Members |url=https://www.amacad.org/new-members-2023 |access-date=2023-05-01 |website=American Academy of Arts & Sciences |language=en}}</ref>
*''Invented Here!'' Honoree, Boston Patent Law Association, for US patent US 9,226,976, “RAAV- Based Compositions and Methods for Treating Alpha-1 Anti-Trypsin Deficiencies,” 2017
* Paper of the Year (Salomon et al., Cell 2015), Oligonucleotide Therapeutics Society<ref>{{Cite news|url=https://www.oligotherapeutics.org/awards-grants/paper-of-the-year/|title=Paper of the Year - Oligonucleotide Therapeutics Society|work=Oligonucleotide Therapeutics Society|access-date=2018-10-30|language=en-US}}</ref>
* Chancellor's Medal for Excellence in Scholarship, University of Massachusetts Medical School, 2014<ref>{{Cite web|url=https://www.umassmed.edu/chancellor/office/chancellors-medals/|title=Chancellor's Medals|date=2014-03-31|website=University of Massachusetts Medical School|language=en-US|access-date=2018-10-30}}</ref>
*“The World’s Most Influential Scientific Minds 2014,” Molecular Biology & Genetics, Thomson-Reuters<ref>{{Cite news|url=https://www.umassmed.edu/news/news-archives/2014/07/three-umms-scientists-named-in-2014-thomson-reuters-report-on-most-influential-scientific-minds/|title=Three UMMS scientists named in 2014 Thomson Reuters Report on most influential scientific minds|date=2014-07-10|work=University of Massachusetts Medical School|access-date=2018-10-30|language=en-US}}</ref>
* Top 20 Translational Researchers of 2014, Nature Biotechnology<ref>{{cite journal |doi=10.1038/bioe.2015.9 |title=Top 20 translational researchers of 2014 |journal=Bioentrepreneur |year=2015 |last1=Huggett |first1=Brady |last2=Paisner |first2=Kathryn |volume=33 |issue=9 |page=897 |pmid=26349903 |doi-access=free }}</ref>
* Fellow, National Academy of Inventors, 2014<ref>{{Cite web|url=http://academyofinventors.org/wp/skin/search-fellows.asp?qFellows=Z&Qa=%25&qSort=FASC|title=Search Fellows - National Academy of Inventors|website=academyofinventors.org|language=en|access-date=2018-10-30}}</ref>
* Outstanding Research Achievement, ''Nature Biotechnology'' SciCafé, 2009
* Schering-Plough Award, American Society of Biochemistry and Molecular Biology, 2009
* Most Highly Cited Researchers, 2002–2012 (Thomson-Reuters)<ref name=":0" />
*W.M. Keck Foundation Young Scholar in Medical Research, 2002–2007
*Top 20 Most Highly Cited Researchers in Molecular Biology and Genetics, 2002–2006, ScienceWatch (Thomson Scientific)<ref name=":1" />
*Pew Scholar in the Biomedical Sciences, 2000–2004<ref>{{Cite web|url=https://www.pewtrusts.org/en/projects/pew-biomedical-scholars/directory-of-pew-scholars/2000/phillip-zamore|title=Phillip D. Zamore, Ph.D.|website=www.pewtrusts.org|access-date=2018-11-09}}</ref>


== Selected publications ==
* Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, É., Tuschl, T., Zamore, P. D. (2001). A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. ''Science'' '''293''', 834-838. <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/11452083</nowiki>
*{{cite journal |doi=10.1126/science.1062961 |pmid=11452083 |title=A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA |journal=Science |volume=293 |issue=5531 |pages=834–838 |year=2001 |last1=Hutvagner |first1=G. |last2=McLachlan |first2=J. |last3=Pasquinelli |first3=A. E. |last4=Bálint |first4=E. |last5=Tuschl |first5=T. |last6=Zamore |first6=P. D. |s2cid=6177608 |doi-access=free }}
* Hutvágner, G., and Zamore, P.D. (2002). A microRNA in a multiple-turnover RNAi enzyme complex. ''Science'' '''297''', 2056-2060. <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/12154197</nowiki>
*{{cite journal |doi=10.1126/science.1073827 |pmid=12154197 |title=A microRNA in a Multiple-Turnover RNAi Enzyme Complex |journal=Science |volume=297 |issue=5589 |pages=2056–2060 |year=2002 |last1=Hutvagner |first1=G. |last2=Zamore |first2=P. D. |bibcode=2002Sci...297.2056H |s2cid=16969059 }}
* Schwarz, D.S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., Zamore, P.D. (2003). Asymmetry in the assembly of the RNAi enzyme complex. ''Cell'' '''115''', 199-208. <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/14567917</nowiki>
*{{cite journal |doi=10.1016/S0092-8674(03)00759-1 |pmid=14567917 |title=Asymmetry in the Assembly of the RNAi Enzyme Complex |journal=Cell |volume=115 |issue=2 |pages=199–208 |year=2003 |last1=Schwarz |first1=Dianne S. |last2=Hutvágner |first2=György |last3=Du |first3=Tingting |last4=Xu |first4=Zuoshang |last5=Aronin |first5=Neil |last6=Zamore |first6=Phillip D. |doi-access=free }}
* Tomari, Y., Du, T., Haley, B., Schwarz, D.S., Bennett, R. Cook, H.A., Koppetsch, B.S., Theurkauf, W.E., Zamore, P.D. (2004). RISC assembly defects in the ''Drosophila'' RNAi mutant armitage. ''Cell'' '''116''', 831-841. <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/15035985</nowiki>
*{{cite journal |doi=10.1016/S0092-8674(04)00218-1 |pmid=15035985 |title=RISC Assembly Defects in the Drosophila RNAi Mutant armitage |journal=Cell |volume=116 |issue=6 |pages=831–841 |year=2004 |last1=Tomari |first1=Yukihide |last2=Du |first2=Tingting |last3=Haley |first3=Benjamin |last4=Schwarz |first4=Dianne S. |last5=Bennett |first5=Ryan |last6=Cook |first6=Heather A. |last7=Koppetsch |first7=Birgit S. |last8=Theurkauf |first8=William E. |last9=Zamore |first9=Phillip D. |doi-access=free }}
* Vagin, V.V., Sigova, A., Li, C., Seitz, H., Gvozdev, V., Zamore, P.D. (2006). A distinct small RNA pathway silences selfish genetic elements in the germ line. ''Science'' '''313''', 320-324. <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/16809489</nowiki>
*{{cite journal |doi=10.1126/science.1129333 |pmid=16809489 |title=A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline |journal=Science |volume=313 |issue=5785 |pages=320–324 |year=2006 |last1=Vagin |first1=V. V. |last2=Sigova |first2=A. |last3=Li |first3=C. |last4=Seitz |first4=H. |last5=Gvozdev |first5=V. |last6=Zamore |first6=P. D. |bibcode=2006Sci...313..320V |s2cid=40471466 }}
* Tomari, Y., Du, T., Zamore, P.D. (2007). Sorting of ''Drosophila'' small silencing RNAs. ''Cell'' '''130''', 299-308. (PMCID: PMC2841505). <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/17662944</nowiki>
*{{cite journal |doi=10.1016/j.cell.2007.05.057 |pmid=17662944 |pmc=2841505 |title=Sorting of Drosophila Small Silencing RNAs |journal=Cell |volume=130 |issue=2 |pages=299–308 |year=2007 |last1=Tomari |first1=Yukihide |last2=Du |first2=Tingting |last3=Zamore |first3=Phillip D. }}
* DiFiglia, M., Sena-Esteves, M., Chase, K., Sapp, E., Pfister, E., Sass, M., Yodel, J., Reeves, P., Pandey, R.K., Rajeev, K.G., Manoharan, M., Sah, D.W.Y., Zamore, P.D., Aronin, N. (2007). Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. ''PNAS'' <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/17940007</nowiki>
*{{cite journal |doi=10.1073/pnas.0708285104 |pmid=17940007 |pmc=2040405 |title=Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits |journal=Proceedings of the National Academy of Sciences |volume=104 |issue=43 |pages=17204–17209 |year=2007 |last1=Difiglia |first1=M. |last2=Sena-Esteves |first2=M. |last3=Chase |first3=K. |last4=Sapp |first4=E. |last5=Pfister |first5=E. |last6=Sass |first6=M. |last7=Yoder |first7=J. |last8=Reeves |first8=P. |last9=Pandey |first9=R. K. |last10=Rajeev |first10=K. G. |last11=Manoharan |first11=M. |last12=Sah |first12=D. W. Y. |last13=Zamore |first13=P. D. |last14=Aronin |first14=N. |doi-access=free |bibcode=2007PNAS..10417204D }}
* Ghildiyal, M., Seitz, H., Horwich, M.D., Li, C., Du, T., Lee, S, Xu, J., Kittler, E.L.W., Zapp, M.L., Weng, Z., Zamore, P.D. (2008). Endogenous siRNAs derived from transposons and mRNAs in ''Drosophila'' somatic cells. ''Science'' '''320''', 1077-1081. (PMCID: PMC2953241). <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/18403677</nowiki>
*{{cite journal |doi=10.1126/science.1157396 |pmid=18403677 |pmc=2953241 |title=Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells |journal=Science |volume=320 |issue=5879 |pages=1077–1081 |year=2008 |last1=Ghildiyal |first1=M. |last2=Seitz |first2=H. |last3=Horwich |first3=M. D. |last4=Li |first4=C. |last5=Du |first5=T. |last6=Lee |first6=S. |last7=Xu |first7=J. |last8=Kittler |first8=E. L.W. |last9=Zapp |first9=M. L. |last10=Weng |first10=Z. |last11=Zamore |first11=P. D. |bibcode=2008Sci...320.1077G }}
* Ameres, S.L., Horwich, M.D., Hung, J., Xu, J., Ghildiyal, M., Weng, Z., Zamore, P.D. (2010). Target RNA-directed trimming and tailing of small silencing RNAs. ''Science'' '''328''', 1534-1539. (PMCID: PMC2902985). <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/20558712</nowiki>
*{{cite journal |doi=10.1126/science.1187058 |pmid=20558712 |pmc=2902985 |title=Target RNA-Directed Trimming and Tailing of Small Silencing RNAs |journal=Science |volume=328 |issue=5985 |pages=1534–1539 |year=2010 |last1=Ameres |first1=S. L. |last2=Horwich |first2=M. D. |last3=Hung |first3=J.-H. |last4=Xu |first4=J. |last5=Ghildiyal |first5=M. |last6=Weng |first6=Z. |last7=Zamore |first7=P. D. |bibcode=2010Sci...328.1534A }}
* Salomon, W.E., Jolly, S.M., Moore, M.J., Zamore, P.D., Serebrov, V. (2015). Single-Molecule imaging reveals that Argonaute reshapes the binding properties of its nucleic acid guides. ''Cell'' '''162''', 84-95. (PMCID: PMC4503223). <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/26140592</nowiki>
*{{cite journal |doi=10.1016/j.cell.2015.06.029 |pmid=26140592 |pmc=4503223 |title=Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of its Nucleic Acid Guides |journal=Cell |volume=162 |issue=1 |pages=84–95 |year=2015 |last1=Salomon |first1=William E. |last2=Jolly |first2=Samson M. |last3=Moore |first3=Melissa J. |last4=Zamore |first4=Phillip D. |last5=Serebrov |first5=Victor}}


==References==
{| class="wikitable"
{{Reflist}}
|+
Phillip D. Zamore
! colspan="2" |[[File:Phillip D. Zamore.jpg|center|thumb|Phillip D. Zamore, 2017]]
|-
!<small>Nationality</small>
|<small>American</small>
|-
!<small>Alma Mater</small>
|<small>Harvard University, Ph.D.</small>
<small>Harvard College, A.B.</small>
|-
! colspan="2" |Scientific Career
|-
!<small>Fields</small>
|<small>Biology</small>
|-
!<small>Institutions</small>
|<small>University of Massachusetts Medical School</small>
<small>The Whitehead Institute for Biomedical Research</small>


{{Authority control}}
<small>Skirball Institute, New York University Medical Center</small>
|-
!<small>Advisors</small>
|<small>Michael Green</small>
<small>Ruth Lehmann</small>
|-
!<small>Website</small>
|[https://www.zamorelab.umassmed.edu/ <small>https://www.zamorelab.umassmed.edu</small>]
|}


{{DEFAULTSORT:Zamore, Phillip D.}}
[[Category:Scientists]]
[[Category:Molecular biologists]]
[[Category:American molecular biologists]]
[[Category:Living people]]
[[Category:UMass Chan Medical School faculty]]
[[Category:Harvard College alumni]]
[[Category:Year of birth missing (living people)]]
[[Category:Harvard Graduate School of Arts and Sciences alumni]]
[[Category:Members of the National Academy of Medicine]]

Latest revision as of 18:07, 29 April 2024

Phillip D. Zamore
Alma materHarvard University, Whitehead Institute
Scientific career
FieldsBiochemistry, molecular biology
InstitutionsUniversity of Massachusetts Chan Medical School, Howard Hughes Medical Institute
Websitezamorelab.umassmed.edu

Phillip D. Zamore is an American molecular biologist and biochemist who co-developed the first in vitro system for studying the mechanism of RNA interference (RNAi). He is the Gretchen Stone Cook Professor of Biomedical Sciences[1] at University of Massachusetts Chan Medical School, Worcester, Massachusetts. Zamore is chair of the RNA Therapeutics Institute (RTI), established in 2009, and has been a Howard Hughes Medical Institute Investigator since 2008.[2]  

Research

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The Zamore lab seeks to understand the molecular mechanisms and biological functions of RNAi and related pathways in animals, including how small RNAs (microRNAs, small interfering RNAs, and PIWI-interacting RNAs) regulate gene expression and suppress transposons.[3] In addition to a focus on basic research, the Zamore lab is working to develop novel nucleic acid-based drugs to treat human disease.[2] Dr. Zamore has more than 60,000 citations on Google Scholar.[4]

Biography

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Zamore received his A.B. in biochemistry and molecular biology from Harvard University in Cambridge, Massachusetts, in 1986 and continued graduate studies with Michael Green at Harvard, receiving his Ph.D. in 1992.[1] After completing postdoctoral studies at The Whitehead Institute for Biomedical Research, MIT, and the Skirball Institute at New York University Medical Center with Ruth Lehmann, James R. Williamson, and David Bartel, Zamore began his academic career as an assistant professor in the Department of Biochemistry and Molecular Pharmacology in 1999 at UMass Medical School in Worcester, Massachusetts. A member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences, Zamore has trained 40 PhD and MD/PhD students and post-doctoral scholars.

Involvement with biotechnology

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Zamore's research has led to a career in biotechnology, co-founding Alnylam Pharmaceuticals in 2002.[5] Alnylam is dedicated to bringing RNAi based therapies to market and developed the first-ever FDA approved RNAi drug, Patisiran, gaining FDA approval in August 2018.[6] In 2014, Dr. Zamore co-founded another RNAi based company; Voyager Therapeutics,[7] which focuses on developing therapeutics for neurodegenerative disorders.

Selected awards and honors

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  • RNA Society / Cold Spring Harbor Laboratory Press Distinguished Research Mentor Award, 2024
  • Member, National Academy of Medicine, 2023[8]
  • Member, National Academy of Sciences, 2023[9]
  • Fellow, American Academy of Arts and Sciences, 2023[10]
  • Invented Here! Honoree, Boston Patent Law Association, for US patent US 9,226,976, “RAAV- Based Compositions and Methods for Treating Alpha-1 Anti-Trypsin Deficiencies,” 2017
  • Paper of the Year (Salomon et al., Cell 2015), Oligonucleotide Therapeutics Society[11]
  • Chancellor's Medal for Excellence in Scholarship, University of Massachusetts Medical School, 2014[12]
  • “The World’s Most Influential Scientific Minds 2014,” Molecular Biology & Genetics, Thomson-Reuters[13]
  • Top 20 Translational Researchers of 2014, Nature Biotechnology[14]
  • Fellow, National Academy of Inventors, 2014[15]
  • Outstanding Research Achievement, Nature Biotechnology SciCafé, 2009
  • Schering-Plough Award, American Society of Biochemistry and Molecular Biology, 2009
  • Most Highly Cited Researchers, 2002–2012 (Thomson-Reuters)[1]
  • W.M. Keck Foundation Young Scholar in Medical Research, 2002–2007
  • Top 20 Most Highly Cited Researchers in Molecular Biology and Genetics, 2002–2006, ScienceWatch (Thomson Scientific)[2]
  • Pew Scholar in the Biomedical Sciences, 2000–2004[16]

Selected publications

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References

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  1. ^ a b c "Phillip Zamore | Profiles RNS". profiles.umassmed.edu. Retrieved 2018-10-30.
  2. ^ a b c "Phillip D. Zamore, PhD". HHMI.org. Retrieved 2018-10-30.
  3. ^ "Phillip Zamore's Laboratory". Phillip Zamore's Laboratory. Retrieved 2018-11-09.
  4. ^ "Phillip D. Zamore - Google Scholar Citations". scholar.google.com. Retrieved 2018-10-30.
  5. ^ "Alnylam SAB".
  6. ^ "FDA approval of Alnylam drug is first ever for RNAi-based therapy - STAT". STAT. 2018-08-10. Retrieved 2018-10-30.
  7. ^ "Founders". Voyager Therapeutics. Retrieved 2018-10-30.
  8. ^ "National Academy of Medicine Elects 100 New Members". October 9, 2023.
  9. ^ "2023 NAS Election". www.nasonline.org. Retrieved 2023-05-09.
  10. ^ "New Members". American Academy of Arts & Sciences. Retrieved 2023-05-01.
  11. ^ "Paper of the Year - Oligonucleotide Therapeutics Society". Oligonucleotide Therapeutics Society. Retrieved 2018-10-30.
  12. ^ "Chancellor's Medals". University of Massachusetts Medical School. 2014-03-31. Retrieved 2018-10-30.
  13. ^ "Three UMMS scientists named in 2014 Thomson Reuters Report on most influential scientific minds". University of Massachusetts Medical School. 2014-07-10. Retrieved 2018-10-30.
  14. ^ Huggett, Brady; Paisner, Kathryn (2015). "Top 20 translational researchers of 2014". Bioentrepreneur. 33 (9): 897. doi:10.1038/bioe.2015.9. PMID 26349903.
  15. ^ "Search Fellows - National Academy of Inventors". academyofinventors.org. Retrieved 2018-10-30.
  16. ^ "Phillip D. Zamore, Ph.D." www.pewtrusts.org. Retrieved 2018-11-09.
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