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{{Talk header}}
==General discussion==
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I know a number of women who have HPV, and think it really sucks, and feel like sex ed failed to warn them of the dangers. I think this article very significantly downplays some of the dangers.
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=="Genital cancer"==
First, I'm not sure if it's fair to imply HPV goes away within 1 year. It doesn't -- some forms will cause irregular pap smears and will contribute to cancer for the rest of your life.
The "Genital cancer" row in HPV types table is confusing. Does it refer to female genitals, male genitals, or both? The impact of HPV types is quite different.


I suspect the current content applies to female genitals but doesn't seem to fit very well with penile cancer. For instance, in this study <ref>https://www.sciencedirect.com/science/article/abs/pii/S0302283815012154?via%3Dihub</ref> analyzing the role of HPV in penile cancer, HPV-16 was the most frequent HPV type detected in both HPV-positive cancers (68.7%) and HGSILs (79.6%), followed by HPV-6 (3.7%) but in the table HPV-6 isn't even present. Another study <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850485/</ref> found single-viral infection of the following types in patients with penile cancer: 45, 35, 18, 52, 68, 31, 53, 6. All of which (except type 6) are currently present in the table. However I haven't been able to find any reference linking penile cancer with the remaining types (33, 39, 51, 56, 58, 59, 26, 66, 73, 82), perhaps these types are only associated with female genitals? Maybe a good solution would be to split "Genital cancer" in two rows, one for female genitals and one for male genitals.
Second, while HPV is endemic, the "bad" forms of HPV aren't yet (the kinds that cause cancer, warts, or other problems) -- lots of people have them, but nowhere near 80% (this figure should be supported more strongly -- it seemed weaker in the source), so it's not fair to imply that "HPV is an almost unavoidable, and invisible consequence of sexual activity." It's really not. With one partner over a lifetime (or a very small number), you probably won't get a bad type. With many partners, you'll almost certainly have to go in for pap smears every few months. It's not as bad as AIDS in symptoms, but it sucks. With future partners, you'll either need to be dishonest about it (not mention you got it, or lie about having it), or you'll have a much harder time getting laid. If you do get laid, you'll spread it more. It's a very bad thing.
[[User:Robert1dB|Robert1dB]] ([[User talk:Robert1dB|talk]]) 22:57, 29 November 2022 (UTC)


{{reflist-talk}}
One other note: there's research that implies a connection between HPV and reoccurent urinary tract infections. It might be good to confirm how good this research is, and put up something about it. I saw it on a pretty sketchy web site, but it linked to a real medical article (http://www.health-science-report.com/cgi-bin/alotek.cgi?topics=1&article=111). I don't have access to the original article, so I can't confirm if it is being misquoted.


=="Oropharyngeal cancer"==
-----
Apologies if I'm missing something obvious (I'm not an expert in the field or even health/biology for that matter), but based on information I found on the net it would seem there's more to HPV and "Oropharyngeal cancer" than just type 16. Quoting from this meta-study <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394168/</ref>: "The most common HPV type detected in oral cancers is HPV16. A notable outlier is a study from South Africa which detected only HPV18, and not HPV16, in patients with oral cancer. HPV18 was detected in a smaller percentage of oral cancers, some oral carcinomas had dual infections with HPV16/18. Rarer types detected in oral cancers were HPV8, HPV31, HPV38, and HPV66."
[[User:Robert1dB|Robert1dB]] ([[User talk:Robert1dB|talk]]) 23:07, 29 November 2022 (UTC)


{{reflist-talk}}
The text on this page is identical to http://www.niaid.nih.gov/factsheets/stdhpv.htm


== Redundant statement ==
I'm guessing that's a US govmt source, so we can use it. COuld someone confirm?


"While cases of warts have been described since the time of ancient Greece, their viral cause was not known until 1907." occurs twice in the article. [[User:Mansell|Mansell]] ([[User talk:Mansell|talk]]) 06:35, 19 March 2023 (UTC)
(same applied to [[Genital wart]], I cut some text and moved it there -- [[User:Tarquin|Tarquin]] 11:19 Feb 26, 2003 (UTC))


== "Cervical Cancer" ==
:It doesn't matter at all, since works of the U.S. federal government are public domain. Of course, that source isn't really an encyclopedic entry. The page is completely different now, though it also seems to be lacking adequate detail, considering how widespread a disease it is.. [[User:Mulad|<nowiki></nowiki>]] &mdash;[[User:Mulad]] [[User talk:Mulad|(talk)]] 16:30, May 6, 2005 (UTC)


"HPV is necessary for cervical cancer to occur." Looking through the citation linked for this information, there is no information which supports this claim. There are other articles which say HPV negative cervical cancer can occur. <ref>https://pubmed.ncbi.nlm.nih.gov/34073478/</ref>
From the American Cancer Society Website: http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_cervical_cancer_8.asp?rnav=cri
[[User:Stew240|Stew240]] ([[User talk:Stew240|talk]]) 09:38, 18 April 2023 (UTC)
:"...condoms do not protect against HPV..."
:"...certain types of sexual behavior increase a woman's risk of getting HPV: sex at an early age, having many sexual partners, having sex with uncircumcised males..."
:"...it is necessary to have had HPV for cervical cancer to develop..."


{{reflist-talk}}
:: I know circumcision is the norm in the US, but it bothers me rather a lot that I'm effectively accused of putting women at risk of cancer by not mutilating myself. What's the science behind that? There's no actual explanation on that page. [[User:Goatboy|Chris]] 11:03, 27 August 2005 (UTC)


== Discovered ==
There is a statistically insignificant increase in HPV transmission from uncircumsized men to females and other men (and vise-versa in both cases). This doesnt mean that the same will hold true through more study. ITs rather doubtful should a firm and significant link be found that it would be related to the actual pysical functioning of the genitallia, but rahter realted to lifestyle. More firmly religious people are cicumsized per capita than religiously liberal and non-religious peoples; which makes it probable that they are havign more sex with more partners. In any case, a condom pretty much solves the problem aside from rare cases where HPV is spread even with the use of a condom in which case circumsision has nothing to do with it anyway. --[[User:LouieS|LouieS]] 03:26, 29 August 2005 (UTC)


Why no mention of when HPV was discovered ? [[Special:Contributions/70.190.65.59|70.190.65.59]] ([[User talk:70.190.65.59|talk]]) 04:41, 26 April 2023 (UTC)
== expand ==

this needs more info.

* how is it transmitted? other sites say by "skin to skin contact". but you can't get it from holding hands. what do they mean ''exactly''?

* does the virus stay in your body and contagious after the symptoms have cleared up? can you still give it to others? does it ever fully disappear? (i believe the virus stays in one's body and contagious forever).

* does it create symptoms in both men and women? (i believe symptoms in men are rare)

* a google search shows several different vaccine studies. can we get more details about them?

You CAN get HPV from holding hands and kissing, HPV is simply a virus that causes warts of any kind, not only genital warts; though genital warts can be spread even without sexual activity. The virus staying in your body depends upon they type, many types a killed through an immune respose within eight months (sourced from NIAID), HPV can be sprad to others without and symptoms present. Symptoms in women are more frequent but less often noticed. There is a vaccine in the works effective agains 16, 18, and 31 i believe which are the main HPV contributors to cancer. Though HPV is NOT the only way for cervical cancer to develop though it is the most common cause, I don't know where ACS gets their facts from, but those are bad ones. http://www.ashastd.org/hpvccrc/patientfaq.html --[[User:LouieS|LouieS]] 18:38, 22 Jun 2005 (UTC)

== taxonomy of HPV ==
The taxonomy of HPV has changed. E-M De Villiers et al publication in 2004 indicateds that
Papillomavirus is the Family.
alpha is the genus
species 9 is one of the oncogenic species
and within species 9 are
the oncogenic types: including type 16.
Within HPV type 16 are the variants of HPV 16 that make it slightly different the world round.

== NPOV; sources ==

The article seems to the lack the former and needs the latter. [[User:Andrevan|<b><font color="mediumblue">Andre</font></b>]] ([[User_talk:Andrevan|<font color=royalblue>talk</font>]]) 19:55, 19 October 2005 (UTC)
:I can work on it some, what in particular strikes you as needing work? [[User:Delldot|Delldot]] 18:06, 6 November 2005 (UTC)

== "student"? ==

"HPV is a student..."? (Complete with a link to "student" entry)

I assume this a typo for "virus"?

: Yeah, that was [[Wikipedia:vandalism|vandalism]]. The person's been [[Wikipedia:vandalism in progress|warned]]. Thanks for noticing! [[User:Delldot|Delldot]] 18:06, 6 November 2005 (UTC)

==NPOV and quotes in controversy section==
I tried to [[Wikipedia:NPOV|NPOV]] the Controversy section of the article by representing the other side as well, though if you think I've gone too far in that direction you might tweak it some or add more info.

Also, I was concerned because there was a quotation in there that wasn't cited. There were three sets of quotes. Here's how it looked:
''"Because the vaccine protects against a sexually transmitted virus, many conservatives oppose making it mandatory, citing fears that it could send a subtle message condoning sexual activity before marriage...'I've talked to some who have said, "This is going to sabotage our abstinence message,' " said Gene Rudd, associate executive director of the Christian Medical and Dental Associations.'' So I removed the outer set of quotes. Does anyone know who we're qoting with the outside quotes? I was worried this text might be cut and pasted from somewhere. Thanks, [[user:delldot|delldot]] | [[user talk:delldot|talk]] 18:11, 18 November 2005 (UTC)

== oncogenic HPV ==

The reference below disputes that HPV 16 & HPV 18 are the most common. I wonder whether this is due to geographical variation (like [[HIV]]-1, the primary strain in North America, vs. HIV-2, the primary strain in Africa).

Anyone have an idea about the geographic variance of HPV strains?

Andersson S, Mints M, Sallstrom J, Wilander E. The relative distribution of oncogenic types of human papillomavirus in benign, pre-malignant and malignant cervical biopsies. A study with human papillomavirus deoxyribonucleic acid sequence analysis. Cancer Detect Prev. 2005;29(1):37-41. Epub 2005 Jan 26. PMID 15734215

[[User:Nephron|Nephron]] 00:16, 6 February 2006 (UTC)

== Missing out on treatments. ==

[[It could be helpful if there was information regarding how the infection can be treated - what '''treatment''' can be offered to a victim.
As it says there has been found no cure then we know that, but options of treatments are an important part.
Correct me if I am wrong - I might not be seeing it.
]]

:''Since the treatments for common warts, genital warts, cervical pre-cancer and cervical cancer are very different, I think detailed discussion of treatment options belongs in those separate articles. [[User:Retroid|Retroid]] 22:06, 10 June 2006 (UTC)

== treatments ==

Treatments: medications, freeze warts, laser treatment, cutting and radiation (cancer).

== What are these magical words? ==
...whose mission is to generate a cornified layer that seals the body and prevents dessecation. In this upper layer the late viral proteins L1 and L2 are expressed. They bind the viral DNA and autoassemble, giving rise to the complete virions, ready for a new infection, that are released as the dead keratinocytes descamate...

The first word dessecation? Is this passage really talking about dehydration?
Secondly, descamate??? Is not a word that I can find at all, but is apparently a googlewhack.

Was this just vandalism, or a misspelling of a real word? I am not studying biology, so I really haven't a clue.

-Redwraith9
:first time at site; these look like dessicate and desquamate. [[User:Sfahey|Sfahey]] 20:56, 18 August 2006 (UTC)

== Rearrangement ==

This discussion page leads me to believe that most people who arrive at this article are primarily interested in HPV-related diseases. I therefore moved the general discussion of papillomavirus biology to the main article [[Papillomavirus]]. I also attempted to re-focus the intro and put the various HPV-related diseases in perspective. I think the Effects section could be organized a little better, but I wanted to give people a chance to object to the current changes first. I'm compiling a list of HPV-related articles on [[User talk:Retroid|my Talk page]] - feel free to modify. [[User:Retroid|Retroid]] 13:27, 28 May 2006 (UTC)
::I certainly agree the articles (still) have too much overlap, and with (I expect) many more visitors here than to "papillomavirus" it's strange to refer to the latter in the lead paragraph as the "main" article. It seems to me that the best option for divvying up info between "P" and "HPV" should be 1) "HPV" having a brief "Biology of ..." section, with a header saying "See "P""; and 2) "P" having a brief "HPV and human disease" section, with a header saying "Main article: "HPV"". On a different note I am going to move those annoying top of the page comments down "below the box." [[User:Sfahey|Sfahey]] 21:34, 18 August 2006 (UTC)

== HPV 6-11 ==

Can a person contract the virus from merely touching the virgina with a hand, no prenetration?

:''Probably yes. Some epidemiological studies have found that adolescents begin to acquire genital HPV infections prior to engaging in penetrative sexual contact. It's therefore thought that mutual genital "petting" can result in transmission of genital HPV infections.'' [[User:Retroid|Retroid]] 22:03, 10 June 2006 (UTC)

== Prevention ==

There are problems in the passage about prevention:
''"Sexually-transmitted HPV infections may be distributed widely over genital skin and mucosal surfaces, and transmission can occur even when there are no visible symptoms. Thus, the only sure way to prevent genital HPV infection is to abstain from any contact with the genitals of another."''

There is a logical flaw in this statement. Assuming all else is true the second sentence could be reworded as:
"Thus, the only sure way to prevent '''sexually-transmitted''' HPV infections is to abstain from any contact with the genitals of another"

This may still be incorrect, eg. if another person could touch their infected genitals and then touch yours and infect you.

If the only way (other than childbirth) that HPV can only be spread is through "sexual" contact, then "Sexually-transmitted HPV" would be better worded as "All post-natal transmission of HPV is through sexual activity", or more acurately: "All post-natal transmission of HPV occurs through direct genital to genital contact."

I don't know what the situation is, but the current wording needs to be changed.

:You could say, "The only sure way to avoid genital HPV infection would be lifelong sexual abstinence." That's technically accurate since it's thought that occasional infection of infants during birth is generally oral/respiratory (not genital). Anyway, even the reformulated sentence bugs me because it doesn't seem like especially useful advice for most folks. How about "People with greater numbers of sexual partners are at increased risk of developing HPV-related diseases."

:The Prevention section could cover A) Pap smear and new HPV DNA tests, B) the new HPV vaccine, C) limiting # of sexual partners, D) condoms, E) topical microbicides.
:[[User:Retroid|Retroid]] 22:11, 13 June 2006 (UTC)

:Oops, wasn't signed in when I implemented the above changes. 69.140.22.184 is me.
:[[User:Retroid|Retroid]] 18:15, 24 June 2006 (UTC)

==Good==
I probably shouldn't nominated since I once upon a time edited this article, but this is rapidly approaching good/featured article status. Maybe a pass through peer review? Anyway, congrats to Retroid, et al. [[User:Jengod|jengod]] 08:03, 15 July 2006 (UTC)

:Maybe after the introduction is sorted a bit more. It's huge. [[User:72.48.26.130|72.48.26.130]] 07:35, 29 July 2006 (UTC)

::Some material from [[Papillomavirus]] sneaked into the Intro section - in my opinion it resulted in some redundancy and a few bits of relatively arcane biology. I consolidated the redundancies and stripped out the arcane factoids. My theory is that the great majority of people arriving at this article are investigating A) Merck's "a virus causes cancer?!" vaccine ads, B) an abnormal pap smear, C) warts of some kind. So I'm with User 72.48.26.130 - the Intro should be terse and focus on HPV diseases. [[User:Retroid|Retroid]] 23:29, 31 July 2006 (UTC)

::See also [[Talk:Papillomavirus|Talk page]] for main article [[Papillomavirus]]. [[User:Retroid|Retroid]] 14:30, 5 August 2006 (UTC)

==On another note==
The article would benefit from an actual cosmetic image of the HPV symptoms (warts etc) on a living human subject.

:Image of Pap smear cells does the job nicely - good one, Euthman! [[User:Retroid|Retroid]] 14:30, 4 August 2006 (UTC)

:This is about the virus; pictures of genital warts belong in [[genital warts]]. — [[User:Omegatron|Omegatron]] 23:16, 4 August 2006 (UTC)

== Some additions ==

I found the articles about Apoptosis and Necrosis linking to this page, I was checking for a place to insert a link about '[[Apoptosis]]' in this article which may reveal informative on the subject, but I wasn't sure if it would apply to warts in general or common/plantar warts, or where I could insert it, a new text, in the current text or references. --[[User:TiCPU|TiCPU]] 18:52, 31 July 2006 (UTC)

:One function of the papillomavirus oncogenes E6 and E7 is prevention of apoptosis. I added a link to [[Apoptosis]] in an appropriate spot in the main article [[Papillomavirus]] (and vice versa). [[User:Retroid|Retroid]] 14:17, 4 August 2006 (UTC)


== Western disease? ==

Is this disease prevalent outside the West? I'm pretty sure it isn't.

==External link==
A well written article has been written that summarized treatment of HPV in "college-age" patients. This article is located at http://www.collegehealth-e.com/4/n02.htm any thoughts?
:{{unsigned|71.127.172.67}} 03:36, 9 October 2006

:This user was adding www.collegehealth-e.com links to multiple medical articles. And has now engaged in dialogue - thank you. The articles are well written and, more importantly, well sourced. The problem is more of whether content should be added to wikipedia articles or external links. Ideally no external link should be made if it fails to add greater information than the finished article should have once it reaches featured-article status. In this case I think the collegehealth-e.com is generally more detailed. Secondly wikipedia is not here to act as a link to other sources - we don't have one-to-one links to the equivalent article at Encyclopaedia Britannica or Encarta - yet I appreciate that collegehealth-e.com is not trying to be an encyclopaedia on all topics. I am more uncertain the more collegehealth-e.com articles I look at, perhaps this is a useful resource? But if so, should it be a standard external link resource provided by [[Template:Disease infobox]] ?

:Certainly populating multiple wikipedia articles without discussion strikes me as probably spamming... I'm going to raise the issue of the general appropriateness/usefulness of collegehealth-e.com links at the Clinical Medicine wikiproject – so please join discussion at [[Wikipedia talk:WikiProject Clinical medicine#www.collegehealth-e.com links]]. [[User:Davidruben|David Ruben]] <sup> [[User talk:Davidruben|Talk]] </sup> 03:01, 9 October 2006 (UTC)

== Incidence vs. Age Graph ==

Shouldn't the incidence vs. age graph have some sort of metric on the y-axis? [[User:Ahhwhereami|Ahhwhereami]] 01:26, 15 November 2006 (UTC)

== Risk for Anal Cancer -- So WHY not adminstered to young men!!! ==

Why is the vaccine only approved for women?

I guess cervical cancer in heterosexual women of child-bearing age is more important than anal cancer in young gay/bisexual men.

Latest revision as of 12:43, 6 January 2024

"Genital cancer"

[edit]

The "Genital cancer" row in HPV types table is confusing. Does it refer to female genitals, male genitals, or both? The impact of HPV types is quite different.

I suspect the current content applies to female genitals but doesn't seem to fit very well with penile cancer. For instance, in this study [1] analyzing the role of HPV in penile cancer, HPV-16 was the most frequent HPV type detected in both HPV-positive cancers (68.7%) and HGSILs (79.6%), followed by HPV-6 (3.7%) but in the table HPV-6 isn't even present. Another study [2] found single-viral infection of the following types in patients with penile cancer: 45, 35, 18, 52, 68, 31, 53, 6. All of which (except type 6) are currently present in the table. However I haven't been able to find any reference linking penile cancer with the remaining types (33, 39, 51, 56, 58, 59, 26, 66, 73, 82), perhaps these types are only associated with female genitals? Maybe a good solution would be to split "Genital cancer" in two rows, one for female genitals and one for male genitals. Robert1dB (talk) 22:57, 29 November 2022 (UTC)[reply]

References

  1. ^ https://www.sciencedirect.com/science/article/abs/pii/S0302283815012154?via%3Dihub
  2. ^ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850485/

"Oropharyngeal cancer"

[edit]

Apologies if I'm missing something obvious (I'm not an expert in the field or even health/biology for that matter), but based on information I found on the net it would seem there's more to HPV and "Oropharyngeal cancer" than just type 16. Quoting from this meta-study [1]: "The most common HPV type detected in oral cancers is HPV16. A notable outlier is a study from South Africa which detected only HPV18, and not HPV16, in patients with oral cancer. HPV18 was detected in a smaller percentage of oral cancers, some oral carcinomas had dual infections with HPV16/18. Rarer types detected in oral cancers were HPV8, HPV31, HPV38, and HPV66." Robert1dB (talk) 23:07, 29 November 2022 (UTC)[reply]

References

  1. ^ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394168/

Redundant statement

[edit]

"While cases of warts have been described since the time of ancient Greece, their viral cause was not known until 1907." occurs twice in the article. Mansell (talk) 06:35, 19 March 2023 (UTC)[reply]

"Cervical Cancer"

[edit]

"HPV is necessary for cervical cancer to occur." Looking through the citation linked for this information, there is no information which supports this claim. There are other articles which say HPV negative cervical cancer can occur. [1] Stew240 (talk) 09:38, 18 April 2023 (UTC)[reply]

References

  1. ^ https://pubmed.ncbi.nlm.nih.gov/34073478/

Discovered

[edit]

Why no mention of when HPV was discovered ? 70.190.65.59 (talk) 04:41, 26 April 2023 (UTC)[reply]

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