ALS2: Difference between revisions

ALS2
Identifiers
Aliases	ALS2, ALS2CR6, ALSJ, IAHSP, PLSJ, alsin Rho guanine nucleotide exchange factor, alsin Rho guanine nucleotide exchange factor ALS2
External IDs	OMIM: 606352; MGI: 1921268; HomoloGene: 23264; GeneCards: ALS2; OMA:ALS2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	201,782,112 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	59,276,390 bp
RNA expression pattern
	Top expressed in
	Cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; cerebellar vermis; ; tibialis anterior muscle; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; deltoid muscle; ; sural nerve;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; morula; ; zygote; ; muscle of thigh; ; right kidney; ; ventricular zone; ; yolk sac; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; guanyl-nucleotide exchange factor activity; protein serine/threonine kinase activator activity; protein binding;
Cellular component	cytoplasm; vesicle; centrosome; membrane; postsynaptic density; intracellular membrane-bounded organelle; growth cone; ruffle; dendritic spine; axon; soma; dendrite; early endosome; neuron projection; lamellipodium; cytosol; protein-containing complex;
Biological process	protein localization; neuron projection morphogenesis; synaptic transmission, glutamatergic; axonogenesis; locomotory behavior; vesicle organization; regulation of GTPase activity; cell death; in utero embryonic development; behavioral fear response; response to oxidative stress; endosome organization; endosomal transport; positive regulation of GTPase activity; receptor recycling; neuromuscular junction development; Rac protein signal transduction; regulation of Rho protein signal transduction; regulation of endosome size; positive regulation of Rac protein signal transduction; positive regulation of protein kinase activity; positive regulation of protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	57679
	74018
	ENSG00000003393
	ENSMUSG00000026024
	Q96Q42
	Q920R0
	NM_001135745; NM_020919
	NM_001159948; NM_028717; NM_146109
	NP_001129217; NP_065970
	NP_001153420; NP_082993; NP_666221
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 19:53, 19 April 2024

Alsin is a protein that in humans is encoded by the ALS2 gene.^[5]^[6] ALS2 orthologs^[7] have been identified in all mammals for which complete genome data are available.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000003393 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026024 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298. S2CID 52828189.
^ "Entrez Gene: ALS2 amyotrophic lateral sclerosis 2 (juvenile)".
^ "OrthoMaM phylogenetic marker: ALS2 coding sequence". Archived from the original on 2016-03-04. Retrieved 2009-12-09.

Hadano S (2002). "[Causative genes for familial amyotrophic lateral sclerosis]". Seikagaku. 74 (6): 483–9. PMID 12138710.
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Hadano S, Nichol K, Brinkman RR, et al. (1999). "A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34". Genomics. 55 (1): 106–12. doi:10.1006/geno.1998.5637. PMID 9889004.
Hosler BA, Sapp PC, Berger R, et al. (2000). "Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33". Neurogenetics. 2 (1): 34–42. doi:10.1007/s100480050049. PMID 9933298. S2CID 33368578.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Yang Y, Hentati A, Deng HX, et al. (2001). "The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis". Nat. Genet. 29 (2): 160–5. doi:10.1038/ng1001-160. PMID 11586297. S2CID 9036123.
Birkenhäger R, Otto E, Schürmann MJ, et al. (2001). "Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure". Nat. Genet. 29 (3): 310–4. doi:10.1038/ng752. PMID 11687798. S2CID 5892001.
Eymard-Pierre E, Lesca G, Dollet S, et al. (2002). "Infantile-Onset Ascending Hereditary Spastic Paralysis Is Associated with Mutations in the Alsin Gene". Am. J. Hum. Genet. 71 (3): 518–27. doi:10.1086/342359. PMC 379189. PMID 12145748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lesca G, Eymard-Pierre E, Santorelli FM, et al. (2004). "Infantile ascending hereditary spastic paralysis (IAHSP): clinical features in 11 families". Neurology. 60 (4): 674–82. doi:10.1212/01.wnl.0000048207.28790.25. PMID 12601111. S2CID 20968387.
Otomo A, Hadano S, Okada T, et al. (2003). "ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics". Hum. Mol. Genet. 12 (14): 1671–87. doi:10.1093/hmg/ddg184. PMID 12837691.
Nagano I, Murakami T, Shiote M, et al. (2003). "Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis". Neurol. Res. 25 (5): 505–9. doi:10.1179/016164103101201733. PMID 12866199. S2CID 42350605.
Devon RS, Helm JR, Rouleau GA, et al. (2004). "The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings". Clin. Genet. 64 (3): 210–5. doi:10.1034/j.1399-0004.2003.00138.x. PMID 12919135. S2CID 27423316.
Yamanaka K, Vande Velde C, Eymard-Pierre E, et al. (2004). "Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 16041–6. doi:10.1073/pnas.2635267100. PMC 307689. PMID 14668431.
Hand CK, Devon RS, Gros-Louis F, et al. (2004). "Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis". Arch. Neurol. 60 (12): 1768–71. doi:10.1001/archneur.60.12.1768. PMID 14676054.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kanekura K, Hashimoto Y, Niikura T, et al. (2004). "Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants". J. Biol. Chem. 279 (18): 19247–56. doi:10.1074/jbc.M313236200. PMID 14970233.

External links

GeneReviews/NCBI/NIH/UW entry on ALS2-Related Disorders
OMIM entries on ALS2-Related Disorders
Genetics Home Reference- US National Library of Medicine
Human ALS2 genome location and ALS2 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000003393 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026024 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11586298-5] Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298. S2CID 52828189.

[entrez-6] "Entrez Gene: ALS2 amyotrophic lateral sclerosis 2 (juvenile)".

[OrthoMaM-7] "OrthoMaM phylogenetic marker: ALS2 coding sequence". Archived from the original on 2016-03-04. Retrieved 2009-12-09.

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[6]

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
 {{Infobox_gene}}
-'''Alsin''' is a [[protein]] that in humans is encoded by the ''ALS2'' [[gene]].<ref name="pmid11586298">{{cite journal |vauthors=Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, ((Brown RH Jr)), Scherer SW, Rouleau GA, Hayden MR, Ikeda JE | title = A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 | journal = Nat Genet | volume = 29 | issue = 2 | pages = 166–73 |date=Oct 2001 | pmid = 11586298 | pmc =  | doi = 10.1038/ng1001-166 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ALS2 amyotrophic lateral sclerosis 2 (juvenile)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57679| accessdate = }}</ref> ''ALS2'' [[orthologs]] <ref name="OrthoMaM">{{cite web | title = OrthoMaM phylogenetic marker: ALS2 coding sequence | url = http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000003393_ALS2.xml }}</ref> have been identified in all [[mammals]] for which complete genome data are available.
+'''Alsin''' is a [[protein]] that in humans is encoded by the ''ALS2'' [[gene]].<ref name="pmid11586298">{{cite journal |vauthors=Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, ((Brown RH Jr)), Scherer SW, Rouleau GA, Hayden MR, Ikeda JE | title = A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 | journal = Nat Genet | volume = 29 | issue = 2 | pages = 166–73 |date=Oct 2001 | pmid = 11586298 | doi = 10.1038/ng1001-166 | s2cid = 52828189 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ALS2 amyotrophic lateral sclerosis 2 (juvenile)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57679}}</ref> ''ALS2'' [[orthologs]]<ref name="OrthoMaM">{{cite web | title = OrthoMaM phylogenetic marker: ALS2 coding sequence | url = http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000003393_ALS2.xml | access-date = 2009-12-09 | archive-url = https://web.archive.org/web/20160304031500/http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000003393_ALS2.xml | archive-date = 2016-03-04 | url-status = dead }}</ref> have been identified in all [[mammals]] for which complete genome data are available.
 ==See also==
@@ Line 11: / Line 12: @@
 ==Further reading==
 {{refbegin | 2}}
-*{{cite journal  | author=Hadano S |title=[Causative genes for familial amyotrophic lateral sclerosis] |journal=Seikagaku |volume=74 |issue= 6 |pages= 483–9 |year= 2002 |pmid= 12138710 |doi=  }}
+*{{cite journal  | author=Hadano S |title=[Causative genes for familial amyotrophic lateral sclerosis] |journal=Seikagaku |volume=74 |issue= 6 |pages= 483–9 |year= 2002 |pmid= 12138710 }}
-*{{cite journal  | author=Nakajima D |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99  | name-list-format=vanc | author2=Okazaki N  | author3=Yamakawa H  | display-authors=3  | last4=Kikuno  | first4=R  | last5=Ohara  | first5=O  | last6=Nagase  | first6=T  | doi-access=free  }}
+*{{cite journal  | author=Nakajima D |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99  | name-list-style=vanc | author2=Okazaki N  | author3=Yamakawa H  | display-authors=3  | last4=Kikuno  | first4=R  | last5=Ohara  | first5=O  | last6=Nagase  | first6=T  | doi-access=free  }}
-*{{cite journal  | author=Hadano S |title=A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34 |journal=Genomics |volume=55 |issue= 1 |pages= 106–12 |year= 1999 |pmid= 9889004 |doi= 10.1006/geno.1998.5637  | name-list-format=vanc | author2=Nichol K  | author3=Brinkman RR  | display-authors=3  | last4=Nasir  | first4=J  | last5=Martindale  | first5=D  | last6=Koop  | first6=BF  | last7=Nicholson  | first7=DW  | last8=Scherer  | first8=SW  | last9=Ikeda  | first9=JE }}
+*{{cite journal  | author=Hadano S |title=A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34 |journal=Genomics |volume=55 |issue= 1 |pages= 106–12 |year= 1999 |pmid= 9889004 |doi= 10.1006/geno.1998.5637  | name-list-style=vanc | author2=Nichol K  | author3=Brinkman RR  | display-authors=3  | last4=Nasir  | first4=J  | last5=Martindale  | first5=D  | last6=Koop  | first6=BF  | last7=Nicholson  | first7=DW  | last8=Scherer  | first8=SW  | last9=Ikeda  | first9=JE }}
-*{{cite journal  | author=Hosler BA |title=Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33 |journal=Neurogenetics |volume=2 |issue= 1 |pages= 34–42 |year= 2000 |pmid= 9933298 |doi=10.1007/s100480050049  | name-list-format=vanc | author2=Sapp PC  | author3=Berger R  | display-authors=3  | last4=O'Neill  | first4=Gilmore  | last5=Bejaoui  | first5=Khemissa  | last6=Hamida  | first6=Mongi Ben  | last7=Hentati  | first7=Faycal  | last8=Chin  | first8=Wendy  | last9=McKenna-Yasek  | first9=Diane  }}
+*{{cite journal  | author=Hosler BA |title=Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33 |journal=Neurogenetics |volume=2 |issue= 1 |pages= 34–42 |year= 2000 |pmid= 9933298 |doi=10.1007/s100480050049  | name-list-style=vanc | author2=Sapp PC  | author3=Berger R  | display-authors=3  | last4=O'Neill  | first4=Gilmore  | last5=Bejaoui  | first5=Khemissa  | last6=Hamida  | first6=Mongi Ben  | last7=Hentati  | first7=Faycal  | last8=Chin  | first8=Wendy  | last9=McKenna-Yasek  | first9=Diane  |s2cid=33368578 }}
-*{{cite journal  | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi=  10.1093/dnares/7.4.271| name-list-format=vanc | author2=Kikuno R  | author3=Nakayama M  | display-authors=3  | last4=Hirosawa  | first4=M  | last5=Ohara  | first5=O  | doi-access=free }}
+*{{cite journal  | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi=  10.1093/dnares/7.4.271| name-list-style=vanc | author2=Kikuno R  | author3=Nakayama M  | display-authors=3  | last4=Hirosawa  | first4=M  | last5=Ohara  | first5=O  | doi-access=free }}
-*{{cite journal  | author=Yang Y |title=The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis |journal=Nat. Genet. |volume=29 |issue= 2 |pages= 160–5 |year= 2001 |pmid= 11586297 |doi= 10.1038/ng1001-160  | name-list-format=vanc | author2=Hentati A  | author3=Deng HX  | display-authors=3  | last4=Dabbagh  | first4=Omar  | last5=Sasaki  | first5=Toru  | last6=Hirano  | first6=Makito  | last7=Hung  | first7=Wu-Yen  | last8=Ouahchi  | first8=Karim  | last9=Yan  | first9=Jianhua }}
+*{{cite journal  | author=Yang Y |title=The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis |journal=Nat. Genet. |volume=29 |issue= 2 |pages= 160–5 |year= 2001 |pmid= 11586297 |doi= 10.1038/ng1001-160  | name-list-style=vanc | author2=Hentati A  | author3=Deng HX  | display-authors=3  | last4=Dabbagh  | first4=Omar  | last5=Sasaki  | first5=Toru  | last6=Hirano  | first6=Makito  | last7=Hung  | first7=Wu-Yen  | last8=Ouahchi  | first8=Karim  | last9=Yan  | first9=Jianhua |s2cid=9036123 }}
-*{{cite journal  | author=Birkenhäger R |title=Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure |journal=Nat. Genet. |volume=29 |issue= 3 |pages= 310–4 |year= 2001 |pmid= 11687798 |doi= 10.1038/ng752  | name-list-format=vanc | author2=Otto E  | author3=Schürmann MJ  | display-authors=3  | last4=Vollmer  | first4=Martin  | last5=Ruf  | first5=Eva-Maria  | last6=Maier-Lutz  | first6=Irina  | last7=Beekmann  | first7=Frank  | last8=Fekete  | first8=Andrea  | last9=Omran  | first9=Heymut }}
+*{{cite journal  | author=Birkenhäger R |title=Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure |journal=Nat. Genet. |volume=29 |issue= 3 |pages= 310–4 |year= 2001 |pmid= 11687798 |doi= 10.1038/ng752  | name-list-style=vanc | author2=Otto E  | author3=Schürmann MJ  | display-authors=3  | last4=Vollmer  | first4=Martin  | last5=Ruf  | first5=Eva-Maria  | last6=Maier-Lutz  | first6=Irina  | last7=Beekmann  | first7=Frank  | last8=Fekete  | first8=Andrea  | last9=Omran  | first9=Heymut |s2cid=5892001 }}
-*{{cite journal  | author=Eymard-Pierre E |title=Infantile-Onset Ascending Hereditary Spastic Paralysis Is Associated with Mutations in the Alsin Gene |journal=Am. J. Hum. Genet. |volume=71 |issue= 3 |pages= 518–27 |year= 2002 |pmid= 12145748 |doi=10.1086/342359  | pmc=379189  | name-list-format=vanc | author2=Lesca G  | author3=Dollet S  | display-authors=3  | last4=Santorelli  | first4=Filippo Maria  | last5=Di Capua  | first5=Matteo  | last6=Bertini  | first6=Enrico  | last7=Boespflug-Tanguy  | first7=Odile  }}
+*{{cite journal  | author=Eymard-Pierre E |title=Infantile-Onset Ascending Hereditary Spastic Paralysis Is Associated with Mutations in the Alsin Gene |journal=Am. J. Hum. Genet. |volume=71 |issue= 3 |pages= 518–27 |year= 2002 |pmid= 12145748 |doi=10.1086/342359  | pmc=379189  | name-list-style=vanc | author2=Lesca G  | author3=Dollet S  | display-authors=3  | last4=Santorelli  | first4=Filippo Maria  | last5=Di Capua  | first5=Matteo  | last6=Bertini  | first6=Enrico  | last7=Boespflug-Tanguy  | first7=Odile  }}
-*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  | name-list-format=vanc | author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  | name-list-style=vanc | author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Lesca G |title=Infantile ascending hereditary spastic paralysis (IAHSP): clinical features in 11 families |journal=Neurology |volume=60 |issue= 4 |pages= 674–82 |year= 2004 |pmid= 12601111 |doi=  10.1212/01.wnl.0000048207.28790.25| name-list-format=vanc | author2=Eymard-Pierre E  | author3=Santorelli FM  | display-authors=3  | last4=Cusmai  | first4=R  | last5=Di Capua  | first5=M  | last6=Valente  | first6=EM  | last7=Attia-Sobol  | first7=J  | last8=Plauchu  | first8=H  | last9=Leuzzi  | first9=V  }}
+*{{cite journal  | author=Lesca G |title=Infantile ascending hereditary spastic paralysis (IAHSP): clinical features in 11 families |journal=Neurology |volume=60 |issue= 4 |pages= 674–82 |year= 2004 |pmid= 12601111 |doi=  10.1212/01.wnl.0000048207.28790.25| name-list-style=vanc | author2=Eymard-Pierre E  | author3=Santorelli FM  | display-authors=3  | last4=Cusmai  | first4=R  | last5=Di Capua  | first5=M  | last6=Valente  | first6=EM  | last7=Attia-Sobol  | first7=J  | last8=Plauchu  | first8=H  | last9=Leuzzi  | first9=V  |s2cid=20968387 }}
-*{{cite journal  | author=Otomo A |title=ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics |journal=Hum. Mol. Genet. |volume=12 |issue= 14 |pages= 1671–87 |year= 2003 |pmid= 12837691 |doi=10.1093/hmg/ddg184  | name-list-format=vanc | author2=Hadano S  | author3=Okada T  | display-authors=3  | last4=Mizumura  | first4=H  | last5=Kunita  | first5=R  | last6=Nishijima  | first6=H  | last7=Showguchi-Miyata  | first7=J  | last8=Yanagisawa  | first8=Y  | last9=Kohiki  | first9=E  | doi-access=free  }}
+*{{cite journal  | author=Otomo A |title=ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics |journal=Hum. Mol. Genet. |volume=12 |issue= 14 |pages= 1671–87 |year= 2003 |pmid= 12837691 |doi=10.1093/hmg/ddg184  | name-list-style=vanc | author2=Hadano S  | author3=Okada T  | display-authors=3  | last4=Mizumura  | first4=H  | last5=Kunita  | first5=R  | last6=Nishijima  | first6=H  | last7=Showguchi-Miyata  | first7=J  | last8=Yanagisawa  | first8=Y  | last9=Kohiki  | first9=E  | doi-access=free  }}
-*{{cite journal  | author=Nagano I |title=Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis |journal=Neurol. Res. |volume=25 |issue= 5 |pages= 505–9 |year= 2003 |pmid= 12866199 |doi=10.1179/016164103101201733  | name-list-format=vanc | author2=Murakami T  | author3=Shiote M  | display-authors=3  | last4=Manabe  | first4=Yasuhiro  | last5=Hadano  | first5=Shinji  | last6=Yanagisawa  | first6=Yoshiko  | last7=Ikeda  | first7=Joh-E  | last8=Abe  | first8=Koji  }}
+*{{cite journal  | author=Nagano I |title=Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis |journal=Neurol. Res. |volume=25 |issue= 5 |pages= 505–9 |year= 2003 |pmid= 12866199 |doi=10.1179/016164103101201733  | name-list-style=vanc | author2=Murakami T  | author3=Shiote M  | display-authors=3  | last4=Manabe  | first4=Yasuhiro  | last5=Hadano  | first5=Shinji  | last6=Yanagisawa  | first6=Yoshiko  | last7=Ikeda  | first7=Joh-E  | last8=Abe  | first8=Koji  |s2cid=42350605 }}
-*{{cite journal  | author=Devon RS |title=The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings |journal=Clin. Genet. |volume=64 |issue= 3 |pages= 210–5 |year= 2004 |pmid= 12919135 |doi=10.1034/j.1399-0004.2003.00138.x  | name-list-format=vanc | author2=Helm JR  | author3=Rouleau GA  | display-authors=3  | last4=Leitner  | first4=Y  | last5=Lerman-Sagie  | first5=T  | last6=Lev  | first6=D  | last7=Hayden  | first7=MR  }}
+*{{cite journal  | author=Devon RS |title=The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings |journal=Clin. Genet. |volume=64 |issue= 3 |pages= 210–5 |year= 2004 |pmid= 12919135 |doi=10.1034/j.1399-0004.2003.00138.x  | name-list-style=vanc | author2=Helm JR  | author3=Rouleau GA  | display-authors=3  | last4=Leitner  | first4=Y  | last5=Lerman-Sagie  | first5=T  | last6=Lev  | first6=D  | last7=Hayden  | first7=MR  |s2cid=27423316 }}
-*{{cite journal  | author=Yamanaka K |title=Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 26 |pages= 16041–6 |year= 2004 |pmid= 14668431 |doi= 10.1073/pnas.2635267100  | pmc=307689  | name-list-format=vanc | author2=Vande Velde C  | author3=Eymard-Pierre E  | display-authors=3  | last4=Bertini  | first4=E  | last5=Boespflug-Tanguy  | first5=O  | last6=Cleveland  | first6=DW }}
+*{{cite journal  | author=Yamanaka K |title=Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 26 |pages= 16041–6 |year= 2004 |pmid= 14668431 |doi= 10.1073/pnas.2635267100  | pmc=307689  | name-list-style=vanc | author2=Vande Velde C  | author3=Eymard-Pierre E  | display-authors=3  | last4=Bertini  | first4=E  | last5=Boespflug-Tanguy  | first5=O  | last6=Cleveland  | first6=DW |doi-access=free }}
-*{{cite journal  | author=Hand CK |title=Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis |journal=Arch. Neurol. |volume=60 |issue= 12 |pages= 1768–71 |year= 2004 |pmid= 14676054 |doi= 10.1001/archneur.60.12.1768  | name-list-format=vanc | author2=Devon RS  | author3=Gros-Louis F  | display-authors=3  | last4=Rochefort  | first4=D  | last5=Khoris  | first5=J  | last6=Meininger  | first6=V  | last7=Bouchard  | first7=JP  | last8=Camu  | first8=W  | last9=Hayden  | first9=MR | doi-access=free  }}
+*{{cite journal  | author=Hand CK |title=Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis |journal=Arch. Neurol. |volume=60 |issue= 12 |pages= 1768–71 |year= 2004 |pmid= 14676054 |doi= 10.1001/archneur.60.12.1768  | name-list-style=vanc | author2=Devon RS  | author3=Gros-Louis F  | display-authors=3  | last4=Rochefort  | first4=D  | last5=Khoris  | first5=J  | last6=Meininger  | first6=V  | last7=Bouchard  | first7=JP  | last8=Camu  | first8=W  | last9=Hayden  | first9=MR | doi-access=  }}
-*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  | name-list-format=vanc | author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki | doi-access=free  }}
+*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  | name-list-style=vanc | author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki | doi-access=free  }}
-*{{cite journal  | author=Kanekura K |title=Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19247–56 |year= 2004 |pmid= 14970233 |doi= 10.1074/jbc.M313236200  | name-list-format=vanc | author2=Hashimoto Y  | author3=Niikura T  | display-authors=3  | last4=Aiso  | first4=S  | last5=Matsuoka  | first5=M  | last6=Nishimoto  | first6=I | doi-access=free }}
+*{{cite journal  | author=Kanekura K |title=Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19247–56 |year= 2004 |pmid= 14970233 |doi= 10.1074/jbc.M313236200  | name-list-style=vanc | author2=Hashimoto Y  | author3=Niikura T  | display-authors=3  | last4=Aiso  | first4=S  | last5=Matsuoka  | first5=M  | last6=Nishimoto  | first6=I | doi-access=free }}
 {{refend}}
@@ Line 33: / Line 34: @@
 *[https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=iahsp  GeneReviews/NCBI/NIH/UW entry on ALS2-Related Disorders]
 * [https://www.ncbi.nlm.nih.gov/omim/205100,606352,606353,607225,205100,606352,606353,607225  OMIM entries on ALS2-Related Disorders]
-*[http://ghr.nlm.nih.gov/gene/ALS2   Genetics Home Reference- US National Library of Medicine®]
+*[http://ghr.nlm.nih.gov/gene/ALS2   Genetics Home Reference- US National Library of Medicine]
 * {{UCSC gene info|ALS2}}
-{{gene-2-stub}}
 {{GTP-binding protein regulators}}
+{{gene-2-stub}}