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Lewy body dementia (LBD) is an umbrella term for two similar and common subtypes of dementia:^[1] dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD).^[2]^[3]^[4]^[5] Both are characterized by changes in thinking, movement, behavior, and mood.^[1] The two conditions have similar features and may have similar causes, and are believed to belong on a spectrum of Lewy body disease^[2] that includes Parkinson's disease.^[5] As of 2014, they were more often misdiagnosed than any other common dementia.^[6]

The exact cause is unknown, but involves widespread deposits of abnormal clumps of protein that form in neurons of the diseased brain.^[7] Known as Lewy bodies (discovered in 1912 by Frederic Lewy^[8]) and Lewy neurites, these clumps affect both the central nervous system and the autonomic nervous system.^[9] The fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) gives Lewy body disease as the causative subtype of dementia with Lewy bodies, and Parkinson's disease as the causative subtype of Parkinson's disease dementia.^[10] Dementia with Lewy bodies is marked by the presence of Lewy bodies primarily in the cortical regions, and Parkinson's disease dementia with Lewy bodies primarily in the subcortical basal ganglia.^[11]

Classification

The synucleinopathies (dementia with Lewy bodies, Parkinson's disease dementia, and Parkinson's disease) are characterized by shared features of parkinsonism motor symptoms, neuropsychiatric symptoms, impaired cognition, sleep disorders, and visual hallucinations.^[12]^[13] The Lewy body dementias—dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD)—are distinguished by the timing when cognitive and motor symptoms appear.^[14] The two Lewy body dementias are often considered to belong on a spectrum of Lewy body disease that includes Parkinson's disease.^[2]^[5]

MeSH lists Lewy body disease in several categories: as a nervous system disease in two listings, one as a basal ganglia Parkinsonian movement disorder and the other under brain disease as a dementia; as a neurodegenerative disorder listed as a synucleinopathy; and as a neurocognitive disorder listed with dementia.^[15]

A genetic architecture that predisposes an individual to some disease phenotypes is found in Parkinson's disease and the Lewy body dementias. The presence of Lewy bodies is a link between these disorders; the term 'diseases with Lewy bodies' therefore may be more accurate than 'Lewy body disease'.^[16]

Cause and mechanisms

Dementia with Lewy bodies and Parkinson's disease dementia are similar in many ways, suggesting there may be a common pathophysiological mechanism, with PDD and DLB at opposite ends of a Lewy body disease spectrum,^[2] and a shared component of protein deposits in Lewy bodies and Lewy neurites.^[17] Lewy bodies and neurites have been found to develop from the aggregation of misfolded alpha-synuclein, a protein thought to assist in neurotransmitter release and vesicle turnover; whether these misfolded proteins are responsible for the neurodegenerative effects remains unclear, and no definitive link between Lewy bodies and neurodegenerative effects has been found.^[18] DSM-5 gives Lewy body disease as the causative subtype of DLB, and Parkinson's disease as the causative subtype of PDD.^[10] DLB is marked by the presence of Lewy bodies primarily in the cortical regions, and PDD with Lewy bodies primarily in the subcortical basal ganglia.^[11]

Despite differences in the timing of the appearance of symptoms, the two dementias "show remarkably convergent neuropathological changes at autopsy".^[2] The relationship between Parkinson's disease dementia and dementia with Lewy bodies is unclear as of 2020, but there is likely to be genetic overlap, and the two conditions may represent different points on a continuum.^[19]

Diagnosis

Dementia with Lewy bodies and Parkinson's disease dementia have similar neuropathological features, but these features are highly variable and the conditions cannot be distinguished on pathological features alone.^[18] Generally, dementia with Lewy bodies is distinguished from Parkinson's disease dementia by the time frame in which dementia symptoms appear relative to parkinsonian symptoms and is diagnosed when cognitive symptoms begin before or at the same time as parkinsonism. Parkinson's disease dementia is the diagnosis when Parkinson's disease is already well established before the dementia occurs.^[13]

Epidemiology

Between 5% and 25% of diagnosed dementias in older adults are due to one of the Lewy body dementias.^[14]^[a] As of 2014, the Lewy body dementias affect about 1.3 million people in the US and 140,000 in the UK.^[6]

LBD usually develops after the age of 50.^[8] Men are more likely to be diagnosed than women.^[8]

Prognosis

Life expectancy of people with one of the LBD is reduced; following diagnosis it ranges on average from five to eight years.^[22]

Society and culture

Advocacy and awareness

As of 2014, the Lewy body dementias were more often misdiagnosed than any other common dementia.^[6] Most people with DLB had not heard of the condition prior to diagnosis; general awareness about LBD lags well behind that of Parkinson's and Alzheimer's diseases, even though LBD is the second most common dementia, after Alzheimer's.^[6] It is not only frustrating for families and caregivers to find that few people, including many healthcare professionals, are knowledgeable about LBD; lack of knowledge can have significant health consequences because people with LBD have severe sensitivity to antipsychotics often used to treat the symptoms.^[6] The Lewy Body Dementia Association (LBDA) and the UK Lewy Body Society promote awareness and provide support that helps society, by reducing costly use of healthcare, and families with LBD, by reducing stress.^[6] These organizations, and others in Argentina, Australia and Japan, help raise knowledge and help families with LBD become advocates to raise awareness about the disease.^[6]

Notable individuals

Robin Williams, the American actor and comedian, died on August 11, 2014. Before his suicide, he had been diagnosed with Parkinson's disease,^[23] and according to his widow, Susan Schneider Williams, he experienced depression, anxiety, and increasing paranoia.^[24] Upon autopsy, his widow said he was found to have diffuse Lewy body disease,^[23]^[24]^[25] while the autopsy used the term diffuse Lewy body dementia.^[26] The vocabulary associated with Lewy pathology causes confusion.^[27] Lewy body dementia (the umbrella term that encompasses the clinical diagnoses of dementia with Lewy bodies and Parkinson's disease dementia) differs from Lewy body disease (the term used to describe pathological findings of Lewy bodies on autopsy).^[27] Dennis Dickson, a spokesperson for the Lewy Body Dementia Association, clarified the distinction by stating that diffuse Lewy body dementia is more commonly called diffuse Lewy body disease and refers to the underlying disease process.^[26] According to Dickson, "Lewy bodies are generally limited in distribution" in early Parkinson's disease, while in dementia with Lewy bodies, "the Lewy bodies are spread widely throughout the brain, as was the case with Robin Williams."^[26] Ian G. McKeith, professor and researcher of Lewy body dementias, commented that Williams' symptoms and autopsy findings were explained by dementia with Lewy bodies.^[28]

The British author and poet Mervyn Peake died in 1968 and was diagnosed posthumously as a probable case of DLB in a 2003 paper published in JAMA Neurology.^[29] Sahlas said his death was "variously ascribed to Alzheimer disease, Parkinson disease, or postencephalitic parkinsonism".^[29] Based on signs in his work and letters of progressive deterioration, fluctuating cognitive decline, deterioration in visuospatial function, declining attention span, and visual hallucinations and delusions, his may be the earliest known case where DLB was found to have been the likely cause of death.^[29]

Other entertainers and artists who have or died from LBD include Estelle Getty, the actress known for her role as Sophia on the television series The Golden Girls,^[30] Nicholas King, a US actor and horticulturist,^[31] actress Dina Merrill,^[32] Donald Featherstone, who created the plastic pink flamingo,^[33] American radio and television host Casey Kasem,^[34] Canadian singer Pierre Lalonde,^[35]^[36] graphic artist/film set designer Ron Cobb,^[37] American actor Frank Bonner,^[38] and Canadian musician and actor André Gagnon.^[39]

Individuals from industry or government who have or died from LBD include Seymour Berry, US Director of the Bureau of Engraving and Printing,^[40] Los Angeles Times publisher Otis Chandler,^[41] Philip J. Rock, a US Democratic politician of the Illinois Senate,^[42] U.S. media mogul and philanthropist Ted Turner,^[43] and Indian-born British billionaire S. P. Hinduja.^[44]

Arnold R. Hirsch, an American historian who taught at the University of New Orleans,^[45] and Jessie Isabelle Price, an American veterinary microbiologist,^[46] died from LBD.

In the sports realm, Jerry Sloan, American professional basketball player and coach, died from LBD.^[47] Major League Baseball players Tom Seaver,^[48] Andy Carey,^[49] and Bill Buckner died of LBD.^[50] Stan Mikita, Canadian ice hockey player, was diagnosed with possible LBD,^[51] but a post-mortem brain autopsy found that he had chronic traumatic encephalopathy.^[52]

In popular culture

Robin's Wish, a documentary exploring Robin Williams's Lewy body disease and how it contributed to his death, was released in September 2020.^[53]^[54]^[55]

Sleepwalk with Me is a book, one-man comedy, and film about a young man with relationship problems and RBD, a precursor to synucleinopathy, including LBD.^[56]

Notes

^ Kosaka (2017) writes: "Dementia with Lewy bodies (DLB) is now well known to be the second most frequent dementia following Alzheimer disease (AD). Of all types of dementia, AD is known to account for about 50%, DLB about 20% and vascular dementia (VD) about 15%. Thus, AD, DLB, and VD are now considered to be the three major dementias."^[20] The NINDS (2020) says that Lewy body dementia "is one of the most common causes of dementia, after Alzheimer's disease and vascular disease."^[8] Hershey (2019) says, "DLB is the third most common of all the neurodegenerative diseases behind both Alzheimer's disease and Parkinson's disease".^[21]

References

^ ^a ^b Walker Z, Possin KL, Boeve BF, Aarsland D (October 2015). "Lewy body dementias". Lancet (Review). 386 (10004): 1683–97. doi:10.1016/S0140-6736(15)00462-6. PMC 5792067. PMID 26595642.
^ ^a ^b ^c ^d ^e Gomperts SN (April 2016). "Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia". Continuum (Minneap Minn). 22 (2 Dementia): 435–63. doi:10.1212/CON.0000000000000309. PMC 5390937. PMID 27042903.
^ Pezzoli S, Cagnin A, Bandmann O, Venneri A (July 2017). "Structural and Functional Neuroimaging of Visual Hallucinations in Lewy Body Disease: A Systematic Literature Review". Brain Sci. 7 (12): 84. doi:10.3390/brainsci7070084. PMC 5532597. PMID 28714891.
^ Galasko D (May 2017). "Lewy Body Disorders". Neurol Clin. 35 (2): 325–38. doi:10.1016/j.ncl.2017.01.004. PMC 5912679. PMID 28410662.
^ ^a ^b ^c Kon T, Tomiyama M, Wakabayashi K (February 2020). "Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases". Neuropathology. 40 (1): 30–39. doi:10.1111/neup.12597. PMID 31498507. S2CID 201983865.
^ ^a ^b ^c ^d ^e ^f ^g Taylor A, Yardley C (2014). "Advocacy, education, and the role of not-for-profit organizations in Lewy body dementias". Alzheimers Res Ther (Review). 6 (5): 59. doi:10.1186/s13195-014-0059-0. PMC 4468791. PMID 26082807.
^ Spillantini, Maria Grazia; Crowther, R. Anthony; Jakes, Ross; Hasegawa, Masato; Goedert, Michel (1998-05-26). "α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies". Proceedings of the National Academy of Sciences. 95 (11): 6469–6473. doi:10.1073/pnas.95.11.6469. ISSN 0027-8424. PMC 27806. PMID 9600990.
^ ^a ^b ^c ^d "Lewy body dementia: Hope through research". National Institute of Neurological Disorders and Stroke. US National Institutes of Health. January 10, 2020. Retrieved March 18, 2020.
^ Lin YW, Truong D (April 2019). "Diffuse Lewy body disease". J. Neurol. Sci. (Review). 399: 144–50. doi:10.1016/j.jns.2019.02.021. PMID 30807982. S2CID 72335064.
^ ^a ^b Diagnostic and statistical manual of mental disorders : DSM-5 (5th ed.). Arlington, VA: American Psychiatric Association. 2013. pp. 603–604. ISBN 9780890425541.
^ ^a ^b Diagnostic and statistical manual of mental disorders : DSM-5 (5th ed.). Arlington, VA: American Psychiatric Association. 2013. p. 619. ISBN 9780890425541.
^ Velayudhan L, Ffytche D, Ballard C, Aarsland D (September 2017). "New Therapeutic Strategies for Lewy Body Dementias". Curr Neurol Neurosci Rep (Review). 17 (9): 68. doi:10.1007/s11910-017-0778-2. PMID 28741230. S2CID 3739100.
^ ^a ^b McKeith IG, Boeve BF, Dickson DW, et al. (July 2017). "Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium". Neurology (Review). 89 (1): 88–100. doi:10.1212/WNL.0000000000004058. PMC 5496518. PMID 28592453.
^ ^a ^b Connors MH, Quinto L, McKeith IG, et al. (August 2018). "Non-pharmacological interventions for Lewy body dementia: a systematic review". Psychol Med (Review). 48 (11): 1749–58. doi:10.1017/S0033291717003257. PMC 6088773. PMID 29143692.
^ "MeSH Browser". meshb.nlm.nih.gov. Retrieved 17 November 2020.
^ Menšíková K, Matěj R, Colosimo C, et al. (January 2022). "Lewy body disease or diseases with Lewy bodies?". npj Parkinson's Disease (Review). 8 (1): 3. doi:10.1038/s41531-021-00273-9. PMC 8748648. PMID 35013341. Material was copied from this source, which is available under a Creative Commons Attribution 4.0 International License
^ Weil RS, Lashley TL, Bras J, Schrag AE, Schott JM (2017). "Current concepts and controversies in the pathogenesis of Parkinson's disease dementia and Dementia with Lewy Bodies". F1000Res (Review). 6: 1604. doi:10.12688/f1000research.11725.1. PMC 5580419. PMID 28928962.
^ ^a ^b Latimer CS, Montine TJ. "Epidemiology, pathology, and pathogenesis of dementia with Lewy bodies". UpToDate, Inc. Retrieved August 2, 2019.
^ Taylor JP, McKeith IG, Burn DJ, et al. (February 2020). "New evidence on the management of Lewy body dementia" (PDF). Lancet Neurol (Review). 19 (2): 157–69. doi:10.1016/S1474-4422(19)30153-X. hdl:10871/36535. PMC 7017451. PMID 31519472.
^ Kosaka K, ed. (2017). Dementia with Lewy bodies: clinical and biological aspects (1st ed.). Springer: Japan. doi:10.1007/978-4-431-55948-1. ISBN 978-4-431-55948-1. S2CID 45950966.
^ Hershey LA, Coleman-Jackson R (April 2019). "Pharmacological management of dementia with Lewy dodies". Drugs Aging (Review). 36 (4): 309–19. doi:10.1007/s40266-018-00636-7. PMC 6435621. PMID 30680679.
^ Haider A, Spurling BC, Sánchez-Manso JC (2021). "Lewy Body Dementia". StatPearls. PMID 29494048.
^ ^a ^b ^c Gallman S (November 4, 2015). "Robin Williams' widow speaks: Depression didn't kill my husband". CNN. Archived from the original on November 4, 2015. Retrieved April 6, 2018.
^ ^a ^b ^c Williams SS (September 2016). "The terrorist inside my husband's brain". Neurology. 87 (13): 1308–11. doi:10.1212/WNL.0000000000003162. PMID 27672165.
^ Robbins R (September 30, 2016). "How Lewy body dementia gripped Robin Williams". Scientific American. Retrieved April 9, 2018.
^ ^a ^b ^c "LBDA Clarifies Autopsy Report on Comedian, Robin Williams". Lewy Body Dementia Association. November 10, 2014. Archived from the original on August 12, 2020. Retrieved April 19, 2018.
^ ^a ^b Armstrong MJ (2021). "Advances in dementia with Lewy bodies". Ther Adv Neurol Disord (Review). 14: 17562864211057666. doi:10.1177/17562864211057666. PMC 8613883. PMID 34840608.
^ McKeith IG. "Robin Williams had dementia with Lewy bodies – so, what is it and why has it been eclipsed by Alzheimer's?". The Conversation. Archived from the original on November 4, 2016. Retrieved April 6, 2018.
^ ^a ^b ^c Sahlas DJ (June 2003). "Dementia with Lewy bodies and the neurobehavioral decline of Mervyn Peake". Arch. Neurol. 60 (6): 889–92. doi:10.1001/archneur.60.6.889. PMID 12810496.
^ Carlson M (July 24, 2008). "Obituary: Estelle Getty". theguardian.com. Archived from the original on September 2, 2013. Retrieved October 13, 2013.
^ McLellan D (April 23, 2012). "Nicholas King dies at 79; actor helped preserve the Watts Towers". The Los Angeles Times. Retrieved April 19, 2018.
^ Dangremond S (May 23, 2017). "Actress and philanthropist Dina Merrill dies at 93". Town and Country Magazine. Retrieved March 22, 2018.
^ Woo E (June 24, 2015). "Don Featherstone dies at 79; creator of the plastic pink flamingo". Los Angeles Times. Retrieved March 22, 2018.
^ Caffrey J (April 18, 2016). "Casey Kasem and a lesson about end-of-life care". CNN. Retrieved March 22, 2018.
^ Papineau P (June 23, 2016). "L'idole d'une génération s'éteint" (in French). Le Devoir. Retrieved April 9, 2018.
^ Belanger C (June 22, 2016). "Pierre Lalonde souffrait aussi de la démence à corps de Lewy" (in French). Le Journal de Montréal. Retrieved March 22, 2018.
^ Bartlett R, Parker R (September 21, 2020). "Ron Cobb, designer of the 'Alien' Ship and the 'Back to the Future' DeLorean, dies at 83". www.hollywoodreporter.com. Retrieved September 26, 2020.
^ Reid, Tony; Nakamura, Maglio (June 17, 2021). "Frank Bonner, 'WKRP in Cincinnati' Star, Dies at 79". TheWrap. Retrieved June 17, 2021.
^ "Pianist and composer Andre Gagnon, dead at 84, remembered as musical 'jack of all trades'". CTV News. December 3, 2020. Retrieved November 9, 2021.
^ "Seymour Berry, 86; Headed U.S. Agency". Washington Post. December 27, 2008. Retrieved April 19, 2018.
^ Shaw D, Landsberg M (February 27, 2006). "L.A. icon Otis Chandler dies at 78". The Los Angeles Times. Archived from the original on April 26, 2007. Retrieved July 23, 2008.
^ "Philip Rock, ex-Senate leader known for mentoring and bipartisanship, dies". Chicago Sun-Times. January 29, 2016. Archived from the original on February 1, 2016. Retrieved April 19, 2018.
^ Deerwester J (September 28, 2018). "Ted Turner has Lewy Body Dementia". USA Today. Retrieved September 30, 2018.
^ "Indian-origin UK billionaire SP Hinduja dead at 87". 17 May 2023.
^ O'Donnell M (March 26, 2018). "Arnold R. Hirsch dies; analyzed Chicago segregation in influential book". Chicago Sun Times. Retrieved April 19, 2018.
^ "Jessie Isabelle Price Dies On November 12". The Southampton Press. November 23, 2015. Retrieved April 19, 2018.
^ "Hall of Fame coach Jerry Sloan passes away at 78". National Basketball Association (Press release). NBA Media Ventures, LLC. May 22, 2020. Retrieved June 8, 2020.
^ Canova D (September 2, 2020). "Tom Seaver, Mets' star who won 3 Cy Young awards and 311 games, dead at 75". Fox News. Retrieved September 2, 2020.
^ Weber B (January 7, 2012). "Andy Carey, Third Baseman for 1950s Yankees, Dies at 80". The New York Times. p. A26. Retrieved April 19, 2018.
^ Kelly M (May 27, 2019). "Batting champ, All-Star Buckner dies at 69". MLB.com. Retrieved May 27, 2019.
^ Kuc C (June 15, 2015). "For Stan Mikita, all the Blackhawks memories are gone". Chicago Tribune. Archived from the original on June 16, 2015. Retrieved March 22, 2018.
^ "Study shows hockey Hall of Famer Stan Mikita suffered from CTE". USA Today. Associated Press. September 13, 2019. Retrieved June 8, 2020.
^ Huff L (August 6, 2020). "Robin Williams' final days detailed in touching trailer for new documentary Robin's Wish". Entertainment Weekly. Retrieved August 7, 2020.
^ Boone J. "Robin Williams' Struggles on Final Film Set Detailed by His Director". Entertainment Tonight. Retrieved 2020-08-20.
^ VanHoose B. "Robin Williams' Final Days Revealed in Touching New Documentary Robin's Wish". People. Retrieved 2020-08-20.
^ "Sleepwalk with Me: Comedian's sleep disorder experience comes to film". American Academy of Sleep Medicine. January 26, 2012. Retrieved April 22, 2018.

[22] Kosaka (2017) writes: "Dementia with Lewy bodies (DLB) is now well known to be the second most frequent dementia following Alzheimer disease (AD). Of all types of dementia, AD is known to account for about 50%, DLB about 20% and vascular dementia (VD) about 15%. Thus, AD, DLB, and VD are now considered to be the three major dementias."^[20] The NINDS (2020) says that Lewy body dementia "is one of the most common causes of dementia, after Alzheimer's disease and vascular disease."^[8] Hershey (2019) says, "DLB is the third most common of all the neurodegenerative diseases behind both Alzheimer's disease and Parkinson's disease".^[21]

[Walker2015-1] Walker Z, Possin KL, Boeve BF, Aarsland D (October 2015). "Lewy body dementias". Lancet (Review). 386 (10004): 1683–97. doi:10.1016/S0140-6736(15)00462-6. PMC 5792067. PMID 26595642.

[Gomperts2016-2] Gomperts SN (April 2016). "Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia". Continuum (Minneap Minn). 22 (2 Dementia): 435–63. doi:10.1212/CON.0000000000000309. PMC 5390937. PMID 27042903.

[Pezzoli2017-3] Pezzoli S, Cagnin A, Bandmann O, Venneri A (July 2017). "Structural and Functional Neuroimaging of Visual Hallucinations in Lewy Body Disease: A Systematic Literature Review". Brain Sci. 7 (12): 84. doi:10.3390/brainsci7070084. PMC 5532597. PMID 28714891.

[Galasko2017-4] Galasko D (May 2017). "Lewy Body Disorders". Neurol Clin. 35 (2): 325–38. doi:10.1016/j.ncl.2017.01.004. PMC 5912679. PMID 28410662.

[Kon2020-5] Kon T, Tomiyama M, Wakabayashi K (February 2020). "Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases". Neuropathology. 40 (1): 30–39. doi:10.1111/neup.12597. PMID 31498507. S2CID 201983865.

[Taylor2014-6] ^ ^a ^b ^c ^d ^e ^f ^g Taylor A, Yardley C (2014). "Advocacy, education, and the role of not-for-profit organizations in Lewy body dementias". Alzheimers Res Ther (Review). 6 (5): 59. doi:10.1186/s13195-014-0059-0. PMC 4468791. PMID 26082807.

[7] Spillantini, Maria Grazia; Crowther, R. Anthony; Jakes, Ross; Hasegawa, Masato; Goedert, Michel (1998-05-26). "α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies". Proceedings of the National Academy of Sciences. 95 (11): 6469–6473. doi:10.1073/pnas.95.11.6469. ISSN 0027-8424. PMC 27806. PMID 9600990.

[NINDS2020Book-8] "Lewy body dementia: Hope through research". National Institute of Neurological Disorders and Stroke. US National Institutes of Health. January 10, 2020. Retrieved March 18, 2020.

[Lin2019-9] Lin YW, Truong D (April 2019). "Diffuse Lewy body disease". J. Neurol. Sci. (Review). 399: 144–50. doi:10.1016/j.jns.2019.02.021. PMID 30807982. S2CID 72335064.

[DSM5-10] Diagnostic and statistical manual of mental disorders : DSM-5 (5th ed.). Arlington, VA: American Psychiatric Association. 2013. pp. 603–604. ISBN 9780890425541.

[DSM5A-11] Diagnostic and statistical manual of mental disorders : DSM-5 (5th ed.). Arlington, VA: American Psychiatric Association. 2013. p. 619. ISBN 9780890425541.

[Valayudhan2017-12] Velayudhan L, Ffytche D, Ballard C, Aarsland D (September 2017). "New Therapeutic Strategies for Lewy Body Dementias". Curr Neurol Neurosci Rep (Review). 17 (9): 68. doi:10.1007/s11910-017-0778-2. PMID 28741230. S2CID 3739100.

[McKeithConsensus2017-13] McKeith IG, Boeve BF, Dickson DW, et al. (July 2017). "Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium". Neurology (Review). 89 (1): 88–100. doi:10.1212/WNL.0000000000004058. PMC 5496518. PMID 28592453.

[Connors2018-14] Connors MH, Quinto L, McKeith IG, et al. (August 2018). "Non-pharmacological interventions for Lewy body dementia: a systematic review". Psychol Med (Review). 48 (11): 1749–58. doi:10.1017/S0033291717003257. PMC 6088773. PMID 29143692.

[MeSH-15] "MeSH Browser". meshb.nlm.nih.gov. Retrieved 17 November 2020.

[16] Menšíková K, Matěj R, Colosimo C, et al. (January 2022). "Lewy body disease or diseases with Lewy bodies?". npj Parkinson's Disease (Review). 8 (1): 3. doi:10.1038/s41531-021-00273-9. PMC 8748648. PMID 35013341. Material was copied from this source, which is available under a Creative Commons Attribution 4.0 International License

[Weil2017-17] Weil RS, Lashley TL, Bras J, Schrag AE, Schott JM (2017). "Current concepts and controversies in the pathogenesis of Parkinson's disease dementia and Dementia with Lewy Bodies". F1000Res (Review). 6: 1604. doi:10.12688/f1000research.11725.1. PMC 5580419. PMID 28928962.

[Latimer2018-18] Latimer CS, Montine TJ. "Epidemiology, pathology, and pathogenesis of dementia with Lewy bodies". UpToDate, Inc. Retrieved August 2, 2019.

[Taylor2020-19] Taylor JP, McKeith IG, Burn DJ, et al. (February 2020). "New evidence on the management of Lewy body dementia" (PDF). Lancet Neurol (Review). 19 (2): 157–69. doi:10.1016/S1474-4422(19)30153-X. hdl:10871/36535. PMC 7017451. PMID 31519472.

[20] Kosaka K, ed. (2017). Dementia with Lewy bodies: clinical and biological aspects (1st ed.). Springer: Japan. doi:10.1007/978-4-431-55948-1. ISBN 978-4-431-55948-1. S2CID 45950966.

[21] Hershey LA, Coleman-Jackson R (April 2019). "Pharmacological management of dementia with Lewy dodies". Drugs Aging (Review). 36 (4): 309–19. doi:10.1007/s40266-018-00636-7. PMC 6435621. PMID 30680679.

[23] Haider A, Spurling BC, Sánchez-Manso JC (2021). "Lewy Body Dementia". StatPearls. PMID 29494048.

[RobinWidow-24] Gallman S (November 4, 2015). "Robin Williams' widow speaks: Depression didn't kill my husband". CNN. Archived from the original on November 4, 2015. Retrieved April 6, 2018.

[Williams2016-25] Williams SS (September 2016). "The terrorist inside my husband's brain". Neurology. 87 (13): 1308–11. doi:10.1212/WNL.0000000000003162. PMID 27672165.

[HowLewy-26] Robbins R (September 30, 2016). "How Lewy body dementia gripped Robin Williams". Scientific American. Retrieved April 9, 2018.

[LBDA-27] "LBDA Clarifies Autopsy Report on Comedian, Robin Williams". Lewy Body Dementia Association. November 10, 2014. Archived from the original on August 12, 2020. Retrieved April 19, 2018.

[Armstrong2021-28] Armstrong MJ (2021). "Advances in dementia with Lewy bodies". Ther Adv Neurol Disord (Review). 14: 17562864211057666. doi:10.1177/17562864211057666. PMC 8613883. PMID 34840608.

[29] McKeith IG. "Robin Williams had dementia with Lewy bodies – so, what is it and why has it been eclipsed by Alzheimer's?". The Conversation. Archived from the original on November 4, 2016. Retrieved April 6, 2018.

[Sahlas2003-30] Sahlas DJ (June 2003). "Dementia with Lewy bodies and the neurobehavioral decline of Mervyn Peake". Arch. Neurol. 60 (6): 889–92. doi:10.1001/archneur.60.6.889. PMID 12810496.

[guardian-obit-31] Carlson M (July 24, 2008). "Obituary: Estelle Getty". theguardian.com. Archived from the original on September 2, 2013. Retrieved October 13, 2013.

[32] McLellan D (April 23, 2012). "Nicholas King dies at 79; actor helped preserve the Watts Towers". The Los Angeles Times. Retrieved April 19, 2018.

[33] Dangremond S (May 23, 2017). "Actress and philanthropist Dina Merrill dies at 93". Town and Country Magazine. Retrieved March 22, 2018.

[34] Woo E (June 24, 2015). "Don Featherstone dies at 79; creator of the plastic pink flamingo". Los Angeles Times. Retrieved March 22, 2018.

[35] Caffrey J (April 18, 2016). "Casey Kasem and a lesson about end-of-life care". CNN. Retrieved March 22, 2018.

[36] Papineau P (June 23, 2016). "L'idole d'une génération s'éteint" (in French). Le Devoir. Retrieved April 9, 2018.

[37] Belanger C (June 22, 2016). "Pierre Lalonde souffrait aussi de la démence à corps de Lewy" (in French). Le Journal de Montréal. Retrieved March 22, 2018.

[38] Bartlett R, Parker R (September 21, 2020). "Ron Cobb, designer of the 'Alien' Ship and the 'Back to the Future' DeLorean, dies at 83". www.hollywoodreporter.com. Retrieved September 26, 2020.

[39] Reid, Tony; Nakamura, Maglio (June 17, 2021). "Frank Bonner, 'WKRP in Cincinnati' Star, Dies at 79". TheWrap. Retrieved June 17, 2021.

[40] "Pianist and composer Andre Gagnon, dead at 84, remembered as musical 'jack of all trades'". CTV News. December 3, 2020. Retrieved November 9, 2021.

[41] "Seymour Berry, 86; Headed U.S. Agency". Washington Post. December 27, 2008. Retrieved April 19, 2018.

[LatObit-42] Shaw D, Landsberg M (February 27, 2006). "L.A. icon Otis Chandler dies at 78". The Los Angeles Times. Archived from the original on April 26, 2007. Retrieved July 23, 2008.

[43] "Philip Rock, ex-Senate leader known for mentoring and bipartisanship, dies". Chicago Sun-Times. January 29, 2016. Archived from the original on February 1, 2016. Retrieved April 19, 2018.

[44] Deerwester J (September 28, 2018). "Ted Turner has Lewy Body Dementia". USA Today. Retrieved September 30, 2018.

[45] "Indian-origin UK billionaire SP Hinduja dead at 87". 17 May 2023.

[46] O'Donnell M (March 26, 2018). "Arnold R. Hirsch dies; analyzed Chicago segregation in influential book". Chicago Sun Times. Retrieved April 19, 2018.

[47] "Jessie Isabelle Price Dies On November 12". The Southampton Press. November 23, 2015. Retrieved April 19, 2018.

[48] "Hall of Fame coach Jerry Sloan passes away at 78". National Basketball Association (Press release). NBA Media Ventures, LLC. May 22, 2020. Retrieved June 8, 2020.

[49] Canova D (September 2, 2020). "Tom Seaver, Mets' star who won 3 Cy Young awards and 311 games, dead at 75". Fox News. Retrieved September 2, 2020.

[50] Weber B (January 7, 2012). "Andy Carey, Third Baseman for 1950s Yankees, Dies at 80". The New York Times. p. A26. Retrieved April 19, 2018.

[51] Kelly M (May 27, 2019). "Batting champ, All-Star Buckner dies at 69". MLB.com. Retrieved May 27, 2019.

[Kuc-52] Kuc C (June 15, 2015). "For Stan Mikita, all the Blackhawks memories are gone". Chicago Tribune. Archived from the original on June 16, 2015. Retrieved March 22, 2018.

[53] "Study shows hockey Hall of Famer Stan Mikita suffered from CTE". USA Today. Associated Press. September 13, 2019. Retrieved June 8, 2020.

[ew-6aug2020-54] Huff L (August 6, 2020). "Robin Williams' final days detailed in touching trailer for new documentary Robin's Wish". Entertainment Weekly. Retrieved August 7, 2020.

[55] Boone J. "Robin Williams' Struggles on Final Film Set Detailed by His Director". Entertainment Tonight. Retrieved 2020-08-20.

[56] VanHoose B. "Robin Williams' Final Days Revealed in Touching New Documentary Robin's Wish". People. Retrieved 2020-08-20.

[57] "Sleepwalk with Me: Comedian's sleep disorder experience comes to film". American Academy of Sleep Medicine. January 26, 2012. Retrieved April 22, 2018.

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+{{Short description|Umbrella term covering two types of dementia}}
-{{Distinguish|text = [[dementia with Lewy bodies]], one of the Lewy body dementias, along with [[Parkinson's disease dementia]]}}
-{{short description|An umbrella term covering two types of dementia}}
 <!--
-FOR CONSISTENCY IN CITATION FORMATTING, see http://tools.wmflabs.org/citation-template-filling/cgi-bin/index.cgi
+FOR CONSISTENCY IN CITATION FORMATTING, see https://citation-template-filling.toolforge.org/cgi-bin/index.cgi
+-->
--->'''Lewy body dementia''' ('''LBD''', or '''Lewy body disorder''') is an umbrella term<ref name=Walker2015>{{cite journal |vauthors=Walker Z, Possin KL, Boeve BF, Aarsland D |title=Lewy body dementias |journal=Lancet |volume=386 |issue=10004 |pages=1683–97 |date=October 2015 |pmid=26595642 |pmc=5792067 |doi=10.1016/S0140-6736(15)00462-6 |type=Review}}</ref> that encompasses two similar [[dementia]]s, both of which are characterized by abnormal deposits of the protein [[alpha-synuclein]] in the brain:
+'''Lewy body dementia''' (LBD) is an umbrella term for two similar and common subtypes of [[dementia]]:<ref name=Walker2015>{{cite journal |vauthors=Walker Z, Possin KL, Boeve BF, Aarsland D |title=Lewy body dementias |journal=Lancet |volume=386 |issue=10004 |pages=1683–97 |date=October 2015 |pmid=26595642 |pmc=5792067 |doi=10.1016/S0140-6736(15)00462-6 |type=Review}}</ref> [[dementia with Lewy bodies]] (DLB) and
-* [[dementia with Lewy bodies]] (DLB), and
-* [[Parkinson's disease dementia]] (PDD).<ref name=Gomperts2016>{{cite journal |vauthors=Gomperts SN |title=Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia |journal=Continuum (Minneap Minn) |volume=22 |issue=2 Dementia |pages=435–63 |date=April 2016 |pmid=27042903 |pmc=5390937 |doi=10.1212/CON.0000000000000309}}</ref><ref name=Pezzoli2017>{{cite journal |vauthors=Pezzoli S, Cagnin A, Bandmann O, Venneri A |title=Structural and Functional Neuroimaging of Visual Hallucinations in Lewy Body Disease: A Systematic Literature Review |journal=Brain Sci |volume=7 |issue=7 |pages= 84|date=July 2017 |pmid=28714891 |pmc=5532597 |doi=10.3390/brainsci7070084 }}</ref><ref name= Galasko2017>{{cite journal |vauthors=Galasko D |title=Lewy Body Disorders |journal=Neurol Clin |volume=35 |issue=2 |pages=325–38 |date=May 2017 |pmid=28410662 |pmc=5912679 |doi=10.1016/j.ncl.2017.01.004 }}</ref>
+[[Parkinson's disease dementia]] (PDD).<ref name=Gomperts2016>{{cite journal |vauthors=Gomperts SN |title=Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia |journal=Continuum (Minneap Minn) |volume=22 |issue=2 Dementia |pages=435–63 |date=April 2016 |pmid=27042903 |pmc=5390937 |doi=10.1212/CON.0000000000000309}}</ref><ref name=Pezzoli2017>{{cite journal |vauthors=Pezzoli S, Cagnin A, Bandmann O, Venneri A |title=Structural and Functional Neuroimaging of Visual Hallucinations in Lewy Body Disease: A Systematic Literature Review |journal=Brain Sci |volume=7 |issue=12 |pages= 84|date=July 2017 |pmid=28714891 |pmc=5532597 |doi=10.3390/brainsci7070084 |doi-access=free }}</ref><ref name= Galasko2017>{{cite journal |vauthors=Galasko D |title=Lewy Body Disorders |journal=Neurol Clin |volume=35 |issue=2 |pages=325–38 |date=May 2017 |pmid=28410662 |pmc=5912679 |doi=10.1016/j.ncl.2017.01.004 }}</ref><ref name=Kon2020/> Both are characterized by changes in thinking, movement, behavior, and mood.<ref name=Walker2015/> The two conditions have similar features and may have similar causes, and are believed to belong on a spectrum of '''Lewy body disease'''<ref name=Gomperts2016/> that includes [[Parkinson's disease]].<ref name=Kon2020>{{cite journal |vauthors=Kon T, Tomiyama M, Wakabayashi K |title=Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases |journal=Neuropathology |volume=40 |issue=1 |pages=30–39 |date=February 2020  |pmid=31498507 |doi=10.1111/neup.12597|s2cid=201983865 |doi-access=free }}</ref>  As of 2014, they were more often misdiagnosed than any other common dementia.<ref name=Taylor2014/>
+The exact cause is unknown,<!-- NINDS20202 --> but involves widespread deposits of abnormal clumps of protein that form in [[neuron]]s of the diseased brain.<ref>{{Cite journal |last=Spillantini |first=Maria Grazia |last2=Crowther |first2=R. Anthony |last3=Jakes |first3=Ross |last4=Hasegawa |first4=Masato |last5=Goedert |first5=Michel |date=1998-05-26 |title=α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies |url=https://pnas.org/doi/full/10.1073/pnas.95.11.6469 |journal=Proceedings of the National Academy of Sciences |language=en |volume=95 |issue=11 |pages=6469–6473 |doi=10.1073/pnas.95.11.6469 |issn=0027-8424 |pmc=27806 |pmid=9600990}}</ref><!-- Walker2015 --> Known as [[Lewy body|Lewy bodies]] (discovered in 1912 by [[Frederic Lewy]]<ref name= NINDS2020Book/>) and [[Lewy neurite]]s, these clumps affect both the [[central nervous system]] and the [[autonomic nervous system]].<ref name= Lin2019>{{cite journal |vauthors=Lin YW, Truong D |title=Diffuse Lewy body disease |journal=J. Neurol. Sci. |volume=399 |pages=144–50 |date=April 2019 |pmid=30807982 |doi=10.1016/j.jns.2019.02.021 |s2cid=72335064 |type= Review}}</ref> The fifth revision of the ''[[Diagnostic and Statistical Manual of Mental Disorders]]'' ([[DSM-5]]) gives Lewy body disease as the causative subtype of dementia with Lewy bodies, and [[Parkinson's disease]] as the causative subtype of Parkinson's disease dementia.<ref name="DSM5"/> Dementia with Lewy bodies is marked by the presence of Lewy bodies primarily in the [[Cerebral cortex|cortical regions]], and Parkinson's disease dementia with Lewy bodies primarily in the subcortical [[basal ganglia]].<ref name="DSM5A"/>
-The two conditions have similar features, may have similar causes, and can be viewed as part of a spectrum.  As of 2014, they were more often misdiagnosed than any other common dementia.
 ==Classification==
+{{further|Dementia with Lewy bodies#Classification}}
+The [[Synucleinopathy|synucleinopathies]] ([[dementia with Lewy bodies]], [[Parkinson's disease dementia]], and [[Parkinson's disease]]) are characterized by shared features of [[parkinsonism]] motor symptoms, neuropsychiatric symptoms, impaired cognition, [[sleep disorder]]s, and [[visual hallucination]]s.<ref name=Valayudhan2017>{{cite journal |vauthors=Velayudhan L, Ffytche D, Ballard C, Aarsland D |title=New Therapeutic Strategies for Lewy Body Dementias |journal=Curr Neurol Neurosci Rep |volume=17 |issue=9 |pages=68 |date=September 2017 |pmid=28741230 |doi=10.1007/s11910-017-0778-2 |s2cid=3739100 |type= Review}}</ref><ref name=McKeithConsensus2017>{{cite journal |vauthors=McKeith IG, Boeve BF, Dickson DW, ''et al'' |title=Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium |journal=Neurology |volume=89 |issue=1 |pages=88–100 |date=July 2017 |pmid=28592453 |pmc=5496518 |doi=10.1212/WNL.0000000000004058 |type=Review }}</ref> The Lewy body dementias—dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD)—are distinguished by the timing when cognitive and motor symptoms appear.<ref name= Connors2018>{{cite journal |vauthors=Connors MH, Quinto L, McKeith IG, et al|title=Non-pharmacological interventions for Lewy body dementia: a systematic review |journal=Psychol Med |volume=48 |issue=11 |pages=1749–58 |date=August 2018 |pmid=29143692 |pmc=6088773 |doi=10.1017/S0033291717003257 |type= Review}}</ref> The two Lewy body dementias are often considered to belong on a spectrum of Lewy body disease that includes Parkinson's disease.<ref name=Gomperts2016/><ref name=Kon2020/>
+[[MeSH]] lists Lewy body disease in several categories: as a nervous system disease in two listings, one as a basal ganglia Parkinsonian movement disorder and the other under brain disease as a dementia; as a neurodegenerative disorder listed as a synucleinopathy; and as a neurocognitive disorder listed with dementia.<ref name="MeSH">{{cite web |title=MeSH Browser |url=https://meshb.nlm.nih.gov/record/ui?ui=D020961 |website=meshb.nlm.nih.gov |access-date=17 November 2020}}</ref>
-The [[Synucleinopathy|synucleinopathies]] ([[dementia with Lewy bodies]], [[Parkinson's disease dementia]], and [[Parkinson's disease]]) are characterized by shared features of [[parkinsonism]] motor symptoms, neuropsychiatric symptoms, impaired cognition, [[sleep disorders]], and [[visual hallucinations]].<ref name=Valayudhan2017>{{cite journal |vauthors=Velayudhan L, Ffytche D, Ballard C, Aarsland D |title=New Therapeutic Strategies for Lewy Body Dementias |journal=Curr Neurol Neurosci Rep |volume=17 |issue=9 |pages=68 |date=September 2017 |pmid=28741230 |doi=10.1007/s11910-017-0778-2 |type= Review}}</ref><ref name=McKeithConsensus2017>{{cite journal |vauthors=McKeith IG, Boeve BF, Dickson DW, ''et al'' |title=Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium |journal=Neurology |volume=89 |issue=1 |pages=88–100 |date=July 2017 |pmid=28592453 |pmc=5496518 |doi=10.1212/WNL.0000000000004058 |type=Review }}</ref> The Lewy body dementias are considered to consist of the two related disorders, [[dementia with Lewy bodies]] (DLB) and [[Parkinson's disease dementia]] (PDD) that are distinguished by the timing when cognitive and motor symptoms appear.<ref name= Connors2018>{{cite journal |vauthors=Connors MH, Quinto L, McKeith IG, et al|title=Non-pharmacological interventions for Lewy body dementia: a systematic review |journal=Psychol Med |volume=48 |issue=11 |pages=1749–58 |date=August 2018 |pmid=29143692 |pmc=6088773 |doi=10.1017/S0033291717003257 |type= Review}}</ref>
+A genetic architecture that predisposes an individual to some disease [[phenotype]]s is found in Parkinson's disease and the Lewy body dementias. The presence of Lewy bodies is a link between these disorders; the term 'diseases with Lewy bodies' therefore may be more accurate than 'Lewy body disease'.<ref>{{cite journal |vauthors=Menšíková K, Matěj R, Colosimo C, et al |title=Lewy body disease or diseases with Lewy bodies? |journal=npj Parkinson's Disease |volume=8 |issue=1 |pages=3 |date=January 2022 |pmid=35013341 |pmc=8748648 |doi=10.1038/s41531-021-00273-9 |type=Review}} Material was copied from this source, which is available under a [https://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International License]</ref>
 ==Cause and mechanisms==
-{{See|Dementia with Lewy bodies#Pathophysiology}}
+{{Further|Dementia with Lewy bodies#Pathophysiology}}
-Dementia with Lewy bodies and Parkinson's disease dementia are similar in many ways, suggesting there may be a common pathophysiological mechanism, with PDD and DLB at opposite ends of a LBD spectrum, and a shared component of protein deposits in [[Lewy body|Lewy bodies]] and Lewy [[neurite]]s.<ref name=Weil2017>{{cite journal |vauthors=Weil RS, Lashley TL, Bras J, Schrag AE, Schott JM |title=Current concepts and controversies in the pathogenesis of Parkinson's disease dementia and Dementia with Lewy Bodies |journal=F1000Res |volume=6 |issue= |pages=1604 |date=2017 |pmid=28928962 |pmc=5580419 |doi=10.12688/f1000research.11725.1 |type=Review}}</ref> Lewy bodies and neurites have been found to develop from aggregation of misfolded [[alpha-synuclein]], a protein thought to assist in neurotransmitter release and vesicle turnover; whether these misfolded proteins are responsible for the neurodegenerative effects remains unclear, and no definitive link between Lewy bodies and neurodegenerative effects has been found.<ref name=Latimer2018/> Despite differences in the timing of the appearance of symptoms, the two dementias "show remarkably convergent neuropathological changes at autopsy".<ref name=Gomperts2016/> The relationship between Parkinson's disease dementia and dementia with Lewy bodies is unclear as of 2020, but there is likely to be genetic overlap, and the two conditions may represent different points on a continuum.<ref name=Taylor2020>{{cite journal |vauthors=Taylor JP, McKeith IG, Burn DJ, et al |title=New evidence on the management of Lewy body dementia |journal=Lancet Neurol |volume=19 |issue=2 |pages=157–69 |date=February 2020 |pmid=31519472 |doi=10.1016/S1474-4422(19)30153-X |type= Review|hdl=10871/36535 |hdl-access=free |url= https://ore.exeter.ac.uk/repository/bitstream/handle/10871/36535/Management%20Lewy%20body%20dementia_versionsubmittedtoTLNwithappendix.pdf?sequence=10&isAllowed=y<!-- citation consistency, link to free full text in title-->}}</ref>
+Dementia with Lewy bodies and Parkinson's disease dementia are similar in many ways, suggesting there may be a common pathophysiological mechanism, with PDD and DLB at opposite ends of a Lewy body disease spectrum,<ref name=Gomperts2016/> and a shared component of protein deposits in [[Lewy body|Lewy bodies]] and [[Lewy neurite]]s.<ref name=Weil2017>{{cite journal |vauthors=Weil RS, Lashley TL, Bras J, Schrag AE, Schott JM |title=Current concepts and controversies in the pathogenesis of Parkinson's disease dementia and Dementia with Lewy Bodies |journal=F1000Res |volume=6 |pages=1604 |date=2017 |pmid=28928962 |pmc=5580419 |doi=10.12688/f1000research.11725.1 |type=Review |doi-access=free }}</ref> Lewy bodies and neurites have been found to develop from the aggregation of misfolded [[alpha-synuclein]], a protein thought to assist in neurotransmitter release and vesicle turnover; whether these [[misfolded protein]]s are responsible for the neurodegenerative effects remains unclear, and no definitive link between Lewy bodies and neurodegenerative effects has been found.<ref name=Latimer2018/>  DSM-5 gives Lewy body disease as the causative subtype of DLB, and [[Parkinson's disease]] as the causative subtype of PDD.<ref name="DSM5">{{cite book |title=Diagnostic and statistical manual of mental disorders : DSM-5 |date=2013 |publisher=American Psychiatric Association |location=Arlington, VA |isbn=9780890425541 |pages=603–604 |edition=5th}}</ref> DLB is marked by the presence of Lewy bodies primarily in the [[Cerebral cortex|cortical regions]], and PDD with Lewy bodies primarily in the subcortical [[basal ganglia]].<ref name="DSM5A">{{cite book |title=Diagnostic and statistical manual of mental disorders : DSM-5. |date=2013 |publisher=American Psychiatric Association |location=Arlington, VA |isbn=9780890425541 |page=619 |edition=5th}}</ref>
+Despite differences in the timing of the appearance of symptoms, the two dementias "show remarkably convergent neuropathological changes at autopsy".<ref name=Gomperts2016/> The relationship between Parkinson's disease dementia and dementia with Lewy bodies is unclear as of 2020, but there is likely to be genetic overlap, and the two conditions may represent different points on a continuum.<ref name=Taylor2020>{{cite journal |vauthors=Taylor JP, McKeith IG, Burn DJ, et al |title=New evidence on the management of Lewy body dementia |journal=Lancet Neurol |volume=19 |issue=2 |pages=157–69 |date=February 2020 |pmid=31519472 |doi=10.1016/S1474-4422(19)30153-X |pmc=7017451 |type= Review|hdl=10871/36535 |hdl-access=free |url= https://ore.exeter.ac.uk/repository/bitstream/handle/10871/36535/Management%20Lewy%20body%20dementia_versionsubmittedtoTLNwithappendix.pdf?sequence=10&isAllowed=y<!-- citation consistency, link to free full text in title-->}}</ref>
 == Diagnosis ==
-{{See|Dementia with Lewy bodies#Diagnosis}}
+{{Further|Dementia with Lewy bodies#Diagnosis}}
-Dementia with Lewy bodies and Parkinson's disease dementia have similar neuropathological features, but these features are highly variable and the conditions should not be distinguished on pathological features alone.<ref name= Latimer2018>{{Cite web|author= Latimer CS, Montine TJ| url=https://www.uptodate.com/contents/epidemiology-pathology-and-pathogenesis-of-dementia-with-lewy-bodies|title=Epidemiology, pathology, and pathogenesis of dementia with Lewy bodies|publisher=UpToDate, Inc.|access-date=August 2, 2019}}</ref> Generally, DLB is distinguished from PDD dementia by the time frame in which dementia symptoms appear relative to parkinsonian symptoms. DLB is diagnosed when cognitive symptoms begin before or at the same time as parkinsonism, while PDD is the diagnosis when Parkinson's disease is well established before the dementia occurs.<ref name=McKeithConsensus2017/>
+Dementia with Lewy bodies and Parkinson's disease dementia have similar neuropathological features, but these features are highly variable and the conditions cannot be distinguished on pathological features alone.<ref name= Latimer2018>{{Cite web|author= Latimer CS, Montine TJ| url=https://www.uptodate.com/contents/epidemiology-pathology-and-pathogenesis-of-dementia-with-lewy-bodies|title=Epidemiology, pathology, and pathogenesis of dementia with Lewy bodies|publisher=UpToDate, Inc.|access-date=August 2, 2019}}</ref> Generally, dementia with Lewy bodies is distinguished from Parkinson's disease dementia by the time frame in which dementia symptoms appear relative to parkinsonian symptoms and is diagnosed when cognitive symptoms begin before or at the same time as [[parkinsonism]]. Parkinson's disease dementia is the diagnosis when Parkinson's disease is already well established before the dementia occurs.<ref name=McKeithConsensus2017/>
 ==Epidemiology==
+{{further|Dementia with Lewy bodies#Epidemiology}}
-As of 2014, the Lewy body dementias affect about 1.3 million people in the US and 140,000 in the UK.<ref name=Taylor2014>{{cite journal |vauthors=Taylor A, Yardley C |title=Advocacy, education, and the role of not-for-profit organizations in Lewy body dementias |journal=Alzheimers Res Ther |volume=6 |issue=5 |pages=59 |date=2014 |pmid=26082807 |pmc=4468791 |doi=10.1186/s13195-014-0059-0 |type=Review}}</ref> LBD usually develops after the age of 50.<ref name= NINDS2017Book>{{cite web|title=Lewy body dementia: Hope through research |url= https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Lewy-Body-Dementia-Hope-Through-Research |website= National Institute of Neurological Disorders and Stroke |publisher = US National Institutes of Health |accessdate= April 6, 2018|date=December 8, 2017}}</ref>  Between 5% and 25% of diagnosed dementias in older adults are due to Lewy body dementias.<ref name= Connors2018/>
+Between 5% and 25% of diagnosed dementias in older adults are due to one of the Lewy body dementias.<ref name= Connors2018/>{{efn| Kosaka (2017) writes: "Dementia with Lewy bodies (DLB) is now well known to be the second most frequent dementia following Alzheimer disease (AD). Of all types of dementia, AD is known to account for about 50%, DLB about 20% and vascular dementia (VD) about 15%. Thus, AD, DLB, and VD are now considered to be the three major dementias."<ref>{{cite book|veditors= Kosaka K |editor-link= Kenji Kosaka (psychiatrist)|date=2017 |title= Dementia with Lewy bodies: clinical and biological aspects|edition= 1st  |publisher= Springer: Japan |doi= 10.1007/978-4-431-55948-1 |isbn= 978-4-431-55948-1|s2cid= 45950966}}</ref><!-- Page v --> The NINDS (2020) says that Lewy body dementia "is one of the most common causes of dementia, after Alzheimer's disease and vascular disease."<ref name= NINDS2020Book>{{cite web|title=Lewy body dementia: Hope through research |url= https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Lewy-Body-Dementia-Hope-Through-Research |website= National Institute of Neurological Disorders and Stroke |publisher = US National Institutes of Health |access-date= March 18, 2020 |date= January 10, 2020}}</ref> Hershey (2019) says, "DLB is the third most common of all the neurodegenerative diseases behind both Alzheimer's disease and Parkinson's disease".<ref>{{cite journal |vauthors=Hershey LA, Coleman-Jackson R |title=Pharmacological management of dementia with Lewy dodies |journal=Drugs Aging |volume=36 |issue=4 |pages=309–19 |date=April 2019 |pmid=30680679 |pmc=6435621 |doi=10.1007/s40266-018-00636-7 |type= Review}}</ref><!-- Page 309 -->}} As of 2014, the Lewy body dementias affect about 1.3 million people in the US and 140,000 in the UK.<ref name=Taylor2014>{{cite journal |vauthors=Taylor A, Yardley C |title=Advocacy, education, and the role of not-for-profit organizations in Lewy body dementias |journal=Alzheimers Res Ther |volume=6 |issue=5 |pages=59 |date=2014 |pmid=26082807 |pmc=4468791 |doi=10.1186/s13195-014-0059-0 |type=Review |doi-access=free }}</ref>
+LBD usually develops after the age of 50.<ref name= NINDS2020Book/> Men are more likely to be diagnosed than women.<ref name= NINDS2020Book/>
+==Prognosis==
+{{further|Dementia with Lewy bodies#Prognosis}}
+Life expectancy of people with one of the LBD is reduced; following diagnosis it ranges on average from five to eight years.<ref>{{cite journal| vauthors=Haider A, Spurling BC, Sánchez-Manso JC | title=Lewy Body Dementia|date=2021|url=http://www.ncbi.nlm.nih.gov/books/NBK482441/|journal=StatPearls|pmid=29494048}}</ref>
 ==Society and culture==
@@ Line 33: / Line 47: @@
 ===Notable individuals===
-{{further|List of people diagnosed with Parkinson's disease}}
+{{Further|List of people diagnosed with Parkinson's disease}}
 [[File:Robin Williams 2011a.jpg|thumb|right|upright=0.9|Robin Williams (shown in 2011): his widow said he was diagnosed on autopsy with Lewy bodies.<ref name=RobinWidow/><ref name=Williams2016/>]]
-[[Robin Williams]], the American actor and comedian, died on August 11, 2014. Before his suicide by hanging, he had been diagnosed with Parkinson's disease,<ref name=RobinWidow>{{Cite news|author= Gallman S |title = Robin Williams' widow speaks: Depression didn't kill my husband |url = http://www.cnn.com/2015/11/03/health/robin-williams-widow-susan-williams/index.html|work = CNN|accessdate = April 6, 2018 |url-status=live|archiveurl = https://web.archive.org/web/20151104002632/http://www.cnn.com/2015/11/03/health/robin-williams-widow-susan-williams/index.html|archivedate = November 4, 2015 |date= November 4, 2015}}</ref> and according to his widow, Susan Schneider Williams, he experienced depression, [[anxiety]], and increasing [[paranoia]].<ref name=Williams2016>{{cite journal |vauthors=Williams SS |title=The terrorist inside my husband's brain |journal=Neurology |volume=87 |issue=13 |pages=1308–11 |date=September 2016 |pmid=27672165 |doi=10.1212/WNL.0000000000003162 |doi-access=free }}</ref> Upon autopsy, his widow said he was found to have diffuse Lewy body disease,<ref name=RobinWidow/><ref name=Williams2016/><ref name=HowLewy>{{cite news |url= https://www.scientificamerican.com/article/how-lewy-body-dementia-gripped-robin-williams1/ |title= How Lewy body dementia gripped Robin Williams |author= Robbins R |work= Scientific American |date= September 30, 2016 |accessdate= April 9, 2018}}</ref> while the autopsy used the term ''diffuse Lewy body dementia''.<ref name=LBDA/>  Dennis Dickson, a spokesperson for the Lewy Body Dementia Association, clarified the distinction by stating that ''diffuse Lewy body dementia'' is more commonly called ''diffuse Lewy body disease'' and refers to the underlying disease process.<ref name=LBDA>{{cite web |url=https://www.lbda.org/content/lbda-clarifies-autopsy-report-comedian-robin-williams |publisher= [[Lewy Body Dementia Association]] |title= LBDA Clarifies Autopsy Report on Comedian, Robin Williams |date= November 10, 2014 | accessdate = April 19, 2018}}</ref>  According to Dickson, "Lewy bodies are generally limited in distribution", while in [[dementia with Lewy bodies]], "the Lewy bodies are spread widely throughout the brain, as was the case with Robin Williams."<ref name=LBDA/>  [[Ian G. McKeith]], professor and researcher of Lewy body dementias, commented that Williams' symptoms and autopsy findings were explained by dementia with Lewy bodies.<ref>{{Cite news |url= https://theconversation.com/robin-williams-had-dementia-with-lewy-bodies-so-what-is-it-and-why-has-it-been-eclipsed-by-alzheimers-50221 |title= Robin Williams had dementia with Lewy bodies – so, what is it and why has it been eclipsed by Alzheimer's? | author = McKeith IG | newspaper= The Conversation |access-date= April 6, 2018 |url-status=live|archiveurl=https://web.archive.org/web/20161104010452/https://theconversation.com/robin-williams-had-dementia-with-lewy-bodies-so-what-is-it-and-why-has-it-been-eclipsed-by-alzheimers-50221 |archivedate= November 4, 2016 }}</ref>
+[[Robin Williams]], the American actor and comedian, died on August 11, 2014. Before his suicide, he had been diagnosed with Parkinson's disease,<ref name=RobinWidow>{{Cite news|author= Gallman S |title = Robin Williams' widow speaks: Depression didn't kill my husband |url = http://www.cnn.com/2015/11/03/health/robin-williams-widow-susan-williams/index.html|work = CNN|access-date = April 6, 2018 |url-status=live|archive-url = https://web.archive.org/web/20151104002632/http://www.cnn.com/2015/11/03/health/robin-williams-widow-susan-williams/index.html|archive-date = November 4, 2015 |date= November 4, 2015}}</ref> and according to his widow, Susan Schneider Williams, he experienced depression, [[anxiety]], and increasing [[paranoia]].<ref name=Williams2016>{{cite journal |vauthors=Williams SS |title=The terrorist inside my husband's brain |journal=Neurology |volume=87 |issue=13 |pages=1308–11 |date=September 2016 |pmid=27672165 |doi=10.1212/WNL.0000000000003162 |doi-access=free }}</ref> Upon autopsy, his widow said he was found to have diffuse Lewy body disease,<ref name=RobinWidow/><ref name=Williams2016/><ref name=HowLewy>{{cite news |url= https://www.scientificamerican.com/article/how-lewy-body-dementia-gripped-robin-williams1/ |title= How Lewy body dementia gripped Robin Williams |author= Robbins R |work= Scientific American |date= September 30, 2016 |access-date= April 9, 2018}}</ref> while the autopsy used the term ''diffuse Lewy body dementia''.<ref name=LBDA/> The vocabulary associated with Lewy pathology causes confusion.<ref name= Armstrong2021/> ''Lewy body dementia'' (the umbrella term that encompasses the clinical diagnoses of dementia with Lewy bodies and Parkinson's disease dementia) differs from ''Lewy body disease'' (the term used to describe pathological findings of Lewy bodies on autopsy).<ref name= Armstrong2021>{{cite journal |vauthors=Armstrong MJ |title=Advances in dementia with Lewy bodies |journal=Ther Adv Neurol Disord |volume=14 |issue= |pages=17562864211057666 |date=2021 |pmid=34840608 |pmc=8613883 |doi=10.1177/17562864211057666 |type=Review}}</ref> Dennis Dickson, a spokesperson for the Lewy Body Dementia Association, clarified the distinction by stating that ''diffuse Lewy body dementia'' is more commonly called ''diffuse Lewy body disease'' and refers to the underlying disease process.<ref name=LBDA>{{cite web |url=https://www.lbda.org/content/lbda-clarifies-autopsy-report-comedian-robin-williams |publisher= [[Lewy Body Dementia Association]] |title= LBDA Clarifies Autopsy Report on Comedian, Robin Williams |date= November 10, 2014 | access-date = April 19, 2018 |archive-url= https://web.archive.org/web/20200812093153/https://www.lbda.org/content/lbda-clarifies-autopsy-report-comedian-robin-williams |archive-date= August 12, 2020}}</ref>  According to Dickson, "Lewy bodies are generally limited in distribution" in early Parkinson's disease, while in [[dementia with Lewy bodies]], "the Lewy bodies are spread widely throughout the brain, as was the case with Robin Williams."<ref name=LBDA/>  [[Ian G. McKeith]], professor and researcher of Lewy body dementias, commented that Williams' symptoms and autopsy findings were explained by dementia with Lewy bodies.<ref>{{Cite news |url= https://theconversation.com/robin-williams-had-dementia-with-lewy-bodies-so-what-is-it-and-why-has-it-been-eclipsed-by-alzheimers-50221 |title= Robin Williams had dementia with Lewy bodies – so, what is it and why has it been eclipsed by Alzheimer's? | author = McKeith IG | newspaper= The Conversation |access-date= April 6, 2018 |url-status=live|archive-url=https://web.archive.org/web/20161104010452/https://theconversation.com/robin-williams-had-dementia-with-lewy-bodies-so-what-is-it-and-why-has-it-been-eclipsed-by-alzheimers-50221 |archive-date= November 4, 2016 }}</ref>
 The British author and poet [[Mervyn Peake]] died in 1968 and was diagnosed [[Retrospective diagnosis|posthumously]] as a probable case of DLB in a 2003 paper published in ''[[JAMA Neurology]]''.<ref name=Sahlas2003>{{cite journal |vauthors=Sahlas DJ |title=Dementia with Lewy bodies and the neurobehavioral decline of Mervyn Peake |journal=Arch. Neurol. |volume=60 |issue=6 |pages=889–92 |date=June 2003 |pmid=12810496 |doi=10.1001/archneur.60.6.889 |doi-access=free }}</ref> Sahlas said his death was "variously ascribed to Alzheimer disease, Parkinson disease, or postencephalitic parkinsonism".<ref name=Sahlas2003/> Based on signs in his work and letters of progressive deterioration, fluctuating cognitive decline, deterioration in visuospatial function, declining [[attention span]], and visual hallucinations and delusions, his may be the earliest known case where DLB was found to have been the likely cause of death.<ref name=Sahlas2003/>
-Other entertainers and artists who have or died from LBD include [[Estelle Getty]], an actress known for her role in the television series ''[[The Golden Girls]]'',<ref name=guardian-obit>{{cite news |author=Carlson M |title=Obituary: Estelle Getty |url=https://www.theguardian.com/culture/2008/jul/24/television.television |accessdate=October 13, 2013 |newspaper=[[theguardian.com]] |date=July 24, 2008 |url-status=live |archiveurl=https://web.archive.org/web/20130902115947/http://www.theguardian.com/culture/2008/jul/24/television.television |archivedate=September 2, 2013}}</ref> [[Nicholas King]], a US actor and horticulturist,<ref>{{cite news | url= http://www.latimes.com/news/obituaries/la-me-nicholas-king-20120423,0,3790852.story  |author= McLellan D |date= April 23, 2012 |title= Nicholas King dies at 79; actor helped preserve the Watts Towers |work=  The Los Angeles Times |accessdate= April 19, 2018}}</ref> actress [[Dina Merrill]],<ref>{{cite news |url=https://www.townandcountrymag.com/society/a9914626/dina-merrill-obituary/ |title=Actress and philanthropist Dina Merrill dies at 93 |accessdate=March 22, 2018  |work= Town and Country Magazine |date= May 23, 2017 |author= Dangremond S }}</ref>  [[Donald Featherstone (artist)|Donald Featherstone]], who created the plastic pink flamingo,<ref>{{Cite news | url=http://www.latimes.com/local/obituaries/la-me-0624-donald-featherstone-20150624-story.html | title= Don Featherstone dies at 79; creator of the plastic pink flamingo |author= Woo E |date= June 24, 2015 | accessdate= March 22, 2018 |work= Los Angeles Times}}</ref> American radio and television host [[Casey Kasem]],<ref>{{cite news |url=https://www.cnn.com/2014/06/20/health/casey-kasem-end-of-life-care/index.html | title= Casey Kasem and a lesson about end-of-life care |author= Caffrey J |publisher= CNN |date= April 18, 2016 | accessdate= March 22, 2018}}</ref> , Canadian singer [[Pierre Lalonde]], and graphic artist/film set designer [[Ron Cobb]]..<ref>{{cite news|author = Papineau P |url=https://www.ledevoir.com/culture/actualites-culturelles/474105/deces-de-pierre-lalonde| title = L'idole d'une génération s'éteint|publisher=[[Le Devoir]]|date=June 23, 2016|accessdate=April 9, 2018 |language= fr}}</ref><ref>{{cite web|url=http://www.journaldemontreal.com/2016/06/22/pierre-lalonde-souffrait-aussi-de-la-demence-de-corps-de-lewy/|title=Pierre Lalonde souffrait aussi de la démence à corps de Lewy|publisher= Le Journal de Montréal|accessdate=March 22, 2018 |author= Belanger C |language= fr |date= June 22, 2016}}</ref>
+Other entertainers and artists who have or died from LBD include [[Estelle Getty]], the actress known for her role as Sophia on the television series ''[[The Golden Girls]]'',<ref name=guardian-obit>{{cite news |author=Carlson M |title=Obituary: Estelle Getty |url=https://www.theguardian.com/culture/2008/jul/24/television.television |access-date=October 13, 2013 |newspaper=[[theguardian.com]] |date=July 24, 2008 |url-status=live |archive-url=https://web.archive.org/web/20130902115947/http://www.theguardian.com/culture/2008/jul/24/television.television |archive-date=September 2, 2013}}</ref> [[Nicholas King]], a US actor and horticulturist,<ref>{{cite news | url= http://www.latimes.com/news/obituaries/la-me-nicholas-king-20120423,0,3790852.story  |author= McLellan D |date= April 23, 2012 |title= Nicholas King dies at 79; actor helped preserve the Watts Towers |work=  The Los Angeles Times |access-date= April 19, 2018}}</ref> actress [[Dina Merrill]],<ref>{{cite news |url=https://www.townandcountrymag.com/society/a9914626/dina-merrill-obituary/ |title=Actress and philanthropist Dina Merrill dies at 93 |access-date=March 22, 2018  |work= Town and Country Magazine |date= May 23, 2017 |author= Dangremond S }}</ref>  [[Donald Featherstone (artist)|Donald Featherstone]], who created the plastic pink flamingo,<ref>{{Cite news | url=http://www.latimes.com/local/obituaries/la-me-0624-donald-featherstone-20150624-story.html | title= Don Featherstone dies at 79; creator of the plastic pink flamingo |author= Woo E |date= June 24, 2015 | access-date= March 22, 2018 |work= Los Angeles Times}}</ref> American radio and television host [[Casey Kasem]],<ref>{{cite news |url=https://www.cnn.com/2014/06/20/health/casey-kasem-end-of-life-care/index.html | title= Casey Kasem and a lesson about end-of-life care |author= Caffrey J |publisher= CNN |date= April 18, 2016 | access-date= March 22, 2018}}</ref> Canadian singer [[Pierre Lalonde]],<ref>{{cite news|author = Papineau P |url=https://www.ledevoir.com/culture/actualites-culturelles/474105/deces-de-pierre-lalonde| title = L'idole d'une génération s'éteint|publisher=[[Le Devoir]]|date=June 23, 2016|access-date=April 9, 2018 |language= fr}}</ref><ref>{{cite web|url=http://www.journaldemontreal.com/2016/06/22/pierre-lalonde-souffrait-aussi-de-la-demence-de-corps-de-lewy/|title=Pierre Lalonde souffrait aussi de la démence à corps de Lewy|publisher= Le Journal de Montréal|access-date=March 22, 2018 |author= Belanger C |language= fr |date= June 22, 2016}}</ref> graphic artist/film set designer [[Ron Cobb]],<ref>{{cite news |vauthors=Bartlett R, Parker R |title=Ron Cobb, designer of the 'Alien' Ship and the 'Back to the Future' DeLorean, dies at 83 |url=https://www.hollywoodreporter.com/news/ron-cobb-dead-designer-alien-ship-back-future-delorean-was-83-1149219 |work=www.hollywoodreporter.com |date=September 21, 2020 |access-date= September 26, 2020}}</ref> American actor [[Frank Bonner]],<ref>{{Cite web|url=https://www.thewrap.com/frank-bonner-wkrp-in-cincinnati-star-dies-at-79/|title=Frank Bonner, 'WKRP in Cincinnati' Star, Dies at 79|first1=Tony|last1=Reid|first2=Maglio|last2=Nakamura|work=[[TheWrap]]|date=June 17, 2021|access-date=June 17, 2021}}</ref> and Canadian musician and actor [[André Gagnon]].<ref>{{cite web |url=https://montreal.ctvnews.ca/pianist-and-composer-andre-gagnon-dead-at-84-remembered-as-musical-jack-of-all-trades-1.5216668|title=Pianist and composer Andre Gagnon, dead at 84, remembered as musical 'jack of all trades'|date=December 3, 2020|accessdate= November 9, 2021|website=CTV News}}</ref>
-Individuals from industry or government who have or died from LBD are [[Seymour Berry]], US [[Director of the Bureau of Engraving and Printing]],<ref>{{cite news |url= https://www.washingtonpost.com/wp-dyn/content/article/2008/12/26/AR2008122601714.html |title= Seymour Berry, 86; Headed U.S. Agency |date= December 27, 2008 |work= Washington Post |accessdate= April 19, 2018}}</ref> ''[[Los Angeles Times]]'' publisher [[Otis Chandler]],<ref name=LatObit>{{cite news| author = Shaw D, Landsberg M| title = L.A. icon Otis Chandler dies at 78| work = [[The Los Angeles Times]]| date = February 27, 2006| url = http://www.latimes.com/news/local/la-me-chandler-obit,0,7195252.story?page=1&coll=la-home-headlines| accessdate = July 23, 2008| url-status=live| archiveurl = https://web.archive.org/web/20070426114430/http://www.latimes.com/news/local/la-me-chandler-obit,0,7195252.story?page=1&coll=la-home-headlines| archivedate = April 26, 2007}}</ref> [[Philip J. Rock]],
+Individuals from industry or government who have or died from LBD include [[Seymour Berry]], US [[Director of the Bureau of Engraving and Printing]],<ref>{{cite news |url= https://www.washingtonpost.com/wp-dyn/content/article/2008/12/26/AR2008122601714.html |title= Seymour Berry, 86; Headed U.S. Agency |date= December 27, 2008 |newspaper= Washington Post |access-date= April 19, 2018}}</ref> ''[[Los Angeles Times]]'' publisher [[Otis Chandler]],<ref name=LatObit>{{cite news| author = Shaw D, Landsberg M| title = L.A. icon Otis Chandler dies at 78| work = [[The Los Angeles Times]]| date = February 27, 2006| url = http://www.latimes.com/news/local/la-me-chandler-obit,0,7195252.story?page=1&coll=la-home-headlines| access-date = July 23, 2008| url-status=live| archive-url = https://web.archive.org/web/20070426114430/http://www.latimes.com/news/local/la-me-chandler-obit,0,7195252.story?page=1&coll=la-home-headlines| archive-date = April 26, 2007}}</ref> [[Philip J. Rock]],
-a US [[Democratic Party (United States)|Democratic]] politician of the [[Illinois Senate]],<ref>{{cite news |url= http://chicago.suntimes.com/news/7/71/1288547/philip-rock-longest-serving-illinois-senate-president-dies |title= Philip Rock, ex-Senate leader known for mentoring and bipartisanship, dies |work= [[Chicago Sun-Times]] |date=  January 29, 2016 |accessdate= April 19, 2018 | url-status=dead |archiveurl=https://web.archive.org/web/20160201093023/http://chicago.suntimes.com/news/7/71/1288547/philip-rock-longest-serving-illinois-senate-president-dies |archivedate= February 1, 2016 }}</ref> and U.S. media mogul and philanthropist [[Ted Turner]].<ref>{{cite news |url= https://www.usatoday.com/story/life/people/2018/09/28/ted-turner-has-lewy-body-dementia-what-neurological-disorder/1456677002/ |author= Deerwester J |work= USA Today |date= September 28, 2018 |accessdate= September 30, 2018|title= Ted Turner has Lewy Body Dementia}}</ref>
+a US [[Democratic Party (United States)|Democratic]] politician of the [[Illinois Senate]],<ref>{{cite news |url= http://chicago.suntimes.com/news/7/71/1288547/philip-rock-longest-serving-illinois-senate-president-dies |title= Philip Rock, ex-Senate leader known for mentoring and bipartisanship, dies |work= [[Chicago Sun-Times]] |date=  January 29, 2016 |access-date= April 19, 2018 | url-status=dead |archive-url=https://web.archive.org/web/20160201093023/http://chicago.suntimes.com/news/7/71/1288547/philip-rock-longest-serving-illinois-senate-president-dies |archive-date= February 1, 2016 }}</ref> U.S. media mogul and philanthropist [[Ted Turner]],<ref>{{cite news |url= https://www.usatoday.com/story/life/people/2018/09/28/ted-turner-has-lewy-body-dementia-what-neurological-disorder/1456677002/ |author= Deerwester J |work= USA Today |date= September 28, 2018 |access-date= September 30, 2018|title= Ted Turner has Lewy Body Dementia}}</ref> and Indian-born British billionaire [[S. P. Hinduja]].<ref>{{cite web | url=https://www.connectedtoindia.com/indian-origin-uk-billionaire-sp-hinduja-dead-at-87-10987.html | title=Indian-origin UK billionaire SP Hinduja dead at 87 | date=17 May 2023 }}</ref>
-[[Arnold R. Hirsch]], an American historian who taught at the [[University of New Orleans]],<ref>{{cite news |author= O'Donnell M |title= Arnold R. Hirsch dies; analyzed Chicago segregation in influential book |url= https://chicago.suntimes.com/news/arnold-r-hirsch-dies-analyzed-chicago-segregation-in-influential-book/ |accessdate= April 19, 2018 |work= Chicago Sun Times |date= March 26, 2018}}</ref> and [[Jessie Isabelle Price]], an American veterinary [[microbiologist]],<ref>{{cite news |title= Jessie Isabelle Price Dies On November 12 |url= http://www.27east.com/news/article.cfm/Quogue/131382/Jessie-Isabelle-Price-Dies-On-November-12 |accessdate= April 19, 2018 |work= The Southampton Press |date= November 23, 2015}}</ref> died from LBD.
+[[Arnold R. Hirsch]], an American historian who taught at the [[University of New Orleans]],<ref>{{cite news |author= O'Donnell M |title= Arnold R. Hirsch dies; analyzed Chicago segregation in influential book |url= https://chicago.suntimes.com/news/arnold-r-hirsch-dies-analyzed-chicago-segregation-in-influential-book/ |access-date= April 19, 2018 |work= Chicago Sun Times |date= March 26, 2018}}</ref> and [[Jessie Isabelle Price]], an American veterinary [[microbiologist]],<ref>{{cite news |title= Jessie Isabelle Price Dies On November 12 |url= http://www.27east.com/news/article.cfm/Quogue/131382/Jessie-Isabelle-Price-Dies-On-November-12 |access-date= April 19, 2018 |work= The Southampton Press |date= November 23, 2015}}</ref> died from LBD.
-In the sports realm, [[Jerry Sloan]], American professional basketball player and coach, died from DLB.<ref>{{cite press release|title=Hall of Fame coach Jerry Sloan passes away at 78|url= http://www.nba.com/article/2020/05/22/jerry-sloan-passes-away-78|publisher=NBA Media Ventures, LLC|work= [[National Basketball Association]]|date=May 22, 2020|access-date=June 8, 2020}}</ref> [[Major League Baseball]] players [[Tom Seaver]],<ref>{{cite news |url= https://www.foxnews.com/sports/tom-seaver-mets-star-who-won-3-cy-young-awards-and-311-games-dead-at-75 |title= Tom Seaver, Mets' star who won 3 Cy Young awards and 311 games, dead at 75 |accessdate= September 2, 2020 |author= Canova D|date= September 2, 2020 |publisher= Fox News}}</ref> [[Andy Carey]],<ref>{{cite news |url= https://www.nytimes.com/2012/01/08/sports/baseball/andy-carey-third-baseman-for-1950s-yankees-dies-at-80.html |title= Andy Carey, Third Baseman for 1950s Yankees, Dies at 80 |work= The New York Times |accessdate= April 19, 2018 |author= Weber B |date= January 7, 2012 |page= A26}}</ref> and [[Bill Buckner]] died of LBD.<ref>{{cite web|author=Kelly M|title=Batting champ, All-Star Buckner dies at 69|url=https://www.mlb.com/news/bill-buckner-dies|website=MLB.com|date=May 27, 2019|accessdate=May 27, 2019}}</ref> [[Stan Mikita]], Canadian ice hockey player, was diagnosed with possible DLB,<ref name=Kuc>{{cite news|author=Kuc C|title=For Stan Mikita, all the Blackhawks memories are gone|url=http://www.chicagotribune.com/sports/hockey/blackhawks/ct-stan-mikita-blackhawks-spt-0615-20150614-story.html#page=1|accessdate= March 22, 2018 |work= Chicago Tribune |date=June 15, 2015 |url-status=live|archiveurl=https://web.archive.org/web/20150616044959/http://www.chicagotribune.com/sports/hockey/blackhawks/ct-stan-mikita-blackhawks-spt-0615-20150614-story.html#page=1|archivedate=June 16, 2015}}</ref> but a post-mortem brain autopsy found that he had [[chronic traumatic encephalopathy]].<ref>{{cite news |url= https://www.usatoday.com/story/sports/nhl/2019/09/13/study-shows-hockey-great-stan-mikita-suffered-from-cte/40145889/ |work= USA Today  |publisher= Associated Press |date= September 13, 2019 |accessdate= June 8, 2020 |title= Study shows hockey Hall of Famer Stan Mikita suffered from CTE}}</ref>
+In the sports realm, [[Jerry Sloan]], American professional basketball player and coach, died from LBD.<ref>{{cite press release|title=Hall of Fame coach Jerry Sloan passes away at 78|url= http://www.nba.com/article/2020/05/22/jerry-sloan-passes-away-78|publisher=NBA Media Ventures, LLC|work= [[National Basketball Association]]|date=May 22, 2020|access-date=June 8, 2020}}</ref> [[Major League Baseball]] players [[Tom Seaver]],<ref>{{cite news |url= https://www.foxnews.com/sports/tom-seaver-mets-star-who-won-3-cy-young-awards-and-311-games-dead-at-75 |title= Tom Seaver, Mets' star who won 3 Cy Young awards and 311 games, dead at 75 |access-date= September 2, 2020 |author= Canova D|date= September 2, 2020 |publisher= Fox News}}</ref> [[Andy Carey]],<ref>{{cite news |url= https://www.nytimes.com/2012/01/08/sports/baseball/andy-carey-third-baseman-for-1950s-yankees-dies-at-80.html |title= Andy Carey, Third Baseman for 1950s Yankees, Dies at 80 |work= The New York Times |access-date= April 19, 2018 |author= Weber B |date= January 7, 2012 |page= A26}}</ref> and [[Bill Buckner]] died of LBD.<ref>{{cite web|author=Kelly M|title=Batting champ, All-Star Buckner dies at 69|url=https://www.mlb.com/news/bill-buckner-dies|website=MLB.com|date=May 27, 2019|access-date=May 27, 2019}}</ref> [[Stan Mikita]], Canadian ice hockey player, was diagnosed with possible LBD,<ref name=Kuc>{{cite news|author=Kuc C|title=For Stan Mikita, all the Blackhawks memories are gone|url=http://www.chicagotribune.com/sports/hockey/blackhawks/ct-stan-mikita-blackhawks-spt-0615-20150614-story.html#page=1|access-date= March 22, 2018 |work= Chicago Tribune |date=June 15, 2015 |url-status=live|archive-url=https://web.archive.org/web/20150616044959/http://www.chicagotribune.com/sports/hockey/blackhawks/ct-stan-mikita-blackhawks-spt-0615-20150614-story.html#page=1|archive-date=June 16, 2015}}</ref> but a post-mortem brain autopsy found that he had [[chronic traumatic encephalopathy]].<ref>{{cite news |url= https://www.usatoday.com/story/sports/nhl/2019/09/13/study-shows-hockey-great-stan-mikita-suffered-from-cte/40145889/ |work= USA Today  |publisher= Associated Press |date= September 13, 2019 |access-date= June 8, 2020 |title= Study shows hockey Hall of Famer Stan Mikita suffered from CTE}}</ref>
 ===In popular culture===
-''[[Robin's Wish]]'', a documentary exploring Williams' Lewy body disease and how it contributed to his death was released in September 2020.<ref name="ew-6aug2020">{{cite news |author =Huff L |title=Robin Williams' final days detailed in touching trailer for new documentary Robin's Wish |url=https://ew.com/movies/robins-wish-exclusive-trailer-robin-williams-doc/ |accessdate=August 7, 2020 |work=[[Entertainment Weekly]] |date=August 6, 2020}}</ref><ref>{{Cite web|title=Robin Williams' Struggles on Final Film Set Detailed by His Director|url=https://www.etonline.com/robin-williams-documentary-robins-wish-exclusive-clip-151529|access-date=2020-08-20|website=Entertainment Tonight|author= Boone J}}</ref><ref>{{Cite web|title=Robin Williams’ Final Days Revealed in Touching New Documentary Robin’s Wish|url=https://people.com/movies/robin-williams-final-days-revealed-in-new-documentary-robins-wish/|access-date=2020-08-20|website=People.com|author= VanHoose B}}</ref>
+''[[Robin's Wish]]'', a documentary exploring Robin Williams's Lewy body disease and how it contributed to his death, was released in September 2020.<ref name="ew-6aug2020">{{cite magazine |author =Huff L |title=Robin Williams' final days detailed in touching trailer for new documentary Robin's Wish |url=https://ew.com/movies/robins-wish-exclusive-trailer-robin-williams-doc/ |access-date=August 7, 2020 |magazine=[[Entertainment Weekly]] |date=August 6, 2020}}</ref><ref>{{Cite web|title=Robin Williams' Struggles on Final Film Set Detailed by His Director|url=https://www.etonline.com/robin-williams-documentary-robins-wish-exclusive-clip-151529|access-date=2020-08-20|website=Entertainment Tonight|author= Boone J}}</ref><ref>{{Cite web|title=Robin Williams' Final Days Revealed in Touching New Documentary Robin's Wish|url=https://people.com/movies/robin-williams-final-days-revealed-in-new-documentary-robins-wish/|access-date=2020-08-20|website=People|author= VanHoose B}}</ref>
-''[[Sleepwalk with Me]]'' is a book, one-man comedy, and film about a young man with relationship problems and [[REM sleep behavior disorder|RBD]], a precursor to [[synucleinopathy]], including LBD.<ref>{{cite web |url= http://www.sleepeducation.org/news/2012/01/27/sleepwalk-with-me-comedian's-sleep-disorder-experience-comes-to-film |title= Sleepwalk with Me: Comedian's sleep disorder experience comes to film |publisher= American Academy of Sleep Medicine | date= January 26, 2012 |accessdate= April 22, 2018}}</ref>
+''[[Sleepwalk with Me]]'' is a book, one-man comedy, and film about a young man with relationship problems and [[REM sleep behavior disorder|RBD]], a precursor to [[synucleinopathy]], including LBD.<ref>{{cite web |url= http://www.sleepeducation.org/news/2012/01/27/sleepwalk-with-me-comedian's-sleep-disorder-experience-comes-to-film |title= Sleepwalk with Me: Comedian's sleep disorder experience comes to film |publisher= American Academy of Sleep Medicine | date= January 26, 2012 |access-date= April 22, 2018}}</ref>
+== Notes ==
+{{notelist}}
 ==References==
-{{reflist}}
+{{Reflist}}
-==External links==
 {{Medical resources
  | DiseasesDB     =
+ | ICD11          = {{ICD11|6D82}}, {{ICD11|6D85.0}}
  | ICD10          = {{ICD10|G31.8}}† {{ICD10|F02.8}}*
  | ICD9           =
@@ Line 71: / Line 88: @@
 {{Diseases of the nervous system}}
+{{Authority control}}
 {{DEFAULTSORT:Lewy Body dementias}}
 [[Category:Lewy body dementia| ]]
-[[Category:Dementia]]
 [[Category:Cognitive disorders]]
+[[Category:Dementia]]