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'''Ethionine''' is a [[Proteinogenic amino acid|non-proteinogenic]] [[amino acid]] structurally related to [[methionine]], with an [[ethyl group]] in place of the [[methyl group]]. |
'''Ethionine''' is a [[Proteinogenic amino acid|non-proteinogenic]] [[amino acid]] structurally related to [[methionine]], with an [[ethyl group]] in place of the [[methyl group]]. |
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Ethionine is an antimetabolite and methionine [[antagonist]]. It prevents amino acid incorporation into proteins and interferes with cellular use of [[adenosine triphosphate]] (ATP). Because of these pharmacological effects, ethionine is highly toxic and is a potent carcinogen.<ref>{{cite journal|title=Hypomethylation of DNA in ethionine-fed rats|author=Narayan Shivapurkar, Mary J. Wilson and Lionel A. Poirier |journal=Carcinogensis|volume =5|issue=8|pages= |
Ethionine is an antimetabolite and methionine [[antagonist]]. It prevents amino acid incorporation into proteins and interferes with cellular use of [[adenosine triphosphate]] (ATP). Because of these pharmacological effects, ethionine is highly toxic and is a potent carcinogen.<ref>{{cite journal|title=Hypomethylation of DNA in ethionine-fed rats|author=Narayan Shivapurkar, Mary J. Wilson and Lionel A. Poirier |journal=Carcinogensis|volume =5|issue=8|pages=989–992|year=1984|doi=10.1093/carcin/5.8.989|pmid=6744518}}</ref> |
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==References== |
==References== |
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Revision as of 02:15, 23 June 2008
Ethionine is a non-proteinogenic amino acid structurally related to methionine, with an ethyl group in place of the methyl group.
Ethionine is an antimetabolite and methionine antagonist. It prevents amino acid incorporation into proteins and interferes with cellular use of adenosine triphosphate (ATP). Because of these pharmacological effects, ethionine is highly toxic and is a potent carcinogen.[1]
References
- ^ Narayan Shivapurkar, Mary J. Wilson and Lionel A. Poirier (1984). "Hypomethylation of DNA in ethionine-fed rats". Carcinogensis. 5 (8): 989–992. doi:10.1093/carcin/5.8.989. PMID 6744518.
External links
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