Pertuzumab: Difference between revisions
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| source = [[Human]] |
| source = [[Human]] |
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| target = HER2 |
| target = HER2 |
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| CAS_number = |
| CAS_number = 380610-27-5 |
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| ATC_prefix = |
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Revision as of 12:11, 28 November 2008
| Monoclonal antibody | |
|---|---|
| Type | ? |
| Source | Human |
| Target | HER2 |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
Pertuzumab (also called 2C4, trade name Omnitarg) is a monoclonal antibody. The first of its class in a line of agents called "HER dimerization inhibitors". By binding to HER2, it inhibits the dimerization of HER2 with other HER receptors, which is hypothesized to result in slowed tumor growth.[2] Omnitarg is currently being developed by Genentech.
Early clinical trials of pertuzumab in prostate, breast, and ovarian cancers have been met with limited success.[3]
References
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
- ^ a b de Bono, Johann S. (20 January 2007). "Open-Label Phase II Study Evaluating the Efficacy and Safety of Two Doses of Pertuzumab in Castrate Chemotherapy-Naive Patients With Hormone-Refractory Prostate Cancer". Journal of Clinical Oncology. 25 (3): 257–262. doi:10.1200/JCO.2006.07.0888. PMID 17235043.
- ^ Genentech press release - May 15, 2005