Cardiomyopathy: Difference between revisions
added a more general definition, i don't know much about this though. |
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'''Cardiomyopathy''' is the |
'''Cardiomyopathy''' is the deterioration of the [[cardiac muscle]] of the [[heart]] wall. |
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It has a number of causes including [[drug]] and [[ethanol|alcohol]] toxicity, certain [[infection]]s, and various [[genetics|genetic]] and [[idiopathic]] causes. It can lead to [[heart failure]] |
It has a number of causes including [[drug]] and [[ethanol|alcohol]] toxicity, certain [[infection]]s, and various [[genetics|genetic]] and [[idiopathic]] (i.e. unknown) causes. It can lead to [[heart failure]] as the pumping efficiency of the heart is diminshed. |
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Hypertrophic cardiomyopathy (HCM) is a [[genetic disorder]] caused by various [[mutation]]s in 10 genes encoding sarcomeric proteins. However, these mutations only partially account for the variability in left ventricular hypertrophy (LVH) and other phenotypic features of the disease. It has been suggested that in patients with HCM, the final phenotype, including LVH, is the product of the causal mutation in genes encoding sarcomeric proteins, modifier genes and environmental factors. |
Hypertrophic cardiomyopathy (HCM) is a [[genetic disorder]] caused by various [[mutation]]s in 10 genes encoding sarcomeric proteins. However, these mutations only partially account for the variability in left ventricular hypertrophy (LVH) and other phenotypic features of the disease. It has been suggested that in patients with HCM, the final phenotype, including LVH, is the product of the causal mutation in genes encoding sarcomeric proteins, modifier genes and environmental factors. |
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Dilated cardiomyopathy (DCM) is the commonest form of cardiomyopathy, and the leading indication for heart transplantation. Approximately 40% of cases are familial, but the [[genetics]] are poorly understood compared with HCM. In DCM the heart (especially the left ventricle) is enlarged and weakened. |
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External link: http://www.cardiomyopathy.org |
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Revision as of 09:36, 1 March 2004
Cardiomyopathy is the deterioration of the cardiac muscle of the heart wall.
It has a number of causes including drug and alcohol toxicity, certain infections, and various genetic and idiopathic (i.e. unknown) causes. It can lead to heart failure as the pumping efficiency of the heart is diminshed.
Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by various mutations in 10 genes encoding sarcomeric proteins. However, these mutations only partially account for the variability in left ventricular hypertrophy (LVH) and other phenotypic features of the disease. It has been suggested that in patients with HCM, the final phenotype, including LVH, is the product of the causal mutation in genes encoding sarcomeric proteins, modifier genes and environmental factors.
Dilated cardiomyopathy (DCM) is the commonest form of cardiomyopathy, and the leading indication for heart transplantation. Approximately 40% of cases are familial, but the genetics are poorly understood compared with HCM. In DCM the heart (especially the left ventricle) is enlarged and weakened.
External link: http://www.cardiomyopathy.org