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'''AMPA''' (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate) is a [[Chemical compound|compound]] that is a specific [[agonist]] for the [[AMPA receptor]], where it mimics the effects of the [[neurotransmitter]] [[glutamate]].<ref name="Purves">{{cite book | author = Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White | title = Neuroscience. 4th ed. | publisher = Sinauer Associates | pages = 128-33 | year = 2008 | id = ISBN 978-0-87893-697-7}}</ref>
'''AMPA''' (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate) is a [[Chemical compound|compound]] that is a specific [[agonist]] for the [[AMPA receptor]], where it mimics the effects of the [[neurotransmitter]] [[glutamate]].<ref name="Purves">{{cite book | author = Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White | title = Neuroscience. 4th ed. | publisher = Sinauer Associates | pages = 128–33 | year = 2008 | id = ISBN 978-0-87893-697-7}}</ref>


There are two broad categories of [[glutamate receptors]]: [[ionotropic]] receptors and [[metabotropic]] receptors. Ionotropic glutamate receptors are [[ligand gated ion channel]]s whose agonists include AMPA, [[Kainate]] and [[NMDA]]. Metabotropic receptors are [[G-protein coupled receptor]]s and are separated into individual classes. In the [[Chemical synapse|synapse]], these two classes of receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions. AMPA generates fast [[excitatory postsynaptic potential]]s (EPSP).<ref name="Purves" />
There are two broad categories of [[glutamate receptors]]: [[ionotropic]] receptors and [[metabotropic]] receptors. Ionotropic glutamate receptors are [[ligand gated ion channel]]s whose agonists include AMPA, [[Kainate]] and [[NMDA]]. Metabotropic receptors are [[G-protein coupled receptor]]s and are separated into individual classes. In the [[Chemical synapse|synapse]], these two classes of receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions. AMPA generates fast [[excitatory postsynaptic potential]]s (EPSP).<ref name="Purves" />

Revision as of 03:37, 17 December 2009

AMPA
Names
IUPAC names
2-amino-3-(5-methyl-3-oxo-1,2-
oxazol-4-yl)propanoic acid
Identifiers
3D model (JSmol)
ChemSpider
MeSH AMPA
  • InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
  • NC(Cc1c(C)onc1O)C(=O)O
Properties
C7H10N2O4
Molar mass 186.17 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.[1]

There are two broad categories of glutamate receptors: ionotropic receptors and metabotropic receptors. Ionotropic glutamate receptors are ligand gated ion channels whose agonists include AMPA, Kainate and NMDA. Metabotropic receptors are G-protein coupled receptors and are separated into individual classes. In the synapse, these two classes of receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions. AMPA generates fast excitatory postsynaptic potentials (EPSP).[1] AMPA receptors are non-specific cationic channels allowing the passage of Calcium, Sodium and Potassium.

References

  1. ^ a b Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008). Neuroscience. 4th ed. Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7.{{cite book}}: CS1 maint: multiple names: authors list (link)