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'''George Q. Daley''', M.D., Ph.D. is the Samuel E. Lux IV Professor of [[Hematology]]/Oncology and the Director of the Stem Cell Transplantation Program at [[Children’s Hospital Boston]]. He is also Professor in the Department of Biological Chemistry and Molecular Pharmacology at [[Harvard Medical School]]<ref name="harvard">Harvard Medical School White Pages [http://hms.harvard.edu/WhitePagesPublic.asp?task=showperson&id=HVQ2YGNAPzE=&a=hms&r=4&kw=] Retrieved 2010-08-30.</ref>, an investigator of the [[Howard Hughes Medical Institute]]<ref name="hhmi">Investigators, Howard Hughes Medical Institute [http://www.hhmi.org/research/investigators/daley_bio.html] Retrieved 2010-08-30.</ref>, Associate Director of Children’s Stem Cell Program, a member of the Executive Committee of the Harvard Stem Cell Institute<ref name="hsci">Principal Faculty, Harvard Stem Cell Institute [http://www.hsci.harvard.edu/node/700] Retrieved 2010-08-30.</ref>, and past-President of the International Society for Stem Cell Research (2007–2008)<ref name="isscr">Officers, Leadership, International Society for Stem Cell Research [http://www.isscr.org/leadership/board.cfm] Retrieved 2010-08-30.</ref>.
'''George Q. Daley''', M.D., Ph.D. is the Samuel E. Lux IV Professor of [[Hematology]]/Oncology and the Director of the Stem Cell Transplantation Program at [[Children’s Hospital Boston]]. He is also Professor in the Department of Biological Chemistry and Molecular Pharmacology at [[Harvard Medical School]],<ref name="harvard">Harvard Medical School White Pages [http://hms.harvard.edu/WhitePagesPublic.asp?task=showperson&id=HVQ2YGNAPzE=&a=hms&r=4&kw=] Retrieved 2010-08-30.</ref> an investigator of the [[Howard Hughes Medical Institute]],<ref name="hhmi">Investigators, Howard Hughes Medical Institute [http://www.hhmi.org/research/investigators/daley_bio.html] Retrieved 2010-08-30.</ref> Associate Director of Children’s Stem Cell Program, a member of the Executive Committee of the Harvard Stem Cell Institute,<ref name="hsci">Principal Faculty, Harvard Stem Cell Institute [http://www.hsci.harvard.edu/node/700] Retrieved 2010-08-30.</ref> and past-President of the International Society for Stem Cell Research (2007–2008).<ref name="isscr">Officers, Leadership, International Society for Stem Cell Research [http://www.isscr.org/leadership/board.cfm] Retrieved 2010-08-30.</ref>


Dr. Daley seeks to translate insights in [[stem cell]] biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered mouse and human cell culture-based models of human blood disease and cancer.<ref name="stemcell">Biography, Stem Cell Program Leadership, Children's Hospital Boston [http://stemcell.childrenshospital.org/about-us/leadership-faculty-staff/george-daley-md-phd] Retrieved 2010-08-30.</ref> Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with [[Rudolf Jaenisch]])<ref name="mouse">RIDEOUT ET AL, CELL 2002</ref>, the differentiation of germ cells from embryonic stem cells (cited as a "Top Ten Breakthrough" by [[Science magazine]] in 2003)<ref name="nih">Biography, 2004 Recipients, NIH Director's Pioneer Award [http://nihroadmap.nih.gov/pioneer/Recipients04.aspx] Retrieved 2010-08-30.</ref><ref name="GEIJSEN">GEIJSEN ET AL., NATURE 2003/4</ref>
Dr. Daley seeks to translate insights in [[stem cell]] biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered mouse and human cell culture-based models of human blood disease and cancer.<ref name="stemcell">Biography, Stem Cell Program Leadership, Children's Hospital Boston [http://stemcell.childrenshospital.org/about-us/leadership-faculty-staff/george-daley-md-phd] Retrieved 2010-08-30.</ref> Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with [[Rudolf Jaenisch]]),<ref name="mouse">RIDEOUT ET AL, CELL 2002</ref> the differentiation of germ cells from embryonic stem cells (cited as a "Top Ten Breakthrough" by [[Science magazine]] in 2003)<ref name="nih">Biography, 2004 Recipients, NIH Director's Pioneer Award [http://nihroadmap.nih.gov/pioneer/Recipients04.aspx] Retrieved 2010-08-30.</ref><ref name="GEIJSEN">GEIJSEN ET AL., NATURE 2003/4</ref>
, and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the "Breakthrough of the Year" issue of Science magazine in 2008).<ref name="mpm">Bios, Team, MPM Capital [http://www.mpmcapital.com/team/team-detail/george-daley-bio] Retrieved 2010-08-30.</ref><ref name="PARK">PARK ET AL, CELL 2008</ref>
, and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the "Breakthrough of the Year" issue of Science magazine in 2008).<ref name="mpm">Bios, Team, MPM Capital [http://www.mpmcapital.com/team/team-detail/george-daley-bio] Retrieved 2010-08-30.</ref><ref name="PARK">PARK ET AL, CELL 2008</ref>


As a graduate student working with Nobelist Dr. [[David Baltimore]], Dr. Daley demonstrated that the BCR/ABL oncogene induces chronic myeloid leukemia (CML) in a mouse model<ref name="DALEY">DALEY ET AL, SCIENCE 1990</ref>, which validated BCR/ABL as a target for drug blockade and encouraged the development of imatinib (GleevecTM; Novartis), a revolutionary magic-bullet chemotherapy that induces remissions in virtually every CML patient. Dr. Daley’s recent studies have clarified mechanisms of Gleevec resistance and informed novel combination chemotherapeutic regimens.<ref name="stemcell"/>
As a graduate student working with Nobelist Dr. [[David Baltimore]], Dr. Daley demonstrated that the BCR/ABL oncogene induces chronic myeloid leukemia (CML) in a mouse model,<ref name="DALEY">DALEY ET AL, SCIENCE 1990</ref> which validated BCR/ABL as a target for drug blockade and encouraged the development of imatinib (GleevecTM; Novartis), a revolutionary magic-bullet chemotherapy that induces remissions in virtually every CML patient. Dr. Daley’s recent studies have clarified mechanisms of Gleevec resistance and informed novel combination chemotherapeutic regimens.<ref name="stemcell"/>


Dr. Daley received his bachelor's degree magna cum laude from [[Harvard University]] (1982), a Ph.D. in [[biology]] from [[MIT]] (1989), and the M.D. from [[Harvard Medical School]], where he was only the twelfth individual in the school’s history to be awarded the degree summa cum laude (1991). He served as Chief Resident in Internal Medicine at the [[Massachusetts General Hospital]] and is currently a staff physician in Hematology/Oncology at [[Children's Hospital Boston]] and [[Dana Farber Cancer Institute]] in [[Boston, MA]].<ref name="photobooks">Specialists, Children's Hospital Boston [http://children.photobooks.com/directory/profile.asp?dbase=main&setsize=5&last=daley&pict_id=0011780] Retrieved 2010-08-30.</ref>
Dr. Daley received his bachelor's degree magna cum laude from [[Harvard University]] (1982), a Ph.D. in [[biology]] from [[MIT]] (1989), and the M.D. from [[Harvard Medical School]], where he was only the twelfth individual in the school’s history to be awarded the degree summa cum laude (1991). He served as Chief Resident in Internal Medicine at the [[Massachusetts General Hospital]] and is currently a staff physician in Hematology/Oncology at [[Children's Hospital Boston]] and [[Dana Farber Cancer Institute]] in [[Boston, MA]].<ref name="photobooks">Specialists, Children's Hospital Boston [http://children.photobooks.com/directory/profile.asp?dbase=main&setsize=5&last=daley&pict_id=0011780] Retrieved 2010-08-30.</ref>


He has been elected a fellow of the [[American Association for the Advancement of Science]] and a member of the [[American Society for Clinical Investigation]] and American Pediatric Societies. He has received awards recognizing his contributions to medical research from the [[National Institutes of Health]]<ref name="nhlbi">Meet the Scientists, National Heart Lunch and Blood Institute, National Institues of Health [http://www.nhlbi.nih.gov/recovery/researchers/index.php?id=267] Retrieved 2010-08-30.</ref>, the New England Cancer Society, the Burroughs Wellcome Fund, the Edward Mallinckrodt, Jr. Foundation, [[Harvard Medical School]], and the Leukemia and Lymphoma Society of America.<ref name="hsci"/> Dr. Daley was an inaugural winner of the NIH Director’s Pioneer Award, which provides a five year unrestricted grant to pursue highly innovative research<ref name="nih"/>, and received the Judson Daland Prize from the [[American Philosophical Society]] for achievement in patient-oriented research<ref name="aps">Recipients of the Judson Daland Prize, American Philosphical Society [http://www.amphilsoc.org/prizes/dalandistas] Retrieved 2010-08-30.</ref>, and the E. Mead Johnson Award from the [[American Pediatric Society]] for contributions to stem cell research<ref name="spr">Member Information, Society for Pediatric Research [http://www.aps-spr.org/spr/Awards/EMJ.htm] Retrieved 2010-08-30.</ref>.
He has been elected a fellow of the [[American Association for the Advancement of Science]] and a member of the [[American Society for Clinical Investigation]] and American Pediatric Societies. He has received awards recognizing his contributions to medical research from the [[National Institutes of Health]],<ref name="nhlbi">Meet the Scientists, National Heart Lunch and Blood Institute, National Institues of Health [http://www.nhlbi.nih.gov/recovery/researchers/index.php?id=267] Retrieved 2010-08-30.</ref> the New England Cancer Society, the Burroughs Wellcome Fund, the Edward Mallinckrodt, Jr. Foundation, [[Harvard Medical School]], and the Leukemia and Lymphoma Society of America.<ref name="hsci"/> Dr. Daley was an inaugural winner of the NIH Director’s Pioneer Award, which provides a five year unrestricted grant to pursue highly innovative research,<ref name="nih"/> and received the Judson Daland Prize from the [[American Philosophical Society]] for achievement in patient-oriented research,<ref name="aps">Recipients of the Judson Daland Prize, American Philosphical Society [http://www.amphilsoc.org/prizes/dalandistas] Retrieved 2010-08-30.</ref> and the E. Mead Johnson Award from the [[American Pediatric Society]] for contributions to stem cell research.<ref name="spr">Member Information, Society for Pediatric Research [http://www.aps-spr.org/spr/Awards/EMJ.htm] Retrieved 2010-08-30.</ref>


Dr. Daley has been an international leader in advocating for responsible ethical oversight of human stem cell research. On behalf of the international society for stem cell research, he chaired the special international task force that formulated the ISSCR Guidelines for Human Embryonic Stem Cell Research (2007) and as president of the ISSCR empaneled and served on the special task force that produced the ISSCR Guidelines for Clinical Translation of Stem Cells (2008)<ref name="isscrguidelines">Information for Scientists, ISSCR [http://www.isscr.org/clinical_trans/index.cfm] Retrieved 2010-08-30.</ref>, which have served as a roadmap for advancing stem cell science into clinical trials. Dr. Daley has testified at least six times before committees of the [[United States Senate]] and [[United States House of Representatives]] to advocate for expanded governmental support for stem cell research. He serves on the scientific advisory board of the Massachusetts life sciences center and is on the editorial board of several major journals in the stem cell field including Cell Stem Cell, Stem Cells, and Blood.<ref name="stemcell"/>
Dr. Daley has been an international leader in advocating for responsible ethical oversight of human stem cell research. On behalf of the international society for stem cell research, he chaired the special international task force that formulated the ISSCR Guidelines for Human Embryonic Stem Cell Research (2007) and as president of the ISSCR empaneled and served on the special task force that produced the ISSCR Guidelines for Clinical Translation of Stem Cells (2008),<ref name="isscrguidelines">Information for Scientists, ISSCR [http://www.isscr.org/clinical_trans/index.cfm] Retrieved 2010-08-30.</ref> which have served as a roadmap for advancing stem cell science into clinical trials. Dr. Daley has testified at least six times before committees of the [[United States Senate]] and [[United States House of Representatives]] to advocate for expanded governmental support for stem cell research. He serves on the scientific advisory board of the Massachusetts life sciences center and is on the editorial board of several major journals in the stem cell field including Cell Stem Cell, Stem Cells, and Blood.<ref name="stemcell"/>


==References==
==References==
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[[Category:Harvard Medical School alumni]]
[[Category:Harvard Medical School alumni]]

Revision as of 23:05, 26 December 2010

George Q. Daley, M.D., Ph.D. is the Samuel E. Lux IV Professor of Hematology/Oncology and the Director of the Stem Cell Transplantation Program at Children’s Hospital Boston. He is also Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School,[1] an investigator of the Howard Hughes Medical Institute,[2] Associate Director of Children’s Stem Cell Program, a member of the Executive Committee of the Harvard Stem Cell Institute,[3] and past-President of the International Society for Stem Cell Research (2007–2008).[4]

Dr. Daley seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered mouse and human cell culture-based models of human blood disease and cancer.[5] Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch),[6] the differentiation of germ cells from embryonic stem cells (cited as a "Top Ten Breakthrough" by Science magazine in 2003)[7][8] , and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the "Breakthrough of the Year" issue of Science magazine in 2008).[9][10]

As a graduate student working with Nobelist Dr. David Baltimore, Dr. Daley demonstrated that the BCR/ABL oncogene induces chronic myeloid leukemia (CML) in a mouse model,[11] which validated BCR/ABL as a target for drug blockade and encouraged the development of imatinib (GleevecTM; Novartis), a revolutionary magic-bullet chemotherapy that induces remissions in virtually every CML patient. Dr. Daley’s recent studies have clarified mechanisms of Gleevec resistance and informed novel combination chemotherapeutic regimens.[5]

Dr. Daley received his bachelor's degree magna cum laude from Harvard University (1982), a Ph.D. in biology from MIT (1989), and the M.D. from Harvard Medical School, where he was only the twelfth individual in the school’s history to be awarded the degree summa cum laude (1991). He served as Chief Resident in Internal Medicine at the Massachusetts General Hospital and is currently a staff physician in Hematology/Oncology at Children's Hospital Boston and Dana Farber Cancer Institute in Boston, MA.[12]

He has been elected a fellow of the American Association for the Advancement of Science and a member of the American Society for Clinical Investigation and American Pediatric Societies. He has received awards recognizing his contributions to medical research from the National Institutes of Health,[13] the New England Cancer Society, the Burroughs Wellcome Fund, the Edward Mallinckrodt, Jr. Foundation, Harvard Medical School, and the Leukemia and Lymphoma Society of America.[3] Dr. Daley was an inaugural winner of the NIH Director’s Pioneer Award, which provides a five year unrestricted grant to pursue highly innovative research,[7] and received the Judson Daland Prize from the American Philosophical Society for achievement in patient-oriented research,[14] and the E. Mead Johnson Award from the American Pediatric Society for contributions to stem cell research.[15]

Dr. Daley has been an international leader in advocating for responsible ethical oversight of human stem cell research. On behalf of the international society for stem cell research, he chaired the special international task force that formulated the ISSCR Guidelines for Human Embryonic Stem Cell Research (2007) and as president of the ISSCR empaneled and served on the special task force that produced the ISSCR Guidelines for Clinical Translation of Stem Cells (2008),[16] which have served as a roadmap for advancing stem cell science into clinical trials. Dr. Daley has testified at least six times before committees of the United States Senate and United States House of Representatives to advocate for expanded governmental support for stem cell research. He serves on the scientific advisory board of the Massachusetts life sciences center and is on the editorial board of several major journals in the stem cell field including Cell Stem Cell, Stem Cells, and Blood.[5]

References

  1. ^ Harvard Medical School White Pages [1] Retrieved 2010-08-30.
  2. ^ Investigators, Howard Hughes Medical Institute [2] Retrieved 2010-08-30.
  3. ^ a b Principal Faculty, Harvard Stem Cell Institute [3] Retrieved 2010-08-30.
  4. ^ Officers, Leadership, International Society for Stem Cell Research [4] Retrieved 2010-08-30.
  5. ^ a b c Biography, Stem Cell Program Leadership, Children's Hospital Boston [5] Retrieved 2010-08-30.
  6. ^ RIDEOUT ET AL, CELL 2002
  7. ^ a b Biography, 2004 Recipients, NIH Director's Pioneer Award [6] Retrieved 2010-08-30.
  8. ^ GEIJSEN ET AL., NATURE 2003/4
  9. ^ Bios, Team, MPM Capital [7] Retrieved 2010-08-30.
  10. ^ PARK ET AL, CELL 2008
  11. ^ DALEY ET AL, SCIENCE 1990
  12. ^ Specialists, Children's Hospital Boston [8] Retrieved 2010-08-30.
  13. ^ Meet the Scientists, National Heart Lunch and Blood Institute, National Institues of Health [9] Retrieved 2010-08-30.
  14. ^ Recipients of the Judson Daland Prize, American Philosphical Society [10] Retrieved 2010-08-30.
  15. ^ Member Information, Society for Pediatric Research [11] Retrieved 2010-08-30.
  16. ^ Information for Scientists, ISSCR [12] Retrieved 2010-08-30.

Template:Persondata

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