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'''Tobramycin/dexamethasone''' ([[International Nonproprietary Name|INNs]], trade name '''Tobradex''') is a prescription medication in the form of [[eye drops]] and eye ointment, marketed by [[Alcon]]. The active ingredients are [[tobramycin]] 0.3% (an [[antibiotic]]) and [[dexamethasone]] 0.1% (a [[corticosteroid]]). It is prescribed for a wide spectrum of [[bacterial infection|bacterial]] [[human eye|eye]] infections. Tobradex can also be used to clear or contract [[stye]]s that are also found in the eye. It is prescribed for the treatment of pink eye in combination with bacterial infections. Because it contains a steroid, careful use with gradual reduction of doses is required.
'''Tobramycin/dexamethasone''' ([[International Nonproprietary Name|INNs]], trade name '''Tobradex''') is a prescription medication in the form of [[eye drops]] and eye ointment, marketed by [[Alcon]]. The active ingredients are [[tobramycin]] 0.3% (an [[antibiotic]]) and [[dexamethasone]] 0.1% (a [[corticosteroid]]). It is prescribed for a wide spectrum of [[bacterial infection|bacterial]] [[human eye|eye]] infections. Tobradex can also be used to clear or contract [[stye]]s that are also found in the eye. It is prescribed for the treatment of pink eye in combination with bacterial infections. Because it contains a steroid, careful use with gradual reduction of doses is required.


==Contraindications==
== Contraindications ==
It is strongly contraindicated with [[Herpetic infection|herpetic]] and other [[viral infection|viral]] eye infections. Other contraindications include [[fungal infection|fungal]] and [[mycobacterial]] infections because tobramycin is inactive against those, and the corticoid acts as a [[immunosuppressive]] agent, preventing the body's immune system from dealing with the infection. The drops are also contraindicated in patients with [[cornea]]l lesions.<ref name="AustriaCodex">{{cite book|title=Austria-Codex|editor=Haberfeld, H|publisher=Österreichischer Apothekerverlag|location=Vienna|year=2009|edition=2009/2010|isbn=3-85200-196-X|language=German}}</ref><ref>[http://ecatalog.alcon.com/pi/TobraDexSusp_us_en.pdf Tobradex Prescribing Information]. Alcon.</ref>
It is strongly contraindicated with [[Herpetic infection|herpetic]] and other [[viral infection|viral]] eye infections. Other contraindications include [[Fungal infection in animals|fungal]] and [[mycobacteria]]l infections because tobramycin is inactive against those, and the corticoid acts as a [[immunosuppressive]] agent, preventing the body's immune system from dealing with the infection. The drops are also contraindicated in patients with [[cornea]]l lesions.<ref name="AustriaCodex">{{cite book|title=Austria-Codex|editor=Haberfeld, H|publisher=Österreichischer Apothekerverlag|location=Vienna|year=2009|edition=2009/2010|isbn=3-85200-196-X|language=German}}</ref><ref>[http://ecatalog.alcon.com/pi/TobraDexSusp_us_en.pdf Tobradex Prescribing Information]. Alcon.</ref>


==Side effects==
== Side effects ==
Similarly to other corticosteroid eye drops, [[side effects]] include [[hypersensitivity]] and, especially after long-term use, secondary eye infections, [[cataract]] (clouding of the eye lens) and increased [[intraocular pressure]], leading to [[glaucoma]]. Consequently, the drug should not be applied longer than 24 days.<ref name="AustriaCodex"/><ref name="ÖAZ">{{cite journal
Similarly to other corticosteroid eye drops, [[side effect]]s include [[hypersensitivity]] and, especially after long-term use, secondary eye infections, [[cataract]] (clouding of the eye lens) and increased [[intraocular pressure]], leading to [[glaucoma]]. Consequently, the drug should not be applied longer than 24 days.<ref name="AustriaCodex"/><ref name="ÖAZ">{{cite journal
| author = Ch. Faschinger
| author = Ch. Faschinger
| date = 3 January 2011
| date = 3 January 2011

Revision as of 09:55, 5 February 2012

Tobramycin/dexamethasone
Combination of
TobramycinAminoglycoside antibiotic
DexamethasoneGlucocorticoid
Clinical data
Routes of
administration
Ophthalmic
ATC code
Legal status
Legal status
Identifiers
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
  • InChI=1S/C22H29FO5.C18H37N5O9/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24;19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3;5-18,24-28H,1-4,19-23H2/t12-,15+,16+,17+,19+,20+,21+,22+;5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m10/s1 checkY
  • Key:DWLNMMCXGSKYEM-VQHMUFKESA-N checkY
  (verify)

Tobramycin/dexamethasone (INNs, trade name Tobradex) is a prescription medication in the form of eye drops and eye ointment, marketed by Alcon. The active ingredients are tobramycin 0.3% (an antibiotic) and dexamethasone 0.1% (a corticosteroid). It is prescribed for a wide spectrum of bacterial eye infections. Tobradex can also be used to clear or contract styes that are also found in the eye. It is prescribed for the treatment of pink eye in combination with bacterial infections. Because it contains a steroid, careful use with gradual reduction of doses is required.

Contraindications

It is strongly contraindicated with herpetic and other viral eye infections. Other contraindications include fungal and mycobacterial infections because tobramycin is inactive against those, and the corticoid acts as a immunosuppressive agent, preventing the body's immune system from dealing with the infection. The drops are also contraindicated in patients with corneal lesions.[1][2]

Side effects

Similarly to other corticosteroid eye drops, side effects include hypersensitivity and, especially after long-term use, secondary eye infections, cataract (clouding of the eye lens) and increased intraocular pressure, leading to glaucoma. Consequently, the drug should not be applied longer than 24 days.[1][3][4]

Interactions

Anticholinergic eye drops potentiate the risk of increased intraocular pressure. Systemic aminoglycoside antibiotics increase toxicity for ears, nerves and kidney.[1]

References

  1. ^ a b c Haberfeld, H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 3-85200-196-X.
  2. ^ Tobradex Prescribing Information. Alcon.
  3. ^ Ch. Faschinger (3 January 2011). Österreichische Apothekerzeitung (in German) (1/2011): 13. {{cite journal}}: Missing or empty |title= (help)
  4. ^ Dinnendahl, V, Fricke, U, ed. (2010). Arzneistoff-Profile (in German). Vol. 2 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-98-46-3.{{cite book}}: CS1 maint: multiple names: editors list (link)