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The dosage of pertuzumab used in the pivotal phase III CLEOPATRA (Clinical Evaluation of Pertuzumab and Trastuzumab) trial was as follows: IV 840mg loading dose followed by IV 420mg q3w.<ref name="test">Keating GM. Pertuzumab: in the first-line treatment of HER2-positive metastatic breast cancer. ''Drugs 2012 Feb 12; 72 (3): 353-60''.[http://adisonline.com/drugs/pages/articleviewer.aspx?year=2012&issue=72030&article=00005&type=abstract Link text] </ref>
The dosage of pertuzumab used in the pivotal phase III CLEOPATRA (Clinical Evaluation of Pertuzumab and Trastuzumab) trial was as follows: IV 840mg loading dose followed by IV 420mg q3w.<ref name="test">Keating GM. Pertuzumab: in the first-line treatment of HER2-positive metastatic breast cancer. ''Drugs 2012 Feb 12; 72 (3): 353-60''.[http://adisonline.com/drugs/pages/articleviewer.aspx?year=2012&issue=72030&article=00005&type=abstract Link text] </ref>


The pharmacokinetics of intravenous pertuzumab appear to be unaffected by age and no drug-drug interaction has been reported with doectaxel.<ref name="test">Keating GM. Pertuzumab: in the first-line treatment of HER2-positive metastatic breast cancer. ''Drugs 2012 Feb 12; 72 (3): 353-60''.[http://adisonline.com/drugs/pages/articleviewer.aspx?year=2012&issue=72030&article=00005&type=abstract Link text] </ref>
The pharmacokinetics of intravenous pertuzumab appear to be unaffected by age and no drug-drug interaction has been reported with docetaxel. The pharmacokinetics and pharmacodynamics of pertuzumab have recently been summarized in a review by Gillian Keating.<ref name="test">Keating GM. Pertuzumab: in the first-line treatment of HER2-positive metastatic breast cancer. ''Drugs 2012 Feb 12; 72 (3): 353-60''.[http://adisonline.com/drugs/pages/articleviewer.aspx?year=2012&issue=72030&article=00005&type=abstract Link text] </ref>


The combination of pertuzumab plus trastuzumab plus docetaxel, as compared with placebo plus trastuzumab plus docetaxel, when used as first-line treatment for HER2-positive metastatic breast cancer, significantly prolonged progression-free survival, with no increase in cardiac toxic effects in the randomized, double-blind, multinational, phase III CLEOPATRA trial.<ref name=“test”>Baselga J, Cortés J, Kim SB, and the CLEOPATRA Study Group. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. ''N Engl J Med 2012 Jan 12; 366 (2): 109-19''. [http://www.ncbi.nlm.nih.gov/pubmed/22149875 Link text] </ref>
The combination of pertuzumab plus trastuzumab plus docetaxel, as compared with placebo plus trastuzumab plus docetaxel, when used as first-line treatment for HER2-positive metastatic breast cancer, significantly prolonged progression-free survival, with no increase in cardiac toxic effects in the randomized, double-blind, multinational, phase III CLEOPATRA trial.<ref name=“test”>Baselga J, Cortés J, Kim SB, and the CLEOPATRA Study Group. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. ''N Engl J Med 2012 Jan 12; 366 (2): 109-19''. [http://www.ncbi.nlm.nih.gov/pubmed/22149875 Link text] </ref>

Revision as of 21:03, 28 March 2012

Pertuzumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized (from mouse)
TargetHER2
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
UNII
KEGG
 ☒NcheckY (what is this?)  (verify)
The structure of HER2 and pertuzumab

Pertuzumab (also called 2C4, trade name Omnitarg) is a monoclonal antibody. The first of its class in a line of agents called "HER dimerization inhibitors". By binding to HER2, it inhibits the dimerization of HER2 with other HER receptors, which is hypothesized to result in slowed tumor growth.[2] Pertuzumab is currently being developed by Genentech.

Early clinical trials of pertuzumab in prostate, breast, and ovarian cancers have been met with limited success.[3]

The dosage of pertuzumab used in the pivotal phase III CLEOPATRA (Clinical Evaluation of Pertuzumab and Trastuzumab) trial was as follows: IV 840mg loading dose followed by IV 420mg q3w.[4]

The pharmacokinetics of intravenous pertuzumab appear to be unaffected by age and no drug-drug interaction has been reported with docetaxel. The pharmacokinetics and pharmacodynamics of pertuzumab have recently been summarized in a review by Gillian Keating.[4]

The combination of pertuzumab plus trastuzumab plus docetaxel, as compared with placebo plus trastuzumab plus docetaxel, when used as first-line treatment for HER2-positive metastatic breast cancer, significantly prolonged progression-free survival, with no increase in cardiac toxic effects in the randomized, double-blind, multinational, phase III CLEOPATRA trial.[5]

References

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ de Bono, Johann S.; Bellmunt, J; Attard, G; Droz, JP; Miller, K; Flechon, A; Sternberg, C; Parker, C; Zugmaier, G (20 January 2007). "Open-Label Phase II Study Evaluating the Efficacy and Safety of Two Doses of Pertuzumab in Castrate Chemotherapy-Naive Patients With Hormone-Refractory Prostate Cancer". Journal of Clinical Oncology. 25 (3): 257–262. doi:10.1200/JCO.2006.07.0888. PMID 17235043.
  3. ^ Genentech press release - May 15, 2005
  4. ^ a b Keating GM. Pertuzumab: in the first-line treatment of HER2-positive metastatic breast cancer. Drugs 2012 Feb 12; 72 (3): 353-60.Link text
  5. ^ Baselga J, Cortés J, Kim SB, and the CLEOPATRA Study Group. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012 Jan 12; 366 (2): 109-19. Link text


10.1056/NEJMoa1113216