Nicotinate dehydrogenase (cytochrome): Difference between revisions
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'''Nicotinate dehydrogenase ([[cytochrome]])''' ({{EC number|1.17.2.1}}, ''nicotinic acid hydroxylase'', ''nicotinate hydroxylase'') is an [[enzyme]] with system name ''nicotinate:cytochrome 6-oxidoreductase (hydroxylating)''.<ref>{{cite journal | title = Deciphering the genetic determinants for aerobic nicotinic acid degradation: the <em>nic</em> cluster from <em>Pseudomonas putida</em> KT2440 |author = Jimenez, J.I., Canales, A., Jimenez-Barbero, J., Ginalski, K., Rychlewski, L., Garcia, J.L. and Diaz, E. |journal = Proc. Natl. Acad. Sci. USA |year = 2008 |volume = 105 |pages = 11329–11334 |pmid = 18678916}}</ref><ref>{{cite journal | title = Cloning, heterologous expression, and functional characterization of the nicotinate dehydrogenase gene from <em>Pseudomonas putida</em> KT2440 |author = Yang, Y., Yuan, S., Chen, T., Ma, P., Shang, G. and Dai, Y. |journal = Biodegradation |year = 2009 |volume = 20 |pages = 541–549 |pmid = 19118407}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]] |
'''Nicotinate dehydrogenase ([[cytochrome]])''' ({{EC number|1.17.2.1}}, ''nicotinic acid hydroxylase'', ''nicotinate hydroxylase'') is an [[enzyme]] with system name ''nicotinate:cytochrome 6-oxidoreductase (hydroxylating)''.<ref>{{cite journal | title = Deciphering the genetic determinants for aerobic nicotinic acid degradation: the <em>nic</em> cluster from <em>Pseudomonas putida</em> KT2440 |author = Jimenez, J.I., Canales, A., Jimenez-Barbero, J., Ginalski, K., Rychlewski, L., Garcia, J.L. and Diaz, E. |journal = Proc. Natl. Acad. Sci. USA |year = 2008 |volume = 105 |pages = 11329–11334 |pmid = 18678916 |doi=10.1073/pnas.0802273105 |pmc=2516282}}</ref><ref>{{cite journal | title = Cloning, heterologous expression, and functional characterization of the nicotinate dehydrogenase gene from <em>Pseudomonas putida</em> KT2440 |author = Yang, Y., Yuan, S., Chen, T., Ma, P., Shang, G. and Dai, Y. |journal = Biodegradation |year = 2009 |volume = 20 |pages = 541–549 |pmid = 19118407 |doi=10.1007/s10532-008-9243-x |issue=4}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]] |
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: [[nicotinate]] + a [[ferricytochrome]] + H<sub>2</sub>O <math>\rightleftharpoons</math> 6-hydroxynicotinate + a ferrocytochrome + 2 H<sup>+</sup> |
: [[nicotinate]] + a [[ferricytochrome]] + H<sub>2</sub>O <math>\rightleftharpoons</math> 6-hydroxynicotinate + a ferrocytochrome + 2 H<sup>+</sup> |
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Revision as of 21:55, 1 November 2013
| Nicotinate dehydrogenase (cytochrome) | |||||||||
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| Identifiers | |||||||||
| EC no. | 1.17.2.1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Nicotinate dehydrogenase (cytochrome) (EC 1.17.2.1, nicotinic acid hydroxylase, nicotinate hydroxylase) is an enzyme with system name nicotinate:cytochrome 6-oxidoreductase (hydroxylating).[1][2] This enzyme catalyses the following chemical reaction
- nicotinate + a ferricytochrome + H2O 6-hydroxynicotinate + a ferrocytochrome + 2 H+
This two-component enzyme from Pseudomonas belongs to the family of xanthine dehydrogenases.
References
- ^ Jimenez, J.I., Canales, A., Jimenez-Barbero, J., Ginalski, K., Rychlewski, L., Garcia, J.L. and Diaz, E. (2008). "Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440". Proc. Natl. Acad. Sci. USA. 105: 11329–11334. doi:10.1073/pnas.0802273105. PMC 2516282. PMID 18678916.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Yang, Y., Yuan, S., Chen, T., Ma, P., Shang, G. and Dai, Y. (2009). "Cloning, heterologous expression, and functional characterization of the nicotinate dehydrogenase gene from Pseudomonas putida KT2440". Biodegradation. 20 (4): 541–549. doi:10.1007/s10532-008-9243-x. PMID 19118407.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
See also
External links
- Nicotinate+dehydrogenase+(cytochrome) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)