GABA transaminase inhibitor: Difference between revisions

Content deleted Content added

Inline

Revision as of 00:02, 3 November 2013

A GABA transaminase inhibitor is an enzyme inhibitor that acts upon GABA transaminase.^[1]

Examples include valproic acid,^[2] vigabatrin,^[3]^[4] phenylethylidenehydrazine, ethanolamine-O-sulfate (EOS), and L-cycloserine.^[5]

Certain members of this class are used as anticonvulsants.

There is some evidence that Melissa officinalis (lemon balm), and rosmarinic acid it contains, inhibits GABA transaminase.^[6]

References

^ PMID 390993
^ PMID 110294
^ Wang QP, Jammoul F, Duboc A; et al. (2008). "Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina". Eur. J. Neurosci. 27 (8): 2177–87. doi:10.1111/j.1460-9568.2008.06175.x. PMC 2933832. PMID 18412635. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
^ PMID 2399411
^ PMID 3012401
^ PMID 18066140

[Ciesielski_1979-1] PMID 390993

[2] PMID 110294

[pmid18412635-3] Wang QP, Jammoul F, Duboc A; et al. (2008). "Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina". Eur. J. Neurosci. 27 (8): 2177–87. doi:10.1111/j.1460-9568.2008.06175.x. PMC 2933832. PMID 18412635. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

[4] PMID 2399411

[Polc_1986-5] PMID 3012401

[6] PMID 18066140

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
-A '''GABA transaminase inhibitor''' is an [[enzyme inhibitor]] that acts upon [[GABA transaminase]].
+A '''GABA transaminase inhibitor''' is an [[enzyme inhibitor]] that acts upon [[GABA transaminase]].<ref name="Ciesielski 1979">{{pmid|390993}}</ref>
-Examples include [[valproate]], [[vigabatrin]],<ref name="pmid18412635">{{cite journal |author=Wang QP, Jammoul F, Duboc A, ''et al'' |title=Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina |journal=Eur. J. Neurosci. |volume=27 |issue=8 |pages=2177–87 |year=2008 |month=April |pmid=18412635 |pmc=2933832 |doi=10.1111/j.1460-9568.2008.06175.x |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=2008&volume=27&issue=8&spage=2177}}</ref> [[phenylethylidenehydrazine]], [[Ethanolamine-O-sulfate|ethanolamine-''O''-sulfate]] (EOS), and L-cycloserine.<ref name="Polc 1986">{{pmid|3012401}}</ref>
+Examples include [[valproic acid]],<ref>{{pmid|110294}}</ref> [[vigabatrin]],<ref name="pmid18412635">{{cite journal |author=Wang QP, Jammoul F, Duboc A, ''et al'' |title=Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina |journal=Eur. J. Neurosci. |volume=27 |issue=8 |pages=2177–87 |year=2008 |month=April |pmid=18412635 |pmc=2933832 |doi=10.1111/j.1460-9568.2008.06175.x |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=2008&volume=27&issue=8&spage=2177}}</ref><ref>{{pmid|2399411}}</ref> [[phenylethylidenehydrazine]], [[Ethanolamine-O-sulfate|ethanolamine-''O''-sulfate]] (EOS), and L-[[cycloserine]].<ref name="Polc 1986">{{pmid|3012401}}</ref>
 Certain members of this class are used as [[anticonvulsant]]s.