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{{PBB|geneid=2773}} |
{{PBB|geneid=2773}} |
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'''Guanine nucleotide-binding protein G(k) subunit alpha''' is a [[protein]] that in humans is encoded by the ''GNAI3'' [[gene]].<ref name="pmid3109953">{{cite journal | author = Didsbury JR, Snyderman R | title = Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families | journal = FEBS Lett | volume = 219 | issue = 1 | pages = 259–63 | |
'''Guanine nucleotide-binding protein G(k) subunit alpha''' is a [[protein]] that in humans is encoded by the ''GNAI3'' [[gene]].<ref name="pmid3109953">{{cite journal | author = Didsbury JR, Snyderman R | title = Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families | journal = FEBS Lett | volume = 219 | issue = 1 | pages = 259–63 |date=Aug 1987 | pmid = 3109953 | pmc = | doi =10.1016/0014-5793(87)81228-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2773| accessdate = }}</ref> |
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==Interactions== |
==Interactions== |
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GNAI3 has been shown to [[Protein-protein interaction|interact]] with [[RGS14]],<ref name=pmid11387333>{{cite journal |last=Kimple |first=R J |authorlink= |coauthors=De Vries L, Tronchère H, Behe C I, Morris R A, Gist Farquhar M, Siderovski D P | |
GNAI3 has been shown to [[Protein-protein interaction|interact]] with [[RGS14]],<ref name=pmid11387333>{{cite journal |last=Kimple |first=R J |authorlink= |coauthors=De Vries L, Tronchère H, Behe C I, Morris R A, Gist Farquhar M, Siderovski D P |date=Aug 2001 |title=RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity |journal=J. Biol. Chem. |volume=276 |issue=31 |pages=29275–81 |publisher= |location = United States| issn = 0021-9258| pmid = 11387333 |doi = 10.1074/jbc.M103208200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RIC8A]],<ref name=pmid12509430>{{cite journal |last=Tall |first=Gregory G |authorlink= |coauthors=Krumins Andrejs M, Gilman Alfred G |date=Mar 2003 |title=Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor |journal=J. Biol. Chem. |volume=278 |issue=10 |pages=8356–62 |publisher= |location = United States| issn = 0021-9258| pmid = 12509430 |doi = 10.1074/jbc.M211862200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RGS18]],<ref name=pmid11563974>{{cite journal |doi=10.1042/0264-6021:3590109 |last=Yowe |first=D |authorlink= |coauthors=Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie T M, Gutierrez-Ramos C, Hodge M R |date=Oct 2001 |title=RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes |journal=Biochem. J. |volume=359 |issue=Pt 1 |pages=109–18 |publisher= |location = England| issn = 0264-6021| pmid = 11563974 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1222126 }}</ref><ref name=pmid11955952>{{cite journal |doi=10.1016/S0898-6568(02)00012-8 |last=Gagnon |first=Alison W |authorlink= |coauthors=Murray David L, Leadley Robert J |date=Jul 2002 |title=Cloning and characterization of a novel regulator of G protein signalling in human platelets |journal=Cell. Signal. |volume=14 |issue=7 |pages=595–606 |publisher= |location = England| issn = 0898-6568| pmid = 11955952 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[S1PR1]],<ref name=pmid8626678>{{cite journal |doi=10.1074/jbc.271.19.11272 |last=Lee |first=M J |authorlink= |coauthors=Evans M, Hla T |date=May 1996 |title=The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway |journal=J. Biol. Chem. |volume=271 |issue=19 |pages=11272–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8626678 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RGS12]],<ref name=pmid11387333/> [[RGS16]],<ref name=pmid9079700>{{cite journal |doi=10.1074/jbc.272.13.8679 |last=Chen |first=C |authorlink= |coauthors=Zheng B, Han J, Lin S C |date=Mar 1997 |title=Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast |journal=J. Biol. Chem. |volume=272 |issue=13 |pages=8679–85 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9079700 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10072511>{{cite journal |last=Beadling |first=C |authorlink= |coauthors=Druey K M, Richter G, Kehrl J H, Smith K A |date=Mar 1999 |title=Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes |journal=J. Immunol. |volume=162 |issue=5 |pages=2677–82 |publisher= |location = UNITED STATES| issn = 0022-1767| pmid = 10072511 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RGS19]],<ref name=pmid8986788>{{cite journal |doi=10.1073/pnas.93.26.15203 |last=De Vries |first=L |authorlink= |coauthors=Elenko E, Hubler L, Jones T L, Farquhar M G |date=Dec 1996 |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=26 |pages=15203–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8986788 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=26381 }}</ref><ref name=pmid10364213>{{cite journal |doi=10.1074/jbc.274.25.17718 |last=Woulfe |first=D S |authorlink= |coauthors=Stadel J M |date=Jun 1999 |title=Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP |journal=J. Biol. Chem. |volume=274 |issue=25 |pages=17718–24 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10364213 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8524874>{{cite journal |doi=10.1073/pnas.92.25.11916 |last=De Vries |first=L |authorlink= |coauthors=Mousli M, Wurmser A, Farquhar M G |date=Dec 1995 |title=GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=92 |issue=25 |pages=11916–20 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8524874 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=40514 }}</ref> [[RGS10]]<ref name=pmid8774883>{{cite journal |last=Hunt |first=T W |authorlink= |coauthors=Fields T A, Casey P J, Peralta E G |date=Sep 1996 |title=RGS10 is a selective activator of G alpha i GTPase activity |journal=[[Nature (journal)|Nature]] |volume=383 |issue=6596 |pages=175–7 |publisher= |location = ENGLAND| issn = 0028-0836| pmid = 8774883 |doi = 10.1038/383175a0 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[RGS5]].<ref name=pmid9079700/><ref name=pmid11253162>{{cite journal |doi=10.1016/S0024-3205(01)00939-0 |last=Zhou |first=J |authorlink= |coauthors=Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S |date=Feb 2001 |title=Characterization of RGS5 in regulation of G protein-coupled receptor signaling |journal=Life Sci. |volume=68 |issue=13 |pages=1457–69 |publisher= |location = England| issn = 0024-3205| pmid = 11253162 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> |
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==See also== |
==See also== |
Revision as of 23:20, 19 January 2014
Template:PBB Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.[1][2]
Interactions
GNAI3 has been shown to interact with RGS14,[3] RIC8A,[4] RGS18,[5][6] S1PR1,[7] RGS12,[3] RGS16,[8][9] RGS19,[10][11][12] RGS10[13] and RGS5.[8][14]
See also
References
- ^ Didsbury JR, Snyderman R (Aug 1987). "Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families". FEBS Lett. 219 (1): 259–63. doi:10.1016/0014-5793(87)81228-0. PMID 3109953.
- ^ "Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3".
- ^ a b Kimple, R J (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31). United States: 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333.
{{cite journal}}
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suggested) (help)CS1 maint: unflagged free DOI (link) - ^ Tall, Gregory G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10). United States: 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
{{cite journal}}
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,|laysummary=
, and|laysource=
(help); Unknown parameter|coauthors=
ignored (|author=
suggested) (help)CS1 maint: unflagged free DOI (link) - ^ Yowe, D (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". Biochem. J. 359 (Pt 1). England: 109–18. doi:10.1042/0264-6021:3590109. ISSN 0264-6021. PMC 1222126. PMID 11563974.
{{cite journal}}
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,|laysummary=
, and|laysource=
(help); Unknown parameter|coauthors=
ignored (|author=
suggested) (help) - ^ Gagnon, Alison W (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cell. Signal. 14 (7). England: 595–606. doi:10.1016/S0898-6568(02)00012-8. ISSN 0898-6568. PMID 11955952.
{{cite journal}}
: Cite has empty unknown parameters:|laydate=
,|laysummary=
, and|laysource=
(help); Unknown parameter|coauthors=
ignored (|author=
suggested) (help) - ^ Lee, M J (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. 271 (19). UNITED STATES: 11272–9. doi:10.1074/jbc.271.19.11272. ISSN 0021-9258. PMID 8626678.
{{cite journal}}
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,|laysummary=
, and|laysource=
(help); Unknown parameter|coauthors=
ignored (|author=
suggested) (help)CS1 maint: unflagged free DOI (link) - ^ a b Chen, C (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. 272 (13). UNITED STATES: 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700.
{{cite journal}}
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,|laysummary=
, and|laysource=
(help); Unknown parameter|coauthors=
ignored (|author=
suggested) (help)CS1 maint: unflagged free DOI (link) - ^ Beadling, C (Mar 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". J. Immunol. 162 (5). UNITED STATES: 2677–82. ISSN 0022-1767. PMID 10072511.
{{cite journal}}
: Cite has empty unknown parameters:|laydate=
,|laysummary=
, and|laysource=
(help); Unknown parameter|coauthors=
ignored (|author=
suggested) (help) - ^ De Vries, L (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26). UNITED STATES: 15203–8. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788.
{{cite journal}}
: Cite has empty unknown parameters:|laydate=
,|laysummary=
, and|laysource=
(help); Unknown parameter|coauthors=
ignored (|author=
suggested) (help) - ^ Woulfe, D S (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. 274 (25). UNITED STATES: 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213.
{{cite journal}}
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,|laysummary=
, and|laysource=
(help); Unknown parameter|coauthors=
ignored (|author=
suggested) (help)CS1 maint: unflagged free DOI (link) - ^ De Vries, L (Dec 1995). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc. Natl. Acad. Sci. U.S.A. 92 (25). UNITED STATES: 11916–20. doi:10.1073/pnas.92.25.11916. ISSN 0027-8424. PMC 40514. PMID 8524874.
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ignored (|author=
suggested) (help) - ^ Hunt, T W (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596). ENGLAND: 175–7. doi:10.1038/383175a0. ISSN 0028-0836. PMID 8774883.
{{cite journal}}
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ignored (|author=
suggested) (help) - ^ Zhou, J (Feb 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. 68 (13). England: 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162.
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Further reading