Pyroglutamyl-peptidase II: Difference between revisions
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'''Pyroglutamyl-peptidase II''' ({{EC number|3.4.19.6}}, ''thyroliberinase'', ''pyroglutamyl aminopeptidase II'', ''thyrotropin-releasing factor pyroglutamate aminopeptidase'', ''pyroglutamate aminopeptidase II'', ''pyroglutamyl peptidase II'', ''thyroliberin-hydrolyzing pyroglutamate aminopeptidase'', ''thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase'', ''thyrotropin-releasing hormone-degrading peptidase'', ''TRH aminopeptidase'') is an [[enzyme]].<ref>{{cite journal | title = Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond |author = Bauer, K. and Nowak, P. |journal = Eur. J. Biochem. |date = 1979 |volume = 99 |pages = |
'''Pyroglutamyl-peptidase II''' ({{EC number|3.4.19.6}}, ''thyroliberinase'', ''pyroglutamyl aminopeptidase II'', ''thyrotropin-releasing factor pyroglutamate aminopeptidase'', ''pyroglutamate aminopeptidase II'', ''pyroglutamyl peptidase II'', ''thyroliberin-hydrolyzing pyroglutamate aminopeptidase'', ''thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase'', ''thyrotropin-releasing hormone-degrading peptidase'', ''TRH aminopeptidase'') is an [[enzyme]].<ref>{{cite journal | title = Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond |author = Bauer, K. and Nowak, P. |journal = Eur. J. Biochem. |date = 1979 |volume = 99 |pages = 239–246 |pmid = 115687 |doi=10.1111/j.1432-1033.1979.tb13250.x}}</ref><ref>{{cite journal | title = Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain |author = O'Connor, B. and O'Cuinn, G. |journal = Eur. J. Biochem. |date = 1985 |volume = 150 |pages = 47–52 |pmid = 2862039 |doi=10.1111/j.1432-1033.1985.tb08986.x}}</ref><ref>{{cite journal | title = Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme |author = Wilk, S. and Wilk, E.K. |journal = Neurochem. Int. |date = 1989 |volume = 15 |pages = 81–89 |pmid = |doi=10.1016/0197-0186(89)90079-x}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]] |
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: Release of the [[N-terminal]] pyroglutamyl group from pGlu--His-Xaa [[tripeptide]]s and pGlu--His-Xaa-Gly [[tetrapeptide]]s |
: Release of the [[N-terminal]] pyroglutamyl group from pGlu--His-Xaa [[tripeptide]]s and pGlu--His-Xaa-Gly [[tetrapeptide]]s |
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Revision as of 07:59, 9 July 2014
| Pyroglutamyl-peptidase II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.19.6 | ||||||||
| CAS no. | 60063-88-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Pyroglutamyl-peptidase II (EC 3.4.19.6, thyroliberinase, pyroglutamyl aminopeptidase II, thyrotropin-releasing factor pyroglutamate aminopeptidase, pyroglutamate aminopeptidase II, pyroglutamyl peptidase II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading peptidase, TRH aminopeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Release of the N-terminal pyroglutamyl group from pGlu--His-Xaa tripeptides and pGlu--His-Xaa-Gly tetrapeptides
This enzyme is highly specific for thyrotropin releasing hormone.
References
- ^ Bauer, K. and Nowak, P. (1979). "Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond". Eur. J. Biochem. 99: 239–246. doi:10.1111/j.1432-1033.1979.tb13250.x. PMID 115687.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ O'Connor, B. and O'Cuinn, G. (1985). "Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain". Eur. J. Biochem. 150: 47–52. doi:10.1111/j.1432-1033.1985.tb08986.x. PMID 2862039.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Wilk, S. and Wilk, E.K. (1989). "Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme". Neurochem. Int. 15: 81–89. doi:10.1016/0197-0186(89)90079-x.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- Pyroglutamyl-peptidase+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)