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==Interactions==
==Interactions==
GNAI3 has been shown to [[Protein-protein interaction|interact]] with [[RGS14]],<ref name=pmid11387333>{{cite journal |last=Kimple |first=R J |authorlink= |coauthors=De Vries L, Tronchère H, Behe C I, Morris R A, Gist Farquhar M, Siderovski D P |date=Aug 2001 |title=RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity |journal=J. Biol. Chem. |volume=276 |issue=31 |pages=29275–81 |publisher= |location = United States| issn = 0021-9258| pmid = 11387333 |doi = 10.1074/jbc.M103208200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RIC8A]],<ref name=pmid12509430>{{cite journal |last=Tall |first=Gregory G |authorlink= |coauthors=Krumins Andrejs M, Gilman Alfred G |date=Mar 2003 |title=Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor |journal=J. Biol. Chem. |volume=278 |issue=10 |pages=8356–62 |publisher= |location = United States| issn = 0021-9258| pmid = 12509430 |doi = 10.1074/jbc.M211862200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RGS18]],<ref name=pmid11563974>{{cite journal |doi=10.1042/0264-6021:3590109 |last=Yowe |first=D |authorlink= |coauthors=Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie T M, Gutierrez-Ramos C, Hodge M R |date=Oct 2001 |title=RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes |journal=Biochem. J. |volume=359 |issue=Pt 1 |pages=109–18 |publisher= |location = England| issn = 0264-6021| pmid = 11563974 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1222126 }}</ref><ref name=pmid11955952>{{cite journal |doi=10.1016/S0898-6568(02)00012-8 |last=Gagnon |first=Alison W |authorlink= |coauthors=Murray David L, Leadley Robert J |date=Jul 2002 |title=Cloning and characterization of a novel regulator of G protein signalling in human platelets |journal=Cell. Signal. |volume=14 |issue=7 |pages=595–606 |publisher= |location = England| issn = 0898-6568| pmid = 11955952 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[S1PR1]],<ref name=pmid8626678>{{cite journal |doi=10.1074/jbc.271.19.11272 |last=Lee |first=M J |authorlink= |author2=Evans M |author3=Hla T |date=May 1996 |title=The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway |journal=J. Biol. Chem. |volume=271 |issue=19 |pages=11272–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8626678 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RGS12]],<ref name=pmid11387333/> [[RGS16]],<ref name=pmid9079700>{{cite journal |doi=10.1074/jbc.272.13.8679 |last=Chen |first=C |authorlink= |author2=Zheng B |author3=Han J |author4=Lin S C |date=Mar 1997 |title=Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast |journal=J. Biol. Chem. |volume=272 |issue=13 |pages=8679–85 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9079700 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10072511>{{cite journal |last=Beadling |first=C |authorlink= |author2=Druey K M |author3=Richter G |author4=Kehrl J H |author5=Smith K A |date=Mar 1999 |title=Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes |journal=J. Immunol. |volume=162 |issue=5 |pages=2677–82 |publisher= |location = UNITED STATES| issn = 0022-1767| pmid = 10072511 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RGS19]],<ref name=pmid8986788>{{cite journal |doi=10.1073/pnas.93.26.15203 |last=De Vries |first=L |authorlink= |author2=Elenko E |author3=Hubler L |author4=Jones T L |author5=Farquhar M G |date=Dec 1996 |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=26 |pages=15203–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8986788 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=26381 }}</ref><ref name=pmid10364213>{{cite journal |doi=10.1074/jbc.274.25.17718 |last=Woulfe |first=D S |authorlink= |author2=Stadel J M |date=Jun 1999 |title=Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP |journal=J. Biol. Chem. |volume=274 |issue=25 |pages=17718–24 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10364213 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8524874>{{cite journal |doi=10.1073/pnas.92.25.11916 |last=De Vries |first=L |authorlink= |author2=Mousli M |author3=Wurmser A |author4=Farquhar M G |date=Dec 1995 |title=GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=92 |issue=25 |pages=11916–20 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8524874 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=40514 }}</ref> [[RGS10]]<ref name=pmid8774883>{{cite journal |last=Hunt |first=T W |authorlink= |author2=Fields T A |author3=Casey P J |author4=Peralta E G |date=Sep 1996 |title=RGS10 is a selective activator of G alpha i GTPase activity |journal=[[Nature (journal)|Nature]] |volume=383 |issue=6596 |pages=175–7 |publisher= |location = ENGLAND| issn = 0028-0836| pmid = 8774883 |doi = 10.1038/383175a0 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[RGS5]].<ref name=pmid9079700/><ref name=pmid11253162>{{cite journal |doi=10.1016/S0024-3205(01)00939-0 |last=Zhou |first=J |authorlink= |author2=Moroi K |author3=Nishiyama M |author4=Usui H |author5=Seki N |author6=Ishida J |author7=Fukamizu A |author8=Kimura S |date=Feb 2001 |title=Characterization of RGS5 in regulation of G protein-coupled receptor signaling |journal=Life Sci. |volume=68 |issue=13 |pages=1457–69 |publisher= |location = England| issn = 0024-3205| pmid = 11253162 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
GNAI3 has been shown to [[Protein-protein interaction|interact]] with [[RGS14]],<ref name=pmid11387333>{{cite journal |last=Kimple |first=R J |authorlink= |author2=De Vries L |author3=Tronchère H |author4=Behe C I |author5=Morris R A |author6=Gist Farquhar M |author7=Siderovski D P |date=Aug 2001 |title=RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity |journal=J. Biol. Chem. |volume=276 |issue=31 |pages=29275–81 |publisher= |location = United States| issn = 0021-9258| pmid = 11387333 |doi = 10.1074/jbc.M103208200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RIC8A]],<ref name=pmid12509430>{{cite journal |last=Tall |first=Gregory G |authorlink= |author2=Krumins Andrejs M |author3=Gilman Alfred G |date=Mar 2003 |title=Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor |journal=J. Biol. Chem. |volume=278 |issue=10 |pages=8356–62 |publisher= |location = United States| issn = 0021-9258| pmid = 12509430 |doi = 10.1074/jbc.M211862200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RGS18]],<ref name=pmid11563974>{{cite journal |doi=10.1042/0264-6021:3590109 |last=Yowe |first=D |authorlink= |coauthors=Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie T M, Gutierrez-Ramos C, Hodge M R |date=Oct 2001 |title=RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes |journal=Biochem. J. |volume=359 |issue=Pt 1 |pages=109–18 |publisher= |location = England| issn = 0264-6021| pmid = 11563974 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1222126 }}</ref><ref name=pmid11955952>{{cite journal |doi=10.1016/S0898-6568(02)00012-8 |last=Gagnon |first=Alison W |authorlink= |author2=Murray David L |author3=Leadley Robert J |date=Jul 2002 |title=Cloning and characterization of a novel regulator of G protein signalling in human platelets |journal=Cell. Signal. |volume=14 |issue=7 |pages=595–606 |publisher= |location = England| issn = 0898-6568| pmid = 11955952 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[S1PR1]],<ref name=pmid8626678>{{cite journal |doi=10.1074/jbc.271.19.11272 |last=Lee |first=M J |authorlink= |author2=Evans M |author3=Hla T |date=May 1996 |title=The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway |journal=J. Biol. Chem. |volume=271 |issue=19 |pages=11272–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8626678 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RGS12]],<ref name=pmid11387333/> [[RGS16]],<ref name=pmid9079700>{{cite journal |doi=10.1074/jbc.272.13.8679 |last=Chen |first=C |authorlink= |author2=Zheng B |author3=Han J |author4=Lin S C |date=Mar 1997 |title=Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast |journal=J. Biol. Chem. |volume=272 |issue=13 |pages=8679–85 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9079700 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10072511>{{cite journal |last=Beadling |first=C |authorlink= |author2=Druey K M |author3=Richter G |author4=Kehrl J H |author5=Smith K A |date=Mar 1999 |title=Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes |journal=J. Immunol. |volume=162 |issue=5 |pages=2677–82 |publisher= |location = UNITED STATES| issn = 0022-1767| pmid = 10072511 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RGS19]],<ref name=pmid8986788>{{cite journal |doi=10.1073/pnas.93.26.15203 |last=De Vries |first=L |authorlink= |author2=Elenko E |author3=Hubler L |author4=Jones T L |author5=Farquhar M G |date=Dec 1996 |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=26 |pages=15203–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8986788 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=26381 }}</ref><ref name=pmid10364213>{{cite journal |doi=10.1074/jbc.274.25.17718 |last=Woulfe |first=D S |authorlink= |author2=Stadel J M |date=Jun 1999 |title=Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP |journal=J. Biol. Chem. |volume=274 |issue=25 |pages=17718–24 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10364213 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8524874>{{cite journal |doi=10.1073/pnas.92.25.11916 |last=De Vries |first=L |authorlink= |author2=Mousli M |author3=Wurmser A |author4=Farquhar M G |date=Dec 1995 |title=GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=92 |issue=25 |pages=11916–20 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8524874 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=40514 }}</ref> [[RGS10]]<ref name=pmid8774883>{{cite journal |last=Hunt |first=T W |authorlink= |author2=Fields T A |author3=Casey P J |author4=Peralta E G |date=Sep 1996 |title=RGS10 is a selective activator of G alpha i GTPase activity |journal=[[Nature (journal)|Nature]] |volume=383 |issue=6596 |pages=175–7 |publisher= |location = ENGLAND| issn = 0028-0836| pmid = 8774883 |doi = 10.1038/383175a0 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[RGS5]].<ref name=pmid9079700/><ref name=pmid11253162>{{cite journal |doi=10.1016/S0024-3205(01)00939-0 |last=Zhou |first=J |authorlink= |author2=Moroi K |author3=Nishiyama M |author4=Usui H |author5=Seki N |author6=Ishida J |author7=Fukamizu A |author8=Kimura S |date=Feb 2001 |title=Characterization of RGS5 in regulation of G protein-coupled receptor signaling |journal=Life Sci. |volume=68 |issue=13 |pages=1457–69 |publisher= |location = England| issn = 0024-3205| pmid = 11253162 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==See also==
==See also==

Revision as of 07:03, 14 May 2014

Template:PBB Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.[1][2]

Template:PBB Summary

Interactions

GNAI3 has been shown to interact with RGS14,[3] RIC8A,[4] RGS18,[5][6] S1PR1,[7] RGS12,[3] RGS16,[8][9] RGS19,[10][11][12] RGS10[13] and RGS5.[8][14]

See also

References

  1. ^ Didsbury JR, Snyderman R (Aug 1987). "Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families". FEBS Lett. 219 (1): 259–63. doi:10.1016/0014-5793(87)81228-0. PMID 3109953.
  2. ^ "Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3".
  3. ^ a b Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31). United States: 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
  4. ^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10). United States: 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
  5. ^ Yowe, D (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". Biochem. J. 359 (Pt 1). England: 109–18. doi:10.1042/0264-6021:3590109. ISSN 0264-6021. PMC 1222126. PMID 11563974. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  6. ^ Gagnon, Alison W; Murray David L; Leadley Robert J (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cell. Signal. 14 (7). England: 595–606. doi:10.1016/S0898-6568(02)00012-8. ISSN 0898-6568. PMID 11955952. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
  7. ^ Lee, M J; Evans M; Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. 271 (19). UNITED STATES: 11272–9. doi:10.1074/jbc.271.19.11272. ISSN 0021-9258. PMID 8626678. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
  8. ^ a b Chen, C; Zheng B; Han J; Lin S C (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. 272 (13). UNITED STATES: 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
  9. ^ Beadling, C; Druey K M; Richter G; Kehrl J H; Smith K A (Mar 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". J. Immunol. 162 (5). UNITED STATES: 2677–82. ISSN 0022-1767. PMID 10072511. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  10. ^ De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26). UNITED STATES: 15203–8. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  11. ^ Woulfe, D S; Stadel J M (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. 274 (25). UNITED STATES: 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
  12. ^ De Vries, L; Mousli M; Wurmser A; Farquhar M G (Dec 1995). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc. Natl. Acad. Sci. U.S.A. 92 (25). UNITED STATES: 11916–20. doi:10.1073/pnas.92.25.11916. ISSN 0027-8424. PMC 40514. PMID 8524874. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  13. ^ Hunt, T W; Fields T A; Casey P J; Peralta E G (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596). ENGLAND: 175–7. doi:10.1038/383175a0. ISSN 0028-0836. PMID 8774883. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  14. ^ Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (Feb 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. 68 (13). England: 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Further reading

Template:PBB Further reading

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