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This is a list of '''confirmed longevity genes''' from [[model organism|model animals]].
{{wikify-date|May 2006}}
==Confirmed Longevity Genes From Model Animals==
<table>
<table>
<tr><td>'''Podospora'''</td><td>'''Saccharomyces'''</td><td>'''Caenorhabditis'''</td><td>'''Drosophila'''</td><td>'''Mouse'''</td></tr>
<tr><td>''Podospora''</td><td>''Saccharomyces''</td><td>''Caenorhabditis''</td><td>''Drosophila''</td><td>Mouse</td></tr>
<tr><td>''grisea''</td><td>LAG1</td><td>daf-2</td><td>sod1</td><td>Prop-1</td></tr>
<tr><td>''grisea''</td><td>[[LAG1]]</td><td>[[daf-2]]</td><td>[[sod1]]</td><td>[[Prop-1]]</td></tr>
<tr><td></td><td>LAC1</td><td>age-1/daf-23</td><td>cat1</td><td>p66shc</td></tr>
<tr><td></td><td>[[LAC1]]</td><td>[[age-1]]/[[daf-23]]</td><td>[[cat1]]</td><td>[[p66shc]]</td></tr>
<tr><td></td><td>RAS1</td><td>daf-18</td><td>mth</td><td></td></tr>
<tr><td></td><td>[[RAS1]]</td><td>[[daf-18]]</td><td>[[mth]]</td><td>[[mclk1]]</td></tr>
<tr><td></td><td>RAS2</td><td>akt-1/akt-2</td><td></td><td></td></tr>
<tr><td></td><td>[[RAS2]]</td><td>[[akt-1]]/[[akt-2]]</td><td></td><td></td></tr>
<tr><td></td><td>PHB1</td><td>daf-16</td><td></td><td></td></tr>
<tr><td></td><td>[[PHB1]]</td><td>[[daf-16]]</td><td></td><td></td></tr>
<tr><td></td><td>PHB2</td><td>daf-12</td><td></td><td></td></tr>
<tr><td></td><td>[[PHB2]]</td><td>[[daf-12]]</td><td></td><td></td></tr>
<tr><td></td><td>CDC7</td><td>ctl-1</td><td></td><td></td></tr>
<tr><td></td><td>[[CDC7]]</td><td>[[ctl-1]]</td><td></td><td></td></tr>
<tr><td></td><td>BUD1</td><td>old-1</td><td></td><td></td></tr>
<tr><td></td><td>[[BUD1]]</td><td>[[old-1]]</td><td></td><td></td></tr>
<tr><td></td><td>RTG2</td><td>spe-26</td><td></td><td></td></tr>
<tr><td></td><td>[[RTG2]]</td><td>[[spe-26]]</td><td></td><td></td></tr>
<tr><td></td><td>RPD3</td><td>clk-1</td><td></td><td></td></tr>
<tr><td></td><td>RPD3</td><td>[[clk-1]]</td><td></td><td></td></tr>
<tr><td></td><td>HDA1</td><td>mev-1</td><td></td><td></td></tr>
<tr><td></td><td>HDA1</td><td>[[mev-1]]</td><td></td><td></td></tr>
<tr><td></td><td>SIR2</td><td></td><td></td><td></td></tr>
<tr><td></td><td>[[SIR2]]</td><td></td><td></td><td></td></tr>
<tr><td></td><td>SIR4-42</td><td></td><td></td><td></td></tr>
<tr><td></td><td>SIR4-42</td><td></td><td></td><td></td></tr>
<tr><td></td><td>UTH4</td><td></td><td></td><td></td></tr>
<tr><td></td><td>UTH4</td><td></td><td></td><td></td></tr>
<tr><td></td><td>YGL023</td><td></td><td></td><td></td></tr>
<tr><td></td><td>YGL023</td><td></td><td></td><td></td></tr>
<tr><td></td><td>SGS1</td><td></td><td></td><td></td></tr>
<tr><td></td><td>SGS1</td><td></td><td></td><td></td></tr>
<tr><td></td><td>RAD52</td><td></td><td></td><td></td></tr>
<tr><td></td><td>[[RAD52]]</td><td></td><td></td><td></td></tr>
<tr><td></td><td>FOB1</td><td></td><td></td><td></td></tr>
<tr><td></td><td>FOB1</td><td></td><td></td><td></td></tr>
</table>
</table>
The major genetic model organisms used in aging research are the filamentous fungus ('Podospora anserina'), bakers' yeast ('Saccharomyces cerevisiae'), the soil roundworm ('Caenorhabditis elegans'), the fruit fly ('Drosophila melanogaster'), and the mouse ('Mus musculus').
The major genetic model organisms used in aging research are the filamentous fungus (''[[Podospora anserina]]''), bakers' yeast (''[[Saccharomyces cerevisiae]]'), the soil roundworm (''[[Caenorhabditis elegans]]''), the fruit fly (''[[Drosophila melanogaster]]''), and the mouse (''[[Mus musculus]]'').


==See also==
==See also==
* [[List of life extension related topics]]
*[[Senescence]]
*[[List of life extension related topics]]


==External links==
==External links==
*[http://www.sciam.com/article.cfm?chanID=sa006&articleID=000B73EB-3380-13F6-B38083414B7F0000 Scientific American Magazine (March 2006 Issue) Unlocking the Secrets of Longevity Genes]
*[http://www.sciam.com/article.cfm?chanID=sa006&articleID=000B73EB-3380-13F6-B38083414B7F0000 Scientific American Magazine (March 2006 Issue) Unlocking the Secrets of Longevity Genes]
[[Category:Aging]]

Revision as of 20:20, 1 September 2006

This is a list of confirmed longevity genes from model animals.

PodosporaSaccharomycesCaenorhabditisDrosophilaMouse
griseaLAG1daf-2sod1Prop-1
LAC1age-1/daf-23cat1p66shc
RAS1daf-18mthmclk1
RAS2akt-1/akt-2
PHB1daf-16
PHB2daf-12
CDC7ctl-1
BUD1old-1
RTG2spe-26
RPD3clk-1
HDA1mev-1
SIR2
SIR4-42
UTH4
YGL023
SGS1
RAD52
FOB1

The major genetic model organisms used in aging research are the filamentous fungus (Podospora anserina), bakers' yeast (Saccharomyces cerevisiae'), the soil roundworm (Caenorhabditis elegans), the fruit fly (Drosophila melanogaster), and the mouse (Mus musculus).

See also