REV1: Difference between revisions
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'''DNA repair protein REV1''' is a [[protein]] that in humans is encoded by the ''REV1'' [[gene]].<ref name="pmid10536157">{{cite journal | author = Lin W, Xin H, Zhang Y, Wu X, Yuan F, Wang Z | title = The human REV1 gene codes for a DNA template-dependent dCMP transferase | journal = Nucleic Acids Res | volume = 27 | issue = 22 | pages = 4468–75 |date=Dec 1999 | pmid = 10536157 | pmc = 148731 | doi =10.1093/nar/27.22.4468 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: REV1 REV1 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51455| accessdate = }}</ref> <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> |
'''DNA repair protein REV1''' is a [[protein]] that in humans is encoded by the ''REV1'' [[gene]].<ref name="pmid10536157">{{cite journal | author = Lin W, Xin H, Zhang Y, Wu X, Yuan F, Wang Z | title = The human REV1 gene codes for a DNA template-dependent dCMP transferase | journal = Nucleic Acids Res | volume = 27 | issue = 22 | pages = 4468–75 |date=Dec 1999 | pmid = 10536157 | pmc = 148731 | doi =10.1093/nar/27.22.4468 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: REV1 REV1 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51455| accessdate = }}</ref> <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> |
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Revision as of 13:44, 20 May 2016
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | REV1, REV1L, AIBP80, DNA directed polymerase, REV1 DNA directed polymerase | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606134; MGI: 1929074; HomoloGene: 32309; GeneCards: REV1; OMA:REV1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.[5][6] Template:PBB Summary Rev1 is a Y family DNA polymerase; it is sometimes referred to as a deoxycytidyl transferase because it only inserts deoxycytidine (dC) across from lesions. Whether G, A, T, C, or an abasic site, Rev1 will always add a C. Rev1 has the ability to always add a C, because it uses an arginine as a template which complements well with C.[7] Yet it is believed[by whom?] that Rev1 rarely uses its polymerase activity, rather it is thought that Rev1's primary role is as a protein landing pad, whereby it helps direct the recruitment of TLS proteins, especially Pol ζ (Rev3/Rev7).
Interactions
REV1 has been shown to interact with MAD2L2.[8] It is believed that Rev1 may interact with PCNA, once ubiquitylated due to a lesion, and help recruit Pol ζ (Rev3/Rev7) a B family polymerase involved in TLS.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000135945 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026082 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lin W, Xin H, Zhang Y, Wu X, Yuan F, Wang Z (Dec 1999). "The human REV1 gene codes for a DNA template-dependent dCMP transferase". Nucleic Acids Res. 27 (22): 4468–75. doi:10.1093/nar/27.22.4468. PMC 148731. PMID 10536157.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: REV1 REV1 homolog (S. cerevisiae)".
- ^ Nair, DT (Sep 30, 2005). "Rev1 employs a novel mechanism of DNA synthesis using a protein template". Science. doi:10.1126/science.1116336. PMID 16195463. Retrieved Feb 6, 2015.
- ^ Murakumo, Y; Ogura Y; Ishii H; Numata S; Ichihara M; Croce C M; Fishel R; Takahashi M (September 2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38). United States: 35644–51. doi:10.1074/jbc.M102051200. ISSN 0021-9258. PMID 11485998.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysource=, and|laysummary=(help)CS1 maint: unflagged free DOI (link)
Further reading
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