Benperidol: Difference between revisions
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[[File:Benperidol synthesis.svg|thumb|center|500px|Benperidol synthesis:<ref>{{Cite patent|BE|626307}} (1963 to Janssen), C.A. 60, 10690c (1964), corresp. to {{cite patent|GB|989755}}.</ref>]] |
[[File:Benperidol synthesis.svg|thumb|center|500px|Benperidol synthesis:<ref>{{Cite patent|BE|626307}} (1963 to Janssen), C.A. 60, 10690c (1964), corresp. to {{cite patent|GB|989755}}.</ref>]] |
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==See also== |
==See also== |
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*[[Timiperone]] has the same structure but thiourea instead of normal urea. |
*[[Timiperone]] has the same structure but thiourea instead of normal urea. |
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*[[Pimozide]] & [[Oxiperomide]] & [[Neflumozide]] are also made from 4-(1-Benzimidazolinone)piperidine prec. |
*[[Pimozide]] & [[Oxiperomide]] & [[Neflumozide]] are also made from 4-(1-Benzimidazolinone)piperidine prec. |
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*[[Droperidol]] is self-same albeit unsaturation in the piperidine ring. |
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== References == |
== References == |
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Revision as of 16:04, 25 June 2016
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| Clinical data | |
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.016.521 |
| Chemical and physical data | |
| Formula | C22H24FN3O2 |
| Molar mass | 381.443 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Benperidol is a drug which is a highly potent butyrophenone derivative. It is the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).[1] It is an antipsychotic, which can be used for the treatment of schizophrenia,[2] but it is primarily used to control antisocial hypersexual behaviour,[3] and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone acetate.[4]
Benperidol was discovered at Janssen Pharmaceutica in 1961.
Synthesis
See also
- Timiperone has the same structure but thiourea instead of normal urea.
- Pimozide & Oxiperomide & Neflumozide are also made from 4-(1-Benzimidazolinone)piperidine prec.
- Droperidol is self-same albeit unsaturation in the piperidine ring.
References
- ^ Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)
- ^ Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.
- ^ British National Formulary (49th), British Medical Association 2005 p 183
- ^ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.
- ^ BE 626307 (1963 to Janssen), C.A. 60, 10690c (1964), corresp. to GB 989755.
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