Talk:Xylometazoline

Untitled

"1% w/v xylometazoline" dose?! My spray (ratiopharm NasenSpray) is a 0.1 % solution - maybe the figure is wrong in the article? Also, i don't understand the concept of drug resistance to xylmetazoline - as it does the same as adrenaline, a person with high adrenaline production should have chronic nose congestion as well.

actually, if you took xylometazoline too long, and you get chronic congestion, will the chronic congestion fade away after some time?

Thanks, --Abdull 17:48, 10 Jun 2005 (UTC)

The question should be why is there congestion in the first place? and why would any sane person use a drug to remove the sympton for a short while only to make it worst in the future?

I read somewhere that a lack of water in the body is one thing that affects allergies so drinking more water should help. —Preceding unsigned comment added by 195.157.148.189 (talk) 12:21, 27 November 2007 (UTC)

I'd like to bring up the point about resistance to Xylometazoline too. I have a relative thathas been using Otrivine day-to-day for the past couple of years, without decreased effectiveness. I do not understand why the number of receptors would decrease after prologned usage. " Prolonged use of xylometazoline may result in tolerance or a decreased effect of the drug. Both a decrease in the decongestant duration and effect occurs possibly due to receptor down-regulation" source. The article implies that in all cases the vessel becomes resistant (because of the omission of 'can'). This really needs to be cleared up and sourced. Balazsh (talk) 09:34, 15 January 2008 (UTC)

Seeing as how no-one has changed the article, I added the source and modified the language of the article to reflect what I have said above. BalazsH (talk) 14:55, 20 February 2008 (UTC)

Mechanism of action

While the article does describe the mechanism by which xylometazoline exerts its effects on a macroscopic scale, there is no mention at all of receptor action. This article definitely needs at least a cursory mention of whether xylometazoline affects the sigma, NMDA, opioid, or other receptor(s), and other pharmacodynamic and pharmacokinetic information would be great too. it's not in my edition of the PDR or I'd add what I could. Mr0t1633 (talk) 12:27, 2 July 2008 (UTC)

some joker obviously changed the half-life to >10 seconds. i suppose its meant to be >10 hours, or i would have to sniff permanentely. lg — Preceding unsigned comment added by 91.113.175.198 (talk) 14:29, 27 March 2013 (UTC)

Long Term Use

Apart from Rebound Rhinitis medicamentosa, which I have most certainly suffered, I would really appreciate it if anyone could find anything out about any other side effects from long term use of Xylometazoline or Oxymetazoline. I have been using it a lot recently and I am worried that there may be other consequences from using this since it is a vasoconstrictor, and while I know the effect is local, could long term use pose a risk to constricting other vessels? If I am using it often then it must be in my blood even in small amounts. I use it once every 24 hours at night and I don't use the full metered dose, in fact I use maybe ¼ of a full metered dose.

I have tried searching on Google for this but thus far have found little information apart from "not suitable for long term use because of Rebound Rhinitis" or words to that effect. I know this isn't a place for individual medical advice however I believe it would add to the article if there are other possible consequences from long term use. — Preceding unsigned comment added by 86.0.201.161 (talk) 13:17, 6 June 2013 (UTC)

Moved from article

I have moved the following content here because it lacks context/explanation. If anyone wants to use it to improve the article, here it is. -- Ed (Edgar181) 20:17, 8 October 2015 (UTC)

[[File:Xylometazoline synthesis.png|600px|center]] *H. Albrecht, {{US Patent|2868802}} (1959). *H. Albrecht, {{Cite patent|DE|1049387}} (1957).

Banned in the US

Despite it being more effective and not causing rebound rhinitis like oxymetazoline, this drug was banned in the United State USP but is still available for purchase from other countries through Amazon and other online retailers. — Preceding unsigned comment added by 2602:63:C3E6:4400:C42A:BB64:3BEB:44F2 (talk) 15:28, 10 November 2016 (UTC)