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The '''lymphatic endothelium''' is a specialised form of [[epithelium]], distinct from but similar to [[endothelium|vascular endothelium]]. A [[lymph]] [[capillary]] endothelial cell is distinct from other endothelial cells in that [[collagen fiber]]s are directly attached to its [[plasma membrane]].
The '''lymphatic endothelium''' is a specialised form of [[epithelium]], distinct from but similar to [[endothelium|vascular endothelium]]. A [[lymph]] [[capillary]] endothelial cell is distinct from other endothelial cells in that [[collagen fiber]]s are directly attached to its [[plasma membrane]].


Although [[lymphatic]]s were first described by [[Hippocrates]] in 400BC and rediscovered as "milky veins in the gut of a well fed dog" in the 17th century by [[Gasparo Aselli]], they were ignored for centuries until in 1937 [[Howard Florey]] showed that lymphatics enlarge in inflammation. At this stage vascular and lymphatic endothelia were seen to be morphologically distinct and lymphatic vessels considered less important. Later it was discovered that [[VEGF-R3]] and [[VEGF-C]]/[[VEGF-D]] were the key growth factors controlling lymphatic endothelial proliferation. Markers of lymphatic endolthelium were not discovered until relatively recently. These being [[LYVE-1]] (Jackson et al.,1999)<ref name="J.Cell Biol">{{cite journal | title = J.Cell Biol: LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan 1| journal = The Journal of Cell Biology| volume = 144| issue = 4| pages = 789–801| doi = 10.1083/jcb.144.4.789| year = 1999| last1 = Banerji| first1 = Suneale| last2 = Ni| first2 = Jian| last3 = Wang| first3 = Shu-Xia| last4 = Clasper| first4 = Steven| last5 = Su| first5 = Jeffrey| last6 = Tammi| first6 = Raija| last7 = Jones| first7 = Margaret| last8 = Jackson| first8 = David G.}}</ref> and [[PDPN|podoplanin]] (Kerjaschki,1999).<ref name="American Journal of Pathology">{{cite web | title = Am. J. Pathol: Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic andothelium 2| url = http://ajp.amjpathol.org/cgi/content/full/154/2/385?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&titleabstract=Angiosarcomas+express+mixed+endothelial+phenotypes+of+blood+and+lymphatic+capill&searchid=1&FIRSTINDEX=0&firstpage=385&fdate=1/1/1999&tdate=12/31/1999&resourcetype=HWCIT| accessdate = }}</ref>
Although [[lymphatic]]s were first described by [[Hippocrates]] in 400BC and rediscovered as "milky veins in the gut of a well fed dog" in the 17th century by [[Gasparo Aselli]], they were ignored for centuries until in 1937 [[Howard Florey]] showed that lymphatics enlarge in inflammation. At this stage vascular and lymphatic endothelia were seen to be morphologically distinct and lymphatic vessels considered less important. Later it was discovered that [[VEGF-R3]] and [[VEGF-C]]/[[VEGF-D]] were the key growth factors controlling lymphatic endothelial proliferation. Markers of lymphatic endolthelium were not discovered until relatively recently. These being [[LYVE-1]] (Jackson et al.,1999)<ref name="J.Cell Biol">{{cite journal | title = J.Cell Biol: LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan 1| journal = The Journal of Cell Biology| volume = 144| issue = 4| pages = 789–801| doi = 10.1083/jcb.144.4.789| year = 1999| last1 = Banerji| first1 = Suneale| last2 = Ni| first2 = Jian| last3 = Wang| first3 = Shu-Xia| last4 = Clasper| first4 = Steven| last5 = Su| first5 = Jeffrey| last6 = Tammi| first6 = Raija| last7 = Jones| first7 = Margaret| last8 = Jackson| first8 = David G.| pmid = 10037799| pmc = 2132933}}</ref> and [[PDPN|podoplanin]] (Kerjaschki,1999).<ref name="American Journal of Pathology">{{cite web | title = Am. J. Pathol: Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic andothelium 2| url = http://ajp.amjpathol.org/cgi/content/full/154/2/385?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&titleabstract=Angiosarcomas+express+mixed+endothelial+phenotypes+of+blood+and+lymphatic+capill&searchid=1&FIRSTINDEX=0&firstpage=385&fdate=1/1/1999&tdate=12/31/1999&resourcetype=HWCIT| accessdate = }}</ref>


==See also==
==See also==

Revision as of 09:02, 16 February 2020

The lymphatic endothelium is a specialised form of epithelium, distinct from but similar to vascular endothelium. A lymph capillary endothelial cell is distinct from other endothelial cells in that collagen fibers are directly attached to its plasma membrane.

Although lymphatics were first described by Hippocrates in 400BC and rediscovered as "milky veins in the gut of a well fed dog" in the 17th century by Gasparo Aselli, they were ignored for centuries until in 1937 Howard Florey showed that lymphatics enlarge in inflammation. At this stage vascular and lymphatic endothelia were seen to be morphologically distinct and lymphatic vessels considered less important. Later it was discovered that VEGF-R3 and VEGF-C/VEGF-D were the key growth factors controlling lymphatic endothelial proliferation. Markers of lymphatic endolthelium were not discovered until relatively recently. These being LYVE-1 (Jackson et al.,1999)[1] and podoplanin (Kerjaschki,1999).[2]

See also

Endothelium

References

  1. ^ Banerji, Suneale; Ni, Jian; Wang, Shu-Xia; Clasper, Steven; Su, Jeffrey; Tammi, Raija; Jones, Margaret; Jackson, David G. (1999). "J.Cell Biol: LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan 1". The Journal of Cell Biology. 144 (4): 789–801. doi:10.1083/jcb.144.4.789. PMC 2132933. PMID 10037799.
  2. ^ "Am. J. Pathol: Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic andothelium 2".

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