Spark Therapeutics: Difference between revisions
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Revision as of 06:54, 19 December 2019
Company type | Subsidiary |
---|---|
Industry | Biotechnology, Pharmaceutical |
Founded | 2013Philadelphia, Pennsylvania, United States of America | in
Founders | Jeffrey Marrazzo, Katherine High |
Headquarters | , |
Parent | Hoffmann-La Roche |
Website | sparktx |
Spark Therapeutics is a startup pharmaceutical company that develops gene therapies.[1][2][3] It was founded in 2013 by Katherine High and Jeffrey Marrazzo in an effort to commercially develop treatments against haemophilia that High was working on at Children's Hospital of Philadelphia.[4]
In February 2019, Roche announced it would acquire the company for $4.3 billion ($114.50 per share).[5][6] In December 2019, the transaction was completed.[7]
Products and pipeline
Voretigene neparvovec
Voretigene neparvovec, marketed under the tradename Luxturna, is a gene therapy approved by the Food and Drug Administration for treatment of Leber's congenital amaurosis, a rare genetic eye disease.[8]
Fidanacogene elaparvovec
Fidanacogene elaparvovec, previously known by its study ID number SPK-9001,[9] is an experimental drug under investigation for treatment of hemophilia B. Spark partnered with pharmaceutical giant Pfizer to develop fidanacogene elaparvovec.[2] Fidanacogene elaparvovec is an adeno-associated viral vector which is designed to transfer a working copy of the Factor IX gene into the livers of patients who carry non-functioning copies.[10] In July 2018, Pfizer said fidanacogene elaparvovec was entering late stage clinical trials.[11]
SPK-8011
SPK-8011 is an experimental drug under investigation for treatment of hemophilia A. It is entering phase III clinical trials in the United States. The therapy transfers a working copy of the Factor VIII gene into patients who lack one. In Phase II clinical trials, 2 of 7 patients receiving the highest dose of the drug suffered immune responses. One patient had to be hospitalized. The reactions against the treatment were seen as a set back, though Spark suggested that the responses could be controlled with steroids, and promised to move forward with Phase III testing.[12][13]
SPK-7001
SPK-7001 is an experimental drug under investigation for treatment of choroideremia, a genetic disorder that causes blindness.[14]
SPK-3006
SPK-3006 is an experimental drug under investigation for treatment of Pompe disease, a genetic disorder that leads to failure to correctly metabolize glycogen.[14]
SPK-1001
SPK-1001 is an experimental drug under investigation for treatment of Batten disease, a fatal genetic, nervous system disorder.[14]
References
- ^ "Spark Therapeutics reports 3Q loss". Associated Press. 7 November 2017. Retrieved 16 November 2017.
- ^ a b George, John (7 November 2017). "Spark, Pfizer amend agreement for experimental hemophilia gene therapy". Philadelphia Business Journal. Retrieved 16 November 2017.
- ^ Marchione, Marilynn (10 October 2017). "A gene therapy that could cure blindness is on the brink of getting approved". Business Insider. Retrieved 16 November 2017.
- ^ Crow, David (19 October 2017). "Gene therapy helped these children see. Can it transform medicine?". Financial Times. Retrieved 16 November 2017.
- ^ "Roche 'steps up' for gene therapy with $4.3 billion Spark bet". 25 February 2019 – via uk.reuters.com.
- ^ Grover, Natalie (25 October 2019). "UPDATED: FTC staff signs off on Roche $4.3B deal for Spark — report". EndpointNews.
{{cite web}}
: no-break space character in|title=
at position 61 (help) - ^ "Roche completes $4.3B purchase of Philadelphia gene therapy pioneer Spark Therapeutics". 17 December 2019.
- ^ "FDA approves novel gene therapy to treat patients with a rare form of inherited vision loss". FDA. 19 Dec 2017. Retrieved 20 Dec 2017.
- ^ "Pfizer Initiates Pivotal Phase 3 Program for Investigational Hemophilia B Gene Therapy" (Press release). Pfizer. 16 July 2018. Retrieved 2018-07-18.
- ^ Lindsey, George (1 December 2016). "Spk-9001: Adeno-Associated Virus Mediated Gene Transfer for Hemophilia B Achieves Sustained Mean Factor IX Activity Levels of >30% without Immunosuppression". Blood. 128 (22): 3. doi:10.1182/blood.V128.22.3.3. Retrieved 16 November 2017.
- ^ George, John (16 July 2018). "Pfizer begins late-stage testing of Spark's hemophilia B gene therapy". Philadelphia Business Journal. Retrieved 18 July 2018.
- ^ Garde, Damian (7 August 2018). "Spark's gene therapy data answer some burning questions — and raise a few more". Stat. Retrieved 7 August 2018.
- ^ Tirrell, Meg (7 August 2018). "Spark Therapeutics shares lose a third of their value as hemophilia gene therapy trial disappoints investors". CNBC. Retrieved 7 August 2018.
- ^ a b c Morrison, Chris (5 March 2019). "Spark's meteoric rise from hospital-funded spinout to $4.8 billion deal". Nature Biotechnology. Retrieved 8 February 2019.
External links
- Biotechnology companies of the United States
- Haemophilia
- Pharmaceutical companies established in 2013
- Biotechnology companies established in 2013
- 2013 establishments in Pennsylvania
- Companies based in Philadelphia
- Health care companies based in Pennsylvania
- Virotherapy
- Companies formerly listed on NASDAQ
- 2015 initial public offerings
- 2019 mergers and acquisitions
- Hoffmann-La Roche
- American subsidiaries of foreign companies
- United States company stubs
- Medical company stubs