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{{For|the female-specific protein transformer gene in Drosophila melanogaster|Tra (gene)}} |
{{For|the female-specific protein transformer gene in Drosophila melanogaster|Tra (gene)}} |
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{{Infobox_gene}} |
{{Infobox_gene}} |
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'''T-cell receptor alpha locus''' is a [[protein]] that in humans is encoded by the '''TRA''' [[gene]], also known as TCRA or TRA@.<ref name="pmid3875152">{{cite journal |vauthors=Erikson J, Williams DL, Finan J, Nowell PC, Croce CM | title = Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias | journal = Science | volume = 229 | issue = 4715 | pages = 784–6 |date=Sep 1985 | pmid = 3875152 | pmc = | doi =10.1126/science.3875152 }}</ref><ref name="pmid3875483">{{cite journal |vauthors=Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN | title = The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia | journal = EMBO J | volume = 4 | issue = 6 | pages = 1461–5 |date=Oct 1985 | pmid = 3875483 | pmc = 554368 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRA@ T cell receptor alpha locus| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6955| accessdate = }}</ref> It contributes the alpha chain to the larger TCR protein ([[T-cell receptor]]). |
'''T-cell receptor alpha locus''' is a [[protein]] that in humans is encoded by the '''TRA''' [[gene]], also known as TCRA or TRA@.<ref name="pmid3875152">{{cite journal |vauthors=Erikson J, Williams DL, Finan J, Nowell PC, Croce CM | title = Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias | journal = Science | volume = 229 | issue = 4715 | pages = 784–6 |date=Sep 1985 | pmid = 3875152 | pmc = | doi =10.1126/science.3875152 | bibcode = 1985Sci...229..784E }}</ref><ref name="pmid3875483">{{cite journal |vauthors=Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN | title = The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia | journal = EMBO J | volume = 4 | issue = 6 | pages = 1461–5 |date=Oct 1985 | pmid = 3875483 | pmc = 554368 | doi = 10.1002/j.1460-2075.1985.tb03803.x}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRA@ T cell receptor alpha locus| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6955| accessdate = }}</ref> It contributes the alpha chain to the larger TCR protein ([[T-cell receptor]]). |
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*{{cite journal |vauthors=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=10.1101/gad.5.5.880 |doi-access=free }} |
*{{cite journal |vauthors=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=10.1101/gad.5.5.880 |doi-access=free }} |
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*{{cite journal |vauthors=Koning F, Maloy WL, Coligan JE |title=The implications of subunit interactions for the structure of the T cell receptor-CD3 complex |journal=Eur. J. Immunol. |volume=20 |issue= 2 |pages= 299–305 |year= 1990 |pmid= 2138083 |doi=10.1002/eji.1830200211 }} |
*{{cite journal |vauthors=Koning F, Maloy WL, Coligan JE |title=The implications of subunit interactions for the structure of the T cell receptor-CD3 complex |journal=Eur. J. Immunol. |volume=20 |issue= 2 |pages= 299–305 |year= 1990 |pmid= 2138083 |doi=10.1002/eji.1830200211 }} |
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*{{cite journal | author=Dyer MJ |title=T-cell receptor delta/alpha rearrangements in lymphoid neoplasms |journal=Blood |volume=74 |issue= 3 |pages= 1073–83 |year= 1989 |pmid= 2546634 |doi= }} |
*{{cite journal | author=Dyer MJ |title=T-cell receptor delta/alpha rearrangements in lymphoid neoplasms |journal=Blood |volume=74 |issue= 3 |pages= 1073–83 |year= 1989 |pmid= 2546634 |doi= 10.1182/blood.V74.3.1073.1073}} |
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*{{cite journal |vauthors=Chilson OP, Kelly-Chilson AE |title=Mitogenic lectins bind to the antigen receptor on human lymphocytes |journal=Eur. J. Immunol. |volume=19 |issue= 2 |pages= 389–96 |year= 1989 |pmid= 2703017 |doi=10.1002/eji.1830190225 }} |
*{{cite journal |vauthors=Chilson OP, Kelly-Chilson AE |title=Mitogenic lectins bind to the antigen receptor on human lymphocytes |journal=Eur. J. Immunol. |volume=19 |issue= 2 |pages= 389–96 |year= 1989 |pmid= 2703017 |doi=10.1002/eji.1830190225 }} |
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*{{cite journal | author=Yanagi Y |title=Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 10 |pages= 3430–4 |year= 1985 |pmid= 3873654 |doi=10.1073/pnas.82.10.3430 | pmc=397789 |name-list-format=vanc| author2=Chan A | author3=Chin B | display-authors=3 | last4=Minden | first4=M | last5=Mak | first5=TW }} |
*{{cite journal | author=Yanagi Y |title=Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 10 |pages= 3430–4 |year= 1985 |pmid= 3873654 |doi=10.1073/pnas.82.10.3430 | pmc=397789 |name-list-format=vanc| author2=Chan A | author3=Chin B | display-authors=3 | last4=Minden | first4=M | last5=Mak | first5=TW |bibcode=1985PNAS...82.3430Y }} |
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*{{cite journal | author=Sim GK |title=Primary structure of human T-cell receptor alpha-chain |journal=Nature |volume=312 |issue= 5996 |pages= 771–5 |year= 1985 |pmid= 6440030 |doi=10.1038/312771a0 |name-list-format=vanc| author2=Yagüe J | author3=Nelson J | display-authors=3 | last4=Marrack | first4=Philippa | last5=Palmer | first5=Edward | last6=Augustin | first6=Andrei | last7=Kappler | first7=John }} |
*{{cite journal | author=Sim GK |title=Primary structure of human T-cell receptor alpha-chain |journal=Nature |volume=312 |issue= 5996 |pages= 771–5 |year= 1985 |pmid= 6440030 |doi=10.1038/312771a0 |name-list-format=vanc| author2=Yagüe J | author3=Nelson J | display-authors=3 | last4=Marrack | first4=Philippa | last5=Palmer | first5=Edward | last6=Augustin | first6=Andrei | last7=Kappler | first7=John |s2cid=4350315 }} |
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*{{cite journal |vauthors=Kearse KP, Roberts JL, Singer A |title=TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes |journal=Immunity |volume=2 |issue= 4 |pages= 391–9 |year= 1995 |pmid= 7719941 |doi= 10.1016/1074-7613(95)90147-7 }} |
*{{cite journal |vauthors=Kearse KP, Roberts JL, Singer A |title=TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes |journal=Immunity |volume=2 |issue= 4 |pages= 391–9 |year= 1995 |pmid= 7719941 |doi= 10.1016/1074-7613(95)90147-7 }} |
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*{{cite journal |vauthors=Manolios N, Kemp O, Li ZG |title=The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains |journal=Eur. J. Immunol. |volume=24 |issue= 1 |pages= 84–92 |year= 1994 |pmid= 8020575 |doi=10.1002/eji.1830240114 }} |
*{{cite journal |vauthors=Manolios N, Kemp O, Li ZG |title=The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains |journal=Eur. J. Immunol. |volume=24 |issue= 1 |pages= 84–92 |year= 1994 |pmid= 8020575 |doi=10.1002/eji.1830240114 }} |
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Revision as of 02:35, 9 September 2020
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | TRA, IMD7, TCRA, TRA@, TRAC, T-cell receptor alpha locus, TCRD, T cell receptor alpha locus | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | GeneCards: TRA; OMA:TRA - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@.[2][3][4] It contributes the alpha chain to the larger TCR protein (T-cell receptor).
References
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Erikson J, Williams DL, Finan J, Nowell PC, Croce CM (Sep 1985). "Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias". Science. 229 (4715): 784–6. Bibcode:1985Sci...229..784E. doi:10.1126/science.3875152. PMID 3875152.
- ^ Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN (Oct 1985). "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia". EMBO J. 4 (6): 1461–5. doi:10.1002/j.1460-2075.1985.tb03803.x. PMC 554368. PMID 3875483.
- ^ "Entrez Gene: TRA@ T cell receptor alpha locus".
Further reading
- Kenwrick S; Levinson B; Taylor S; et al. (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Suzuki CK; Bonifacino JS; Lin AY; et al. (1991). "Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP". J. Cell Biol. 114 (2): 189–205. doi:10.1083/jcb.114.2.189. PMC 2289081. PMID 1649196.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Travis A, Amsterdam A, Belanger C, Grosschedl R (1991). "LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]". Genes Dev. 5 (5): 880–94. doi:10.1101/gad.5.5.880. PMID 1827423.
- Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083.
- Dyer MJ (1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms". Blood. 74 (3): 1073–83. doi:10.1182/blood.V74.3.1073.1073. PMID 2546634.
- Chilson OP, Kelly-Chilson AE (1989). "Mitogenic lectins bind to the antigen receptor on human lymphocytes". Eur. J. Immunol. 19 (2): 389–96. doi:10.1002/eji.1830190225. PMID 2703017.
- Yanagi Y; Chan A; Chin B; et al. (1985). "Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line". Proc. Natl. Acad. Sci. U.S.A. 82 (10): 3430–4. Bibcode:1985PNAS...82.3430Y. doi:10.1073/pnas.82.10.3430. PMC 397789. PMID 3873654.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Sim GK; Yagüe J; Nelson J; et al. (1985). "Primary structure of human T-cell receptor alpha-chain". Nature. 312 (5996): 771–5. doi:10.1038/312771a0. PMID 6440030. S2CID 4350315.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Kearse KP, Roberts JL, Singer A (1995). "TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes". Immunity. 2 (4): 391–9. doi:10.1016/1074-7613(95)90147-7. PMID 7719941.
- Manolios N, Kemp O, Li ZG (1994). "The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains". Eur. J. Immunol. 24 (1): 84–92. doi:10.1002/eji.1830240114. PMID 8020575.
- Bagga R, Emerson BM (1997). "An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro". Genes Dev. 11 (5): 629–39. doi:10.1101/gad.11.5.629. PMID 9119227.
- San José E, Sahuquillo AG, Bragado R, Alarcón B (1998). "Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model". Eur. J. Immunol. 28 (1): 12–21. doi:10.1002/(SICI)1521-4141(199801)28:01<12::AID-IMMU12>3.0.CO;2-9. PMID 9485181.
- Ding YH; Smith KJ; Garboczi DN; et al. (1998). "Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids". Immunity. 8 (4): 403–11. doi:10.1016/S1074-7613(00)80546-4. PMID 9586631.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Kirchgessner H; Dietrich J; Scherer J; et al. (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Shelton JG; Gülland S; Nicolson K; et al. (2001). "Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits". Mol. Immunol. 38 (4): 259–65. doi:10.1016/S0161-5890(01)00062-1. PMID 11566319.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Pietra G; Romagnani C; Falco M; et al. (2002). "The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition". Eur. J. Immunol. 31 (12): 3687–93. doi:10.1002/1521-4141(200112)31:12<3687::AID-IMMU3687>3.0.CO;2-C. PMID 11745389.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Hennecke J, Wiley DC (2002). "Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity". J. Exp. Med. 195 (5): 571–81. doi:10.1084/jem.20011194. PMC 2193773. PMID 11877480.
- García P; Llano M; de Heredia AB; et al. (2002). "Human T cell receptor-mediated recognition of HLA-E". Eur. J. Immunol. 32 (4): 936–44. doi:10.1002/1521-4141(200204)32:4<936::AID-IMMU936>3.0.CO;2-M. PMID 11920559.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help)
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