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MPV may be higher when there is destruction of platelets. This may be seen in [[immune thrombocytopenic purpura]] (ITP), [[myeloproliferative disease]]s and [[Bernard–Soulier syndrome]]. It may also be related to [[pre-eclampsia]] and recovery from transient [[hypoplasia]].<ref name="Arch Pathol Lab Med. Vol 133, September 2009;1441-43.">[https://docs.google.com/viewer?a=v&q=cache:WD-fbfqdadUJ:www.metromedlab.com/SiteContent/Documents/File/IPN%2520MPV%2520%2520101609.pdf+%22mean+platelet+volume%22&hl=en&gl=us&pid=bl&srcid=ADGEESjXgOqNk6-jITg3Rn_c64mK0iSxOTrt5I6VycZ4yzlEf3z1ycjsY_1nU1H8hiYmppb3QKniYikKEIXM0CDCnwSvavxsO9wmKvgM2778hWm2McGaIv0Dz0GJzND39M3h3G29wxdw&sig=AHIEtbSsN2L1cvMZLM4tJ5snc9_uaKIADQ&pli=1], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..</ref>
MPV may be higher when there is destruction of platelets. This may be seen in [[immune thrombocytopenic purpura]] (ITP), [[myeloproliferative disease]]s and [[Bernard–Soulier syndrome]]. It may also be related to [[pre-eclampsia]] and recovery from transient [[hypoplasia]].<ref name="Arch Pathol Lab Med. Vol 133, September 2009;1441-43.">[https://docs.google.com/viewer?a=v&q=cache:WD-fbfqdadUJ:www.metromedlab.com/SiteContent/Documents/File/IPN%2520MPV%2520%2520101609.pdf+%22mean+platelet+volume%22&hl=en&gl=us&pid=bl&srcid=ADGEESjXgOqNk6-jITg3Rn_c64mK0iSxOTrt5I6VycZ4yzlEf3z1ycjsY_1nU1H8hiYmppb3QKniYikKEIXM0CDCnwSvavxsO9wmKvgM2778hWm2McGaIv0Dz0GJzND39M3h3G29wxdw&sig=AHIEtbSsN2L1cvMZLM4tJ5snc9_uaKIADQ&pli=1], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..</ref>


Abnormally low MPV values may correlate with [[thrombocytopenia]] when it is due to impaired production of [[megakaryocyte|megakaryocytes]] in the [[bone marrow]], such as in [[aplastic anemia]]. A low MPV may indicate [[inflammatory bowel disease]] (IBD), such as [[Crohn's disease]] and [[ulcerative colitis]].<ref>{{cite journal|last=Liu|first=S|author2=Ren, J |author3=Han, G |author4=Wang, G |author5=Gu, G |author6=Xia, Q |author7= Li, J |title=Mean platelet volume: a controversial marker of disease activity in Crohn's disease.|journal=European Journal of Medical Research|date=Oct 12, 2012|volume=17|pages=27|pmid=23058104|doi=10.1186/2047-783x-17-27 |pmc=3519557}}</ref> In addition, low MPV may correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as [[Wiskott–Aldrich syndrome]] (WAS),<ref>{{Cite web |url=https://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/wiskott-aldrich-syndrome |title=Wiskott-Aldrich Syndrome |publisher=Immune Deficiency Foundation |access-date=2019-03-03}}</ref> caused by a genetic mutation of the WAS gene.
Abnormally low MPV values may correlate with [[thrombocytopenia]] when it is due to impaired production of [[megakaryocyte|megakaryocytes]] in the [[bone marrow]], such as in [[aplastic anemia]]. A low MPV may indicate [[inflammatory bowel disease]] (IBD), such as [[Crohn's disease]] and [[ulcerative colitis]].<ref>{{cite journal|last=Liu|first=S|author2=Ren, J |author3=Han, G |author4=Wang, G |author5=Gu, G |author6=Xia, Q |author7= Li, J |title=Mean platelet volume: a controversial marker of disease activity in Crohn's disease.|journal=European Journal of Medical Research|date=Oct 12, 2012|volume=17|pages=27|pmid=23058104|doi=10.1186/2047-783x-17-27 |pmc=3519557}}</ref> A high MPV is also a bad prognostic marker in patients with sepsis or septic shock.<ref>{{Cite journal|last=Mangalesh|first=Sridhar|last2=Dudani|first2=Sharmila|last3=Malik|first3=Ajay|date=2021-03-24|title=Platelet Indices and Their Kinetics Predict Mortality in Patients of Sepsis|url=http://link.springer.com/10.1007/s12288-021-01411-2|journal=Indian Journal of Hematology and Blood Transfusion|language=en|doi=10.1007/s12288-021-01411-2|issn=0971-4502|pmc=PMC7988247|pmid=33776267}}</ref><ref>{{Cite journal|last=Gao|first=Yanxia|last2=Li|first2=Yi|last3=Yu|first3=Xuezhong|last4=Guo|first4=Shigong|last5=Ji|first5=Xu|last6=Sun|first6=Tongwen|last7=Lan|first7=Chao|last8=Lavergne|first8=Valery|last9=Ghannoum|first9=Marc|last10=Li|first10=Li|date=2014-08-13|editor-last=Stover|editor-first=Cordula M.|title=The Impact of Various Platelet Indices as Prognostic Markers of Septic Shock|url=https://dx.plos.org/10.1371/journal.pone.0103761|journal=PLoS ONE|language=en|volume=9|issue=8|pages=e103761|doi=10.1371/journal.pone.0103761|issn=1932-6203|pmc=PMC4131909|pmid=25118886}}</ref> In addition, low MPV may correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as [[Wiskott–Aldrich syndrome]] (WAS),<ref>{{Cite web |url=https://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/wiskott-aldrich-syndrome |title=Wiskott-Aldrich Syndrome |publisher=Immune Deficiency Foundation |access-date=2019-03-03}}</ref> caused by a genetic mutation of the WAS gene.


Sample for MPV testing is obtained in a Lavender-Top EDTA tube. A typical range of platelet volumes is 9.4–12.3&nbsp;fL<ref>{{Cite web|url=https://www.healthcare.uiowa.edu/path_handbook/rhandbook/test299.html|title=CBC (Complete Blood Count), Blood|website=www.healthcare.uiowa.edu|access-date=2018-02-22}}</ref> ([[femtolitre]]), equivalent to spheres 2.65 to 2.9&nbsp;[[Micrometre|µm]] in diameter.
Sample for MPV testing is obtained in a Lavender-Top EDTA tube. A typical range of platelet volumes is 9.4–12.3&nbsp;fL<ref>{{Cite web|url=https://www.healthcare.uiowa.edu/path_handbook/rhandbook/test299.html|title=CBC (Complete Blood Count), Blood|website=www.healthcare.uiowa.edu|access-date=2018-02-22}}</ref> ([[femtolitre]]), equivalent to spheres 2.65 to 2.9&nbsp;[[Micrometre|µm]] in diameter.

Revision as of 04:29, 17 June 2021

Mean platelet volume
Purposecan be used to make inferences about platelet production in bone marrow or platelet destruction problems

Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems.[1]

MPV may be higher when there is destruction of platelets. This may be seen in immune thrombocytopenic purpura (ITP), myeloproliferative diseases and Bernard–Soulier syndrome. It may also be related to pre-eclampsia and recovery from transient hypoplasia.[2]

Abnormally low MPV values may correlate with thrombocytopenia when it is due to impaired production of megakaryocytes in the bone marrow, such as in aplastic anemia. A low MPV may indicate inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis.[3] A high MPV is also a bad prognostic marker in patients with sepsis or septic shock.[4][5] In addition, low MPV may correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as Wiskott–Aldrich syndrome (WAS),[6] caused by a genetic mutation of the WAS gene.

Sample for MPV testing is obtained in a Lavender-Top EDTA tube. A typical range of platelet volumes is 9.4–12.3 fL[7] (femtolitre), equivalent to spheres 2.65 to 2.9 µm in diameter.

Conditions associated with altered MPV

Decreased MPV

Increased MPV

Inherited thrombocytopenia with normal MPV

References

  1. ^ [1], Lab Tests Online.
  2. ^ [2], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..
  3. ^ Liu, S; Ren, J; Han, G; Wang, G; Gu, G; Xia, Q; Li, J (Oct 12, 2012). "Mean platelet volume: a controversial marker of disease activity in Crohn's disease". European Journal of Medical Research. 17: 27. doi:10.1186/2047-783x-17-27. PMC 3519557. PMID 23058104.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ Mangalesh, Sridhar; Dudani, Sharmila; Malik, Ajay (2021-03-24). "Platelet Indices and Their Kinetics Predict Mortality in Patients of Sepsis". Indian Journal of Hematology and Blood Transfusion. doi:10.1007/s12288-021-01411-2. ISSN 0971-4502. PMC 7988247. PMID 33776267.{{cite journal}}: CS1 maint: PMC format (link)
  5. ^ Gao, Yanxia; Li, Yi; Yu, Xuezhong; Guo, Shigong; Ji, Xu; Sun, Tongwen; Lan, Chao; Lavergne, Valery; Ghannoum, Marc; Li, Li (2014-08-13). Stover, Cordula M. (ed.). "The Impact of Various Platelet Indices as Prognostic Markers of Septic Shock". PLoS ONE. 9 (8): e103761. doi:10.1371/journal.pone.0103761. ISSN 1932-6203. PMC 4131909. PMID 25118886.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
  6. ^ "Wiskott-Aldrich Syndrome". Immune Deficiency Foundation. Retrieved 2019-03-03.
  7. ^ "CBC (Complete Blood Count), Blood". www.healthcare.uiowa.edu. Retrieved 2018-02-22.
  8. ^ "Bernard-Soulier Syndrome Workup: Approach Considerations". emedicine.staging.medscape.com. Retrieved 2018-02-22.
  9. ^ McClatchey, Kenneth D. (2002). Clinical Laboratory Medicine. Lippincott Williams & Wilkins. ISBN 9780683307511.


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