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'''Eva Nogales''' (born in Madrid, Spain) is a [[biophysicist]] at the [[Lawrence Berkeley National Laboratory]]. She is head of the Division of Biochemistry, Biophysics and Structural Biology of the Department of Molecular and Cell Biology at the [[University of California, Berkeley]] and a [[Howard Hughes Medical Institute]] investigator.
'''Eva Nogales''' (born in Madrid, Spain) is a [[biophysicist]] at the [[Lawrence Berkeley National Laboratory]] and a Professor at the [[University of California, Berkeley]], where she served head of the Division of Biochemistry, Biophysics and Structural Biology of the Department of Molecular and Cell Biology (2015-2020). She is a [[Howard Hughes Medical Institute]] investigator.


Nogales is a pioneer in using [[Electron microscope|electron microscopy]] for the structural and functional characterization of macromolecular complexes. She used [[electron crystallography]] to obtain the first structure of [[tubulin]] and identify the binding site of the important anti-cancer drug [[Paclitaxel|taxol]]. She is a leader in combining [[Transmission electron cryomicroscopy|cryo-EM]], computational image analysis and [[Assay|biochemical assays]] to gain insights into function and regulation of biological complexes and [[molecular machine]]s.<ref>{{Cite news|url=https://www.mdtmag.com/news/2016/12/how-see-living-machines|title=How to See Living Machines|date=2016-12-07|work=Medical Design Technology|access-date=2018-02-03}}</ref> Her work has uncovered aspects of cellular function that are relevant to the treatment of cancer and other diseases.<ref>{{Cite web|url=https://www.hhmi.org/scientists/eva-nogales|title=Eva Nogales|website=HHMI.org|language=en|access-date=2019-03-23}}</ref>
Nogales is a pioneer in using [[Electron microscope|electron microscopy]] for the structural and functional characterization of macromolecular complexes. She used [[electron crystallography]] to obtain the first structure of [[tubulin]] and identify the binding site of the important anti-cancer drug [[Paclitaxel|taxol]]. She is a leader in combining [[Transmission electron cryomicroscopy|cryo-EM]], computational image analysis and [[Assay|biochemical assays]] to gain insights into function and regulation of biological complexes and [[molecular machine]]s.<ref>{{Cite news|url=https://www.mdtmag.com/news/2016/12/how-see-living-machines|title=How to See Living Machines|date=2016-12-07|work=Medical Design Technology|access-date=2018-02-03}}</ref> Her work has uncovered aspects of cellular function that are relevant to the treatment of cancer and other diseases.<ref>{{Cite web|url=https://www.hhmi.org/scientists/eva-nogales|title=Eva Nogales|website=HHMI.org|language=en|access-date=2019-03-23}}</ref>
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==Career==
==Career==
During her post-doctoral work in the laboratory of Ken Downing at [[Keele University]], Eva Nogales was the first to determine the atomic structure of [[tubulin]] and the location of the taxol-binding site by [[electron crystallography]].<ref>{{Cite journal|last1=Nogales|first1=E.|last2=Wolf|first2=S. G.|last3=Khan|first3=I. A.|last4=Ludueña|first4=R. F.|last5=Downing|first5=K. H.|date=1995-06-01|title=Structure of tubulin at 6.5 A and location of the taxol-binding site|journal=Nature|volume=375|issue=6530|pages=424–427|doi=10.1038/375424a0|issn=0028-0836|pmid=7760939|bibcode=1995Natur.375..424N|s2cid=4338992}}</ref><ref>Nogales, E., Wolf, S. G. and Downing, K. H. (1998.) Structure of the ab tubulin dimer by electron crystallography. ''Nature'', 391, 199-203.</ref><ref>{{Cite journal|last1=Nogales|first1=E.|last2=Whittaker|first2=M.|last3=Milligan|first3=R. A.|last4=Downing|first4=K. H.|date=1999-01-08|title=High-resolution model of the microtubule|journal=Cell|volume=96|issue=1|pages=79–88|issn=0092-8674|pmid=9989499|doi=10.1016/s0092-8674(00)80961-7|s2cid=18422680}}</ref> She joined [[Lawrence Berkeley National Laboratory]] as a staff scientist in 1995 and became an assistant professor in the Department of Molecular and Cell Biology at the [[University of California, Berkeley]] in 1998. In 2000 she became an investigator in the [[Howard Hughes Medical Institute]]. As [[Transmission electron cryomicroscopy|cryo-EM]] techniques became more powerful,<ref>{{Cite journal|last=Callaway|first=Ewen|date=2015-09-10|title=The revolution will not be crystallized: a new method sweeps through structural biology|journal=Nature|volume=525|issue=7568|pages=172–174|doi=10.1038/525172a|issn=1476-4687|pmid=26354465|bibcode=2015Natur.525..172C|doi-access=free}}</ref> she became a leader in applying cryo-EM to the study of microtubule structure and function<ref>{{Cite journal|last1=Downing|first1=Kenneth H.|last2=Nogales|first2=Eva|date=2010|title=Cryoelectron microscopy applications in the study of tubulin structure, microtubule architecture, dynamics and assemblies, and interaction of microtubules with motors|journal=Methods in Enzymology|volume=483|pages=121–142|doi=10.1016/S0076-6879(10)83006-X|issn=1557-7988|pmc=4165512|pmid=20888472|isbn=9780123849939}}</ref> and other large [[macromolecular assemblies]] such as [[eukaryotic transcription]] and translation initiation complexes<ref>Michael A. Cianfrocco, George A. Kassavetis, Patricia Grob, Jie Fang, Tamar Juven-Gershon, James T. Kadonaga, Eva Nogales (2013.) Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State. ''Cell'', 152(1):120-131.</ref><ref>{{Cite web|url=https://www.genengnews.com/news/stop-motion-view-of-dna-binding-complex-may-animate-drug-discovery/|title=Stop-Motion View of DNA-Binding Complex May Animate Drug Discovery|date=2018-11-20|website=GEN - Genetic Engineering and Biotechnology News|language=en-US|access-date=2019-03-23}}</ref> and [[telomerase]].<ref>{{Cite web|url=https://www.technologynetworks.com/drug-discovery/articles/the-3d-structure-of-telomerase-uncovering-its-role-in-human-disease-300278|title=The 3D Structure of Telomerase: Uncovering Its Role in Human Disease|website=Drug Discovery from Technology Networks|language=en|access-date=2019-03-23}}</ref>
During her post-doctoral work in the laboratory of Ken Downing at the [[Lawrence Berkeley National Laboratory]], Eva Nogales was the first to determine the atomic structure of [[tubulin]] and the location of the taxol-binding site by [[electron crystallography]].<ref>{{Cite journal|last1=Nogales|first1=E.|last2=Wolf|first2=S. G.|last3=Khan|first3=I. A.|last4=Ludueña|first4=R. F.|last5=Downing|first5=K. H.|date=1995-06-01|title=Structure of tubulin at 6.5 A and location of the taxol-binding site|journal=Nature|volume=375|issue=6530|pages=424–427|doi=10.1038/375424a0|issn=0028-0836|pmid=7760939|bibcode=1995Natur.375..424N|s2cid=4338992}}</ref><ref>Nogales, E., Wolf, S. G. and Downing, K. H. (1998.) Structure of the ab tubulin dimer by electron crystallography. ''Nature'', 391, 199-203.</ref><ref>{{Cite journal|last1=Nogales|first1=E.|last2=Whittaker|first2=M.|last3=Milligan|first3=R. A.|last4=Downing|first4=K. H.|date=1999-01-08|title=High-resolution model of the microtubule|journal=Cell|volume=96|issue=1|pages=79–88|issn=0092-8674|pmid=9989499|doi=10.1016/s0092-8674(00)80961-7|s2cid=18422680}}</ref> She became an assistant professor in the Department of Molecular and Cell Biology at the [[University of California, Berkeley]] in 1998. In 2000 she became an investigator in the [[Howard Hughes Medical Institute]]. As [[Transmission electron cryomicroscopy|cryo-EM]] techniques became more powerful,<ref>{{Cite journal|last=Callaway|first=Ewen|date=2015-09-10|title=The revolution will not be crystallized: a new method sweeps through structural biology|journal=Nature|volume=525|issue=7568|pages=172–174|doi=10.1038/525172a|issn=1476-4687|pmid=26354465|bibcode=2015Natur.525..172C|doi-access=free}}</ref> she became a leader in applying cryo-EM to the study of microtubule structure and function<ref>{{Cite journal|last1=Downing|first1=Kenneth H.|last2=Nogales|first2=Eva|date=2010|title=Cryoelectron microscopy applications in the study of tubulin structure, microtubule architecture, dynamics and assemblies, and interaction of microtubules with motors|journal=Methods in Enzymology|volume=483|pages=121–142|doi=10.1016/S0076-6879(10)83006-X|issn=1557-7988|pmc=4165512|pmid=20888472|isbn=9780123849939}}</ref> and other large [[macromolecular assemblies]] such as [[eukaryotic transcription]] and translation initiation complexes<ref>Michael A. Cianfrocco, George A. Kassavetis, Patricia Grob, Jie Fang, Tamar Juven-Gershon, James T. Kadonaga, Eva Nogales (2013.) Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State. ''Cell'', 152(1):120-131.</ref><ref>{{Cite web|url=https://www.genengnews.com/news/stop-motion-view-of-dna-binding-complex-may-animate-drug-discovery/|title=Stop-Motion View of DNA-Binding Complex May Animate Drug Discovery|date=2018-11-20|website=GEN - Genetic Engineering and Biotechnology News|language=en-US|access-date=2019-03-23}}</ref> , the polycomb complex PRC2, and [[telomerase]].<ref>{{Cite web|url=https://www.technologynetworks.com/drug-discovery/articles/the-3d-structure-of-telomerase-uncovering-its-role-in-human-disease-300278|title=The 3D Structure of Telomerase: Uncovering Its Role in Human Disease|website=Drug Discovery from Technology Networks|language=en|access-date=2019-03-23}}</ref>


==Awards==
==Awards==

Revision as of 17:13, 1 July 2021

Eva Nogales
Born
Madrid, Spain
Alma materB.S., physics, Autonomous University of Madrid in 1988, Ph.D., University of Keele, 1992
Occupation(s)Biophysicist, professor
Employer(s)University of California, Berkeley, Howard Hughes Medical Institute, Synchrotron Radiation Source
Known forThe first to determine the atomic structure of tubulin by electron crystallography
SpouseHoward Padmore
ChildrenTwo children
AwardsEarly Career Award, American Society for Cell Biology (2005)
Chabot Science Award for Excellence (2006)

Eva Nogales (born in Madrid, Spain) is a biophysicist at the Lawrence Berkeley National Laboratory and a Professor at the University of California, Berkeley, where she served head of the Division of Biochemistry, Biophysics and Structural Biology of the Department of Molecular and Cell Biology (2015-2020). She is a Howard Hughes Medical Institute investigator.

Nogales is a pioneer in using electron microscopy for the structural and functional characterization of macromolecular complexes. She used electron crystallography to obtain the first structure of tubulin and identify the binding site of the important anti-cancer drug taxol. She is a leader in combining cryo-EM, computational image analysis and biochemical assays to gain insights into function and regulation of biological complexes and molecular machines.[1] Her work has uncovered aspects of cellular function that are relevant to the treatment of cancer and other diseases.[2]

Early life and education

Eva Nogales obtained her B.S. degree in physics from the Autonomous University of Madrid in 1988. She later earned her Ph.D. from the University of Keele in 1992 while working at the Synchrotron Radiation Source under the supervision of Joan Bordas.

Career

During her post-doctoral work in the laboratory of Ken Downing at the Lawrence Berkeley National Laboratory, Eva Nogales was the first to determine the atomic structure of tubulin and the location of the taxol-binding site by electron crystallography.[3][4][5] She became an assistant professor in the Department of Molecular and Cell Biology at the University of California, Berkeley in 1998. In 2000 she became an investigator in the Howard Hughes Medical Institute. As cryo-EM techniques became more powerful,[6] she became a leader in applying cryo-EM to the study of microtubule structure and function[7] and other large macromolecular assemblies such as eukaryotic transcription and translation initiation complexes[8][9] , the polycomb complex PRC2, and telomerase.[10]

Awards

Personal life

Nogales is married to Howard Padmore and they have two children.

References

  1. ^ "How to See Living Machines". Medical Design Technology. 2016-12-07. Retrieved 2018-02-03.
  2. ^ "Eva Nogales". HHMI.org. Retrieved 2019-03-23.
  3. ^ Nogales, E.; Wolf, S. G.; Khan, I. A.; Ludueña, R. F.; Downing, K. H. (1995-06-01). "Structure of tubulin at 6.5 A and location of the taxol-binding site". Nature. 375 (6530): 424–427. Bibcode:1995Natur.375..424N. doi:10.1038/375424a0. ISSN 0028-0836. PMID 7760939. S2CID 4338992.
  4. ^ Nogales, E., Wolf, S. G. and Downing, K. H. (1998.) Structure of the ab tubulin dimer by electron crystallography. Nature, 391, 199-203.
  5. ^ Nogales, E.; Whittaker, M.; Milligan, R. A.; Downing, K. H. (1999-01-08). "High-resolution model of the microtubule". Cell. 96 (1): 79–88. doi:10.1016/s0092-8674(00)80961-7. ISSN 0092-8674. PMID 9989499. S2CID 18422680.
  6. ^ Callaway, Ewen (2015-09-10). "The revolution will not be crystallized: a new method sweeps through structural biology". Nature. 525 (7568): 172–174. Bibcode:2015Natur.525..172C. doi:10.1038/525172a. ISSN 1476-4687. PMID 26354465.
  7. ^ Downing, Kenneth H.; Nogales, Eva (2010). "Cryoelectron microscopy applications in the study of tubulin structure, microtubule architecture, dynamics and assemblies, and interaction of microtubules with motors". Methods in Enzymology. 483: 121–142. doi:10.1016/S0076-6879(10)83006-X. ISBN 9780123849939. ISSN 1557-7988. PMC 4165512. PMID 20888472.
  8. ^ Michael A. Cianfrocco, George A. Kassavetis, Patricia Grob, Jie Fang, Tamar Juven-Gershon, James T. Kadonaga, Eva Nogales (2013.) Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State. Cell, 152(1):120-131.
  9. ^ "Stop-Motion View of DNA-Binding Complex May Animate Drug Discovery". GEN - Genetic Engineering and Biotechnology News. 2018-11-20. Retrieved 2019-03-23.
  10. ^ "The 3D Structure of Telomerase: Uncovering Its Role in Human Disease". Drug Discovery from Technology Networks. Retrieved 2019-03-23.
  11. ^ "Early Career Life Scientist Award". ASCB. Retrieved 2019-03-23.
  12. ^ "Announcing the winners of the 2015 Protein Society Awards". EurekAlert!. Retrieved 2019-03-23.
  13. ^ "9 campus faculty selected for membership in American Academy of Arts and Sciences | The Daily Californian". The Daily Californian. 2016-04-22. Retrieved 2018-02-03.
  14. ^ "Women in Cell Biology Awards". ASCB. Retrieved 2019-03-23.
  15. ^ "Nogales Receives 2019 Grimwade Medal". Biosciences Area. 2019-03-07. Retrieved 2019-03-23.


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