1-Decanol: Difference between revisions
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| BoilingPtC = 232.9 |
| BoilingPtC = 232.9 |
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| Appearance = Viscous liquid |
| Appearance = Viscous liquid |
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| Solubility = 37 mg/L at 20°C<ref>https://pubchem.ncbi.nlm.nih.gov/compound/1-decanol</ref> |
| Solubility = 37 mg/L at 20°C<ref>{{Cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/1-decanol|title=1-Decanol}}</ref> |
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==Uses== |
==Uses== |
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Decanol is used in the manufacture of [[plasticizer]]s, [[lubricant]]s, [[surfactant]]s and solvents. Its ability to permeate the skin has led to it being investigated as a penetration enhancer for [[transdermal]] drug delivery.<ref>{{cite journal|last1=Kanikkannan|first1=N|last2=Singh|first2=Mandip|title=Skin permeation enhancement effect and skin irritation of saturated fatty alcohols|journal=International Journal of Pharmaceutics|date=November 2002|volume=248|issue=1–2|pages=219–228|doi=10.1016/S0378-5173(02)00454-4}}</ref><ref>{{cite journal|last1=Williams|first1=Adrian C|last2=Barry|first2=Brian W|title=Penetration enhancers|journal=Advanced Drug Delivery Reviews|date=March 2004|volume=56|issue=5|pages=603–618|doi=10.1016/j.addr.2003.10.025}}</ref> |
Decanol is used in the manufacture of [[plasticizer]]s, [[lubricant]]s, [[surfactant]]s and solvents. Its ability to permeate the skin has led to it being investigated as a penetration enhancer for [[transdermal]] drug delivery.<ref>{{cite journal|last1=Kanikkannan|first1=N|last2=Singh|first2=Mandip|title=Skin permeation enhancement effect and skin irritation of saturated fatty alcohols|journal=International Journal of Pharmaceutics|date=November 2002|volume=248|issue=1–2|pages=219–228|doi=10.1016/S0378-5173(02)00454-4|pmid=12429475}}</ref><ref>{{cite journal|last1=Williams|first1=Adrian C|last2=Barry|first2=Brian W|title=Penetration enhancers|journal=Advanced Drug Delivery Reviews|date=March 2004|volume=56|issue=5|pages=603–618|doi=10.1016/j.addr.2003.10.025|pmid=15019749}}</ref> |
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==Safety== |
==Safety== |
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Revision as of 23:26, 27 July 2021
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| Names | |
|---|---|
| Preferred IUPAC name
Decan-1-ol | |
| Other names
decyl alcohol
n-decyl alcohol capric alcohol epal 10 antak agent 504 | |
| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.003.597 |
| KEGG | |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C10H21OH | |
| Molar mass | 158.28 g/mol |
| Appearance | Viscous liquid |
| Density | 0.8297 g/cm3 |
| Melting point | 6.4 °C (43.5 °F; 279.5 K) |
| Boiling point | 232.9 °C (451.2 °F; 506.0 K) |
| 37 mg/L at 20°C[2] | |
| log P | 4.57 |
| Viscosity | 12.048 mPa.s (@ 25 °C) |
| Hazards | |
| Flash point | 108 °C (226 °F; 381 K) |
| Safety data sheet (SDS) | Oxford MSDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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1-Decanol is a straight chain fatty alcohol with ten carbon atoms and the molecular formula C10H21OH. It is a colorless to light yellow viscous liquid that is insoluble in water and has an aromatic odor.[3] The interfacial tension against water at 20 °C is 8.97 mN/m.
Production
Decanol can be prepared by the hydrogenation of decanoic acid, which occurs in modest quantities in coconut oil (about 10%) and palm kernel oil (about 4%). It may also be produced synthetically via the Ziegler process.
Uses
Decanol is used in the manufacture of plasticizers, lubricants, surfactants and solvents. Its ability to permeate the skin has led to it being investigated as a penetration enhancer for transdermal drug delivery.[4][5]
Safety
Like other medium chain fatty alcohols, 1-decanol is able to permeate the skin which can lead to irritation.
References
- ^ Merck Index, 12th Edition, 2911.
- ^ "1-Decanol".
- ^ "SAFETY DATA SHEET". Acros Organics. Retrieved 23 April 2015.[permanent dead link]
- ^ Kanikkannan, N; Singh, Mandip (November 2002). "Skin permeation enhancement effect and skin irritation of saturated fatty alcohols". International Journal of Pharmaceutics. 248 (1–2): 219–228. doi:10.1016/S0378-5173(02)00454-4. PMID 12429475.
- ^ Williams, Adrian C; Barry, Brian W (March 2004). "Penetration enhancers". Advanced Drug Delivery Reviews. 56 (5): 603–618. doi:10.1016/j.addr.2003.10.025. PMID 15019749.
