Acantholysis: Difference between revisions

Acantholysis
Acantholysis
	Foot-and-mouth disease - acantholysis in a sample of a skin vesicle: Necrosis of the stratum spinosum can be observed, and keratinocytes floating in the vesicular fluid (spongiosa).
Specialty	Dermatology

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Revision as of 15:11, 3 August 2021

Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes,^[1] seen in diseases such as pemphigus vulgaris.^[2] It is absent in bullous pemphigoid, making it useful for differential diagnosis.

This histological feature is also seen in herpes simplex infections (HSV 1 and 2) and varicella zoster infections (chicken pox and shingles).

^ Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
^ "Acantholysis - Medical Definition from MediLexicon". medilexicon.com. Archived from the original on 2016-07-31. Retrieved 2017-04-22.

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 This [[Histology|histological]] feature is also seen in [[Herpes simplex#Signs and symptoms|herpes simplex infections]] (HSV 1 and 2) and [[Varicella zoster virus|varicella zoster infections]] (chicken pox and shingles).
-[[File:Pemphigus vulgaris - Suprabasal epidermal acantholysis.jpg|thumb|306x306px|Histology of [[Pemphigus vulgaris]] ([[H&E stain|H&E]]; 40x) - Suprabasal epidermal [[acantholysis]] and cleft formation. The blister cavity contains rounded acantholytic cells with intensely eosinophilic cytoplasm and a perinuclear halo. The floor of the blister is lined with intact [[Keratinocyte|keratinocytes]] resembling the typical “tombstone pattern”.]]
 == See also ==