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'''Chromosome 11 open reading frame 53''' is a protein that in humans is encoded by the C11orf53 gene.<ref>{{cite web |title="C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/341032 |website=www.ncbi.nlm.nih.gov}}</ref> Reduction in C11orf53 gene expression is associated with increased odds of occurrence of colorectal cancer.<ref>{{cite journal |last1=Delgado |first1=Ana Paula |last2=Brandao |first2=Pamela |last3=Chapado |first3=Maria Julia |last4=Hamid |first4=Shelin |last5=Narayanan |first5=Ramaswamy |title=Open Reading Frames Associated with Cancer in the Dark Matter of the Human Genome |journal=Cancer Genomics & Proteomics |date=July 2014 |volume=11 |issue=4 |pages=201-213 |pmid=25048349}}</ref> Specifically sequence variation (rs3802842) close to the C11orf53 gene locus that lowers the expression of C11orf53 has been observed in the colonic mucosal cells immediately adjacent to colon cancer tumors.<ref>{{cite journal |last1=Biancolella |first1=M |last2=Fortini |first2=BK |last3=Tring |first3=S |last4=Plummer |first4=SJ |last5=Mendoza-Fandino |first5=GA |last6=Hartiala |first6=J |last7=Hitchler |first7=MJ |last8=Yan |first8=C |last9=Schumacher |first9=FR |last10=Conti |first10=DV |last11=Edlund |first11=CK |last12=Noushmehr |first12=H |last13=Coetzee |first13=SG |last14=Bresalier |first14=RS |last15=Ahnen |first15=DJ |last16=Barry |first16=EL |last17=Berman |first17=BP |last18=Rice |first18=JC |last19=Coetzee |first19=GA |last20=Casey |first20=G |title=Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1. |journal=Human molecular genetics |date=15 April 2014 |volume=23 |issue=8 |pages=2198-209 |doi=10.1093/hmg/ddt584 |pmid=24256810|pmc=3959808 }}</ref><ref>{{cite journal |last1=Closa |first1=A |last2=Cordero |first2=D |last3=Sanz-Pamplona |first3=R |last4=Solé |first4=X |last5=Crous-Bou |first5=M |last6=Paré-Brunet |first6=L |last7=Berenguer |first7=A |last8=Guino |first8=E |last9=Lopez-Doriga |first9=A |last10=Guardiola |first10=J |last11=Biondo |first11=S |last12=Salazar |first12=R |last13=Moreno |first13=V |title=Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis. |journal=Carcinogenesis |date=September 2014 |volume=35 |issue=9 |pages=2039-46 |doi=10.1093/carcin/bgu092 |pmid=24760461|pmc=4146415 }}</ref> C11orf53 downregulation aids in cells' ability to survive in acidic conditions, which are typical of the tumor microenvironment. <ref>{{cite journal |last1=Funato |first1=Y |last2=Yoshida |first2=A |last3=Hirata |first3=Y |last4=Hashizume |first4=O |last5=Yamazaki |first5=D |last6=Miki |first6=H |title=The oncogenic PRL protein causes acid addiction of cells by stimulating lysosomal exocytosis. |journal=Developmental Cell |date=2020 |volume=55 |issue=4 |pages=387-397 |doi=10.1016/j.devcel.2020.08.009 |pmid=32918875}}</ref> CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made the cells resistant to the BCL2 inhibitor Ventoclax, further supporting a role in cancer predisposition.<ref>{{cite web |title=C11orf53 CRISPR Screens (Homo sapiens) |url=https://orcs.thebiogrid.org/Gene/341032 |website=orcs.thebiogrid.org}}</ref><ref>{{cite journal |last1=Nechiporuk |first1=T |last2=Kurtz |first2=SE |last3=Nikolova |first3=O |last4=Liu |first4=T |last5=Jones |first5=CL |last6=D'Alessandro |first6=A |last7=Culp-Hill |first7=R |last8=d'Almeida |first8=A |last9=Joshi |first9=SK |last10=Rosenberg |first10=M |last11=Tognon |first11=CE |last12=Danilov |first12=AV |last13=Druker |first13=BJ |last14=Chang |first14=BH |last15=McWeeney |first15=SK |last16=Tyner |first16=JW |title=The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells. |journal=Cancer discovery |date=July 2019 |volume=9 |issue=7 |pages=910-925 |doi=10.1158/2159-8290.CD-19-0125 |pmid=31048320|pmc=6606338 }}</ref>
'''Chromosome 11 open reading frame 53''' is a protein that in humans is encoded by the C11orf53 gene.<ref>{{cite web |title="C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/341032 |website=www.ncbi.nlm.nih.gov}}</ref> Reduction in C11orf53 gene expression is associated with increased odds of occurrence of colorectal cancer.<ref>{{cite journal |last1=Delgado |first1=Ana Paula |last2=Brandao |first2=Pamela |last3=Chapado |first3=Maria Julia |last4=Hamid |first4=Shelin |last5=Narayanan |first5=Ramaswamy |title=Open Reading Frames Associated with Cancer in the Dark Matter of the Human Genome |journal=Cancer Genomics & Proteomics |date=July 2014 |volume=11 |issue=4 |pages=201–213 |pmid=25048349}}</ref> Specifically sequence variation (rs3802842) close to the C11orf53 gene locus that lowers the expression of C11orf53 has been observed in the colonic mucosal cells immediately adjacent to colon cancer tumors.<ref>{{cite journal |last1=Biancolella |first1=M |last2=Fortini |first2=BK |last3=Tring |first3=S |last4=Plummer |first4=SJ |last5=Mendoza-Fandino |first5=GA |last6=Hartiala |first6=J |last7=Hitchler |first7=MJ |last8=Yan |first8=C |last9=Schumacher |first9=FR |last10=Conti |first10=DV |last11=Edlund |first11=CK |last12=Noushmehr |first12=H |last13=Coetzee |first13=SG |last14=Bresalier |first14=RS |last15=Ahnen |first15=DJ |last16=Barry |first16=EL |last17=Berman |first17=BP |last18=Rice |first18=JC |last19=Coetzee |first19=GA |last20=Casey |first20=G |title=Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1. |journal=Human Molecular Genetics |date=15 April 2014 |volume=23 |issue=8 |pages=2198–209 |doi=10.1093/hmg/ddt584 |pmid=24256810|pmc=3959808 }}</ref><ref>{{cite journal |last1=Closa |first1=A |last2=Cordero |first2=D |last3=Sanz-Pamplona |first3=R |last4=Solé |first4=X |last5=Crous-Bou |first5=M |last6=Paré-Brunet |first6=L |last7=Berenguer |first7=A |last8=Guino |first8=E |last9=Lopez-Doriga |first9=A |last10=Guardiola |first10=J |last11=Biondo |first11=S |last12=Salazar |first12=R |last13=Moreno |first13=V |title=Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis. |journal=Carcinogenesis |date=September 2014 |volume=35 |issue=9 |pages=2039–46 |doi=10.1093/carcin/bgu092 |pmid=24760461|pmc=4146415 }}</ref> C11orf53 downregulation aids in cells' ability to survive in acidic conditions, which are typical of the tumor microenvironment. <ref>{{cite journal |last1=Funato |first1=Y |last2=Yoshida |first2=A |last3=Hirata |first3=Y |last4=Hashizume |first4=O |last5=Yamazaki |first5=D |last6=Miki |first6=H |title=The oncogenic PRL protein causes acid addiction of cells by stimulating lysosomal exocytosis. |journal=Developmental Cell |date=2020 |volume=55 |issue=4 |pages=387–397 |doi=10.1016/j.devcel.2020.08.009 |pmid=32918875}}</ref> CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made the cells resistant to the BCL2 inhibitor Ventoclax, further supporting a role in cancer predisposition.<ref>{{cite web |title=C11orf53 CRISPR Screens (Homo sapiens) |url=https://orcs.thebiogrid.org/Gene/341032 |website=orcs.thebiogrid.org}}</ref><ref>{{cite journal |last1=Nechiporuk |first1=T |last2=Kurtz |first2=SE |last3=Nikolova |first3=O |last4=Liu |first4=T |last5=Jones |first5=CL |last6=D'Alessandro |first6=A |last7=Culp-Hill |first7=R |last8=d'Almeida |first8=A |last9=Joshi |first9=SK |last10=Rosenberg |first10=M |last11=Tognon |first11=CE |last12=Danilov |first12=AV |last13=Druker |first13=BJ |last14=Chang |first14=BH |last15=McWeeney |first15=SK |last16=Tyner |first16=JW |title=The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells. |journal=Cancer Discovery |date=July 2019 |volume=9 |issue=7 |pages=910–925 |doi=10.1158/2159-8290.CD-19-0125 |pmid=31048320|pmc=6606338 }}</ref>


Additional roles have been proposed.<ref>{{cite web |title=C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/341032 |website=www.ncbi.nlm.nih.gov}}</ref><ref>{{cite journal |last1=Oláh |first1=J |last2=Vincze |first2=O |last3=Virók |first3=D |last4=Simon |first4=D |last5=Bozsó |first5=Z |last6=Tõkési |first6=N |last7=Horváth |first7=I |last8=Hlavanda |first8=E |last9=Kovács |first9=J |last10=Magyar |first10=A |last11=Szũcs |first11=M |last12=Orosz |first12=F |last13=Penke |first13=B |last14=Ovádi |first14=J |title=Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. |journal=The Journal of biological chemistry |date=30 September 2011 |volume=286 |issue=39 |pages=34088-100 |doi=10.1074/jbc.M111.243907 |pmid=21832049|pmc=3190826 }}</ref>
Additional roles have been proposed.<ref>{{cite web |title=C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/341032 |website=www.ncbi.nlm.nih.gov}}</ref><ref>{{cite journal |last1=Oláh |first1=J |last2=Vincze |first2=O |last3=Virók |first3=D |last4=Simon |first4=D |last5=Bozsó |first5=Z |last6=Tõkési |first6=N |last7=Horváth |first7=I |last8=Hlavanda |first8=E |last9=Kovács |first9=J |last10=Magyar |first10=A |last11=Szũcs |first11=M |last12=Orosz |first12=F |last13=Penke |first13=B |last14=Ovádi |first14=J |title=Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. |journal=The Journal of Biological Chemistry |date=30 September 2011 |volume=286 |issue=39 |pages=34088–100 |doi=10.1074/jbc.M111.243907 |pmid=21832049|pmc=3190826 }}</ref>


==References==
==References==

Revision as of 22:05, 3 August 2021

Chromosome 11 open reading frame 53 is a protein that in humans is encoded by the C11orf53 gene.[1] Reduction in C11orf53 gene expression is associated with increased odds of occurrence of colorectal cancer.[2] Specifically sequence variation (rs3802842) close to the C11orf53 gene locus that lowers the expression of C11orf53 has been observed in the colonic mucosal cells immediately adjacent to colon cancer tumors.[3][4] C11orf53 downregulation aids in cells' ability to survive in acidic conditions, which are typical of the tumor microenvironment. [5] CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made the cells resistant to the BCL2 inhibitor Ventoclax, further supporting a role in cancer predisposition.[6][7]

Additional roles have been proposed.[8][9]

References

  1. ^ ""C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
  2. ^ Delgado, Ana Paula; Brandao, Pamela; Chapado, Maria Julia; Hamid, Shelin; Narayanan, Ramaswamy (July 2014). "Open Reading Frames Associated with Cancer in the Dark Matter of the Human Genome". Cancer Genomics & Proteomics. 11 (4): 201–213. PMID 25048349.
  3. ^ Biancolella, M; Fortini, BK; Tring, S; Plummer, SJ; Mendoza-Fandino, GA; Hartiala, J; Hitchler, MJ; Yan, C; Schumacher, FR; Conti, DV; Edlund, CK; Noushmehr, H; Coetzee, SG; Bresalier, RS; Ahnen, DJ; Barry, EL; Berman, BP; Rice, JC; Coetzee, GA; Casey, G (15 April 2014). "Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1". Human Molecular Genetics. 23 (8): 2198–209. doi:10.1093/hmg/ddt584. PMC 3959808. PMID 24256810.
  4. ^ Closa, A; Cordero, D; Sanz-Pamplona, R; Solé, X; Crous-Bou, M; Paré-Brunet, L; Berenguer, A; Guino, E; Lopez-Doriga, A; Guardiola, J; Biondo, S; Salazar, R; Moreno, V (September 2014). "Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis". Carcinogenesis. 35 (9): 2039–46. doi:10.1093/carcin/bgu092. PMC 4146415. PMID 24760461.
  5. ^ Funato, Y; Yoshida, A; Hirata, Y; Hashizume, O; Yamazaki, D; Miki, H (2020). "The oncogenic PRL protein causes acid addiction of cells by stimulating lysosomal exocytosis". Developmental Cell. 55 (4): 387–397. doi:10.1016/j.devcel.2020.08.009. PMID 32918875.
  6. ^ "C11orf53 CRISPR Screens (Homo sapiens)". orcs.thebiogrid.org.
  7. ^ Nechiporuk, T; Kurtz, SE; Nikolova, O; Liu, T; Jones, CL; D'Alessandro, A; Culp-Hill, R; d'Almeida, A; Joshi, SK; Rosenberg, M; Tognon, CE; Danilov, AV; Druker, BJ; Chang, BH; McWeeney, SK; Tyner, JW (July 2019). "The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells". Cancer Discovery. 9 (7): 910–925. doi:10.1158/2159-8290.CD-19-0125. PMC 6606338. PMID 31048320.
  8. ^ "C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
  9. ^ Oláh, J; Vincze, O; Virók, D; Simon, D; Bozsó, Z; Tõkési, N; Horváth, I; Hlavanda, E; Kovács, J; Magyar, A; Szũcs, M; Orosz, F; Penke, B; Ovádi, J (30 September 2011). "Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc.M111.243907. PMC 3190826. PMID 21832049.{{cite journal}}: CS1 maint: unflagged free DOI (link)
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