Transdermal analgesic patch: Difference between revisions
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==Counterirritant patches== |
==Counterirritant patches== |
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Counterirritant patches contain ingredients such as [[capsaicin]], [[methyl salicylate]], [[camphor]], or [[menthol]], which are thought to mask pain signals by causing other sensations (itching, warmth, or cooling) in the areas they are applied to.<ref name=USPharm>{{cite web |last=Pray |first=W. Steven |title=The pharmacist's role in the appropriate selection of a nonprescription product for pain relief |work=U.S. Pharmacist |url=http://www.uspharmacist.com/continuing_education/ceviewtest/lessonid/105845/ |date=1 September 2008 |accessdate=2010-03-24}}</ref> In the [[United States]], patches sold under the brand name Salonpas are approved by the [[Food and Drug Administration]] under a [[New Drug Application]] (NDA) for the treatment of mild to moderate pain caused by [[soft tissue injury]] (e.g. strains |
Counterirritant patches contain ingredients such as [[capsaicin]], [[methyl salicylate]], [[camphor]], or [[menthol]], which are thought to mask pain signals by causing other sensations (itching, warmth, or cooling) in the areas they are applied to.<ref name=USPharm>{{cite web |last=Pray |first=W. Steven |title=The pharmacist's role in the appropriate selection of a nonprescription product for pain relief |work=U.S. Pharmacist |url=http://www.uspharmacist.com/continuing_education/ceviewtest/lessonid/105845/ |date=1 September 2008 |accessdate=2010-03-24}}</ref> In the [[United States]], patches sold under the brand name Salonpas are approved by the [[Food and Drug Administration]] under a [[New Drug Application]] (NDA) for the treatment of mild to moderate pain caused by [[soft tissue injury]] (e.g., strains, sprains), [[arthritis]], or [[backache]]. While Salonpas patches may provide some relief, the effects are not strong and the evidence supporting their efficacy is weak.<ref>{{cite web |last1=Hall |first1=Harriet |authorlink=Harriet Hall|title=Salonpas |url=https://sciencebasedmedicine.org/salonpas/ |website=Science-Based Medicine |access-date=14 April 2021 |archive-url=https://web.archive.org/web/20210205165707/https://sciencebasedmedicine.org/salonpas/ |archive-date=13 April 2021}}</ref> |
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Other products, including |
Other products, including [[Bengay]] and [[Mentholatum]], which are not covered by NDA, indicate relief of minor pain.<ref name=USPharm/> Counterirritant patches are sold over-the-counter and do not require a prescription. Other over-the-counter products marketed for the relief of minor injury or arthritis pain include Absorbine Jr. Pain Relief, Excedrin Cooling Pads, and Icy Hot Patches.<ref>{{cite journal |last=Levy |first=Sandra |title=External painkillers lead sales in analgesics market |journal=Drug Topics |date=10 December 2001 |url=http://drugtopics.modernmedicine.com/drugtopics/Pain+Management/External-painkillers-lead-sales-in-analgesics-mark/ArticleStandard/Article/detail/118028?contextCategoryId=6962 |accessdate=2010-03-24}}</ref> |
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In [[Japan]] Salonpas, produced by [[Hisamitsu Pharmaceutical]], remains a popular brand. Other manufacturers, including Yutoku Pharmaceutical, SS Pharmaceutical, and Suzuki Nippondo also produce similar over-the-counter patches containing methyl salicylate or glycol salicylate.<ref>{{cite book |last=Ghosh |first=Tapash K. |author2=William R. Pfister |author3=Su Il Yum |title=Transdermal and Topical Drug Delivery Systems |publisher=Informa Health Care |year=1997 |isbn=1-57491-041-8}}</ref> |
In [[Japan]], Salonpas, produced by [[Hisamitsu Pharmaceutical]], remains a popular brand. Other manufacturers, including Yutoku Pharmaceutical, SS Pharmaceutical, and Suzuki Nippondo also produce similar over-the-counter patches containing methyl salicylate or glycol salicylate.<ref>{{cite book |last=Ghosh |first=Tapash K. |author2=William R. Pfister |author3=Su Il Yum |title=Transdermal and Topical Drug Delivery Systems |publisher=Informa Health Care |year=1997 |isbn=1-57491-041-8}}</ref> |
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In [[Australia]], patches sold under the brand names [[Eco Pain]] |
In [[Australia]], patches sold under the brand names [[Eco Pain]] and Dencorub are approved by the [[Therapeutic Goods Administration]] and listed on the Australian Register for Therapeutic Goods (ARTG) as a Class 1 Medical Device. They are approved for sale over-the-counter for the treatment of mild pain caused by [[soft tissue injury]] (e.g., strains, sprains), [[arthritis]], or [[backache]]. |
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==Fentanyl patches== |
==Fentanyl patches== |
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{{Main|Fentanyl|Duragesic}} |
{{Main|Fentanyl|Duragesic}} |
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Fentanyl transdermal patches are sold under the brand name Duragesic |
Fentanyl transdermal patches are sold under the brand name Duragesic or as [[Generic drug|generic]] equivalents. Fentanyl is an [[opioid]] with rapid onset of pain relief; it is often used to treat [[Pain#Breakthrough_pain|breakthrough pain]]. Fentanyl patches release fentanyl through the skin and may provide pain relief for up to 72 hours.<ref name=MedlinePlus>{{cite web |url=https://medlineplus.gov/druginfo/meds/a601202.html |title=Fentanyl Transdermal Patch |author=American Society of Health-System Pharmacists, Inc. |date=15 January 2021 |website=MedlinePlus |access-date=3 August 2021}}</ref> |
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Several deaths or life-threatening overdoses have been linked to misuse of fentanyl patches.<ref name=FDA>{{cite web |author=US Department of Health and Human Services |title=Information for Healthcare Professionals: Fentanyl Transdermal System (marketed as Duragesic and generics) |work=US Food and Drug Administration Postmarket Drug Safety Information for Patients and Providers |url=https://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm084307.htm |date=21 December 2007 |accessdate=2010-03-24}}</ref> Fentanyl patches are indicated only for patients with moderate to severe chronic pain who have been taking regular narcotic pain medication for more than a week and who are considered opioid-tolerant. Overdose can occur when patients use more patches than prescribed, change the patches too frequently, or expose the |
Several deaths or life-threatening overdoses have been linked to misuse of fentanyl patches.<ref name=FDA>{{cite web |author=US Department of Health and Human Services |title=Information for Healthcare Professionals: Fentanyl Transdermal System (marketed as Duragesic and generics) |work=US Food and Drug Administration Postmarket Drug Safety Information for Patients and Providers |url=https://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm084307.htm |date=21 December 2007 |accessdate=2010-03-24}}</ref> Fentanyl patches are indicated only for patients with moderate to severe chronic pain who have been taking regular narcotic pain medication for more than a week and who are considered opioid-tolerant. Overdose can occur when patients use more patches than prescribed, change the patches too frequently, or expose the patches to extreme heat.<ref name=FDA/> |
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==See also== |
==See also== |
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*[[Alza Corporation]] |
*[[Alza Corporation]] |
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*[[Hisamitsu Pharmaceutical]] |
*[[Hisamitsu Pharmaceutical]] |
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*[[Mentholatum|The Mentholatum Company, Inc.]] |
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*[[Novartis]] |
*[[Novartis]] |
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*[[W.F. Young, Inc.]] |
*[[W.F. Young, Inc.]] |
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Revision as of 22:58, 3 August 2021
A transdermal analgesic or pain relief patch is a medicated adhesive patch used to relieve minor to severe pain. There are two primary types of analgesic patches: patches containing counterirritants, which are used to treat mild to moderate pain, and patches containing fentanyl, a narcotic used to relieve moderate to severe pain in opioid-tolerant patients.
Counterirritant patches
Counterirritant patches contain ingredients such as capsaicin, methyl salicylate, camphor, or menthol, which are thought to mask pain signals by causing other sensations (itching, warmth, or cooling) in the areas they are applied to.[1] In the United States, patches sold under the brand name Salonpas are approved by the Food and Drug Administration under a New Drug Application (NDA) for the treatment of mild to moderate pain caused by soft tissue injury (e.g., strains, sprains), arthritis, or backache. While Salonpas patches may provide some relief, the effects are not strong and the evidence supporting their efficacy is weak.[2]
Other products, including Bengay and Mentholatum, which are not covered by NDA, indicate relief of minor pain.[1] Counterirritant patches are sold over-the-counter and do not require a prescription. Other over-the-counter products marketed for the relief of minor injury or arthritis pain include Absorbine Jr. Pain Relief, Excedrin Cooling Pads, and Icy Hot Patches.[3]
In Japan, Salonpas, produced by Hisamitsu Pharmaceutical, remains a popular brand. Other manufacturers, including Yutoku Pharmaceutical, SS Pharmaceutical, and Suzuki Nippondo also produce similar over-the-counter patches containing methyl salicylate or glycol salicylate.[4]
In Australia, patches sold under the brand names Eco Pain and Dencorub are approved by the Therapeutic Goods Administration and listed on the Australian Register for Therapeutic Goods (ARTG) as a Class 1 Medical Device. They are approved for sale over-the-counter for the treatment of mild pain caused by soft tissue injury (e.g., strains, sprains), arthritis, or backache.
Fentanyl patches
Fentanyl transdermal patches are sold under the brand name Duragesic or as generic equivalents. Fentanyl is an opioid with rapid onset of pain relief; it is often used to treat breakthrough pain. Fentanyl patches release fentanyl through the skin and may provide pain relief for up to 72 hours.[5]
Several deaths or life-threatening overdoses have been linked to misuse of fentanyl patches.[6] Fentanyl patches are indicated only for patients with moderate to severe chronic pain who have been taking regular narcotic pain medication for more than a week and who are considered opioid-tolerant. Overdose can occur when patients use more patches than prescribed, change the patches too frequently, or expose the patches to extreme heat.[6]
See also
- Manufacturers
- Products
References
- ^ a b Pray, W. Steven (1 September 2008). "The pharmacist's role in the appropriate selection of a nonprescription product for pain relief". U.S. Pharmacist. Retrieved 2010-03-24.
- ^ Hall, Harriet. "Salonpas". Science-Based Medicine. Archived from the original on 13 April 2021. Retrieved 14 April 2021.
{{cite web}}:|archive-date=/|archive-url=timestamp mismatch; 5 February 2021 suggested (help) - ^ Levy, Sandra (10 December 2001). "External painkillers lead sales in analgesics market". Drug Topics. Retrieved 2010-03-24.
- ^ Ghosh, Tapash K.; William R. Pfister; Su Il Yum (1997). Transdermal and Topical Drug Delivery Systems. Informa Health Care. ISBN 1-57491-041-8.
- ^ American Society of Health-System Pharmacists, Inc. (15 January 2021). "Fentanyl Transdermal Patch". MedlinePlus. Retrieved 3 August 2021.
- ^ a b US Department of Health and Human Services (21 December 2007). "Information for Healthcare Professionals: Fentanyl Transdermal System (marketed as Duragesic and generics)". US Food and Drug Administration Postmarket Drug Safety Information for Patients and Providers. Retrieved 2010-03-24.