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[[File:GCCRI EAB Image.jpg|thumb|300x300px|Greehey CCRI is a part of the [[UTHSCSA]].]]
[[File:Greehey Children's Cancer Research Institute, San Antonio, Texas (2 April 2007).jpg|thumb|right|300px|Greehey CCRI is a part of the [[UTHSCSA]].]]The '''Greehey Children's Cancer Research Institute''' is a research center in [[San Antonio]], [[Texas]], US.
The '''[https://gccri.uthscsa.edu Greehey Children's Cancer Research Institute]''' is a pediatric cancer research center in [[San Antonio]], [[Texas]], US.

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas — research, clinical, and education.

== Research Strengths ==
Our strengths include cancer genomics, DNA damage, RNA biology, and drug development.

We are developing expertise in drug delivery, focusing on nanotechnology-driven delivery of small RNA mimics and inhibitors.

The Pediatric Translational Working Group, formed as part of the Mays Cancer Center P30, meets regularly to coordinate discoveries to develop novel therapies.

== Research Focus ==

* [https://gccri.uthscsa.edu/programs/biostatistics-bioinformatics/ Bioinformatics and genomics]
* [https://gccri.uthscsa.edu/programs/cancer-genetics/ Cancer Control]
* [https://gccri.uthscsa.edu/programs/cancer-genetics/ Cancer Genetics]
* [https://gccri.uthscsa.edu/programs/experimental-therapeutics/ Experimental Therapeutics]
* [https://gccri.uthscsa.edu/programs/experimental-therapeutics/ Hematologic Malignancies]
* [https://gccri.uthscsa.edu/research/molecular-oncogenesis/ Molecular Oncogenesis]
* [https://gccri.uthscsa.edu/programs/pptc/ Pediatric Preclinical Testing Program (PPTP)]
*RNA biology

== Core Facilities ==

* [https://gccri.uthscsa.edu/services/cbbi/ Computational biology and bioinformatics]
* [https://gccri.uthscsa.edu/services/genome-sequencing-facility/ Genome Sequencing Facility (GSF)]
* [https://gccri.uthscsa.edu/services/rnai-high-throughput-screening-facility/ RNAi/CRISPR High Throughput Screening Facility]
* [https://gccri.uthscsa.edu/services/pdx-core/ Greehey CCRI Xenograft & Cell-Lines Core]

== Clinical ==
Greehey CCRI interacts with members of the [https://www.uthscsa.edu/patient-care/physicians/services/pediatric-hematologyoncology UT Health San Antonio, Division of Pediatric Hematology-Oncology] to provide support for clinical research, banking of clinical specimens, and annotation of such specimens to facilitate patient-oriented research. As our clinical mission includes performing research that translates into clinical care, Greehey CCRI supports infrastructure for human subjects’ research and investigator-initiated trials in pediatric cancer. Since much of the research in pediatric cancer includes participation in cooperative group trials, Greehey CCRI supports the involvement of investigators in [https://www.childrensoncologygroup.org/ Children’s Oncology Group] participation.

[https://cancer.uthscsa.edu/ UT Health San Antonio MD Anderson Cancer Center] has become a member of The [https://poeticphase1.org/ Pediatric Oncology Experimental Therapeutics Investigators’ Consortium (POETIC);] pediatric oncology studies focus on the biologic basis for anti-cancer therapy, and in particular, attempt to explore and evaluate new agents and novel combinations of therapies early in clinical development.

== Education ==
The educational mission of the Greehey Children’s Cancer Research Institute is to train the next generation of researchers in pediatric cancer research. This includes creating a pipeline of trainees through our program for undergraduates engaged in summer research.

== Greehey CCRI Principal Investigators ==
With over 300 collective years of PhD-level research experience, the Greehey Children's Cancer Research Institute and the faculty have created specialized cancer and research centers that focus on advancing scientific knowledge relevant to childhood cancer and accelerating that knowledge into innovative cures for all ages.

* '''[https://gccri.uthscsa.edu/lab/aune/ Gregory Aune, MD, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/bishop/ Alexander J. R. Bishop, D.Phil]'''
* '''[https://gccri.uthscsa.edu/lab/chen/ Yidong Chen, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/gupta/ Yogesh K. Gupta, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/houghton Peter Houghton, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/ignatius-lab/ Myron Ignatius, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/kitagawa/ Katsumi Kitagawa, Pharm.D., PhD]'''
* '''[https://gccri.uthscsa.edu/lab/kurmasheva-lab/ Raushan Kurmasheva, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/lai/ Zhao Lai, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/libich David S. Libich, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/penalva Luiz O.F. Penalva, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/pertsemlidis Alexander Pertsemlidis, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/rao Manjeet Rao, PhD]''' ''Director (interim)''
* '''[https://gccri.uthscsa.edu/lab/shiio Yuzuru Shiio, MD, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/tomlinson Gail Tomlinson, MD, PhD]'''
* '''[https://gccri.uthscsa.edu/lab/wang Xiaojing Wang, PhD]'''
* [https://gccri.uthscsa.edu/lab/zheng '''Siyuan Zheng, PhD'''<br />] The facility is part of the [[University of Texas Health Science Center at San Antonio]].<ref>http://gccri.uthscsa.edu</ref>

== Get Involved ==
Cancer kills more children in America every year than any other disease. That fact alone is reason enough to search for cures and better treatments for the cancers affecting children. But there are more good reasons than that one for concentrating our efforts and philanthropic dollars on the search for the new knowledge that is needed. Children’s cancers arise in tissues that are easier to observe and analyze, and are a superb model for cancers that occur at all ages.

=== Becoming part of the solution ===
We believe that what is needed is a complete understanding of the cancer cell at a molecular level. What is more, we believe that this understanding, ''for the first time in human history, is actually possible''. There has been a fortunate conjunction of events that holds great promise for this historic search for answers. The map of the human genome has given us an image of relative “normalcy” against which departures can be observed and measured. Advances in technology allow scientists to peer inside the previously mysterious structures and processes of tumor cells and their components in ways never before possible.

Very few of us have escaped the experience of watching someone we love suffer from the disease we call cancer. You probably wanted answers at the time, and now, on behalf of the children who suffer from this disease, you can help pursue those answers by helping the Greehey Children’s Cancer Research Institute as it begins its work.

Your gift can make a difference in the recruiting of the best scientists to work on this problem, in purchasing the finest equipment, and in putting the two together. What is more, your gift will go directly to fund one of the labs, with every dime expended on research.

=== Tumor Donation: Donate your discarded tumor tissue and become a [https://gccri.uthscsa.edu/get-involved/tumor-donation/ Greehey CCRI Hero] ===
The Greehey Children’s Cancer Research Institute (GCCRI) at UT Health San Antonio is the largest free-standing pediatric cancer research institute in Texas. Our mission is to understand the causes and biology of childhood cancer with the goal of finding better treatments that minimize the toxic side effects. At Greehey CCRI we are currently banking tumors collected from children, adolescents, and young adults with consent from patients. This research is supported with funding from the Cancer Research Institute of Texas.

=== [https://makelivesbetter.uthscsa.edu/gccridonate The Ambassador’s Circle] ===
The Greehey Children’s Cancer Research Institute Ambassadors’ Circle is a group of outstanding community leaders who are key proponents of one of the nation’s premier children’s cancer research institute.

Members of the Ambassadors’ Circle do what all ambassadors do . . . serve as advocates and goodwill ambassadors for this prestigious research institute. What is more, they financially support Greehey Children’s Cancer Research Institute, helping ensure that important components of the Institute’s programs are funded.

Learn More about the [https://makelivesbetter.uthscsa.edu/gccridonate Ambassadors’ Circle]

=== [https://GearUpAgainstKidsCancer.org Gear Up Against Kids Cancer Bike Ride] ===
The “Gear Up Against Kids Cancer” bike ride was created to raise public awareness of this childhood-stealing disease and support Greehey CCRI’s mission to translate today’s discoveries in childhood cancer into tomorrow’s treatments.  Proceeds generated will be used to provide pilot grants for innovative research projects that hold great promise but don’t yet qualify for federal or more extensive funding. You are helping to keep the research funding for these potentially lifesaving projects geared up and moving!  

Your participation or sponsorship makes a direct impact on pediatric cancer research right here in San Antonio! Every dollar raised supports cutting-edge research programs that help train the next generation of pediatric cancer research scientists and specialists.

Learn more at: [https://GearUpAgainstKidsCancer.org GearUpAgainstKidsCancer.org]


The institute was established in 1999 under a $200,000,000 endowment from the State of Texas tobacco settlement, at the time the largest single oncology endowment in US history. The $50 million facility was completed in 2004. The facility is part of the [[University of Texas Health Science Center at San Antonio]].<ref>http://gccri.uthscsa.edu</ref>
==See also==
==See also==
* [[South Texas Medical Center]]
* [[South Texas Medical Center]]
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==External links==
* [http://gccri.uthscsa.edu/ Official Website]
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Revision as of 12:41, 6 December 2021

Greehey CCRI is a part of the UTHSCSA.

The Greehey Children's Cancer Research Institute is a research center in San Antonio, Texas, US.

The institute was established in 1999 under a $200,000,000 endowment from the State of Texas tobacco settlement, at the time the largest single oncology endowment in US history. The $50 million facility was completed in 2004. The facility is part of the University of Texas Health Science Center at San Antonio.[1]

See also

References

  1. ^ http://gccri.uthscsa.edu


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