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Deleted and re-wrote the second half of the lead section. Added wikilinks in the body of the text. Added external link to "white matter disease (WMD)" and "cerebral microbleeds".
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'''Cerebral atrophy''' is a common feature of many of the [[Brain diseases|diseases that affect the brain]].<ref>{{Cite web |url=http://www.ninds.nih.gov/disorders/cerebral_atrophy/cerebral_atrophy.htm |title=Cerebral Atrophy Information Page: National Institute of Neurological Disorders and Stroke (NINDS)<!-- Bot generated title --> |access-date=2014-03-28 |archive-url=https://web.archive.org/web/20160304200045/http://www.altibbi.com/%D9%85%D8%B5%D8%B7%D9%84%D8%AD%D8%A7%D8%AA-%D8%B7%D8%A8%D9%8A%D8%A9//%D8%B6%D9%85%D9%88%D8%B1-%D8%A7%D9%84%D8%AF%D9%85%D8%A7%D8%BA |archive-date=2016-03-04 |url-status=dead }}</ref> [[Atrophy]] of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins. In brain tissue, atrophy describes a loss of [[neuron]]s and the connections between them. Atrophy can be generalized, which means that all of the brain has shrunk; or it can be focal, affecting only a limited area of the brain and resulting in a decrease of the functions that area of the brain controls. If the [[cerebral hemispheres]] (the two lobes of the brain that form the [[cerebrum]]) are affected, conscious thought and voluntary processes may be impaired.
'''Cerebral atrophy''' is a common feature of many of the [[Brain diseases|diseases that affect the brain]].<ref>{{Cite web |url=http://www.ninds.nih.gov/disorders/cerebral_atrophy/cerebral_atrophy.htm |title=Cerebral Atrophy Information Page: National Institute of Neurological Disorders and Stroke (NINDS)<!-- Bot generated title --> |access-date=2014-03-28 |archive-url=https://web.archive.org/web/20160304200045/http://www.altibbi.com/%D9%85%D8%B5%D8%B7%D9%84%D8%AD%D8%A7%D8%AA-%D8%B7%D8%A8%D9%8A%D8%A9//%D8%B6%D9%85%D9%88%D8%B1-%D8%A7%D9%84%D8%AF%D9%85%D8%A7%D8%BA |archive-date=2016-03-04 |url-status=dead }}</ref> [[Atrophy]] of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins. In brain tissue, atrophy describes a loss of [[neuron]]s and the connections between them. Brain atrophy can be classified into two main categories: generalized and focal atrophy<ref name=":4">{{Cite journal|last=Harris|first=Taylor C.|last2=de Rooij|first2=Rijk|last3=Kuhl|first3=Ellen|date=2019|title=The Shrinking Brain: Cerebral Atrophy Following Traumatic Brain Injury|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757025/|journal=Annals of Biomedical Engineering|volume=47|issue=9|pages=1941–1959|doi=10.1007/s10439-018-02148-2|issn=0090-6964|pmc=6757025|pmid=30341741}}</ref>. Generalized atrophy occurs across the entire brain whereas focal atrophy affects cells in a specific location<ref name=":4" />. If the [[cerebral hemispheres]] (the two lobes of the brain that form the [[cerebrum]]) are affected, conscious thought and voluntary processes may be impaired.


Some degree of cerebral shrinkage occurs naturally with the dynamic process of [[Ageing|aging]]<ref name=":5">{{Cite journal|last=Sungura|first=R.|last2=Onyambu|first2=C.|last3=Mpolya|first3=E.|last4=Sauli|first4=E.|last5=Vianney|first5=J-M|date=2021-03|title=The extended scope of neuroimaging and prospects in brain atrophy mitigation: A systematic review|url=https://linkinghub.elsevier.com/retrieve/pii/S2214751920304369|journal=Interdisciplinary Neurosurgery|language=en|volume=23|pages=100875|doi=10.1016/j.inat.2020.100875}}</ref>.The human brain completes growth and attains its full maturity at 25 years of age<ref>{{Cite journal|last=Sharma|first=Sushil|last2=Arain|last3=Mathur|last4=Rais|last5=Nel|last6=Sandhu|last7=Haque|last8=Johal|date=2013-04|title=Maturation of the adolescent brain|url=http://www.dovepress.com/maturation-of-the-adolescent-brain-peer-reviewed-article-NDT|journal=Neuropsychiatric Disease and Treatment|language=en|pages=449|doi=10.2147/NDT.S39776|issn=1176-6328|pmc=PMC3621648|pmid=23579318}}</ref>. Structural changes continue during adulthood as brain shrinkage commences after the age of 35, at a rate of 0.2% per year<ref name=":6">{{Cite book|last=Siegel|first=Jay A.|title=Encyclopedia of Forensic Sciences|last2=Saukko|first2=Pekka J.|last3=Houck|first3=Max M.|year=2013|isbn=978-0-12-382166-9}}</ref>. The rate of decline is accelerated when individuals reach 70 years old<ref>{{Cite journal|last=Peters|first=R|date=2006-2|title=Ageing and the brain|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596698/|journal=Postgraduate Medical Journal|volume=82|issue=964|pages=84–88|doi=10.1136/pgmj.2005.036665|issn=0032-5473|pmc=2596698|pmid=16461469}}</ref>. By the age of 90, the human brain will have experienced a 15% loss of its initial peak weight<ref name=":6" />. Besides brain atrophy, aging has also been associated with [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964019/ white matter disease] (WMD) and [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428007/ cerebral microbleeds]<ref name=":5" />.
Some degree of cerebral shrinkage occurs naturally with age.{{citation needed|date=September 2018}} The human brain completes growth and attains its maximum mass at around age 25{{Citation needed|date=October 2015}}; it gradually loses mass with each decade of life, although the rate of loss is comparatively tiny until the age of 60, when approximately 0.5 to 1% of brain volume is lost per year. By age 75, the brain is an average of 15% smaller than it was at 25. Some areas of the brain such as short-term memory are affected more than others and men lose more brain mass overall than women.{{Citation needed|date=April 2015}}

Brain atrophy does not affect all regions with the same intensity as shown by neuroimaging.<ref>[http://www.brainmarkers.com Brainmarkers.com] {{webarchive|url=https://web.archive.org/web/20160304235036/http://www.brainmarkers.com/ |date=March 4, 2016 }}</ref>


==Symptoms==
==Symptoms==
Many diseases that cause cerebral atrophy are associated with dementia, [[seizure]]s, and a group of language disorders called the [[aphasia]]s. Dementia is characterized by a progressive impairment of memory and intellectual function that is severe enough to interfere with social and work skills. Memory, orientation, abstraction, ability to learn, visual-spatial perception, and higher executive functions such as planning, organizing and sequencing may also be impaired. Seizures can take different forms, appearing as disorientation, strange repetitive movements, loss of consciousness, or convulsions. Aphasias are a group of disorders characterized by disturbances in speaking and understanding language. Receptive aphasia causes impaired comprehension. Expressive aphasia is reflected in odd choices of words, the use of partial phrases, disjointed clauses, and incomplete sentences.
Many diseases that cause cerebral atrophy are associated with dementia, [[seizure]]s, and a group of language disorders called the [[aphasia]]s. [[Dementia]] is characterized by a progressive impairment of memory and intellectual function that is severe enough to interfere with social and work skills. Memory, orientation, abstraction, ability to learn, visual-spatial perception, and higher executive functions such as planning, organizing and sequencing may also be impaired. Seizures can take different forms, appearing as disorientation, strange repetitive movements, loss of consciousness, or convulsions. Aphasias are a group of disorders characterized by disturbances in speaking and understanding language. [[Receptive aphasia]] causes impaired comprehension. [[Expressive aphasia]] is reflected in odd choices of words, the use of partial phrases, disjointed clauses, and incomplete sentences.


== Causes ==
== Causes ==

Revision as of 16:31, 9 December 2021

Cerebral atrophy is a common feature of many of the diseases that affect the brain.[1] Atrophy of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins. In brain tissue, atrophy describes a loss of neurons and the connections between them. Brain atrophy can be classified into two main categories: generalized and focal atrophy[2]. Generalized atrophy occurs across the entire brain whereas focal atrophy affects cells in a specific location[2]. If the cerebral hemispheres (the two lobes of the brain that form the cerebrum) are affected, conscious thought and voluntary processes may be impaired.

Some degree of cerebral shrinkage occurs naturally with the dynamic process of aging[3].The human brain completes growth and attains its full maturity at 25 years of age[4]. Structural changes continue during adulthood as brain shrinkage commences after the age of 35, at a rate of 0.2% per year[5]. The rate of decline is accelerated when individuals reach 70 years old[6]. By the age of 90, the human brain will have experienced a 15% loss of its initial peak weight[5]. Besides brain atrophy, aging has also been associated with white matter disease (WMD) and cerebral microbleeds[3].

Symptoms

Many diseases that cause cerebral atrophy are associated with dementia, seizures, and a group of language disorders called the aphasias. Dementia is characterized by a progressive impairment of memory and intellectual function that is severe enough to interfere with social and work skills. Memory, orientation, abstraction, ability to learn, visual-spatial perception, and higher executive functions such as planning, organizing and sequencing may also be impaired. Seizures can take different forms, appearing as disorientation, strange repetitive movements, loss of consciousness, or convulsions. Aphasias are a group of disorders characterized by disturbances in speaking and understanding language. Receptive aphasia causes impaired comprehension. Expressive aphasia is reflected in odd choices of words, the use of partial phrases, disjointed clauses, and incomplete sentences.

Causes

The pattern and rate of progression of cerebral atrophy depends on the disease involved.

Injury

  • Stroke, loss of brain function due to a sudden interruption of blood supply in the brain
  • Traumatic brain injury
  • Corticosteroid use (There appears to be correlations between degree of dosing with corticosteroids and cerebral atrophy)[7]
  • Environmental pollutants [8]

Diseases and disorders

Pick's disease showing brain atrophy,
  • Alzheimer's disease (High resolution MRI scans have shown the progression of cerebral atrophy in Alzheimer's disease)[9]
  • Cerebral palsy, in which lesions (damaged areas) may impair motor coordination
  • Senile dementia, fronto-temporal dementia, and vascular dementia
  • Pick's disease, causes progressive destruction of nerve cells in the brain
  • Huntington's disease, and other genetic disorders that cause build-up of toxic levels of proteins in neurons
  • Leukodystrophies, such as Krabbe disease, which destroy the myelin sheath that protects axons
  • Multiple sclerosis, which causes inflammation, myelin damage, and lesions in cerebral tissue
  • Epilepsy, in which lesions cause abnormal electrochemical discharges that result in seizures
  • Anorexia nervosa, bulimia nervosa, and other eating disorders
  • Malnutrition, caused by lack or excess of nutrition from foods
  • Type II diabetes, where the body does not use insulin properly resulting in high blood sugar
  • Bipolar disorder,[10] significant loss of brain tissue during manic episodes; however it's not verified whether the episodes cause brain tissue loss or vice versa
  • Schizophrenia[11]
  • Mitochondrial encephalomyopathies, such as Kearns–Sayre syndrome, which interfere with the basic functions of neurons
  • Posterior cortical atrophy: In the most posterior area of the brain lies the visual cortex, the area of the brain where visual information is received and processed. When cortical atrophy occurs in this brain area due to neurodegeneration, the first symptom is impairment in vision. A common vision impairment seen in patients with posterior cortical atrophy is simultanagnosia, where a person is unable to see multiple locations at once or to quickly shift attention between these locations. When looking at images of a brain suffering from posterior cortical atrophy, one can see a loss in volume of the dorsal and ventral visual pathways, where visual stimuli is brought to the visual cortex and integrated information is sent back out to other areas of the brain. Because this disorder results in visual impairments, there is often a missed or delayed diagnosis, as the assumption is that there is a problem is in the eyes when the reality is that the problem is all the way in the back of the brain.[12]
  • Prion diseases, a group of invariably fatal encephalopathies that cause the progressive death of neurons.

Infections

Where an infectious agent or the inflammatory reaction to it destroys neurons and their axons, these include...

Drug-induced

  • Alcohol (partially reversible):[13] Standardized MRI evidence suggest chronic alcoholism (alcohol use disorder) is associated with widespread cortical atrophy and major brain changes. In contrast to healthy controls, macrostructural findings indicate alcoholic brains are smaller in mass and volume.[14] Neuroimaging studies also show that cortical shrinkage in “uncomplicated alcoholism” is most severe in the frontal lobe in comparison to the other divisions of the cerebral cortex[15]. In addition, neurological diseases that co-occur with excessive alcohol consumption—such as Wernicke-Korsakoff syndrome (WKS)—are characterized by substantial volume deficits of the diencephalon structures.[15] In comparison to unaffected, non-alcoholic participants, tissue degeneration in WKS patients is found in specific white matter structures including the corpus callosum, the hippocampus, the subcortical basal ganglia (hypothalamus, thalamus, putamen), and the mammillary bodies.[16]
  • Neuroleptic

Diagnosis

Neurofilament light chain

Main article: Neurofilament light chain

Cerebrospinal fluid (CSF) is a fluid that is found exclusively in the brain and spinal cord that circulates between sections of the brain offering an extra layer of protection. Studies have shown that biomarkers in the CSF and plasma can be tracked for their presence in different parts of the brain—and their presence can tell us about cerebral atrophy. One study took advantage of biomarkers, namely one called neurofilament light chain (NFL), in patients with Alzheimer’s Disease. Neurofilament light chain is a protein that is important in the growth and branching of neurons—cells found in the brain. In Alzheimer’s Disease, neurons will stop working or die in a process called neurodegeneration. By tracking NFL, researchers can see this neurodegeneration, which this study showed was associated with brain atrophy and later cognitive decline in Alzheimer's patients. Other biomarkers like Ng – a protein important in long-term potentiation and memory – have been tracked for their associations with brain atrophy as well, but NFL had the greatest association.[17]

Measures

Brain CT with different grading systems of cerebral atrophy (seen as decreased size of gyri and secondary increased size of sulci):[18]
- Medial temporal lobe atrophy (MTA)
- Posterior atrophy (PA)
- Frontal cortical atrophy (fGCA)

CT and MRI are most commonly used to observe the brain for cerebral atrophy. A CT scan takes cross sectional images of the brain using X-rays, while an MRI uses a magnetic field. With both measures, multiple images can be compared to see if there is a loss in brain volume over time.[19]

Difference from hydrocephalus

Cerebral atrophy can be hard to distinguish from hydrocephalus because both cerebral atrophy and hydrocephalus involve an increase in cerebrospinal fluid (CSF) volume. In cerebral atrophy, this increase in CSF volume comes as a result of the decrease in cortical volume. In hydrocephalus, the increase in volume happens due to the CSF itself.[19]

Typical imaging findings in normal pressure hydrocephalus versus brain atrophy.[20]
Normal pressure hydrocephalus Brain atrophy
Preferable projection Coronal plane at the level of the posterior commissure of the brain.
Modality in this example CT MRI
CSF spaces over the convexity near the vertex (red ellipse ) Narrowed convexity ("tight convexity") as well as medial cisterns Widened vertex (red arrow) and medial cisterns (green arrow)
Callosal angle (blue V) Acute angle Obtuse angle
Most likely cause of leucoaraiosis (periventricular signal alterations, blue arrows ) Transependymal cerebrospinal fluid diapedesis Vascular encephalopathy, in this case suggested by unilateral occurrence

Treatment

Cerebral atrophy is not usually preventable. However, there are steps that can be taken to reduce the risk:

  • controlling blood pressure
  • a healthy balanced diet including omega-3's and antioxidants
  • staying active mentally, physically, and socially.[21]

Reversibility of cerebral atrophy

While most cerebral atrophy is said to be irreversible, recent studies that show this is not always the case. A child who was treated with ACTH originally showed atrophy, but four months after treatment the brain was seemingly normal again.[22]

As previously mentioned, chronic alcoholism is known to be associated with significant brain damage.[14] The pronounced shrinkage in the frontal lobes and cerebellum of alcoholics correlates with serious impairments in executive and psychomotor functions. However, longitudinal studies suggest that some of these brain damages are partially reversible with abstinence[16]. In response to drinking cessation, bodies of gray and white matter including the cerebral cortex, the limbic system (amygdala, hippocampus, thalamus), the cerebellum, and the brainstem all showed a general increase in brain volume.[15] Similarly, ventricular enlargement—which reflects atrophy of surrounding brain regions—is also reduced in abstinent alcoholics. Following extended sobriety, the volume of the lateral and third ventricles was decreased, and abstainers showed an improvement in working memory and balance.[16] Finally, evidence for the recovery of brain volume with continued sobriety is supported by the improvement in neuropsychological performance. Compared to the control participants, abstinent alcoholic patients scored significantly better on tests measuring cognitive, sensory, and motor functions including abstract reasoning, memory, visuospatial ability, and gait and balance.[16] That being said, while short-term abstinence suffices to produce structural and functional recovery, some alcohol-induced brain changes may persist even after long-term sobriety.[16]

See also

References

  1. ^ "Cerebral Atrophy Information Page: National Institute of Neurological Disorders and Stroke (NINDS)". Archived from the original on 2016-03-04. Retrieved 2014-03-28.
  2. ^ a b Harris, Taylor C.; de Rooij, Rijk; Kuhl, Ellen (2019). "The Shrinking Brain: Cerebral Atrophy Following Traumatic Brain Injury". Annals of Biomedical Engineering. 47 (9): 1941–1959. doi:10.1007/s10439-018-02148-2. ISSN 0090-6964. PMC 6757025. PMID 30341741.
  3. ^ a b Sungura, R.; Onyambu, C.; Mpolya, E.; Sauli, E.; Vianney, J-M (2021-03). "The extended scope of neuroimaging and prospects in brain atrophy mitigation: A systematic review". Interdisciplinary Neurosurgery. 23: 100875. doi:10.1016/j.inat.2020.100875. {{cite journal}}: Check date values in: |date= (help)
  4. ^ Sharma, Sushil; Arain; Mathur; Rais; Nel; Sandhu; Haque; Johal (2013-04). "Maturation of the adolescent brain". Neuropsychiatric Disease and Treatment: 449. doi:10.2147/NDT.S39776. ISSN 1176-6328. PMC 3621648. PMID 23579318. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
  5. ^ a b Siegel, Jay A.; Saukko, Pekka J.; Houck, Max M. (2013). Encyclopedia of Forensic Sciences. ISBN 978-0-12-382166-9.
  6. ^ Peters, R (2006-2). "Ageing and the brain". Postgraduate Medical Journal. 82 (964): 84–88. doi:10.1136/pgmj.2005.036665. ISSN 0032-5473. PMC 2596698. PMID 16461469. {{cite journal}}: Check date values in: |date= (help)
  7. ^ Steroids and Apparent Cerebral Atrophy on Computed Tomograph... : Journal of Computer Assisted Tomography
  8. ^ "IQs are falling - and have been for years".
  9. ^ Fox Nick C, Schott Jonathan M (2004). "Imaging cerebral atrophy: normal ageing to Alzheimer's disease". The Lancet. 363 (9406): 392–394. doi:10.1016/S0140-6736(04)15441-X. PMID 15074306. S2CID 20494612.
  10. ^ "Study links manic depression with brain tissue loss". EurekAlert!. Retrieved 2017-03-21.
  11. ^ Andreasen, Nancy C.; Liu, Dawei; Ziebell, Steven; Vora, Anvi; Ho, Beng-Choon (2013-06-01). "Relapse Duration, Treatment Intensity, and Brain Tissue Loss in Schizophrenia: A Prospective Longitudinal MRI Study". The American Journal of Psychiatry. 170 (6): 609–615. doi:10.1176/appi.ajp.2013.12050674. ISSN 0002-953X. PMC 3835590. PMID 23558429.
  12. ^ Maia, da Silva MN, Millington RS, Bridge H, James-Galton M, Plant GT (2017). "Visual Dysfunction in Posterior Cortical Atrophy". Front Neurol. 8: 389. doi:10.3389/fneur.2017.00389. PMC 5561011. PMID 28861031.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  13. ^ Pereira, Joana B.; Westman, Eric; Hansson, Oskar; Alzheimer's Disease Neuroimaging Initiative (October 2017). "Partially reversible atrophy in abstinent chronic alcoholics". Neurobiology of Aging. 58: 14–29. doi:10.1016/j.neurobiolaging.2017.06.002. PMID 28692877. S2CID 46854877.
  14. ^ a b Meyer, Jerrold S.; Quenzer, Linda F. (2013). Psychopharmacology: Drugs, The Brain, and Behavior (2nd ed.). Sinauer Associates.
  15. ^ a b c Zahr, Natalie M.; Pfefferbaum, Adolf (2017). "Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models". Alcohol Research: Current Reviews. 38 (2): 183–206. ISSN 2169-4796. PMC 5513685. PMID 28988573.
  16. ^ a b c d e Rosenbloom, Margaret J.; Pfefferbaum, Adolf (2008). "Magnetic Resonance Imaging of the Living Brain". Alcohol Research & Health. 31 (4): 362–376. ISSN 1535-7414. PMC 3860463. PMID 23584010.
  17. ^ Pereira JB, Westman E, Hansson O (October 2017). "Association between cerebrospinal fluid and plasma neurodegeneration biomarkers with brain atrophy in Alzheimer's disease". Neurobiology of Aging. 58: 14–29. doi:10.1016/j.neurobiolaging.2017.06.002. PMID 28692877. S2CID 46854877.
  18. ^ Velickaite, V.; Giedraitis, V.; Ström, K.; Alafuzoff, I.; Zetterberg, H.; Lannfelt, L.; Kilander, L.; Larsson, E-M.; Ingelsson, M. (2017). "Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease". BMC Geriatrics. 17 (1): 208. doi:10.1186/s12877-017-0601-6. ISSN 1471-2318. PMC 5591537. PMID 28886705.{{cite journal}}: CS1 maint: unflagged free DOI (link) Creative Commons Attribution 4.0 International License
  19. ^ a b "Cerebral Atrophy".
  20. ^ Damasceno, Benito Pereira (2015). "Neuroimaging in normal pressure hydrocephalus". Dementia & Neuropsychologia. 9 (4): 350–355. doi:10.1590/1980-57642015DN94000350. ISSN 1980-5764. PMC 5619317. PMID 29213984.
  21. ^ "Cerebral Atrophy: Causes". Archived from the original on 26 January 2015. Retrieved 26 January 2015.
  22. ^ Gordon Neil (2008). "Apparent Cerebral Atrophy in Patients on Treatment with Steroids". Developmental Medicine & Child Neurology. 22 (4): 502–506. doi:10.1111/j.1469-8749.1980.tb04355.x. PMID 6250932. S2CID 32099986.
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