Talk:Immune system

Image for "Helper T cells" subsection

Function of T helper cells: Antigen-presenting cells (APCs) present antigen on their Class II MHC molecules (MHC2). Helper T cells recognize these, with the help of their expression of CD4 co-receptor (CD4+). The activation of a resting helper T cell causes it to release cytokines and other stimulatory signals (green arrows) that stimulate the activity of macrophages, killer T cells and B cells, the latter producing antibodies. The stimulation of B cells and macrophages succeeds a proliferation of T helper cells.

This image is problematic for reasons I stated above in Image review. I'm tempted to create a diagram showing a CD4+ T cell at center, with an array of functions depicted around it - in the 4 corners, perhaps - cytotoxic ("killer") CD8+ T cell licensing, delayed type hypersensitivity using interferon gamma and granulomatous inflammation as a really important example (it's the basis of the Mantoux test for latent TB), B cell help in the germinal center reaction (the basis for conjugate vaccines that have been so dramatically effective, and the regulatory T cell role. I'll do my best to make it as simple/accessible as desired. Any thoughts? — soupvector (talk) 02:16, 4 December 2020 (UTC)

Yes. Thanks. Are you considering something like this [1]? Graham Beards (talk) 08:42, 4 December 2020 (UTC)

Yes, figure 2 in that paper is the sort of thing I was thinking of, but is a bit more detailed perhaps than we need for this article. — soupvector (talk) 13:41, 4 December 2020 (UTC)

Excellent. Thanks. Graham Beards (talk) 18:33, 4 December 2020 (UTC)

Cell structure addition

Graham Beards this appears to be a COI addition; is it needed, and is it in the right place? [2] SandyGeorgia (Talk) 15:44, 15 December 2020 (UTC)

PS, if I am unable to decipher why this content is there, perhaps our readers won't either. And the last sentence is uncited, just as we are asking Wehwalt to have a look as to swapping this in to TFA ... and it's a one-paragraph section. SandyGeorgia (Talk) 15:51, 15 December 2020 (UTC)

It's WP:RECENT that can be deleted. I agree, it doesn't help the reader.Graham Beards (talk) 16:40, 15 December 2020 (UTC)

Concern raised at WP:ERRORS

Please see here. I'd be grateful if someone would post a response there, though much of it may be a matter for this talk page.--Wehwalt (talk) 13:21, 30 December 2020 (UTC)

I don't regard any of the concerns to be errors.

• With regard to the use of the definite article, this is what our sources use; see for example: Sompayrac L (2019). How the immune system works. Hoboken, NJ: Wiley-Blackwell. ISBN 978-1-119-54212-4. OCLC 1083261548. (my emphasis).
• As for the use of the word "diseases". The immune system is not only important in "infectious disease" and "damage", among others in plays a role in embryology. I think, for the Lead, it's ok to lack a little precision here.
• It's not really a medical topic; it's biology.
• "The figure legend contains no errors. But an improved legend could be proposed on the article's Talk Page.
• The "other mechanisms that protect us from harm" have nothing at all to do with immunity. We draw the line where our sources do. Again see Sompayrac.
• The article is stable, and has been for years. The improvements and updates that have been made for its second time as TFA, should not be regarded as symptom of instability.

Graham Beards (talk) 15:16, 30 December 2020 (UTC)

Organs

I came to this article looking for information on immune system organs such as lymph nodes and the spleen. I noticed this information is absent. A search of the article turns up "lymph node" one time, and spleen zero times. If you think it fits, consider adding a section or paragraph somewhere listing and describing the immune system organs. This might also be a good candidate for a diagram. Maybe something similar to this. –Novem Linguae (talk) 12:50, 10 May 2021 (UTC)

Did you miss "Organs of the lymphatic system" at the bottom? Graham Beards (talk) 14:05, 10 May 2021 (UTC)

I did miss it. Thanks for pointing it out. Perhaps it deserves more weight than a collapsed navbox, but up to you guys. –Novem Linguae (talk) 19:00, 10 May 2021 (UTC)

Vitamin D

Why does this article put a sharp focus on Vitamin D? And not on other hormones that regulate immune cells? In the paragraph 'Vitamin D', nothing is explained about how this vitamin mechanistically modulates T-cells, only that T-cells extend calcitriol receptors. To get the relevance across, it might be worthwhile to explain that vitamin D deficiency is associated with autoimmune diseases. Eosino (talk) 16:21, 31 March 2022 (UTC)

Agree that the previous content was both vague from in vitro research and outdated. I replaced the content and sources with this edit. Discussing vitamin D - even with inconclusive content to reflect the current state of science - seems reasonable, as there is plentiful attention in laboratory research to identify vitamin D effects on immune cells. However, no WP:MEDRS reviews exist to establish a cause-and-effect relationship between vitamin D and immune function. Zefr (talk) 17:17, 31 March 2022 (UTC)