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== '''Q: Can N1..N9 be used directly as a flu vaccine (with a promoter) ?''' ==
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== '''Q: Can [[N1..N9]] be used [[directly]] as a flu [[vaccine]] (with a promoter) ?''' ==


'''IF'''
(1) there are a limited number of types of Neuraminidases (9 according to the article),
(2) if at least one type of Neuraminidases is present on every flu viron,
(3) if Neuraminidases subtypes (ex : N2) can be specifically recognized
as antigens by the immune system, and
(4) the immugenic epitopes on each Neuraminidases subtype are reasonably
well conserved over various flu virus mutations,

'''then'''

can '''vaccines''' be developped that '''DIRECTLY target Neuraminidases ''' -
(eg. a cocktail of N1, N2, N3..N9 with a promoter) to encourage
an immune response that is '''not diffusely aimed''' at a broad range
of viral antigens, but - rather - that is '''focussed''' on
a limited number (9) of more widely '''conserved''' antigens ?

Does anyone have information on this ?

Regards,

[[User:129.78.64.100|129.78.64.100]] 09:35, 20 February 2007 (UTC) G. Holt


(Please let me know at : ghol7955@gmp.usyd.edu.au
(Please don't spam me though!)
Thank you!
)

Revision as of 21:19, 20 February 2007