Intraneural perineurioma: Difference between revisions
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An '''intraneural perineurioma''' is a rare [[benign tumor]] within the sheath of a single nerve that grows but typically does not recur or [[metastasize]]. These lesions are only composed of perineurial cells, cloned from a single cell. They are distinct from [[schwannoma]] and [[neurofibroma]]. |
An '''intraneural perineurioma''' is a rare [[benign tumor]] within the sheath of a single nerve that grows but typically does not recur or [[metastasize]]. These lesions are only composed of perineurial cells, cloned from a single cell. They are distinct from [[schwannoma]] and [[neurofibroma]]. |
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Intraneural perineurioma is a neoplastic proliferation of perineurial cells with unique immunohistochemistry and ultrastructural features, and it is distinct from other onion bulb Schwann cell-derived entities. Despite harboring molecular abnormalities of the long arm of chromosome 22, intraneural perineurioma has not been associated with neurofibromatosis.<ref>{{cite journal |journal=Archives of Pathology & Laboratory Medicine |year=2007 |volume=131 |issue=9 |pages=1382–92 |title= Intraneural perineurioma: a systematic review with illustrative cases|author1=Boyanton BL Jr |author2=Jones JK |author3=Shenaq SM |author4=Hicks MJ |author5=Bhattacharjee MB |pmid=17824794 |doi=10.1043/1543-2165(2007)131[1382:IPASRW]2.0.CO;2}}</ref> |
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Due to the involvement of one or more nerve fascicles, intraneural perineuriomas are distinguished by a localized, solitary expansion of peripheral nerves. These tumors develop slowly or stay stable over time.<ref>Mauermann ML, Amrami KK, Kuntz NL, Spinner RJ, Dyck PJ, Bosch EP, Engelstad J, Felmlee |
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JP. Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth. Brain. 2009; 132:2265–2276. [PubMed: 19567701] |
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== References == |
== References == |
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Revision as of 18:08, 12 July 2022
An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but typically does not recur or metastasize. These lesions are only composed of perineurial cells, cloned from a single cell. They are distinct from schwannoma and neurofibroma.
Intraneural perineurioma is a neoplastic proliferation of perineurial cells with unique immunohistochemistry and ultrastructural features, and it is distinct from other onion bulb Schwann cell-derived entities. Despite harboring molecular abnormalities of the long arm of chromosome 22, intraneural perineurioma has not been associated with neurofibromatosis.[1]
Due to the involvement of one or more nerve fascicles, intraneural perineuriomas are distinguished by a localized, solitary expansion of peripheral nerves. These tumors develop slowly or stay stable over time.[2]
References
- ^ Boyanton BL Jr; Jones JK; Shenaq SM; Hicks MJ; Bhattacharjee MB (2007). "Intraneural perineurioma: a systematic review with illustrative cases". Archives of Pathology & Laboratory Medicine. 131 (9): 1382–92. doi:10.1043/1543-2165(2007)131[1382:IPASRW]2.0.CO;2. PMID 17824794.
- ^ Mauermann ML, Amrami KK, Kuntz NL, Spinner RJ, Dyck PJ, Bosch EP, Engelstad J, Felmlee JP. Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth. Brain. 2009; 132:2265–2276. [PubMed: 19567701]
Further reading
- Macarenco RS, Ellinger F, Oliveira AM (2007). "Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm". Archives of Pathology & Laboratory Medicine. 131 (4): 625–36. doi:10.1043/1543-2165(2007)131[625:PADAUP]2.0.CO;2. PMID 17425397.
- Kum YS, Kim JK, Cho CH, Kim HK (2009). "Intraneural reticular perineurioma of the hypoglossal nerve". Head Neck. 31 (6): 833–7. doi:10.1002/hed.20965. PMID 18972430.
- Chung JH, Jeong SH, Dhong ES, Han SK (2014). "Surgical removal of intraneural perineurioma arising in the brachial plexus using an interfascicular dissection technique". Arch Plast Surg. 41 (3): 296–9. doi:10.5999/aps.2014.41.3.296. PMC 4037780. PMID 24883285.
- Emory TS, Scheithauer BW, Hirose T, Wood M, Onofrio BM, Jenkins RB (1995). "Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22". Am J Clin Pathol. 103 (6): 696–704. doi:10.1093/ajcp/103.6.696. PMID 7785653.