'''Propiomazine''', sold under the brand name '''Propavan''' among others, is an [[antihistamine]] which is used to treat [[insomnia]] and to produce [[sedation]] and relieve [[anxiety]] before or during [[surgery]] or other procedures and in combination with [[analgesic]]s as well as during [[childbirth|labor]].<ref name="MortonHall2012">{{cite book | author1 = I.K. Morton |author2= Judith M. Hall | date = 6 December 2012 | title = Concise Dictionary of Pharmacological Agents: Properties and Synonyms | publisher = Springer Science & Business Media | pages = 234– | isbn = 9789401144391 | oclc = 1243535030 | url = https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA234}}</ref>{{Additional citation needed|date=July 2022}} Propiomazine is a [[phenothiazine]],<ref name="MortonHall2012" /> but is not used therapeutically as a [[neuroleptic]] because it does not block [[dopamine receptors]] well.{{Citation needed|date=July 2022}}
'''Propiomazine''', sold under the brand name '''Propavan''' among others, is an [[antihistamine]] which is used to treat [[insomnia]] and to produce [[sedation]] and relieve [[anxiety]] before or during [[surgery]] or other procedures and in combination with [[analgesic]]s as well as during [[childbirth|labor]].<ref name="MortonHall2012">{{cite book | vauthors= Morton IK, Hall JM | date = 6 December 2012 | title = Concise Dictionary of Pharmacological Agents: Properties and Synonyms | publisher = Springer Science & Business Media | pages = 234– | isbn = 9789401144391 | oclc = 1243535030 | url = https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA234}}</ref>{{Additional citation needed|date=July 2022}} Propiomazine is a [[phenothiazine]],<ref name="MortonHall2012" /> but is not used therapeutically as a [[neuroleptic]] because it does not block [[dopamine receptors]] well.{{Citation needed|date=July 2022}}
==Medical uses==
==Medical uses==
Propiomazine has been used in the treatment of [[insomnia]], though little evidence exists to inform its use for this indication.<ref name="De CrescenzoD'AlòOstinelli2022">{{cite journal | last1 = De Crescenzo |first1= Franco | last2 = D'Alò | first2 = Gian Loreto | last3 = Ostinelli | first3 = Edoardo G | last4 = Ciabattini | first4 = Marco | last5 = Di Franco | first5 = Valeria | last6 = Watanabe | first6 = Norio | last7 = Kurtulmus | first7 = Ayse | last8 = Tomlinson | first8 = Anneka | last9 = Mitrova | first9 = Zuzana | last10 = Foti | first10 = Francesca | last11 = Del Giovane |first11=Cinzia| last12 = Quested |first12= Digby J | last13 = Cowen | first13 = Phil J | last14 = Barbui | first14 = Corrado | last15 = Amato | first15 = Laura | last16 = Efthimiou | first16 = Orestis | last17 = Cipriani | first17 = Andrea | title = Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis | journal = The Lancet | date = July 2022 | volume = 400 | issue = 10347 | pages = 170–184 | issn = 0140-6736 | doi = 10.1016/S0140-6736(22)00878-9 | pmid = | url = }}</ref>
Propiomazine has been used in the treatment of [[insomnia]], though little evidence exists to inform its use for this indication.<ref name="De CrescenzoD'AlòOstinelli2022">{{cite journal | vauthors = De Crescenzo F, Foti F, Ciabattini M, Del Giovane C, Watanabe N, Schepisi MS, Quested DJ, Cipriani A, Barbui C, Amato, Efthimiou O, Cipriani A | title = Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis | journal = The Lancet | date = July 2022 | volume = 400 | issue = 10347 | pages = 170–184 | issn = 0140-6736 | doi = 10.1016/S0140-6736(22)00878-9 | pmc = 6457748 | pmid = }}</ref>
==Side effects==
==Side effects==
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===Brand names===
===Brand names===
Propiomazine has been sold under the brand names Dorevan, Dorévane, Indorm, Largon, Phenoctyl, Propavan, Propial, and Serentin.<ref name="Negwer2001">{{cite book | author = Martin Negwer | date = 2001 | title = Organic-chemical Drugs and Their Synonyms: An International Survey, Volume 3 | edition = 8 | publisher = Wiley-VCH | page = 1946 | isbn = 978-3-527-30247-5 | oclc = 50441207 | url = https://books.google.com/books?id=zmpqAAAAMAAJ | quote = Propiomazine**, Propionylpromethazine ... 9600-02 (7787-02) R Maleate (1:1) S 1678 C.B., Dorevan, Dorévane, Indorm, Phenoctyl, Propavan, Propial, Serentin, Wy-1359 U Sedative (pre-anesthetic), hypnotic ...}}</ref><ref name="SwissPharmaceuticalSociety2000">{{cite book | editor = Swiss Pharmaceutical Society | author = Swiss Pharmaceutical Society | date = 2000 | title = Index Nominum 2000: International Drug Directory | publisher = Taylor & Francis | pages = 887– | isbn = 978-3-88763-075-1 | url = https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA887}}</ref>
Propiomazine has been sold under the brand names Dorevan, Dorévane, Indorm, Largon, Phenoctyl, Propavan, Propial, and Serentin.<ref name="Negwer2001">{{cite book | vauthors = Negwer M | date = 2001 | title = Organic-chemical Drugs and Their Synonyms: An International Survey, Volume 3 | edition = 8 | publisher = Wiley-VCH | page = 1946 | isbn = 978-3-527-30247-5 | oclc = 50441207 | url = https://books.google.com/books?id=zmpqAAAAMAAJ | quote = Propiomazine**, Propionylpromethazine ... 9600-02 (7787-02) R Maleate (1:1) S 1678 C.B., Dorevan, Dorévane, Indorm, Phenoctyl, Propavan, Propial, Serentin, Wy-1359 U Sedative (pre-anesthetic), hypnotic ...}}</ref><ref name="SwissPharmaceuticalSociety2000">{{cite book | author = Swiss Pharmaceutical Society | date = 2000 | title = Index Nominum 2000: International Drug Directory | publisher = Taylor & Francis | pages = 887– | isbn = 978-3-88763-075-1 | url = https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA887}}</ref>
===Availability===
===Availability===
In 2000, propiomazine continued to be marketed only in [[Sweden]].<ref name="SwissPharmaceuticalSociety2000" />
In 2000, propiomazine continued to be marketed only in [[Sweden]].<ref name="SwissPharmaceuticalSociety2000" />
Propiomazine has been used in the treatment of insomnia, though little evidence exists to inform its use for this indication.[2]
Side effects
Drowsiness is a usual side effect. Rare, serious side effects include convulsions (seizures); difficult or unusually fast breathing; fast or irregular heartbeat or pulse; fever (high); high or low blood pressure; loss of bladder control; muscle stiffness (severe); unusual increase in sweating; unusually pale skin; and unusual tiredness or weakness.[citation needed]
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