Doramectin: Difference between revisions

Doramectin
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Injection, Topical and Oral
ATCvet code	QP54AA03 (WHO) ;
Legal status
Legal status	Veterinary use only;
Identifiers
	IUPAC name (1'R,2S,4'S,5S,6R,8'R,10'E,12'R,13'S,14'E,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one;
CAS Number	117704-25-3 ;
PubChem CID	9832750;
ChemSpider	8008478 ;
UNII	KGD7A54H5P;
KEGG	D01129 ;
CompTox Dashboard (EPA)	DTXSID9048982 ;
ECHA InfoCard	100.123.125
Chemical and physical data
Formula	C50H74O14
Molar mass	899.114 g·mol−1
	InChI InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1 ; Key:QLFZZSKTJWDQOS-YDBLARSUSA-N ;
	(verify)

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Revision as of 20:44, 8 December 2022

Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle.^[1]

It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Similarly to other drugs of this family, it is produced by fermentation by selected strains of Streptomyces avermitilis.^[2]^[3] Its spectrum includes: Haemonchus, Ostertagia, Trichostrongylus, Cooperia, and Oesophagostomum species and Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus, and Psoroptes bovis, among many other internal and external parasites. It is available as an injection and as a 5-mg/ml topical solution.^{[citation needed]}

Doramectin is also marketed in many Latin-American and some Asia and Africa countries as Doramec L.A. (manufactured by Agrovet Market Animal Health^[4]) in a 1% Doramectin Long Acting Injectable Solution for cattle, sheep, swine^[5] and others. Its oleous carrier confers to Doramec L.A. a slow and prolonged liberation, extending its action up to 42 days.

Doramectin is also available for horses^[5] as an oral, flavored, bioadhesive gel under the name Doraquest L.A. Oral Gel.^[6] It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.

References

^ Pfizer Animal Health. "DECTOMAX Injectable." Archived August 14, 2007, at the Wayback Machine Last accessed July 14, 2007.
^ Dectomax product information (Zoetis US)
^ Goudie AC, Evans NA, Gration KA, Bishop BF, Gibson SP, Holdom KS, Kaye B, Wicks SR, Lewis D, Weatherley AJ (July 1993). "Doramectin--a potent novel endectocide". Veterinary Parasitology. 49 (1): 5–15. doi:10.1016/0304-4017(93)90218-c. PMID 8236738.
^ Agrovet Market Animal Health-Doramec L.A.
^ ^a ^b Agrovet Market Animal Health
^ Agrovet Market Animal Health-Doraquest L.A. Oral Gel

[1] Pfizer Animal Health. "DECTOMAX Injectable." Archived August 14, 2007, at the Wayback Machine Last accessed July 14, 2007.

[2] Dectomax product information (Zoetis US)

[pmid8236738-3] Goudie AC, Evans NA, Gration KA, Bishop BF, Gibson SP, Holdom KS, Kaye B, Wicks SR, Lewis D, Weatherley AJ (July 1993). "Doramectin--a potent novel endectocide". Veterinary Parasitology. 49 (1): 5–15. doi:10.1016/0304-4017(93)90218-c. PMID 8236738.

[4] Agrovet Market Animal Health-Doramec L.A.

[Agrovet_Market_Animal_Health_-_Peru-5] Agrovet Market Animal Health

[6] Agrovet Market Animal Health-Doraquest L.A. Oral Gel

[1]

[2]

[3]

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[6]

@@ Line 54: / Line 54: @@
 '''Doramectin''' ('''Dectomax''') is a [[veterinary drug]] approved by the [[Food and Drug Administration]] (FDA) for the treatment of parasites such as gastrointestinal [[roundworm]]s, [[lungworm]]s, [[eyeworm]]s, [[Larva|grub]]s, [[sucking lice]] and [[mange mite]]s in cattle.<ref>Pfizer Animal Health. [http://www.pfizerah.com/product_overview.asp?drug=DT&country=US&Lang=EN&species=BF "DECTOMAX Injectable."] {{webarchive |url=https://web.archive.org/web/20070814064418/http://www.pfizerah.com/product_overview.asp?drug=DT&country=US&Lang=EN&species=BF |date=August 14, 2007 }} Last accessed July 14, 2007.</ref>
-It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of [[ivermectin]]. Similarly to other drugs of this family, it is produced by fermentation by selected strains of ''[[Streptomyces avermitilis]]''.<ref>[https://www.zoetisus.com/products/beef/dectomax-pour-on-solution.aspx Dectomax product information (Zoetis US)]</ref><ref name="pmid8236738">{{cite journal | vauthors = Goudie AC, Evans NA, Gration KA, Bishop BF, Gibson SP, Holdom KS, Kaye B, Wicks SR, Lewis D, Weatherley AJ | title = Doramectin--a potent novel endectocide | journal = Veterinary Parasitology | volume = 49 | issue = 1 | pages = 5–15 | date = July 1993 | pmid = 8236738 | doi = 10.1016/0304-4017(93)90218-c  }}</ref> Its spectrum includes: ''[[Haemonchus]], [[Ostertagia]], [[Trichostrongylus]], [[Cooperia (nematode)|Cooperia]]'', and ''[[Oesophagostomum]]'' species and ''[[Dictyocaulus viviparus]]'', ''[[Dermatobia hominis]], [[Boophilus microplus]]'', and ''[[Psoroptes bovis]]'', among many other internal and external parasites. It is available as an [[Injection (medicine)|injection]] and as a 5-mg/ml [[topical]] solution.{{cn}}
+It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of [[ivermectin]]. Similarly to other drugs of this family, it is produced by fermentation by selected strains of ''[[Streptomyces avermitilis]]''.<ref>[https://www.zoetisus.com/products/beef/dectomax-pour-on-solution.aspx Dectomax product information (Zoetis US)]</ref><ref name="pmid8236738">{{cite journal | vauthors = Goudie AC, Evans NA, Gration KA, Bishop BF, Gibson SP, Holdom KS, Kaye B, Wicks SR, Lewis D, Weatherley AJ | title = Doramectin--a potent novel endectocide | journal = Veterinary Parasitology | volume = 49 | issue = 1 | pages = 5–15 | date = July 1993 | pmid = 8236738 | doi = 10.1016/0304-4017(93)90218-c  }}</ref> Its spectrum includes: ''[[Haemonchus]], [[Ostertagia]], [[Trichostrongylus]], [[Cooperia (nematode)|Cooperia]]'', and ''[[Oesophagostomum]]'' species and ''[[Dictyocaulus viviparus]]'', ''[[Dermatobia hominis]], [[Boophilus microplus]]'', and ''[[Psoroptes bovis]]'', among many other internal and external parasites. It is available as an [[Injection (medicine)|injection]] and as a 5-mg/ml [[topical]] solution.{{cn|date=December 2022}}
 Doramectin is also marketed in many Latin-American and some Asia and Africa countries as Doramec L.A. (manufactured by Agrovet Market Animal Health<ref>[http://www.agrovetmarket.com/ViewCatalogUI.aspx?.language=2&.product=73 Agrovet Market Animal Health-Doramec L.A.]</ref>) in a 1% Doramectin Long Acting Injectable Solution for [[cattle]], [[sheep]], [[swine]]<ref name="Agrovet Market Animal Health - Peru">[http://www.agrovetmarket.com Agrovet Market Animal Health]</ref> and others. Its oleous carrier confers to Doramec L.A. a slow and prolonged liberation, extending its action up to 42 days.