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== Research ==
== Research ==
Roeder used budding yeast as a model system to examine meiosis. She discovered the Zip1 protein,<ref>{{cite journal |last1=Sym |first1=Mary |last2=Engebrecht |first2=JoAnne |last3=Roeder |first3=G. Shirleen |title=ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis |journal=Cell |date=12 February 1993 |volume=72 |issue=3 |pages=365–378 |doi=10.1016/0092-8674(93)90114-6 |pmid=7916652 |s2cid=6174855 |url=https://doi.org/10.1016/0092-8674(93)90114-6 |language=English |issn=0092-8674|doi-access=free }}</ref> and discovered two distinct processes that regulate the [[Homologous recombination|recombination]] between [[chromosome]]s in meiosis and also a process inhibiting recombination.<ref name=":1">{{Cite web|title="G Shirleen Roeder, Yale University"|url=http://www.nasonline.org/member-directory/members/20020185.html|access-date=November 14, 2018|website=National Academy of Sciences}}</ref>
Roeder used budding yeast as a model system to examine meiosis. She discovered the Zip1 protein,<ref>{{cite journal |last1=Sym |first1=Mary |last2=Engebrecht |first2=JoAnne |last3=Roeder |first3=G. Shirleen |title=ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis |journal=Cell |date=12 February 1993 |volume=72 |issue=3 |pages=365–378 |doi=10.1016/0092-8674(93)90114-6 |pmid=7916652 |s2cid=6174855 |language=English |issn=0092-8674|doi-access=free }}</ref> and discovered two distinct processes that regulate the [[Homologous recombination|recombination]] between [[chromosome]]s in meiosis and also a process inhibiting recombination.<ref name=":1">{{Cite web|title="G Shirleen Roeder, Yale University"|url=http://www.nasonline.org/member-directory/members/20020185.html|access-date=November 14, 2018|website=National Academy of Sciences}}</ref>


==Selected publications==
==Selected publications==
*{{cite journal |last1=Roeder |first1=G. Shirleen |title=Meiotic chromosomes: it takes two to tango |journal=Genes & Development |date=15 October 1997 |volume=11 |issue=20 |pages=2600–2621 |doi=10.1101/gad.11.20.2600 |pmid=9334324 |url=http://genesdev.cshlp.org/content/11/20/2600.short |language=en |issn=0890-9369|doi-access=free }}
*{{cite journal |last1=Roeder |first1=G. Shirleen |title=Meiotic chromosomes: it takes two to tango |journal=Genes & Development |date=15 October 1997 |volume=11 |issue=20 |pages=2600–2621 |doi=10.1101/gad.11.20.2600 |pmid=9334324 |url=http://genesdev.cshlp.org/content/11/20/2600.short |language=en |issn=0890-9369|doi-access=free }}
*{{cite journal |last1=Sym |first1=Mary |last2=Engebrecht |first2=JoAnne |last3=Roeder |first3=G. Shirleen |title=ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis |journal=Cell |date=12 February 1993 |volume=72 |issue=3 |pages=365–378 |doi=10.1016/0092-8674(93)90114-6 |pmid=7916652 |s2cid=6174855 |url=https://doi.org/10.1016/0092-8674(93)90114-6 |language=English |issn=0092-8674|doi-access=free }}
*{{cite journal |last1=Sym |first1=Mary |last2=Engebrecht |first2=JoAnne |last3=Roeder |first3=G. Shirleen |title=ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis |journal=Cell |date=12 February 1993 |volume=72 |issue=3 |pages=365–378 |doi=10.1016/0092-8674(93)90114-6 |pmid=7916652 |s2cid=6174855 |language=English |issn=0092-8674|doi-access=free }}
*{{cite journal |last1=Roeder |first1=G. Shirleen |last2=Bailis |first2=Julie M. |title=The pachytene checkpoint |journal=Trends in Genetics |date=1 September 2000 |volume=16 |issue=9 |pages=395–403 |doi=10.1016/S0168-9525(00)02080-1 |pmid=10973068 |url=https://doi.org/10.1016/S0168-9525(00)02080-1 |language=English |issn=0168-9525}}
*{{cite journal |last1=Roeder |first1=G. Shirleen |last2=Bailis |first2=Julie M. |title=The pachytene checkpoint |journal=Trends in Genetics |date=1 September 2000 |volume=16 |issue=9 |pages=395–403 |doi=10.1016/S0168-9525(00)02080-1 |pmid=10973068 |url=https://doi.org/10.1016/S0168-9525(00)02080-1 |language=English |issn=0168-9525}}
*{{cite journal |last1=Ross-Macdonald |first1=Petra |last2=Roeder |first2=G. Shirleen |title=Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction |journal=Cell |date=16 December 1994 |volume=79 |issue=6 |pages=1069–1080 |doi=10.1016/0092-8674(94)90037-X |pmid=8001134 |s2cid=28539509 |url=https://doi.org/10.1016/0092-8674(94)90037-X |language=English |issn=0092-8674}}
*{{cite journal |last1=Ross-Macdonald |first1=Petra |last2=Roeder |first2=G. Shirleen |title=Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction |journal=Cell |date=16 December 1994 |volume=79 |issue=6 |pages=1069–1080 |doi=10.1016/0092-8674(94)90037-X |pmid=8001134 |s2cid=28539509 |url=https://doi.org/10.1016/0092-8674(94)90037-X |language=English |issn=0092-8674}}

Revision as of 04:39, 12 March 2023

G. Shirleen Roeder
Alma materUniversity of Toronto
Scientific career
ThesisRecombination, maturation and packaging of the bacteriophage T7 chromosome (1978)

Glenna Shirleen Roeder is a geneticist known for identifying and characterizing the yeast genes that regulate the process of meiosis with particular emphasis on synapsis.

Education and career

Roeder has a B.Sc. from Dalhousie University (1973)[1][2] and earned her Ph.D. in 1978 from the University of Toronto.[3] Following her Ph.D. she was a postdoctoral fellow at Cornell University before moving to the faculty at Yale University in 1981.[4] In 2001 she was named the Eugene Higgins Professor of Genetics in the Molecular, Cellular, and Developmental Biology Department at Yale University.[4] Roeder retired in 2012[1] and, as of 2021, she is Professor Emeritus at Yale University.[5]

Research

Roeder used budding yeast as a model system to examine meiosis. She discovered the Zip1 protein,[6] and discovered two distinct processes that regulate the recombination between chromosomes in meiosis and also a process inhibiting recombination.[7]

Selected publications

  • Roeder, G. Shirleen (15 October 1997). "Meiotic chromosomes: it takes two to tango". Genes & Development. 11 (20): 2600–2621. doi:10.1101/gad.11.20.2600. ISSN 0890-9369. PMID 9334324.
  • Sym, Mary; Engebrecht, JoAnne; Roeder, G. Shirleen (12 February 1993). "ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis". Cell. 72 (3): 365–378. doi:10.1016/0092-8674(93)90114-6. ISSN 0092-8674. PMID 7916652. S2CID 6174855.
  • Roeder, G. Shirleen; Bailis, Julie M. (1 September 2000). "The pachytene checkpoint". Trends in Genetics. 16 (9): 395–403. doi:10.1016/S0168-9525(00)02080-1. ISSN 0168-9525. PMID 10973068.
  • Ross-Macdonald, Petra; Roeder, G. Shirleen (16 December 1994). "Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction". Cell. 79 (6): 1069–1080. doi:10.1016/0092-8674(94)90037-X. ISSN 0092-8674. PMID 8001134. S2CID 28539509.

Awards and honors

In 1984, Roeder received a Young Investigator award from the National Science Foundation.[8] She was named an HHMI investigator in 1997,[9] and was elected to the National Academy of Sciences in 2009.[7] In 2010, she was chosen as a Fellow of the American Association for the Advancement of Science[10] and elected to the American Academy of Microbiology.[11][12]

References

  1. ^ a b "Faculty retirement tribute to G. Shirleen Roeder". Yale University. 2012. Archived from the original on December 30, 2021. Retrieved December 30, 2021.
  2. ^ "science.ca : Shirleen Roeder". www.science.ca. Retrieved 2021-12-30.
  3. ^ Roeder, Glenna Shirleen (1978). Recombination, maturation and packaging of the bacteriophage T7 chromosome (Thesis). Toronto: [publisher not identified].
  4. ^ a b "Geneticist Shirleen Roeder named Eugene Higgins Professor". Yale Bulletin and Calendar. June 15, 2001. Retrieved 2021-12-30.{{cite web}}: CS1 maint: url-status (link)
  5. ^ "G Shirleen Roeder, Ph.D. | Molecular, Cellular and Developmental Biology". mcdb.yale.edu. Retrieved 2021-12-30.
  6. ^ Sym, Mary; Engebrecht, JoAnne; Roeder, G. Shirleen (12 February 1993). "ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis". Cell. 72 (3): 365–378. doi:10.1016/0092-8674(93)90114-6. ISSN 0092-8674. PMID 7916652. S2CID 6174855.
  7. ^ a b ""G Shirleen Roeder, Yale University"". National Academy of Sciences. Retrieved November 14, 2018.
  8. ^ "NSF Award Search: Award # 8351607 - Presidential Young Investigator Award". www.nsf.gov. Retrieved 2021-12-30.
  9. ^ ""G. Shirleen Roeder, PhD"". Howard Hughes Medical Institute. Retrieved November 14, 2018.
  10. ^ Luna, Regina (September 1, 2010). ""Yale Scientists Awarded AAAS Fellowship"". Yale Scientific. Retrieved November 14, 2018.
  11. ^ ""AAM Fellows G. Shirleen Roeder"". American Academy of Microbiology. Retrieved November 14, 2018.{{cite web}}: CS1 maint: url-status (link)
  12. ^ "78 scientists elected to the American Academy of Microbiology". EurekAlert!. Retrieved 2021-12-30.


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